LOCUS       NM_031767               6690 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus sortilin 1 (Sort1), mRNA.
ACCESSION   NM_031767 XM_001070445 XM_001070486 XM_001076150 XM_342317
VERSION     NM_031767.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6690)
  AUTHORS   Long,S., Liu,Z. and Wang,Y.
  TITLE     Sortilin inhibition in microglial cells cannot alleviate ischemia
            and hypoxia-induced neuronal injury in co-culture
  JOURNAL   Neuroreport 35 (5), 320-327 (2024)
   PUBMED   38305117
  REMARK    GeneRIF: Sortilin inhibition in microglial cells cannot alleviate
            ischemia and hypoxia-induced neuronal injury in co-culture.
REFERENCE   2  (bases 1 to 6690)
  AUTHORS   Aguilera,A.C., Leiva,N., Alvarez,P.A., Pulcini,G., Pereyra,L.L.,
            Morales,C.R., Sosa,M.A. and Carvelli,L.
  TITLE     Sortilin knock-down alters the expression and distribution of
            cathepsin D and prosaposin and up-regulates the cation-dependent
            mannose-6-phosphate receptor in rat epididymal cells
  JOURNAL   Sci Rep 13 (1), 3461 (2023)
   PUBMED   36859404
  REMARK    GeneRIF: Sortilin knock-down alters the expression and distribution
            of cathepsin D and prosaposin and up-regulates the cation-dependent
            mannose-6-phosphate receptor in rat epididymal cells.
            Erratum:[Sci Rep. 2023 Mar 13;13(1):4152. doi:
            10.1038/s41598-023-31255-x.. PMID: 36914707]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6690)
  AUTHORS   Toth,A.E., Helms,H.C., Harazin,A., Johnsen,K.B., Goldeman,C.,
            Burkhart,A., Thomsen,M.S., Kempen,P.J., Klepe,A., Lipka,D.V.,
            Moller,P.L., Andresen,T.L., Nyegaard,M., Moos,T., Brodin,B. and
            Nielsen,M.S.
  TITLE     Sortilin regulates blood-brain barrier integrity
  JOURNAL   FEBS J 289 (4), 1062-1079 (2022)
   PUBMED   34626084
  REMARK    GeneRIF: Sortilin regulates blood-brain barrier integrity.
REFERENCE   4  (bases 1 to 6690)
  AUTHORS   Zhang,Z., Jiang,W., Yang,H., Lin,Q. and Qin,X.
  TITLE     The miR-182/SORT1 axis regulates vascular smooth muscle cell
            calcification in vitro and in vivo
  JOURNAL   Exp Cell Res 362 (2), 324-331 (2018)
   PUBMED   29196163
  REMARK    GeneRIF: A luciferase reporter assay confirmed that SORT1 is the
            direct target of miR-182. Our study suggests that SORT1 plays a
            vital role in the development of arterial calcification and is
            regulated by miR-182.
REFERENCE   5  (bases 1 to 6690)
  AUTHORS   Ye,Z., Austin,E., Schaid,D.J., Bailey,K.R., Pellikka,P.A. and
            Kullo,I.J.
  TITLE     A DAB2IP genotype: sex interaction is associated with abdominal
            aortic aneurysm expansion
  JOURNAL   J Investig Med 65 (7), 1077-1082 (2017)
   PUBMED   28698188
REFERENCE   6  (bases 1 to 6690)
  AUTHORS   Nielsen,M.S., Madsen,P., Christensen,E.I., Nykjaer,A., Gliemann,J.,
            Kasper,D., Pohlmann,R. and Petersen,C.M.
  TITLE     The sortilin cytoplasmic tail conveys Golgi-endosome transport and
            binds the VHS domain of the GGA2 sorting protein
  JOURNAL   EMBO J 20 (9), 2180-2190 (2001)
   PUBMED   11331584
REFERENCE   7  (bases 1 to 6690)
  AUTHORS   Nielsen,M.S., Jacobsen,C., Olivecrona,G., Gliemann,J. and
            Petersen,C.M.
  TITLE     Sortilin/neurotensin receptor-3 binds and mediates degradation of
            lipoprotein lipase
  JOURNAL   J Biol Chem 274 (13), 8832-8836 (1999)
   PUBMED   10085125
REFERENCE   8  (bases 1 to 6690)
  AUTHORS   Mazella,J., Zsurger,N., Navarro,V., Chabry,J., Kaghad,M., Caput,D.,
            Ferrara,P., Vita,N., Gully,D., Maffrand,J.P. and Vincent,J.P.
