LOCUS       NM_030584                669 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus sclerostin (Sost), mRNA.
ACCESSION   NM_030584
VERSION     NM_030584.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 669)
  AUTHORS   Osumi,R., Wang,Z., Ishihara,Y., Odagaki,N., Iimura,T. and
            Kamioka,H.
  TITLE     Changes in the intra- and peri-cellular sclerostin distribution in
            lacuno-canalicular system induced by mechanical unloading
  JOURNAL   J Bone Miner Metab 39 (2), 148-159 (2021)
   PUBMED   32844318
  REMARK    GeneRIF: Changes in the intra- and peri-cellular sclerostin
            distribution in lacuno-canalicular system induced by mechanical
            unloading.
            Erratum:[J Bone Miner Metab. 2021 Mar;39(2):160-162. doi:
            10.1007/s00774-020-01155-5.. PMID: 33025107]
REFERENCE   2  (bases 1 to 669)
  AUTHORS   Huang,Y., Wang,X., Wu,F., Lu,Y., Liang,G. and Liu,A.
  TITLE     The Possible Role of Sclerostin in the Pathogenesis of
            Tympanosclerosis
  JOURNAL   Audiol Neurootol 26 (2), 102-110 (2021)
   PUBMED   33508832
  REMARK    GeneRIF: The Possible Role of Sclerostin in the Pathogenesis of
            Tympanosclerosis.
REFERENCE   3  (bases 1 to 669)
  AUTHORS   De Mare,A., Maudsley,S., Azmi,A., Hendrickx,J.O., Opdebeeck,B.,
            Neven,E., D'Haese,P.C. and Verhulst,A.
  TITLE     Sclerostin as Regulatory Molecule in Vascular Media Calcification
            and the Bone-Vascular Axis
  JOURNAL   Toxins (Basel) 11 (7), 428 (2019)
   PUBMED   31330917
  REMARK    GeneRIF: Sclerostin as Regulatory Molecule in Vascular Media
            Calcification and the Bone-Vascular Axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 669)
  AUTHORS   Korn,P., Kramer,I., Schlottig,F., Todtman,N., Eckelt,U., Burki,A.,
            Ferguson,S.J., Kautz,A., Schnabelrauch,M., Range,U., Kneissel,M.
            and Stadlinger,B.
  TITLE     Systemic sclerostin antibody treatment increases osseointegration
            and biomechanical competence of zoledronic-acid-coated dental
            implants in a rat osteoporosis model
  JOURNAL   Eur Cell Mater 37, 333-346 (2019)
   PUBMED   31112281
  REMARK    GeneRIF: The combination of ZOL and the osteoanabolic sclerostin
            antibody was more effective than either agent alone.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 669)
  AUTHORS   Wang,J., Qiu,X., Xu,T., Sheng,Z. and Yao,L.
  TITLE     Sclerostin/Receptor Related Protein 4 and Ginkgo Biloba Extract
            Alleviates beta-Glycerophosphate-Induced Vascular Smooth Muscle
            Cell Calcification By Inhibiting Wnt/beta-Catenin Pathway
  JOURNAL   Blood Purif 47 Suppl 1 (Suppl 1), 17-23 (2019)
   PUBMED   30699436
  REMARK    GeneRIF: beta-GP induced VSMC calcification by activating the
            Wnt/beta-catenin signaling pathway. Sclerostin and Lrp4 were
            involved in beta-GP-induced VSMC calcification and play an
            important role. GBE could alleviate VSMC calcification induced by
            beta-GP through inhibiting the Wnt/beta-catenin signaling pathway.
REFERENCE   6  (bases 1 to 669)
  AUTHORS   Keller,H. and Kneissel,M.
  TITLE     SOST is a target gene for PTH in bone
  JOURNAL   Bone 37 (2), 148-158 (2005)
   PUBMED   15946907
  REMARK    GeneRIF: SOST regulation may play a role in mediating PTH action in
            bone
REFERENCE   7  (bases 1 to 669)
  AUTHORS   Semenov,M., Tamai,K. and He,X.
  TITLE     SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
  JOURNAL   J Biol Chem 280 (29), 26770-26775 (2005)
   PUBMED   15908424
REFERENCE   8  (bases 1 to 669)
  AUTHORS   Winkler,D.G., Yu,C., Geoghegan,J.C., Ojala,E.W., Skonier,J.E.,
            Shpektor,D., Sutherland,M.K. and Latham,J.A.
