LOCUS       NM_001100716            6018 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SOS Ras/Rac guanine nucleotide exchange factor 1
            (Sos1), mRNA.
ACCESSION   NM_001100716 XM_001062567 XM_233820
VERSION     NM_001100716.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6018)
  AUTHORS   Ren,X., Jing,Y.X., Zhou,Z.W. and Yang,J.W.
  TITLE     Knockdown of circRNA-Memo1 Reduces Hypoxia/Reoxygenation Injury in
            Human Brain Endothelial Cells Through miRNA-17-5p/SOS1 Axis
  JOURNAL   Mol Neurobiol 59 (4), 2085-2097 (2022)
   PUBMED   35041140
REFERENCE   2  (bases 1 to 6018)
  AUTHORS   Mishra,M., Duraisamy,A.J., Bhattacharjee,S. and Kowluru,R.A.
  TITLE     Adaptor Protein p66Shc: A Link Between Cytosolic and Mitochondrial
            Dysfunction in the Development of Diabetic Retinopathy
  JOURNAL   Antioxid Redox Signal 30 (13), 1621-1634 (2019)
   PUBMED   30105917
REFERENCE   3  (bases 1 to 6018)
  AUTHORS   Campos-Parra,A.D., Padua-Bracho,A., Pedroza-Torres,A.,
            Figueroa-Gonzalez,G., Fernandez-Retana,J., Millan-Catalan,O.,
            Peralta-Zaragoza,O., Cantu de Leon,D., Herrera,L.A. and
            Perez-Plasencia,C.
  TITLE     Comprehensive transcriptome analysis identifies pathways with
            therapeutic potential in locally advanced cervical cancer
  JOURNAL   Gynecol Oncol 143 (2), 406-413 (2016)
   PUBMED   27581326
REFERENCE   4  (bases 1 to 6018)
  AUTHORS   Zhou,J., Du,T., Li,B., Rong,Y., Verkhratsky,A. and Peng,L.
  TITLE     Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During
            Brain Ischemia/Reperfusion
  JOURNAL   ASN Neuro 7 (5), 1759091415602463 (2015)
   PUBMED   26442853
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6018)
  AUTHORS   Baltanas,F.C., Perez-Andres,M., Ginel-Picardo,A., Diaz,D.,
            Jimeno,D., Liceras-Boillos,P., Kortum,R.L., Samelson,L.E., Orfao,A.
            and Santos,E.
  TITLE     Functional redundancy of Sos1 and Sos2 for lymphopoiesis and
            organismal homeostasis and survival
  JOURNAL   Mol Cell Biol 33 (22), 4562-4578 (2013)
   PUBMED   24043312
REFERENCE   6  (bases 1 to 6018)
  AUTHORS   Chen,R.H., Corbalan-Garcia,S. and Bar-Sagi,D.
  TITLE     The role of the PH domain in the signal-dependent membrane
            targeting of Sos
  JOURNAL   EMBO J 16 (6), 1351-1359 (1997)
   PUBMED   9135150
REFERENCE   7  (bases 1 to 6018)
  AUTHORS   Wang,D.Z., Hammond,V.E., Abud,H.E., Bertoncello,I., McAvoy,J.W. and
            Bowtell,D.D.
  TITLE     Mutation in Sos1 dominantly enhances a weak allele of the EGFR,
            demonstrating a requirement for Sos1 in EGFR signaling and
            development
  JOURNAL   Genes Dev 11 (3), 309-320 (1997)
   PUBMED   9030684
REFERENCE   8  (bases 1 to 6018)
  AUTHORS   Rosen,L.B. and Greenberg,M.E.
  TITLE     Stimulation of growth factor receptor signal transduction by
            activation of voltage-sensitive calcium channels
  JOURNAL   Proc Natl Acad Sci U S A 93 (3), 1113-1118 (1996)
   PUBMED   8577724
REFERENCE   9  (bases 1 to 6018)
  AUTHORS   Pelicci,G., Giordano,S., Zhen,Z., Salcini,A.E., Lanfrancone,L.,
            Bardelli,A., Panayotou,G., Waterfield,M.D., Ponzetto,C.,
            Pelicci,P.G. et al.
