LOCUS       NM_001135561            5365 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus SOS Ras/Rho guanine nucleotide exchange factor 2
            (Sos2), mRNA.
ACCESSION   NM_001135561 XM_001080400
VERSION     NM_001135561.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5365)
  AUTHORS   Baltanas,F.C., Perez-Andres,M., Ginel-Picardo,A., Diaz,D.,
            Jimeno,D., Liceras-Boillos,P., Kortum,R.L., Samelson,L.E., Orfao,A.
            and Santos,E.
  TITLE     Functional redundancy of Sos1 and Sos2 for lymphopoiesis and
            organismal homeostasis and survival
  JOURNAL   Mol Cell Biol 33 (22), 4562-4578 (2013)
   PUBMED   24043312
REFERENCE   2  (bases 1 to 5365)
  AUTHORS   Mihara,M., Hashizume,M., Yoshida,H., Suzuki,M. and Shiina,M.
  TITLE     IL-6/IL-6 receptor system and its role in physiological and
            pathological conditions
  JOURNAL   Clin Sci (Lond) 122 (4), 143-159 (2012)
   PUBMED   22029668
  REMARK    Review article
REFERENCE   3  (bases 1 to 5365)
  AUTHORS   Shi,G.X., Jin,L. and Andres,D.A.
  TITLE     Src-dependent TrkA transactivation is required for pituitary
            adenylate cyclase-activating polypeptide 38-mediated Rit activation
            and neuronal differentiation
  JOURNAL   Mol Biol Cell 21 (9), 1597-1608 (2010)
   PUBMED   20219970
REFERENCE   4  (bases 1 to 5365)
  AUTHORS   Citri,A. and Yarden,Y.
  TITLE     EGF-ERBB signalling: towards the systems level
  JOURNAL   Nat Rev Mol Cell Biol 7 (7), 505-516 (2006)
   PUBMED   16829981
  REMARK    Review article
REFERENCE   5  (bases 1 to 5365)
  AUTHORS   Aoki,K., Nakamura,T., Fujikawa,K. and Matsuda,M.
  TITLE     Local phosphatidylinositol 3,4,5-trisphosphate accumulation
            recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite
            outgrowth in nerve growth factor-stimulated PC12 cells
  JOURNAL   Mol Biol Cell 16 (5), 2207-2217 (2005)
   PUBMED   15728722
REFERENCE   6  (bases 1 to 5365)
  AUTHORS   Khamzina,L., Gruppuso,P.A. and Wands,J.R.
  TITLE     Insulin signaling through insulin receptor substrate 1 and 2 in
            normal liver development
  JOURNAL   Gastroenterology 125 (2), 572-585 (2003)
   PUBMED   12891559
REFERENCE   7  (bases 1 to 5365)
  AUTHORS   Kontkanen,O., Toronen,P., Lakso,M., Wong,G. and Castren,E.
  TITLE     Antipsychotic drug treatment induces differential gene expression
            in the rat cortex
  JOURNAL   J Neurochem 83 (5), 1043-1053 (2002)
   PUBMED   12437575
REFERENCE   8  (bases 1 to 5365)
  AUTHORS   Najib,S. and Sanchez-Margalet,V.
  TITLE     Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the
            Grb2-SOS complex in insulin receptor signaling
  JOURNAL   J Cell Biochem 86 (1), 99-106 (2002)
   PUBMED   12112020
  REMARK    GeneRIF: Sam68 associates with the SH3 domains of Grb2 recruiting
            GAP to the Grb2-SOS complex in insulin receptor signaling
REFERENCE   9  (bases 1 to 5365)
  AUTHORS   Kim,Y.B., Inoue,T., Nakajima,R., Shirai-Morishita,Y., Tokuyama,K.
            and Suzuki,M.