  TITLE     The 100-kDa neurotensin receptor is gp95/sortilin, a
            non-G-protein-coupled receptor
  JOURNAL   J Biol Chem 273 (41), 26273-26276 (1998)
   PUBMED   9756851
REFERENCE   9  (bases 1 to 6690)
  AUTHORS   Morris,N.J., Ross,S.A., Lane,W.S., Moestrup,S.K., Petersen,C.M.,
            Keller,S.R. and Lienhard,G.E.
  TITLE     Sortilin is the major 110-kDa protein in GLUT4 vesicles from
            adipocytes
  JOURNAL   J Biol Chem 273 (6), 3582-3587 (1998)
   PUBMED   9452485
REFERENCE   10 (bases 1 to 6690)
  AUTHORS   Lin,B.Z., Pilch,P.F. and Kandror,K.V.
  TITLE     Sortilin is a major protein component of Glut4-containing vesicles
  JOURNAL   J Biol Chem 272 (39), 24145-24147 (1997)
   PUBMED   9305862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Oct 25, 2008 this sequence version replaced
            XM_001070445.1, XM_001070486.1, XM_342317.3, XM_001076150.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.9772.1,
                                           SRR26643293.14066.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               JAXUCZ010000002.1  198612495-198612817
            324-383             JAXUCZ010000002.1  198637209-198637268
            384-457             JAXUCZ010000002.1  198638906-198638979
            458-560             JAXUCZ010000002.1  198651549-198651651
            561-725             JAXUCZ010000002.1  198652578-198652742
            726-799             JAXUCZ010000002.1  198654719-198654792
            800-849             JAXUCZ010000002.1  198657818-198657867
            850-980             JAXUCZ010000002.1  198661386-198661516
            981-1125            JAXUCZ010000002.1  198664560-198664704
            1126-1281           JAXUCZ010000002.1  198665375-198665530
            1282-1388           JAXUCZ010000002.1  198668954-198669060
            1389-1491           JAXUCZ010000002.1  198673573-198673675
            1492-1660           JAXUCZ010000002.1  198674392-198674560
            1661-1851           JAXUCZ010000002.1  198675318-198675508
            1852-2041           JAXUCZ010000002.1  198677235-198677424
            2042-2158           JAXUCZ010000002.1  198680157-198680273
            2159-2267           JAXUCZ010000002.1  198682831-198682939
            2268-2374           JAXUCZ010000002.1  198685255-198685361
            2375-2486           JAXUCZ010000002.1  198685600-198685711
            2487-6690           JAXUCZ010000002.1  198686278-198690481
FEATURES             Location/Qualifiers
     source          1..6690
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..6690
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /note="sortilin 1"
                     /db_xref="GeneID:83576"
                     /db_xref="RGD:619999"
     exon            1..323
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..2501
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /note="NTR3; gp110; glycoprotein 110; neurotensin receptor
                     3"
                     /codon_start=1
                     /product="sortilin precursor"
                     /protein_id="NP_113955.1"
                     /db_xref="GeneID:83576"
                     /db_xref="RGD:619999"
                     /translation="MERPRGAADGLLRWPLGLLLLLQLLPPAAVGQDRLDAPPPPAPP
                     LLRWAGPVGVSWGLRAAAPGGPVPRAGRWRRGAPAEDQDCGRLPDFIAKLTNNTHQHV
                     FDDLSGSVSLSWVGDSTGVILVLTTFQVPLVIVSFGQSKLYRSEDYGKNFKDITNLIN
                     NTFIRTEFGMAIGPENSGKVILTAEVSGGSRGGRVFRSSDFAKNFVQTDLPFHPLTQM
                     MYSPQNSDYLLALSTENGLWVSKNFGEKWEEIHKAVCLAKWGPNNIIFFTTHVNGSCK
                     ADLGALELWRTSDLGKTFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDT
                     WSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHL
                     YTTTGGETDFTNVTSLRGVYITSTLSEDNSIQSMITFDQGGRWEHLQKPENSKCDATA
                     KNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDD
                     GGYSWAKMLEGPHYYTILDSGGIIVAIEHSNRPINVIKFSTDEGQCWQSYVFSQEPVY
                     FTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCEENDYTTWLAHSTD
                     PGDYKDGCILGYKEQFLRLRKSSVCQNGRDYVVAKQPSICPCSLEDFLCDFGYFRPEN
                     ASECVEQPELKGHELEFCLYGKEEHLTTNGYRKIPGDRCQGGMNPAREVKDLKKKCTS
                     NFLNPKKQNSKSSSVPIILAIVGLMLVTVVAGVLIVKKYVCGGRFLVHRYSVLQQHAE
                     ADGVEALDTASHAKSGYHDDSDEDLLE"
     exon            324..383
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /inference="alignment:Splign:2.1.0"
     exon            384..457
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /inference="alignment:Splign:2.1.0"
     exon            458..560
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /inference="alignment:Splign:2.1.0"
     exon            561..725
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /inference="alignment:Splign:2.1.0"
     exon            726..799
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /inference="alignment:Splign:2.1.0"
     exon            800..849
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /inference="alignment:Splign:2.1.0"
     exon            850..980
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1125
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1281
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1388
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1491
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1660
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1851
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2041
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2158
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2267
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2374
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2486
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..6690
                     /gene="Sort1"
                     /gene_synonym="Nt3; Nts3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcggcgtct gcattcggcg gcgatggagc ggccccgggg agctgcggac ggccttttgc
       61 gctggcccct tggcctcctc ctgctcctgc agctgctgcc gccagccgcc gtcggccagg
      121 accggctgga cgcgccgccg cctcccgcgc ctcctctgct gcgctgggcc ggtccggtcg
      181 gggtgagctg ggggctgcgc gccgccgcgc ccgggggccc tgtcccccgc gctggccgtt
      241 ggcgccgcgg cgcgcctgca gaggatcagg actgcggccg cctcccggac ttcatcgcca
      301 agctgaccaa caatacgcac cagcatgtct ttgatgacct cagtggctca gtgtccttgt
      361 cctgggttgg agacagcact ggggttattc tcgtcctgac tactttccaa gtgccactgg
      421 taattgtgag ttttggacag tccaagttat atcgcagtga ggattacgga aagaatttta
      481 aggacattac gaatctcatc aataacacct tcattcggac ggagttcggc atggctattg
      541 gtcccgagaa ctctggaaag gtgatattaa cagcagaggt gtctggggga agccgaggag
      601 gaagagtgtt caggtcatca gactttgcca agaactttgt acagacagac ctcccctttc
      661 atcctctgac tcagatgatg tacagccctc agaattctga ttacctgtta gctctcagca
      721 ctgaaaatgg cctgtgggtg tccaagaatt ttggggaaaa atgggaagaa atccacaaag
      781 cagtatgttt ggccaaatgg ggaccaaaca acatcatctt ctttaccacc catgtgaatg
      841 gctcctgcaa agctgatctt ggtgccctgg aattatggag aacatccgac ttggggaaaa
      901 ccttcaaaac cattggtgtg aaaatctact catttggtct tgggggccgt ttcctcttcg
      961 cctctgtgat ggctgataag gatacaacaa gaaggatcca cgtgtcaaca gaccaagggg