  TITLE     Noggin and sclerostin bone morphogenetic protein antagonists form a
            mutually inhibitory complex
  JOURNAL   J Biol Chem 279 (35), 36293-36298 (2004)
   PUBMED   15199066
  REMARK    GeneRIF: noggin and sclerostin form a mutually inhibitory complex
            that fine-tunes of BMP activity in bone homeostasis
REFERENCE   9  (bases 1 to 669)
  AUTHORS   Winkler,D.G., Sutherland,M.K., Geoghegan,J.C., Yu,C., Hayes,T.,
            Skonier,J.E., Shpektor,D., Jonas,M., Kovacevich,B.R.,
            Staehling-Hampton,K., Appleby,M., Brunkow,M.E. and Latham,J.A.
  TITLE     Osteocyte control of bone formation via sclerostin, a novel BMP
            antagonist
  JOURNAL   EMBO J 22 (23), 6267-6276 (2003)
   PUBMED   14633986
REFERENCE   10 (bases 1 to 669)
  AUTHORS   Brunkow,M.E., Gardner,J.C., Van Ness,J., Paeper,B.W.,
            Kovacevich,B.R., Proll,S., Skonier,J.E., Zhao,L., Sabo,P.J., Fu,Y.,
            Alisch,R.S., Gillett,L., Colbert,T., Tacconi,P., Galas,D.,
            Hamersma,H., Beighton,P. and Mulligan,J.
  TITLE     Bone dysplasia sclerosteosis results from loss of the SOST gene
            product, a novel cystine knot-containing protein
  JOURNAL   Am J Hum Genet 68 (3), 577-589 (2001)
   PUBMED   11179006
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_030584.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF326741.1, BE101082.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               JAXUCZ010000010.1  87415520-87415766   c
            248-669             JAXUCZ010000010.1  87412722-87413143   c
FEATURES             Location/Qualifiers
     source          1..669
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..669
                     /gene="Sost"
                     /note="sclerostin"
                     /db_xref="GeneID:80722"
                     /db_xref="RGD:69358"
     exon            1..247
                     /gene="Sost"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..669
                     /gene="Sost"
                     /note="sclerosteosis"
                     /codon_start=1
                     /product="sclerostin precursor"
                     /protein_id="NP_085073.1"
                     /db_xref="GeneID:80722"
                     /db_xref="RGD:69358"
                     /translation="MQLSLAPCLACLLVHAAFVAVESQGWQAFKNDATEIIPGLREYP
                     EPPQELENNQTMNRAENGGRPPHHPYDTKDVSEYSCRELHYTRFVTDGPCRSAKPVTE
                     LVCSGQCGPARLLPNAIGRVKWWRPNGPDFRCIPDRYRAQRVQLLCPGGAAPRSRKVR
                     LVASCKCKRLTRFHNQSELKDFGPETARPQKGRKPRPRARGAKANQAELENAY"
     exon            248..669
                     /gene="Sost"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accgagtgcc ctcctccttc tggcaccatg cagctctcac tagccccttg ccttgcctgc
       61 ctgcttgtac atgcagcctt cgttgctgtg gagagccagg ggtggcaagc cttcaagaat
      121 gatgccacag aaatcatccc gggactcaga gagtacccag agcctcctca ggaactagag
      181 aacaaccaga ccatgaaccg ggccgagaac ggaggcagac ccccccacca tccttatgac
      241 accaaagacg tgtccgagta cagctgccgc gagctgcact acacccgctt cgtgaccgac
      301 ggcccgtgcc gcagtgccaa gccggtcacc gagttggtgt gctcgggcca gtgcggcccc
      361 gcgcggctgc tgcccaacgc catcgggcgc gtgaagtggt ggcgcccgaa cggacccgac
      421 ttccgctgca tcccggatcg ctaccgcgcg cagcgggtgc agctgctgtg ccccggcggc
      481 gcggcgccgc gctcgcgcaa ggtgcgtctg gtggcctcgt gcaagtgcaa gcgcctcacc
      541 cgcttccaca accagtcgga gctcaaggac ttcggacctg agaccgcgcg gccgcagaag
      601 ggtcgcaagc cgcggccccg cgcccgggga gccaaagcca accaggcgga gctggagaac
      661 gcctactag
//