  TITLE     The motogenic and mitogenic responses to HGF are amplified by the
            Shc adaptor protein
  JOURNAL   Oncogene 10 (8), 1631-1638 (1995)
   PUBMED   7731718
REFERENCE   10 (bases 1 to 6018)
  AUTHORS   Duronio,V., Welham,M.J., Abraham,S., Dryden,P. and Schrader,J.W.
  TITLE     p21ras activation via hemopoietin receptors and c-kit requires
            tyrosine kinase activity but not tyrosine phosphorylation of p21ras
            GTPase-activating protein
  JOURNAL   Proc Natl Acad Sci U S A 89 (5), 1587-1591 (1992)
   PUBMED   1371879
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AAHX01041857.1, AAHX01041858.1, AAHX01041859.1, AAHX01041860.1,
            AAHX01041861.1 and AAHX01041862.1.
            
            On or before Dec 12, 2007 this sequence version replaced
            XM_001062567.1, XM_233820.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132262,
                              SAMD00132266 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AAHX01041857.1     1559-1658           c
            101-226             AAHX01041858.1     15345-15470
            227-358             AAHX01041859.1     1131-1262
            359-523             AAHX01041860.1     882-1046
            524-733             AAHX01041860.1     2650-2859
            734-877             AAHX01041860.1     5718-5861
            878-988             AAHX01041860.1     9500-9610
            989-1087            AAHX01041860.1     9689-9787
            1088-1215           AAHX01041860.1     19122-19249
            1216-1871           AAHX01041860.1     19996-20651
            1872-1953           AAHX01041860.1     28992-29073
            1954-2076           AAHX01041860.1     30062-30184
            2077-2180           AAHX01041860.1     30497-30600
            2181-2403           AAHX01041860.1     31817-32039
            2404-2523           AAHX01041860.1     33109-33228
            2524-2686           AAHX01041860.1     37459-37621
            2687-2804           AAHX01041860.1     38845-38962
            2805-2977           AAHX01041861.1     1123-1295           c
            2978-3094           AAHX01041861.1     803-919             c
            3095-3362           AAHX01041862.1     570-837
            3363-3481           AAHX01041862.1     6192-6310
            3482-6018           AAHX01041862.1     7446-9982
FEATURES             Location/Qualifiers
     source          1..6018
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..6018
                     /gene="Sos1"
                     /note="SOS Ras/Rac guanine nucleotide exchange factor 1"
                     /db_xref="GeneID:313845"
                     /db_xref="RGD:1310949"
     exon            1..100
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..3973
                     /gene="Sos1"
                     /codon_start=1
                     /product="son of sevenless homolog 1"
                     /protein_id="NP_001094186.1"
                     /db_xref="GeneID:313845"
                     /db_xref="RGD:1310949"
                     /translation="MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNEDA
                     LQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNP
                     LSLPAERIHHLLREVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQ
                     DIKVAMCADKVLMDMFHQDVEDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRE
                     LNLIIKVFREPFVSNSKLFSSYDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPH
                     PLVGSCFEDLAEELAFDPYESYARDVLRPGFHERFLSQLSKPGAALYLQSIGEGFKEA
                     VQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECMKQAITALLNVQSGMEKICS
                     KNLAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGTL
                     TRVGAKHERHIFLFDGLMICCKSNHGQPRLPGASNAEYRLKEKFFMRKVQINDKDDTS
                     EYKHAFEIILKDGNSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEH
                     MRLPSADVYRFAEPDSEENILFEENVQPKAGIPIIKAGTVVKLIERLTYHMYADPNFV
                     RTFLTTYRSFCKPQELLNLLIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYI
                     QPVQLRVLNVCRHWVEHHFYDFERDVDLLQRMEEFIGTVRGKAMKKWVESITKIIQRK
                     KIARDNGPGHNITFQNSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRA
                     VQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRII
                     EILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKK
                     YLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLRRHGKELINFSKRRRVAEITGEIQ
                     QYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKK
                     YSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAPNSPRTPLT
                     PPPASSASSNTDVCSVFDSDHSASPFHSRSASVSSISLSKGTEEVPVPPPVPPRRRPE
                     SAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISDRTSISDPPESPPLLPPRE
                     PVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPPPQTPSPHGTRRHLPSP
                     PLTQEVDLHSIAGPPVPPRQSTSQLIPKLPPKTYKREHTHPSMHRDGPPLLENAHSS"
     exon            101..226
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            227..358
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            359..523
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            524..733
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..877
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            878..988
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1087
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1215
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1871
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1953
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2076
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2180
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2403
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2523
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2686
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2804
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2977
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3094
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3362
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            3363..3481
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
     exon            3482..6018
                     /gene="Sos1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccgcaggc accatgcagg cgcagcagct gccctacgag tttttcagcg aggagaacgc
       61 gcccaagtgg cgggggctgc tggtgcctgc gctgaaaaag gttcaggggc aagttcaccc
      121 tactcttgag tctaatgagg atgctcttca gtatgttgaa gaattaattt tgcaattact
      181 aaatatgcta tgccaagctc agccccggag tgcttcagat gtggaggaac gtgttcaaaa
      241 aagtttccct catccaattg ataagtgggc aatagctgat gcccaatcag ctattgaaaa
      301 gaggaagaga aggaaccctt tatccctgcc agcagaaaga attcatcatt tattaaggga
      361 ggtcctgggt tataaaattg accaccaggt ttctgtttac atagtagcag tattagaata
      421 catttctgca gatattttaa agctggtggg gaattatgta agaaatatac ggcattatga
