LOCUS       NM_017052               2197 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus sorbitol dehydrogenase (Sord), mRNA.
ACCESSION   NM_017052
VERSION     NM_017052.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2197)
  AUTHORS   Rebelo,A.P., Abad,C., Dohrn,M.F., Li,J.J., Tieu,E.K., Medina,J.,
            Yanick,C., Huang,J., Zotter,B., Young,J.I., Saporta,M.,
            Scherer,S.S., Walz,K. and Zuchner,S.
  TITLE     SORD-deficient rats develop a motor-predominant peripheral
            neuropathy unveiling novel pathophysiological insights
  JOURNAL   Brain 147 (9), 3131-3143 (2024)
   PUBMED   38538210
  REMARK    GeneRIF: SORD-deficient rats develop a motor-predominant peripheral
            neuropathy unveiling novel pathophysiological insights.
REFERENCE   2  (bases 1 to 2197)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2197)
  AUTHORS   Li,Y., Zhang,Y., Qiu,F. and Qiu,Z.
  TITLE     Proteomic identification of exosomal LRG1: a potential urinary
            biomarker for detecting NSCLC
  JOURNAL   Electrophoresis 32 (15), 1976-1983 (2011)
   PUBMED   21557262
REFERENCE   4  (bases 1 to 2197)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   5  (bases 1 to 2197)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 2197)
  AUTHORS   Karlsson,C., Jornvall,H. and Hoog,J.O.
  TITLE     Sorbitol dehydrogenase: cDNA coding for the rat enzyme. Variations
            within the alcohol dehydrogenase family independent of quaternary
            structure and metal content
  JOURNAL   Eur J Biochem 198 (3), 761-765 (1991)
   PUBMED   2050152
REFERENCE   7  (bases 1 to 2197)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   8  (bases 1 to 2197)
  AUTHORS   Maret,W. and Auld,D.S.
  TITLE     Purification and characterization of human liver sorbitol
            dehydrogenase
  JOURNAL   Biochemistry 27 (5), 1622-1628 (1988)
   PUBMED   3365415
REFERENCE   9  (bases 1 to 2197)
  AUTHORS   Andrews,S.J. and Peters,J.
  TITLE     Linkage analyses and biochemical genetics of sorbitol
            dehydrogenase-1 (Sdh-1) in the mouse
  JOURNAL   Biochem Genet 21 (7-8), 809-817 (1983)
   PUBMED   6626150
REFERENCE   10 (bases 1 to 2197)
  AUTHORS   Holmes,R.S., Jones,J.T. and Peters,J.
  TITLE     Genetic variation, cellular distribution and ontogeny of sorbitol
            dehydrogenase and alcohol dehydrogenase isozymes in male
            reproductive tissues of the mouse
  JOURNAL   J Exp Zool 206 (2), 279-288 (1978)
   PUBMED   722274
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088398.1.
            
            On Oct 8, 2005 this sequence version replaced NM_017052.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088398.1, X59037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2197
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..2197
                     /gene="Sord"
                     /gene_synonym="SDH; XDH"
                     /note="sorbitol dehydrogenase"
                     /db_xref="GeneID:24788"
                     /db_xref="RGD:3734"
     exon            1..149
                     /gene="Sord"
                     /gene_synonym="SDH; XDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1157
                     /gene="Sord"
                     /gene_synonym="SDH; XDH"
                     /EC_number="1.1.1.14"
                     /EC_number="1.1.1.9"
                     /note="L-iditol 2-dehydrogenase; polyol dehydrogenase;
                     xylitol dehydrogenase"
                     /codon_start=1
                     /product="sorbitol dehydrogenase"
                     /protein_id="NP_058748.2"
                     /db_xref="GeneID:24788"
                     /db_xref="RGD:3734"
                     /translation="MAAPAKGENLSLVVHGPGDIRLENYPIPELGPNDVLLKMHSVGI
                     CGSDVHYWEHGRIGDFVVKKPMVLGHEAAGTVTKVGPMVKHLKPGDRVAIEPGVPREI
                     DEFCKIGRYNLTPSIFFCATPPDDGNLCRFYKHSADFCYKLPDSVTFEEGALIEPLSV
                     GIYACRRGSVSLGNKVLVCGAGPIGIVTLLVAKAMGASQVVVIDLSASRLAKAKEVGA
                     DFTIQVAKETPHDIAKKVESVLGSKPEVTIECTGAESSVQTGIYATHSGGTLVVVGMG
