LOCUS       NM_053519              10537 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus sortilin related receptor 1 (Sorl1), mRNA.
ACCESSION   NM_053519
VERSION     NM_053519.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10537)
  AUTHORS   Schmidt,V., Schulz,N., Yan,X., Schurmann,A., Kempa,S., Kern,M.,
            Bluher,M., Poy,M.N., Olivecrona,G. and Willnow,T.E.
  TITLE     SORLA facilitates insulin receptor signaling in adipocytes and
            exacerbates obesity
  JOURNAL   J Clin Invest 126 (7), 2706-2720 (2016)
   PUBMED   27322061
REFERENCE   2  (bases 1 to 10537)
  AUTHORS   Whittle,A.J., Jiang,M., Peirce,V., Relat,J., Virtue,S., Ebinuma,H.,
            Fukamachi,I., Yamaguchi,T., Takahashi,M., Murano,T., Tatsuno,I.,
            Takeuchi,M., Nakaseko,C., Jin,W., Jin,Z., Campbell,M.,
            Schneider,W.J., Vidal-Puig,A. and Bujo,H.
  TITLE     Soluble LR11/SorLA represses thermogenesis in adipose tissue and
            correlates with BMI in humans
  JOURNAL   Nat Commun 6, 8951 (2015)
   PUBMED   26584636
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10537)
  AUTHORS   Caglayan,S., Takagi-Niidome,S., Liao,F., Carlo,A.S., Schmidt,V.,
            Burgert,T., Kitago,Y., Fuchtbauer,E.M., Fuchtbauer,A.,
            Holtzman,D.M., Takagi,J. and Willnow,T.E.
  TITLE     Lysosomal sorting of amyloid-beta by the SORLA receptor is impaired
            by a familial Alzheimer's disease mutation
  JOURNAL   Sci Transl Med 6 (223), 223ra20 (2014)
   PUBMED   24523320
REFERENCE   4  (bases 1 to 10537)
  AUTHORS   Burgert,T., Schmidt,V., Caglayan,S., Lin,F., Fuchtbauer,A.,
            Fuchtbauer,E.M., Nykjaer,A., Carlo,A.S. and Willnow,T.E.
  TITLE     SORLA-dependent and -independent functions for PACS1 in control of
            amyloidogenic processes
  JOURNAL   Mol Cell Biol 33 (21), 4308-4320 (2013)
   PUBMED   24001769
REFERENCE   5  (bases 1 to 10537)
  AUTHORS   Capsoni,S., Carlo,A.S., Vignone,D., Amato,G., Criscuolo,C.,
            Willnow,T.E. and Cattaneo,A.
  TITLE     SorLA deficiency dissects amyloid pathology from tau and
            cholinergic neurodegeneration in a mouse model of Alzheimer's
            disease
  JOURNAL   J Alzheimers Dis 33 (2), 357-371 (2013)
   PUBMED   22986780
REFERENCE   6  (bases 1 to 10537)
  AUTHORS   Jacobsen,L., Madsen,P., Jacobsen,C., Nielsen,M.S., Gliemann,J. and
            Petersen,C.M.
  TITLE     Activation and functional characterization of the mosaic receptor
            SorLA/LR11
  JOURNAL   J Biol Chem 276 (25), 22788-22796 (2001)
   PUBMED   11294867
REFERENCE   7  (bases 1 to 10537)
  AUTHORS   Hampe,W., Riedel,I.B., Lintzel,J., Bader,C.O., Franke,I. and
            Schaller,H.C.
  TITLE     Ectodomain shedding, translocation and synthesis of SorLA are
            stimulated by its ligand head activator
  JOURNAL   J Cell Sci 113 Pt 24, 4475-4485 (2000)
   PUBMED   11082041
REFERENCE   8  (bases 1 to 10537)
  AUTHORS   Hirayama,S., Bujo,H., Yamazaki,H., Kanaki,T., Takahashi,K.,
            Kobayashi,J., Schneider,W.J. and Saito,Y.