      481 aattacaaaa caagacatta aagtggcaat gtgtgctgat aaggtattga tggatatgtt
      541 tcatcaagat gtagaagata taaatatctt atctttaact gatgaagaac cttccacctc
      601 aggagaacaa acttactatg atttggtaaa agcattcatg gcagaaattc gacaatatat
      661 aagagaatta aatctaatta taaaggtttt tcgagaaccc tttgtctcta attccaagtt
      721 gttttcatct tatgatgtag aaaacatatt tagtcgtata gtggatatcc atgaacttag
      781 tgtaaagtta ctgggccata tagaagacac tgtagagatg acagatgaag gcagtcccca
      841 cccgttagtc ggaagctgtt ttgaagactt agcagaagaa ctggcctttg acccatatga
      901 gtcctatgct cgggatgttc tgcggcccgg attccatgag cgttttctca gtcagctatc
      961 aaagcctggg gcagcacttt atctgcagtc cataggtgaa ggcttcaaag aggccgttca
     1021 gtatgtcctg ccccggctgc tgctcgcccc tgtgtaccac tgtctgcatt actttgaact
     1081 tctgaagcag ttagaagaaa agagcgaaga tcaagaagat aaggagtgta tgaaacaagc
     1141 aataacagcc ctgcttaatg tccaaagtgg catggaaaaa atttgctcca aaaatcttgc
     1201 aaaacgaaga ctgagtgagt ctgcatgtcg gttttacagc cagcaaatga aggggaaaca
     1261 actggccatc aagaagatga atgagattca gaagaacatt gatggttggg aggggaaaga
     1321 cattggacaa tgctgcaatg agtttataat ggaaggaact cttacacgtg taggagccaa
     1381 acacgagaga cacatatttc tcttcgatgg cttaatgatt tgctgtaaat caaatcatgg
     1441 gcagccaaga cttcctggtg ctagcaatgc agaatatcgg cttaaagaaa agttttttat
     1501 gcgaaaggta cagattaacg ataaggatga caccagtgaa tacaagcacg ctttcgaaat
     1561 aattctgaag gatggaaata gtgttatatt ttctgccaag tcagctgaag agaagaataa
     1621 ctggatggca gccctgatat ccctgcagta ccgcagcacg ctggagagaa tgctggacgt
     1681 tacaatgctg caggaggaga aggaggagca catgaggctg ccgagtgctg acgtgtacag
     1741 gtttgcagag cccgactctg aggagaacat tctgtttgaa gagaacgtgc agcccaaggc
     1801 tggcatcccc atcatcaagg cagggacagt ggttaagctg attgagaggc tcacgtacca
     1861 catgtacgca gatccaaatt ttgttcggac atttcttaca acatacagat cattttgcaa
     1921 acctcaagaa ctactgaatc ttctaataga aagatttgaa attccagagc ctgagccaac
     1981 agaagctgat cgcatagcta tagagaatgg agatcagccc ctgagcgcag agctgaaaag
     2041 gtttagaaag gagtatatcc agcctgtaca gctgagggtg ttaaacgtgt gtcggcactg
     2101 ggtggagcac catttctatg actttgaaag agatgtagac cttttacaga gaatggagga
     2161 atttattgga acagtaagag gtaaagcaat gaaaaaatgg gtcgaatcca tcactaagat
     2221 aatccaaagg aaaaaaattg caagagacaa tggcccaggt cataatatta catttcagaa
     2281 ttcacctccc acagttgagt ggcacataag cagacctggg catatagaga cttttgactt
     2341 gctcacccta cacccaatag aaattgctcg acaactcact ttacttgaat cagatctata
     2401 ccgagctgtg cagccatcag aattagttgg aagtgtgtgg acaaaagaag ataaagaaat
     2461 taactctcct aaccttctga aaatgattcg gcacaccacc aacctcactc tgtggtttga
     2521 gaaatgtatt gtagaaacag agaacttaga agaaagagta gcagtagtga gtcgaataat
     2581 tgagattcta caagtctttc aagagctgaa caacttcaat ggtgtcctgg aagttgttag
     2641 tgctatgaac tcgtcacctg tttacagact ggaccacaca tttgagcaaa taccaagtag
     2701 acaaaagaaa attttagaag aagctcatga gttgagtgaa gatcactata agaaatattt
     2761 ggcaaaactc aggtctatta atccaccatg tgtgcctttc tttggaattt atctcacaaa
     2821 tatcttgaaa acagaagaag gcaaccctga ggtcctaaga agacatggaa aagagcttat
     2881 caacttcagc aagaggagga gagtggccga gataacagga gagatccagc agtaccaaaa
     2941 ccagccttac tgcttacggg tagagtcaga catcaagaga ttctttgaaa acttgaatcc
     3001 aatgggaaat agcatggaga aggaatttac agactatcta ttcaacaaat ccctagaaat
     3061 agaaccacgg aaccctaagc ctcttccaag atttccaaaa aaatacagct atcccctaaa
     3121 atctcctggt gttcgtccat caaatccaag accaggaacc atgaggcacc ctacacctct
     3181 gcagcaggag ccaaggaaaa tcagctacag tcggattcct gagagcgaga cagaaagtac