  TITLE     Effect of long-term exercise on gene expression of insulin
            signaling pathway intermediates in skeletal muscle
  JOURNAL   Biochem Biophys Res Commun 254 (3), 720-727 (1999)
   PUBMED   9920808
REFERENCE   10 (bases 1 to 5365)
  AUTHORS   Skolnik,E.Y., Batzer,A., Li,N., Lee,C.H., Lowenstein,E.,
            Mohammadi,M., Margolis,B. and Schlessinger,J.
  TITLE     The function of GRB2 in linking the insulin receptor to Ras
            signaling pathways
  JOURNAL   Science 260 (5116), 1953-1955 (1993)
   PUBMED   8316835
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Oct 1, 2008 this sequence version replaced XM_001080400.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.16093.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                JAXUCZ010000006.1  93891903-93891989   c
            88-213              JAXUCZ010000006.1  93856631-93856756   c
            214-345             JAXUCZ010000006.1  93850470-93850601   c
            346-510             JAXUCZ010000006.1  93849049-93849213   c
            511-717             JAXUCZ010000006.1  93840645-93840851   c
            718-861             JAXUCZ010000006.1  93837073-93837216   c
            862-972             JAXUCZ010000006.1  93833397-93833507   c
            973-1071            JAXUCZ010000006.1  93828646-93828744   c
            1072-1199           JAXUCZ010000006.1  93814350-93814477   c
            1200-1855           JAXUCZ010000006.1  93813112-93813767   c
            1856-1937           JAXUCZ010000006.1  93812530-93812611   c
            1938-2060           JAXUCZ010000006.1  93810948-93811070   c
            2061-2164           JAXUCZ010000006.1  93807928-93808031   c
            2165-2387           JAXUCZ010000006.1  93806565-93806787   c
            2388-2507           JAXUCZ010000006.1  93803656-93803775   c
            2508-2670           JAXUCZ010000006.1  93803348-93803510   c
            2671-2788           JAXUCZ010000006.1  93792764-93792881   c
            2789-2961           JAXUCZ010000006.1  93790894-93791066   c
            2962-3078           JAXUCZ010000006.1  93788319-93788435   c
            3079-3340           JAXUCZ010000006.1  93785667-93785928   c
            3341-3382           JAXUCZ010000006.1  93783988-93784029   c
            3383-3492           JAXUCZ010000006.1  93781800-93781909   c
            3493-5365           JAXUCZ010000006.1  93778971-93780843   c
FEATURES             Location/Qualifiers
     source          1..5365
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..5365
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /note="SOS Ras/Rho guanine nucleotide exchange factor 2"
                     /db_xref="GeneID:85384"
                     /db_xref="RGD:620435"
     CDS             1..4002
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /note="son of sevenless 1"
                     /codon_start=1
                     /product="son of sevenless homolog 2"
                     /protein_id="NP_001129033.1"
                     /db_xref="GeneID:85384"
                     /db_xref="RGD:620435"
                     /translation="MQQAPQPYEFFSEENSPKWRGLLVPALRKVQEQVHPTLSANEES
                     LYYIEELIFQLLNKLCLAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNP
                     LLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQ
                     DIKVSMCADKVLMDMFDQDDDIGLVSLCEEEPCSSGELNYYDLVRTEIAEERQYLREL
                     NMIIKVFREAFLSDKKLFKSSEIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHP
                     LAGSCFEDLAEEQAFDPYETLSQDILAPEFNDHFSKLMARPAVALHFQSIADGFKEAV
                     RYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQ
                     HSPRRRPGDPVCLFYNRQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLT
                     RIGAKHERHIFLFDGLMISCKPNHCQTRLPGYSSAEYRLKEKFVMRKIQICDKEDACE
                     YKHAFELVSKDENSVIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPL
                     RLPRPDVYRFVVTDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVR
                     TFLTTYRSFCKPQELLSLLIERFEIPDPEPTEADKLALEKGEQPISADLKRFRKEYVQ
                     PVQLRVLNVFRHWVEHHFYDFERDLELLERLEAFISSVRGKAMKKWVESIAKIIKRKK
                     QAQANGVSHNITFESPPPPVEWHISRAGQSETFDLMTLHPIEIARQLTLLESDLYRRV
                     QPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIVE
                     ILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRRVLDDAVELSQDHFKKY
                     LVKLKSINPPCVPFFGIYLTNILKTEEGNSDFLKRKGKDLINFSKRRKVAEITGEIQQ
                     YQNQPYCLRTEPEMRRFFENLNPMGLLSEKEFTDYLFNKSHEIEPRNCKQPPRFPRKS
                     TFSLKSPGIRPNASRHGSTSGTFRGHPTPLEREPYKISFSRIAETELESTVSAPTSPN
                     TPSTPPVSASSDHSVFLDVDLNSSCGSNTIFAPVLLPHSKSFFSSCGSLHKLSEEPLV
                     PPPLPPRKKFDHDAPNSKGAMKSDDDPPAIPPRQPPPPKVKPRAPVLTGTFEGPVPSP
                     PPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHPHRDPDWLRDVSTCPNSPST
                     PPPTPSPRIPRRCHLPSPSHNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPL
                     YRLPLFENAETPQ"
     exon            1..87
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            88..213
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            214..345
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..510
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..717
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..861
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            862..972
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1071
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1199
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1855
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1937
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2060
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2164
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2387
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2507
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2670
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2788
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2961
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            2962..3078
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3340
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            3341..3382
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            3383..3492
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..5365
                     /gene="Sos2"
                     /gene_synonym="Sos1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcagcagg cgccgcagcc ctacgagttc ttcagcgaag agaacagccc gaaatggcgg