  TITLE     Differential expression of LR11 during proliferation and
            differentiation of cultured neuroblastoma cells
  JOURNAL   Biochem Biophys Res Commun 275 (2), 365-373 (2000)
   PUBMED   10964672
REFERENCE   9  (bases 1 to 10537)
  AUTHORS   Posse De Chaves,E.I., Vance,D.E., Campenot,R.B., Kiss,R.S. and
            Vance,J.E.
  TITLE     Uptake of lipoproteins for axonal growth of sympathetic neurons
  JOURNAL   J Biol Chem 275 (26), 19883-19890 (2000)
   PUBMED   10867025
REFERENCE   10 (bases 1 to 10537)
  AUTHORS   Kanaki,T., Bujo,H., Hirayama,S., Ishii,I., Morisaki,N.,
            Schneider,W.J. and Saito,Y.
  TITLE     Expression of LR11, a mosaic LDL receptor family member, is
            markedly increased in atherosclerotic lesions
  JOURNAL   Arterioscler Thromb Vasc Biol 19 (11), 2687-2695 (1999)
   PUBMED   10559012
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132272, SAMD00132294
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..10537
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..10537
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /note="sortilin related receptor 1"
                     /db_xref="GeneID:300652"
                     /db_xref="RGD:619914"
     CDS             1..6648
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /note="sortilin-related receptor, LDLR class A
                     repeats-containing; LDLR relative with 11 ligand-binding
                     repeats; sortilin-related receptor-like; sorting
                     protein-related receptor containing LDLR class A repeats;
                     low-density lipoprotein receptor relative with 11
                     ligand-binding repeats"
                     /codon_start=1
                     /product="sortilin-related receptor precursor"
                     /protein_id="NP_445971.1"
                     /db_xref="GeneID:300652"
                     /db_xref="RGD:619914"
                     /translation="MATRSSRRESRLPFLFTLVALLPPGALGGGWTQRLHGGGAPLPQ
                     DRGFFVVQGDPHELRLGTHGDAWGASPAARKPLRTRRSAALQPQPIQVYGQVSLNDSH
                     NQMVVHWAGEKSNVIVALARDSLALTRPKSSDVYVSYDYGKSFNKISEKLNFGVGNSS
                     EAVISQFYHSPADNKRYIFVDAYARYLWITFDFGSTIHGFSIPFRAADLLLHSKASNL
                     LLGFDSSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDQPNTIYIERHEPFGFST
                     VFRSTDFFQSRENQEVILEEVRDFQLRDKYLFATKVVHLPGSQQQSSVQLWVSFGRKP
                     MRAAQFVTKHPINEYYIADASEDQVFVCVSHSNNSTNLYISEAEGLKFSLSLENVLYY
                     SPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMSEENMRSVITFDKGGTW
                     EFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATG
                     SVGKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQGMETNELKYSTN
                     EGETWKTFVFSEKPVFVYGLLTEPGEKSTVFTIFGSNKESVHSWLILQVNATDALGVP
                     CTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDY
                     ECDFGFKMSEDISLEVCVPDPEFSGKPYSPPVPCPVGSSYRRTRGYRKISGDTCSGGD
                     VEARLEGELVPCPLAEENEFILYAMRKSIYRYDLASGATEQLPLSGLRAAVALDFDYE
                     HNCLYWSDLALDTIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKI
                     EVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYR
                     LVSEDVKWPNGISVDGHWIYWTDAYLDCIERITFSGQQRSVILDNLPHPYAIAVFKNE
                     IYWDDWSQLSIFRASKYSRSQVETLASQLTGLMDMKIFYKGKNAGSNACIPQPCSLLC
                     LPKANNSKSCRCPEGVASSVLPSGYLMCDCPQGYERKNNTCVKEENTCLRNQYHCSNG
                     NCINSIWWCDFDNDCGDMSDERNCPTTICDADTQFRCQESGTCIPLSYKCDLEDDCGD
                     NSDESHCEMHQCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNF
                     QCHNGHCIPQRWACDGDADCQDGSDEDPISCEKKCNGFHCPNGTCIPSSKHCDGLRDC
                     PDGSDEQHCEPFCTRFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDATFAGCSQDPE
                     FHKECDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFHCEN
                     GRCIPNRWKCDRENDCGDWSDEKDCGDSHIFPSPTPGPSTCLPNYFRCSSGACVMGTW
                     VCDGYRDCADGSDEEACPSLANSTAASTPTQLGQCDRFEFECRQPKKCIPNWKRCDGH
                     QDCQDGQDEANCPTHSTLTCMSREFKCEDGEACIVLSERCDGFLDCSDESDEKACSDE
                     LTVYKVQNLQWIADFSGDVTLTWTRPKKMPSASCVYNVYYRVVGESIWKTLETHSNKT
                     STVLKVLKPDTTYQVKVQVHCLSKVHNTNDFVTLRTPEGLPDAPRNLQLSLNSEEEGV
                     ILGHWAPPVHTHGLIREYIVEYSRSGSKMWASQRAASNSTEIKNLLLNALYTVRVAAV
                     TSRGIGNWSDSKSITTTKGKVIQAPNIHIDSYDENSLSFTLTMDGDIKVNGYVVNLFW
                     SFDAHKQEKKTLNFRGGSSLSHKVSNLTAHTSYEVSAWAKTDLGDSPLAFEHILTRGI
                     SPPAPSLKAKAINQTAVECIWTGPKNVVYGIFYATSFLDLYRNPKSLTTSLHNKTVIV
                     SKDEQYLFLVRVLIPYQGPSSDYVVVKMIPDSRLPPRHLHAVQIGKTSAVIKWESPYD
                     SPDQDLFYAIAVKDLIRKTDRSYKVRSRNSTVEYSLSKLEPGGKYHIIVQLGNMSKDS
                     SIKITTVSLSAPDALKIITENDHVLLFWKSLALKEKQFNETRGYEIHMFDSAVNLTAY
                     LGNTTDNFFKVSNLKMGHNYTFTVQARCLFGSQICGEPAVLLYDELSSGGDATVVQTA
                     RSTDVAAVVVPILFLILLSLGVGFAVLYTKHRRLQSSFTAFANSHYSSRLGSAIFSSG
                     DDLGEDDEDAPMITGFSDDVPMVIA"
     exon            1..285
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            286..402
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            403..528
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            529..690
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            691..758
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            759..939
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1041
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1211
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1404
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1522
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1596
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1685
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1864
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..2051
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2180
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2266
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2439
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2571