     1021 acacatggag catggcacag cttccctctg tgggacagga gcaattctat tctattctgg
     1081 cagccaacga tgacatggtg ttcatgcatg tagatgaacc tggagatact ggatttggta
     1141 caatctttac ctctgatgac cgaggcattg tctactctaa gtctctggac agacatctct
     1201 ataccaccac aggcggggag accgacttta ccaacgtgac ttccctccgt ggagtctata
     1261 taacaagcac actctcagaa gataattcca ttcagagcat gatcactttt gaccagggag
     1321 gacggtggga gcatctgcag aagccggaga acagcaagtg cgatgctacc gcaaagaaca
     1381 agaatgagtg cagccttcat atccatgctt cttacagcat ctcccagaag ctaaatgttc
     1441 caatggcccc actctccgag cccaatgccg tgggcatagt catcgctcac ggtagtgtgg
     1501 gagacgccat ctcggtgatg gtcccagacg tgtacatctc agatgatggg ggttactctt
     1561 gggcaaagat gctagaagga ccgcattatt ataccatcct ggactctgga ggcatcatcg
     1621 tggccattga acacagcaac cgtcctatca atgtgattaa gttctccaca gacgaaggcc
     1681 agtgctggca gagctatgtg ttcagtcagg agcccgtcta cttcaccggg ctggcttccg
     1741 agccgggagc caggtccatg aacatcagca tctggggatt cacggagtct ttccttaccc
     1801 gccagtgggt ctcctacaca attgatttca aagacatcct tgagcgcaac tgtgaagaga
     1861 atgactatac cacatggctg gcacactcca ctgaccccgg agattacaaa gatggctgca
     1921 ttttgggcta taaagagcag ttcctacggc tacggaagtc atccgtctgt cagaatggtc
     1981 gagactatgt tgtggccaag cagccatcca tctgtccctg ttccctggag gacttcctct
     2041 gtgactttgg ctacttccgt ccagagaatg cctcagagtg tgtggagcag ccggaactga
     2101 agggtcatga gttagagttc tgtctgtatg gcaaagagga gcacctgacc acaaatgggt
     2161 accggaaaat cccaggagac agatgccaag ggggaatgaa tccggcccga gaagtaaaag
     2221 acttgaagaa gaaatgcaca agcaacttct taaaccccaa gaagcagaat tccaagtcga
     2281 gttctgtccc tatcatcctg gccatcgtgg gactgatgct tgtcactgtc gtagcaggag
     2341 tcctcattgt gaagaagtat gtctgtggcg gaaggttcct ggtgcaccgg tactcggtgc
     2401 ttcagcagca cgcagaggct gacggggtgg aggctttgga tacggcctcc cacgctaaaa
     2461 gcggttatca cgatgattca gacgaggacc tcctggaata gctcttctga ggagctggga
     2521 ctgagtgtgc atggagccac agtacctcct acattccctg aggctctgac ttggggaaat
     2581 aaatccccca ctgcgtcggc cccagctctc tttctgccgc ttccacccac gcccaaagga
     2641 cctacactaa agaaagcagg gtgggggtgg ggaccccaac tgatctcagt tggctctgaa
     2701 aagagggggg caattttaaa ttctttaaca tttttgtttc aatttctgtc ttttgtaaaa
     2761 gtgtgggctt taggcttctc tcggtttgtt ttgtatgtta agggacatga cttgggattc
     2821 aaagggattg cttcgctgcc cccactcttg tgtgtcctgt ctggtgcccg ccccagggca
     2881 tctgccaact ccaccatcaa ctcaactccc acatcatacc tggtgctgtc cctgggctct
     2941 gctggtcatg cgaagccacc tcagagaagg aaacagaggg tgcagtgact ggcgccgcct
     3001 ggccagcttc cctccatccg tggacagccc tgttcaaaga gtaccgtgca ccagtgcacc
     3061 agccctgctg cggcttcctc acccccaccc cacccccaac cacgactcta aggcacagtg
     3121 acttttcttt tcccgtttaa ttaggcaata cccttgttaa ttgccctttg gcaactaact
     3181 taatcatgtg cttccaacac actaaatagg gaaaacttac agggcaatat tattcttgtg
     3241 gcaagaagga gggagggaca gaattgacta gatctaacac ctattaaaga caaaactggc
     3301 tgcttccaag ctctttcaag ctgtgctttg tggtgccagt ggcgctgtca aggcttggct
     3361 cgaagcctgc ccaggctccg ccatcccttt cctggagttc gttgttcagg gcacaatgcg
     3421 gccaccagac tgacagccat agctgtccat ttttaccatc acccactgta aaggctcagt
     3481 gtcgagctac cgccatggct gcttattgct tcctctgagg ttgctcccgt tcagagaact
     3541 gggactagga gtgttttcag gttgatggac tttttcagac tcaaagttac gttaccagac
     3601 tatcctccca cttcccccag tttagctgag ttggttgtta tccagaaccc tttggctaaa
     3661 cccactgaag gcacgtttct agatggtgct gtgtgtggtt gatacattgc tttcgtgttt
     3721 taaatttaag gaaattttct atctgatatt tttccaaatt aagtaagttg tagaatgaga
     3781 ttggcggatg tgggggcggc catctggtag gggaaaggta cagagattca tctgaataca