       61 ggactgttgg tcccggccct gcggaaggtt caggagcaag tgcaccccac cctgtcggct
      121 aacgaagagt ctctctatta catcgaagaa ctcatctttc aactgctcaa taagctgtgc
      181 ctggctcaac cgaggactgt tcaagatgtt gaggaacgag ttcaaaagac ttttcctcat
      241 cctattgata aatgggcaat tgctgatgca cagtctgcca tagagaaacg aaaacgaaga
      301 aatcctctct tactacctgt ggacaaaatc catccttcct tgaaggaagt tttggggtat
      361 aaagtggact accatgtatc cctctacatt gtggctgtat tggagtatat ctcagcagat
      421 attttgaaat tggctggtaa ttatgttttt aatatccggc attatgaaat atctcagcaa
      481 gacattaaag tgtcaatgtg tgcagataag gttttgatgg acatgtttga ccaggatgac
      541 gatataggct tggtttctct ctgtgaagag gaaccttgtt cttctggtga gctaaactat
      601 tatgaccttg ttagaactga aatcgcagaa gaaagacagt atctacggga actgaatatg
      661 atcattaaag tattccggga agcctttctt tcagacaaaa agttgttcaa gtcttctgaa
      721 attgaaaaga ttttcagtaa catttcagat atacatgaac tgactgtgaa acttttaggt
      781 ttgattgaag acacagtaga aatgacagat gaaagcagtc ctcacccgct agctggtagc
      841 tgctttgaag atttagcaga ggagcaggct tttgacccct atgaaacgtt atcacaggac
      901 attcttgctc cagagtttaa tgaccacttc agcaagttga tggccagacc tgcagttgct
      961 ctgcactttc agtccattgc tgacggcttt aaggaggctg ttcgatatgt ccttccgcgc
     1021 ctcatgctgg tgccggtgta tcattgttgg cattactttg aattattaaa gcagttgaaa
     1081 gcatgtagcg aagaacagga agaccgagag tgtttgaatc aggctatcac tgccctcatg
     1141 aacctccaag gcagcatgga ccggatttac aagcagcact cgccaaggcg ccggccaggg
     1201 gatcctgttt gcctttttta caatcgtcaa ttaagaagca agcacctggc tatcaaaaaa
     1261 atgaatgaaa ttcagaaaaa cattgatggg tgggaaggca aagatattgg acagtgttgt
     1321 aatgagttca taatggaagg accattgacc agaattggtg ctaagcatga aaggcatatt
     1381 ttcctcttcg atggcttaat gatcagctgt aaacccaatc attgccagac tcgacttcca
     1441 gggtatagta gtgcagaata caggttaaaa gagaagtttg tcatgaggaa aattcaaatc
     1501 tgtgataaag aagacgcttg tgaatacaaa catgcttttg aattagtatc caaagatgaa
     1561 aacagtgtaa tatttgctgc caagtcagct gaagagaaaa acaactggat ggcagccctt
     1621 atctcccttc actatcggag cactctagat agaatgctgg actctgtgtt actgaaagag
     1681 gagaacgagc agcccctgcg gctaccgcgg ccagacgtgt accgcttcgt ggtgacagac
     1741 tcagaggaga acatagtttt tgaagacaac ttgcaaagca gaagtggaat ccccattatt
     1801 aaaggaggca ccgtggtgaa actgatcgaa aggctaacat atcacatgta tgcagatccc
     1861 aattttgttc gtactttcct tactacgtat cgttcatttt gtaagccaca ggaattgcta
     1921 agcttgctga tagaacggtt tgaaattcca gatccagagc ctactgaggc cgacaaactg
     1981 gcgctagaga aaggcgagca gccaatcagc gcagatctga aaagattccg caaggaatat
     2041 gtccaacccg tgcaacttag ggtcttgaat gtctttcgcc actgggttga gcatcatttt
     2101 tatgactttg aaagagactt ggaattgctt gaaagactgg aagccttcat ttcaagtgta
     2161 agagggaaag ccatgaagaa gtgggtagaa tccattgcta aaatcatcaa gaggaagaag
     2221 caagctcagg ccaatggagt aagccataat atcacctttg aaagtccgcc tccaccggtt
     2281 gaatggcaca taagtagggc gggacagtct gaaacctttg accttatgac acttcatccc
     2341 atagagattg cacggcagtt aacactcttg gaatctgatc tctacaggag agtccagcct
     2401 tctgaacttg tagggagtgt ctggaccaaa gaagataaag aaataaattc tccaaatcta
     2461 ttaaaaatga ttcgccatac aacaaacctc actttgtggt ttgaaaaatg cattgtggaa
     2521 gcagaaaact ttgaagaacg ggtggcagtg ctcagcagaa tagtagaaat tctgcaagtg
     2581 tttcaagatc tgaataattt caatggcgtg ttggagatag tcagtgcagt caattcagtg
     2641 tcagtgtaca gactagacca cacatttgag gcattgcagg aaaggaagcg gagagttttg