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2663
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..2910
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..3049
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..3223
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3337
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3460
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3580
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            3581..3706
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            3707..3814
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            3815..3946
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            3947..4078
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            4079..4213
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            4214..4369
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            4370..4519
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            4520..4651
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            4652..4778
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            4779..4948
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            4949..5061
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            5062..5166
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            5167..5239
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            5240..5322
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            5323..5422
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            5423..5607
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            5608..5727
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            5728..5892
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            5893..6067
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            6068..6174
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            6175..6367
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            6368..6580
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            6581..10537
                     /gene="Sorl1"
                     /gene_synonym="Lr11; RGD619914; SorLA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcgacac ggagcagcag gagggagtcg agactccctt tcctattcac cctggtcgct
       61 ctgctgcccc ccggggctct cggcgggggc tggacgcaga gattgcatgg tggcggagcg
      121 cccttgcccc aggaccgcgg cttcttcgtg gtgcagggcg acccgcacga gctgcggctg
      181 ggaacgcacg gggatgcctg gggggcgagc ccagcggcca ggaagccact caggacgcgg
      241 cggagcgctg ctttgcagcc ccagcctatc caggtgtatg gacaggtcag cctgaatgac
      301 tcccacaatc agatggtggt gcactgggct ggagagaaaa gcaacgtgat cgtggcatta
      361 gcccgagaca gcctggcatt gacaaggccc aagagcagtg atgtatatgt gtcttatgac
      421 tatggaaaat cattcaataa gatttcagag aagctgaact ttggtgtggg aaacagcagt
      481 gaagccgtga tctcccaatt ctaccacagc cctgccgaca acaagaggta catctttgtg
      541 gatgcttatg cccgatacct ctggatcacg tttgacttcg gcagcacgat ccatggcttc
      601 tccatcccat tccgggcggc tgatctcctc cttcatagca aggcctccaa cctcctcttg