     3841 gcttagacat tggctggaca ggaagatggg gtgtaggtct ctggtgtccc tccccctgct
     3901 gtgctgatca gtccctccaa ctaccactag gacattcttt agtaggtcca tcttgctgtc
     3961 acttcattct gtgactagaa agtcagtgga aagtaaatgt gccaaactag cttgtcagaa
     4021 ttcgtgagca gatggccgag tccgctcctc cccagaggga acaaacagtg tcagggaaag
     4081 aggggaggaa gaggagggag agccagagag atgctgactt gcagctccat gagtcatgga
     4141 acgtggtcta gaaaatgaag ttagggtcgt ttctgggaag agaagaccag aggatgctct
     4201 agtctttagc ttgttcactt tgtaatgatt ctaaaataat tccaaagata tagcagctca
     4261 taagttatca aagtccagcc tcaccccctg ccaaggggag agatgtgttt ccactacagt
     4321 ctctcccagc acatccccag gttggtgtgg gtaggtaggc cagtgcatgg tgatcttgcc
     4381 tagtgtctgg atggacttca cactcgtccc cagccatcaa agactggggt gctctgccgc
     4441 taatggtttc tgggatttct ataggacatg gccgctttgg gatcatttct cttttgagca
     4501 ccgcactatt cttgccgtag atagcactca ggaacaaagg ctgagtcagc cacccagagt
     4561 cctcggagct ctgaaacaca agttatgcaa ggtcctggct cctggcagca gagcttctct
     4621 agggcgactg gctggggccg agggcgctga ggcgttcctt gcagagccat tattttgaca
     4681 cctttttgtt ttcttttgga gaacaagttt atctccctgc ttcatgactg agacgaaaag
     4741 tgatggtgat tgggggcacc ctctctccct tggagagtca ctgttggatg agtcctctgc
     4801 ccttttgctt ctctctgtag ctcactgact tgggtactgc tcctacaaca gcttccagaa
     4861 gcattcacat gcacaaatgt gcgaccccag ccagcagttt aagctcctta agctgtttta
     4921 aaaaaacaaa aaaaccttct gctttggttt gtcctgtgca gccctggggc ggcatcggca
     4981 tcactggtga acttaccact attctcggca ctgtggtggc cgatgggctg gttctggaga
     5041 cttgggcaga aggatttagc attgttaggc agctcagaca tattggaaag tccattgtgg
     5101 cctgagtttt aaattccaat ttttttttct tggcttggga ccttaggggc ttggagtttt
     5161 cctgagaccg gtgccgtggc tgaatgcgct gtgctgtgaa ttgaatggaa caacgctttg
     5221 aggcccttag agagtgactg cagctgcagg gtgggctcag gagccttggg ccccactgcc
     5281 tctgaacctg catgcgtgca gtcccatgcg cctggctttc ccctgcacca ggtgcaggct
     5341 gctggtgtag tcccctgcct gctcacagct ggtcccctag cctttcctct ctggcattgt
     5401 agtatcatgg gccaccctcg gctcctttat tcatagtcag gcctatgaac catgctggac
     5461 taagtatgct gaactgtccc ttcatcagga tactcgaggg gagaaaggcc attccaacaa
     5521 gcgccagagt gagagggctg gcatggcatc gctcacttac tgctctgcag gtaaagcaca
     5581 tgggtagaga gcctccagcg ctcggaagag ccctgccact gcacactggc aaagggctcg
     5641 ctcacgtatc agtacagccc tcccaactcc acactcagca gggatgcact ggactgctga
     5701 tgtcgggcag ggcacatctc agttttctat ccccttccca ccagagggaa aaggagcatg
     5761 aactttaatg tcttttggaa caaaaccaaa gtttaaggtt tgccatatga tcagtgacag
     5821 ggaagcccag agccggccag caggtgccag attttctgtc ccactggcca gtcctgcacc
     5881 aggtgcaggc tgctctgggc ttgttgaaac cacagatgca ggtgggtttc gtggttccat
     5941 tcgttatatc attaagaatt ggagcattaa cttgaaactg tcttcaaaga cttgctgtgt
     6001 gcactgtctc acactactac attctctgca tctgtttata taagataaca caagccaatc
     6061 tgtaccttta tatatatata tgtgtgtgtg tacatatata catgtataaa ctgtatagtg
     6121 tacatgttaa tgacttatca gtatgccccg aatttttagt gcagttctca tcctccgcat
     6181 gccctcagct gtggtcaggt gacctcctgt cccctggtgg ctcagccgag tccctgtgtt
     6241 tgagcctcca gggagaaggg ttggggctgc attctcctta tccccatgca cagaaacgct
     6301 cagggtcccc acgtgcctgt tgtcctcccc tctggtcttc tgttcccttt ctgagcatgt
     6361 ggcccttccc ccggctgtga ggggcggctg ccttcctggg agagcaggat caagaccacc
     6421 actgcatgtg tactgaaaac tccggacttc tgccctcttg ggacagaaca ttgcatgtga
     6481 ggtgggatta tcaagtttca aaaacctgtg tcaattatac agcaaagcca gaccacataa
     6541 cgacatccca caaaatggaa ataaaacgca aaatctcttt agcattgtgt aaataaatct
     6601 ggacgtgttt aactttgtac tggtaatttt ctgtatattt gcaatatttg ggttagaaat
     6661 aaaacagcct ggactttggt acctaaccta
//