     2701 gatgacgctg tggaattaag tcaggatcac tttaaaaaat acctagtaaa acttaaatca
     2761 atcaatccac cttgtgtgcc tttttttgga atatatttaa caaatattct gaagactgaa
     2821 gaagggaaca gcgactttct aaagaggaaa gggaaagatt tgatcaattt cagtaagagg
     2881 agaaaagtgg ctgaaataac cggagagatt cagcagtatc agaaccaacc atactgctta
     2941 cggacagaac cagagatgag gagattcttt gaaaacctca atcccatggg acttttatct
     3001 gaaaaagagt ttacagatta tttgttcaac aaatctcatg aaattgaacc ccgaaactgc
     3061 aaacaaccac ctcgatttcc taggaagtca accttttcct taaaatctcc tggaataagg
     3121 cccaatgcca gccgccatgg ctctacctca ggcacgttcc gaggtcaccc aacccctctg
     3181 gaaagggagc cttataagat aagctttagc aggatcgccg agacggagct agaatccacg
     3241 gtgtcagcac cgacatctcc caacacccca tccaccccac ctgtgtctgc ttcttcagac
     3301 cacagcgtgt ttctagatgt ggacctcaat agctcctgtg gcagcaatac catctttgct
     3361 ccagtcctct tgccacactc aaagtctttc ttcagctcat gtggaagtct acacaaactg
     3421 agtgaagagc cactagttcc tcctccgctt ccccctcgga aaaagtttga tcacgatgct
     3481 ccgaactcca agggagctat gaaatcggat gatgaccctc ctgctattcc accaagacaa
     3541 ccccctcctc caaaggtaaa gccaagagct cctgtcctca cgggtacatt tgaagggcct
     3601 gtgcccagtc cacctccacc tcctcccaga gaccctcttc ctgatactcc tccaccagtt
     3661 cctcttcggc ctccggaaca ctttataaac tgtccgttta atctccagcc gcctccgctg
     3721 ggacatcctc acagagaccc agactggctc agagacgtta gcacatgccc taattcacca
     3781 agcactcctc cccctacgcc ctcgccacgg attccacgca gatgccattt gcccagcccc
     3841 agtcacaaca atcttgctca ccctccagct cctcccgttc caccaaggca gaattcaagc
     3901 cctcacctac caaaactgcc accaaagact tacaagcggg agctttcaca cccgccattg
     3961 tacagactac ctttgtttga aaatgcagaa actcctcagt gaccttggcc acgtgtagtc
     4021 attgacactg gattagtatt tgtaaaggtt tttaatttat tcaaaaaaga catagtattt
     4081 tagtactttt tacagaaatg ctactgatca aataagcttt taagaactag taaaattgtc
     4141 agatggcagt ggtgcacacc tccaattcca gcactcggaa ggcagaggca ggtgggtttc
     4201 agggtttgag agcaacctgg tctatagagc aagttccagg acagccaggg ctacacagaa
     4261 aaaccttgtc tcaaaaagtc aaaaccaaaa caaaaagaaa agaatctgaa atactaaaat
     4321 gcaaaagccc ctcctcaccg tggccctcag gggatcagta gcactgcctg atcagctcct
     4381 ccgtgctgcc caaggccagt ataacgaatc tgtattgcac tgtactctgc tagaacatgg
     4441 ctgagaacgt ttctgactgc actgacaggg gctagcctcg agggagctct caggcctgag
     4501 tgatagatgc ctttttaaga caatgaattt acgcagatcc agaggatgtg tggtggtatt
     4561 actggttttt aaccctctga ccaccttcta gcttttaact tcgtttggtt tttacatcta
     4621 ggagaattat gaataatacc cactgttctt aaactctttg aggccatgtc ttaaatgtca
     4681 gtatttgctg ctgaagacaa aacggaaaat agaatgaaat aatagaatgc actgtgttta
     4741 ttattttggt aagattataa acaactctgt ataacctgat tacagaaggg catgtatctc
     4801 attaagatgt gccttttgtt ttgcagtgtg tggtgtcttt agctaatgat ttgcctattg
     4861 tttgggaaaa caaaattaat atgccatata tgtacagttt atttatattg tatatattta
     4921 aagaaaatgc taataaccta tataaatgta agtgacttga ggcctataat acaatctgct
     4981 attttactaa tttgtaagtc cagaacaaaa gtttcttatg gcataagaac caactgccat
     5041 ctgccttgtc ttcacaccta ttaactgtct ttaatctcgt gttaactgaa atttttaaag
     5101 tttttccaga ttagtaatat ttaaacagaa aatactttaa aagctttatt aaattttttt
     5161 tttaatcaga caggataaag cttttcccat ttggatactc tcgttcaaag tgatcaacgt
     5221 atgttgtgct gatagtgcag tagcccccat tgtaaagtag ccaaaagcca tgttgtttat
     5281 ctactggtct gtggccttct actgtgcttt gcatcagagt tcttaacaag gttaataaat
     5341 cacctcagtc ttaatttgta aaaga
//