      661 ggctttgaca gctctcaccc caacaagcag ctatggaagt cggatgattt tggccagacc
      721 tggatcatga ttcaggaaca tgtgaagtcc ttttcttggg ggatcgaccc ctatgaccag
      781 ccgaacacta tctacatcga gcggcatgaa ccctttgggt tctccacagt gttccgcagc
      841 acagacttct tccagtcccg ggaaaaccag gaagtgatcc tggaggaagt gagagacttt
      901 cagcttcggg acaagtacct gtttgctaca aaggtggtgc atcttccggg cagccagcag
      961 cagtcatctg tccagctctg ggtctccttt ggccggaagc ctatgcgagc agcccagttt
     1021 gtcacaaagc atcctattaa cgaatactac atcgccgatg cctccgaaga ccaggtcttc
     1081 gtgtgcgtca gccacagcaa caatagtact aacctgtaca tctcagaggc ggaggggctg
     1141 aaattctccc tatccttgga gaatgtgctg tattatagcc caggaggggc cggcagtgac
     1201 accctggtga ggtattttgc aaacgagccg tttgccgact ttcaccgagt ggagggctta
     1261 caaggagtct acattgccac cctgattaat ggatctatga gtgaggagaa catgaggtcg
     1321 gtcatcacct ttgacaaagg gggaacctgg gaatttcttc aggccccggc cttcacagga
     1381 tatggagaga aaatcaattg tgagctctct cagggctgct ccctccacct ggcccagcgc
     1441 ctcagtcaac tgctcaacct ccaacttcgg aggatgccga tcctgtccaa ggagtcagcc
     1501 cccggcctca tcatcgccac cggctctgtg ggaaagaact tggccagcaa gaccaacgtg
     1561 tacatctcta gcagtgccgg agcccggtgg agagaggctc ttccaggacc tcattactat
     1621 acttggggtg accatggagg catcatcatg gccattgccc agggcatgga gaccaacgag
     1681 ctgaagtaca gcaccaatga aggcgagacc tggaagacgt tcgtcttctc tgagaagcct
     1741 gtgtttgtgt atgggcttct cacggaacct ggcgagaaga gcaccgtctt caccatcttc
     1801 ggctctaaca aggagagtgt ccacagctgg ctcatcctgc aggtcaatgc caccgacgcc
     1861 ttgggggttc cttgcacgga aaacgactac aagctgtggt ccccatctga tgagcggggg
     1921 aacgagtgtt tgctaggaca caagacagtt ttcaaaagga ggacccctca cgcaacgtgc
     1981 tttaatgggg aagactttga ccggccggtg gtcgtgtcca actgctcctg cacccgggag
     2041 gactacgaat gtgactttgg cttcaagatg agtgaagata tctccttaga ggtttgtgtt
     2101 ccagaccctg agttttctgg gaagccctac agccctcctg tgccttgtcc cgtgggttct
     2161 tcctacagga gaacaagagg ctatcggaag atttctgggg atacgtgcag tggaggagat
     2221 gttgaggcac ggctggaggg ggagctggtc ccctgtcccc tggcagaaga gaatgagttc
     2281 atcctgtacg ccatgcggaa atccatctac cgctacgact tggcctcggg agccacggaa
     2341 cagcttcctc tctcggggct gcgggcagcc gtggccctgg actttgacta tgagcacaac
     2401 tgcctgtatt ggtctgacct ggcgctggac accatccagc gtctctgctt gaatgggagc
     2461 acagggcaag aggtgatcat caattctggc ctggagaccg tggaggcttt ggcctttgaa
     2521 cccctcagcc agttacttta ctgggtggat gccggcttta aaaagatcga ggtagctaat
     2581 ccagatggtg acttccggct gacaatcgtc aattcctctg tgcttgatcg acccagggct
     2641 ctagtccttg tgccccaaga gggggtgatg ttctggactg actggggaga cttgaagcct
     2701 ggaatttacc ggagcaacat ggatgggtct gctgcctatc gccttgtgtc agaggacgtg
     2761 aagtggccta atggcatctc tgtggacggc cactggattt actggacgga cgcttacctg
     2821 gactgtatcg agcgcatcac tttcagtggc cagcagcgtt cagtcatcct tgacaacctc
     2881 ccacaccctt acgccattgc cgtctttaag aacgagatct actgggacga ctggtcgcag
     2941 ctcagtatct tcagagcttc caagtacagc aggtcccagg tggagaccct agcgagccag
     3001 ctcaccggcc tgatggacat gaagatcttc tacaaaggaa agaacgccgg aagcaatgcc
     3061 tgcattcctc agccctgcag tctactgtgc ctccctaagg ccaacaacag caaaagctgc