     3241 agcgtcggca ccaaactccc cgagaacacc gctgacgccg cctcctgcgt ccagcgcctc
     3301 cagtaacaca gacgtctgca gcgtgttcga ttccgaccac tccgcaagcc cttttcactc
     3361 aagatctgct tcagtctcat ctataagttt atccaagggc accgaggaag tgcctgtccc
     3421 tcctcctgtc ccccctcgaa gacgaccaga gtctgcccca gcggaatcct ccccatccaa
     3481 gattatgtct aagcacttgg atagcccccc agcgattcct cctaggcagc ccacatcgaa
     3541 agcctattca ccacgatact caatatcaga tcggacctct atatcagatc ctcccgagag
     3601 ccctcccttg ttaccaccac gagaacctgt gaggacaccc gatgttttct caagctcgcc
     3661 attacatctc caacctcccc cgttgggcaa aaagagtgac catggcaatg ccttcttccc
     3721 aaacagccca tcccccttta caccgccacc tcctcaaacc ccgtctcctc acggcacgag
     3781 aaggcatctg ccatcaccac cactgacaca ggaagtggac ctccattcca ttgctgggcc
     3841 tcccgttcct ccacggcaaa gcacttctca acttatcccc aaactccctc caaaaactta
     3901 caaaagggag cacacacacc catccatgca cagagatgga ccgccactgc tggagaatgc
     3961 ccattcttcc tgagttcctc taaactggga cccagttccc aacccaaatc cattgctggc
     4021 aatggatgca ctgaacatgc cagcactgag gagttacaag gagaactcca aacactaacg
     4081 actctacttc aacatgtagt aagacaatga ttttaaccta cacgtaacta tgaggtgaga
     4141 tggtattcca gcttagaggg tgagactgat ctagaggagc tggacgtctg actgcacctg
     4201 gacaccacgg ggaggggggg actttcctgg ccaataggca ggagccctcc tcattgtgaa
     4261 gggatggaaa acggtctcgt gtccaacagg cccatatgtt gacagtcttt gtaattcaaa
     4321 atattatgca cttttaaaaa ctcttaaaca gggatctcct cctcctttgt tttcctttgc
     4381 tttactcttc tgctttagaa tgttttcata caagtcattc agaggactgt gagaaaggct
     4441 gtggtgcctg gccttgtggg aaccaaggcc cagcactgta ccgcagtcct gtttacagat
     4501 tactacagtg aaccgagtgg gtaccgaggc ttcaccaaag aggtacttgt tgttattgtt
     4561 attgttttaa gaataattat gccaatttta ggaacattcc ctacctaccc ctactcacaa
     4621 ataaaatgtg gtggtgttgc cttcaaacaa aaactttgac gtcatgaaca tgatcgaaga
     4681 ggaacttgtt aaagcgtaac tgtcaagtat gctatccaca cttaggagac tgttaatctc
     4741 tgctagactc gtccccagcc cctctgtccc tcagacgttt actggtaata tctgtcctgg
     4801 cttgtggctg tccctctaac tgtccacaga aacgcaggca cccaatgtga gcaggaacac
     4861 gctgggctcc tgacaccttc tgtgtttcac taatagttga acagttagca tacctagaat
     4921 taccttgcat cgcctaaatc atgtgtatat agtgaatgtt atataatata cctgacaggt
     4981 ctgtttttat ttaattgaat aaagataaac tactttgttt ggctggcata tattaaatta
     5041 ttatatggag aaaatggttg cttcttcttt cttggggttg aaaagcagac aaacactaag
     5101 catgaagcac gtgtggtacg cctgggtgcc tgggtcttac agagttactc aagctggagt
     5161 ttggcgcgaa gggaaatact ggcttaaaat gggatctttt aggcagagcc ttgcagcttt
     5221 ctaagtttct tgacaaccac gcatattcgc taagatatgt actgaacatt cttctttgct
     5281 taagaccttt ggttccatca gagcgcctcc ttagagcatc tccctgcatc attaataccc
     5341 catcatggtt catgaagcct cgtactgctc ttctcagtcc aacagatact gtgactaaaa
     5401 tgcatgcaac ttgaagagaa aacatttcct tatctccact gtgtctgaac tgcagtgctc
     5461 catccttagt cagcgtcagt gtgcgcatgt gtcctcagga atgcctcggc atctcagtaa
     5521 ctcttaacaa ccgctgcacc atgctggcag ctcagtgctc attggcacag taaatgtccg
     5581 tcttggcagt gcggcttctg tcttctaagg tcagaaggat acccattgcg tcatcatgag
     5641 gctagagctg attcactctc actcagctac agtatccatt tttctctttg taaaatgtct
     5701 cctttttaaa aaagagtcct caaaagttaa ttttaaaccc cttcttagat gaaaagtgtc
     5761 catttggcca ctcattgaac aaatgaccat tcattgaaca aaaacagcta agcatactta
     5821 ttaatgtaaa acttatgatg taatgcacat ccccaaacct cccatgactt tttcgatcag
     5881 cctaactgtc cctagaattt cctatggctt attgatcact gtttgatcat cctgccctta
     5941 cctcaaatga gaatctaagg aaagcagcgt tagaaaccca ttcagtgtct ctgagggtct
     6001 ctgcagcaag cgcctcct
//