     3121 aggtgtccag aaggcgtggc cagcagtgtc ctcccctctg ggtacctgat gtgtgactgc
     3181 cctcagggct acgagaggaa gaacaacacc tgtgtcaaag aagagaacac ctgtcttcgc
     3241 aaccagtacc actgcagcaa cggcaactgt atcaacagca tttggtggtg tgatttcgac
     3301 aacgactgtg gcgatatgag tgacgagagg aattgcccca cgaccatctg tgatgcagac
     3361 actcagttcc ggtgccagga gtcggggact tgtattccac tctcctataa gtgtgacctt
     3421 gaagatgact gtggagataa cagtgatgag agtcactgtg agatgcacca gtgtcgcagc
     3481 gacgagttca actgtagctc tgggatgtgc atccggtcct cctgggtgtg cgacggagac
     3541 aacgactgtc gggactggtc tgatgaagcc aactgcaccg ccatctacca cacctgtgag
     3601 gcctccaact tccaatgcca caatggccac tgcatccccc agcgatgggc atgtgacggt
     3661 gacgcggatt gccaggacgg ctctgatgaa gatcccatca gctgtgagaa aaagtgcaat
     3721 ggattccact gcccaaacgg cacgtgcatc ccatccagca agcattgtga cgggctgcgg
     3781 gactgccccg acggctctga cgagcagcac tgtgagccct tctgcacacg tttcatggac
     3841 tttgtgtgta agaaccgtca gcagtgtctg ttccactcca tggtgtgtga cgggatcatc
     3901 cagtgccgag atggctctga tgaggatgcc accttcgccg gatgctccca agacccggag
     3961 ttccacaagg agtgtgacga gttcggcttc cagtgtcaga acggagtgtg catcagcttg
     4021 atttggaaat gcgatgggat ggatgactgc ggagactact ctgacgaggc caactgtgaa
     4081 aaccccacag aagccccgaa ctgctcccgc tacttccagt tccactgtga gaatggccgc
     4141 tgcatcccca acaggtggaa atgtgacaga gagaatgact gcggggactg gtctgatgag
     4201 aaggactgtg gagattcaca cattttcccc tcccccaccc ccggaccgtc cacatgtctg
     4261 cccaattact tccgatgcag cagcggggcc tgcgtgatgg gcacctgggt gtgcgacggc
     4321 tacagggact gtgctgatgg ctcagatgag gaagcctgcc cctctctagc aaactccact
     4381 gccgcctcca ctcccaccca gcttgggcag tgtgaccgat ttgagttcga gtgccgccaa
     4441 ccaaagaaat gtatccccaa ctggaagcgc tgtgatggcc accaggattg ccaagacggc
     4501 caggacgaag ccaactgccc cactcacagc accttgacgt gtatgagcag ggagttcaag
     4561 tgtgaggacg gcgaggcgtg cattgtgctc tcggagcgct gtgacggctt cctggattgc
     4621 tctgatgaga gtgatgagaa ggcctgcagc gatgagttaa cagtatataa agtccagaat
     4681 cttcaatgga tagctgattt ctctggggat gtgactttga cctggacgcg accaaaaaaa
     4741 atgccatctg cttcttgtgt atacaatgtg tactacaggg tggttggaga gagcatatgg
     4801 aagaccctgg aaacccatag caataaaaca agcactgtgc tgaaggtcct gaagccagac
     4861 accacgtacc aggttaaggt ccaggtgcac tgccttagca aggtgcacaa caccaatgac
     4921 tttgtgaccc tgaggactcc agaggggttg ccggatgccc ctcggaatct ccagctctcc
     4981 ctaaacagtg aagaggaagg tgtgattctt gggcactggg ctcctcccgt ccacacccat
     5041 ggcctcatcc gtgagtacat tgtggaatac agccggagtg gatccaagat gtgggcctcc
     5101 cagagagctg ccagcaactc tacagagata aagaacttac tgctcaatgc cctctacacc
     5161 gtccgagtgg ctgcggtgac tagtcgggga ataggaaact ggagtgattc caaatccatc
     5221 accaccacaa aaggaaaagt gatccaagca ccaaatatcc acattgacag ctacgatgaa
     5281 aattctctca gctttaccct gaccatggac ggtgacatca aggtcaatgg ctatgtggtg
     5341 aaccttttct ggtcatttga tgcccacaaa caagaaaaga aaaccttgaa cttccgagga
     5401 ggaagctcgc tgtcacacaa agtgagcaat ctgacagctc atacgtccta tgaggtttct
     5461 gcctgggcca agacagactt gggggacagt cctctggcct ttgagcacat cttgaccaga
     5521 ggcatcagtc cacctgctcc tagtctcaaa gccaaggcca tcaatcagac tgcagtggag
     5581 tgcatctgga ctggccccaa gaatgtggtg tatggtattt tctacgccac atccttcctc
     5641 gacctctacc gaaaccctaa gagtttaact acttcactcc acaataagac agtcattgtc
     5701 agcaaggatg agcagtattt gtttctggtc cgggtgttga tcccttacca agggccgtcc
     5761 tccgactacg ttgtggtgaa gatgatccca gacagcaggc ttccacctcg gcacctacat
     5821 gccgtccaaa taggcaagac ctcagcagtc atcaagtggg agtcacccta cgactctcct
     5881 gaccaggacc tgttctacgc cattgcagtg aaagatctga tccgaaagac ggacaggagc
     5941 tacaaagtca gatcccgcaa cagtactgtg gagtacagcc ttagcaagct ggagcctgga
     6001 gggaaatacc atatcattgt ccagctggga aacatgagca aggactccag cataaaaatc
     6061 accaccgtct cattgtcagc acctgatgcc ttaaaaatca taaccgaaaa cgaccacgtt
     6121 ctcctctttt ggaaaagtct agctttaaag gaaaagcagt tcaatgaaac caggggctac
     6181 gagatacaca tgtttgacag tgccgtgaat ctcaccgctt accttgggaa tactactgac
     6241 aatttcttta aagtgtccaa cctgaagatg ggtcacaatt acactttcac ggtccaggct
     6301 cgatgtctct ttggtagcca gatctgcggg gagcctgccg tgctgctgta tgacgaactg
     6361 agctcaggtg gagatgccac agtggtccag actgccaggt ctactgacgt cgcggccgtg
     6421 gtggttccta tcttgttcct gatcctgctg agcctgggag tcggctttgc cgtcctctac
     6481 acgaagcacc gccgcttaca aagcagcttc actgcctttg ccaacagcca ctacagctcc
     6541 aggctgggct ccgccatctt ctcttccggg gatgacctag gagaggacga cgaagatgct
     6601 cccatgatta ccggattctc agacgatgtc cccatggtga tagcgtgaag agcttttctc
     6661 attagaaacc aaatggtgta aatattttat ttgataaaga tagttgatgg tttattttaa
     6721 aagatgcact ttgagttgca atatgttatt tttatatggg ccaaaactac aaaaaaaaaa
     6781 aaaaagagga aagaaaggaa tgaatgaata aactttgtag tatcaactgt gaacttgaaa
     6841 ccgggttgat tttagtgacc acattatttg atttgacgtc atcttacagg gccgtgcttg
     6901 ctgggcatgc ttttaagtct gtgagatcat tttgcttcat taagttgacc attcttttcg
     6961 ttttcctaag acacagaaat gtatttaata aaaccttcaa gagagagtaa tgaatggggt
     7021 acattctcct tgaaaactgc tcagatttta catctcgttt gggtttagtt tacataagta
     7081 tgtgggtgtc ttgtggggga aggttccgtg ctattgtctt tgttaattta ttgggactct
     7141 gtgtaaggcc atattttagt ggctgtctga aaccccatgt gtgaagggcc ccttgcccaa
     7201 cagggttggg gtagggagca ggagcaacct gtttttattt gctcctgtgt cagggacagg
     7261 tctttggcag aagaggattc taggtcactg ctagattccg attcaactgc cctgtaaccc
     7321 gggaagccct gcaagccata gcctgtcttc tagtaatccg tggtctttta ctgtgcatgt
     7381 ctctgtacaa agtgtacctc tggaagctgc caagtgataa cactgctttc ttatacactg
     7441 ggatcattgt cacttgaaaa aaaattactg tggttgtggg agaaaggtct agatctgtgc
     7501 cacgatagat atgcatttcg aatgtacgcc atgtctccat ttcatttgag ttttcccttt
     7561 gttttcctca ccaccaaaga atctcaaatg taaaacttca tattgggttc taaccactga
     7621 ctcaaaagtc cattctgata tatgcagtca ttttgaattt ggtcctgtgc cttctccgga
     7681 tcccttccct tcccttctgc ctccctcacc cgctccctca gccatccata gagagtttgt
     7741 aggtgtttcc agggatggag gggatataaa catttgacct ctctctccat cagcagattt
     7801 gttcatttgc tttctctgtg aaacgccatg attgtctaaa caaacccccc agccctgaac
     7861 ccctctgtat cacatcaacg gccacttgaa agtgctgctg cctgccttgt ggcctccacc
     7921 cacccttcag cctgacttgt aggcaccgat gtccaacccg tcgtgacttg tgctgtgtga
     7981 acaacctcac tgaggatttc ctcccagcgg aaaagcagcg agctctgcga ctatcccaaa
     8041 gctatgcctc tgaacacgtt ttctatatgc aagatttgtg aaaaccgcct ccttcccgtg
     8101 cagcgtgtcc ctctgaagtg cttagtttct tttaacgaga agtatcattc ttgcattgtg
     8161 atagggtctc cgtttacctg agggttgttt ggaaaataag agccaatttt tcttaggata
     8221 tgtaagtaca ttaaacgagc attctgacct gtagatacat agtgtgccat gcggccatag
     8281 ctcctggtgt caaatgctag gagtaaagag tcttcttaca aattactttt ctcctctttc
     8341 ctgtcaccct ctttttcact attgtttttc ccccagactg gaatttcctc agccttttct
     8401 tgtcttgctt tgaagttttg ttcaatgttc ctcccctcct accacttcca cttaaataaa
     8461 gtctttaagt agctgaaaga ttaacagtct ggtgggaggc aaagccattg aactgaacca
     8521 ctaggaaagt atattttctt cttctcttat cctgccaagt ttttggtggc atttggagaa
     8581 gctggtgtaa aaggctatga ggcattgttt gccattactc ctcagtgaag cctttgcaca
     8641 gagcatatgt ctctggcagg cagtgcgagc tgttgccaag catcagaacc ggtctccagg
     8701 gcctcccgac gctgaaccat agccctgtac agacccaccg ccacccctct cctcggaaga
     8761 tgcactgtgc tgtttgaaaa catgtagccg tttcaggcta gagtatttta tataaataga
     8821 tgagcttagg tcccgaagac caaggcggat agatgcagct atgtgtaaat tgtctatttt
     8881 tgtgaacttc tcaagcacgc aactcctgtc tccccctgcc ttgtggaggt ttggatgttc
     8941 ccctgtcatc tgcaagagtc cagaggttgg ggtgacaata ggaagtgaaa ataagctatg
     9001 tgtagtctcg gagagttccc acctcccagg gagtgaaaca tactgcaatg ccaggtactt
     9061 ggttccctgt ggactgtgtg gaaactggat tttctctttt ctatattgaa taccctttga
     9121 gatttgtggg acatgggtcc acatggattt agtgacagag cagagttcct tcaagaactc
     9181 ttggagaggg gccacatctg aggagacagg caagaatcta atcactgctc gatgcccggt
     9241 aagctggaga gctccgactg ctgccagaca accggccggc actctgactt tgggaggagt
     9301 ggcccttgag gctctacctc tgattgcatc actgtgcatg actgcaagct agcaggggac
     9361 actcccttgc atgttccctc ctgtccagat ggcctgctag atagagaaca ggcccttcag
     9421 aaggcattag gtgtctggaa gtgagctaag aaggacagtg ggatggtgag ccccttacag
     9481 atggataagt accagtgtct ctttggttca ccttgccttc agatgtccct ggtgggacag
     9541 cacaactagc aggaccctag gcccctgatt ccagacccat ctcctatgtt aactccctgt
     9601 cccataaaga aggctatggt gtgttcctga gaatctttcc ttcagtggag aggtgagggt
     9661 cccctcagga gagagactca gacacatatc taagttgaat atcatcccca ttgcagttgt
     9721 aagaattgac tctaaactct gcagaaactc ccttctgttg gattgtatct cgacattcct
     9781 gtgatgtctt tcttagctgg agtgtgtgct gcctttcagg tacaactttt gtgtaatata
     9841 agccagagca ttaagtttat atagactact ttctatgcaa gactgagata gggacaaggt
     9901 tgcaggaaat gtgcgctgtt ggctacacgg acaagaagtg cactgtcaga atagtatccc
     9961 tgaacagagc ggagggagga ttagttgcat gtgtttctgc ctacttgttt tgagcagcca
    10021 ataaatttaa tcatcagagc tgagtgacaa cccaagaatg gtactggttt catgtgtgat
    10081 gacttcaatg ggctgagcat gaatgccaga gtggagcatc gttaccctca gagagtccat
    10141 gtccctcctc gtttaaagac tcttttttga gacttactaa acactttagg caaagtcaga
    10201 aggatctgca gcaaaataaa ggcctgttct gctcttattt aaagtgaaac actgtgtact
    10261 tgcttttctc caaagtaaaa ttaggttatt tataacttca atcgccttgg ctaggtttcc
    10321 aagtcactga tttctgctga agattttact acattgttgc acaattttaa gataatttct
    10381 tttgtcttgg tgtcaatctt tttcactgga taaaaattta actgggttaa agaaaaacaa
    10441 taaaaaaaaa ataaagacac cgccatcacc tatttaaata tccactgtgt gtgtcgtaaa
    10501 gttgttcttt tgagtgcaat aaagatagct taacaca
//