                     PEMINLPLVHAAVREVDIKGVFRYCNTWPMAVSMLASKTLNVKPLVTHRFPLEKAVEA
                     FETAKKGLGLKVMIKCDPNDQNP"
     exon            150..183
                     /gene="Sord"
                     /gene_synonym="SDH; XDH"
                     /inference="alignment:Splign:2.1.0"
     exon            184..348
                     /gene="Sord"
                     /gene_synonym="SDH; XDH"
                     /inference="alignment:Splign:2.1.0"
     exon            349..508
                     /gene="Sord"
                     /gene_synonym="SDH; XDH"
                     /inference="alignment:Splign:2.1.0"
     exon            509..627
                     /gene="Sord"
                     /gene_synonym="SDH; XDH"
                     /inference="alignment:Splign:2.1.0"
     exon            628..693
                     /gene="Sord"
                     /gene_synonym="SDH; XDH"
                     /inference="alignment:Splign:2.1.0"
     exon            694..869
                     /gene="Sord"
                     /gene_synonym="SDH; XDH"
                     /inference="alignment:Splign:2.1.0"
     exon            870..991
                     /gene="Sord"
                     /gene_synonym="SDH; XDH"
                     /inference="alignment:Splign:2.1.0"
     exon            992..2139
                     /gene="Sord"
                     /gene_synonym="SDH; XDH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tactccagac ccttggcggt ttgacgagca gaaacaccag ctccccgccg gatccagccg
       61 acacctcaaa gcaagagagc gacatggcag ctcctgctaa gggcgagaac ctgtccctgg
      121 tggtgcacgg acctggagac attcgcctgg agaactaccc aatccctgag ctgggcccaa
      181 atgatgtgtt actaaagatg cattcggtgg ggatctgtgg ctcggatgtt cactactggg
      241 agcatggccg aattggggac ttcgttgtga aaaagccaat ggtgcttggg catgaagctg
      301 ctggaacagt cacaaaagtg ggaccgatgg tgaaacatct aaaaccagga gatcgggtgg
      361 ccatcgagcc tggcgttccc cgagaaatag atgaattctg caagatcggc cgatacaatc
      421 tgacgccatc catcttcttc tgtgccacgc ccccagatga tgggaacctc tgccgcttct
      481 acaagcacag cgctgacttc tgctacaagc ttcctgatag tgtcaccttt gaagaagggg
      541 ccctgattga gcctctctct gtggggatct atgcctgccg tcgaggttcg gtttccctgg
      601 ggaacaaggt ccttgtgtgt ggagctgggc caattgggat agtcactttg cttgtggcca
      661 aagcaatggg agcttctcaa gtagtggtga ttgacctctc tgcttctcgg ttagccaagg
      721 ccaaggaagt tggagcagac tttaccatcc aggttgccaa agagacccct cacgacattg
      781 ccaagaaggt ggaaagtgtg ctggggagca agccagaggt caccatcgaa tgcacgggag
      841 cggagtcctc tgtccagacg ggcatctatg ccactcactc tggcgggacc ttggtggttg
      901 tgggaatggg ccccgagatg atcaatttac ccctagtgca cgcagctgtg cgggaggtgg
      961 acatcaaagg cgtgtttcga tactgcaaca cgtggccgat ggcagtttcc atgcttgcat
     1021 cgaagacttt gaatgtaaag cccttagtga cccataggtt ccccctggag aaggctgtag
     1081 aagcctttga aacagccaaa aagggactgg ggctgaaagt tatgatcaag tgtgacccca
     1141 atgaccagaa cccctaaatg tgattgctct atgcccttag cccactctct cagcatctaa
     1201 gggctaaatg gaccagaagg ggaagccatt aatgcagaac cttctttttg aatggtagga
     1261 ataataaact cataagccga gagccttaga ggagctggcg tgccttaaag acagaagtag
     1321 gggcaccttg ggggacctcg tagccagaat gagatgcgta tactgagtaa agtctagaac
     1381 caagagtctg gcagagaggt cccggaaatg ccctttctca gtaccttctt tgggtgagga
     1441 gacgaagcat gccttcgtcc atgttccaat gtgggtgcca gagagtgggg ctaacatgga
     1501 gaaatgacgt cattaacatg ggagtggccc cagagctgtt cagagcacag tgtttcccaa
     1561 gtgtcatttg atttgagggg aataagggca ctcagctctg cctcagctca gaattctgtc
     1621 cttacatttg caaagtggag gccttcttcc caacagtgct cattcatgtt caggagcagt
     1681 actggttgct aagcaaccag gagacttcca cccaaagatc ctaaatccag cctaactcat
     1741 acaagagggc cacaggaggg cttgagtttc ccactcacag gattcgcctc ctctcccagg
     1801 ctcactccta ggcaattatt atcccatccc actcagaaga tgctcccctt ctcggctgtt
     1861 aaggctagtg atatctgatg gatgggtatc acagagccta attaaattat ggggcttttc
     1921 tttataagat ctgggtccaa atcatgccct ttgtgatctt aagataatca agaagagcac
     1981 agtaactgtg gtgtaacttg ggctgcagtc tgtaatccac ctcttcagct atgagtaggg
     2041 gacacgtgaa aaaaaaaaga ctctgctgga gaagaccatg gccaacacct gagctttctc
     2101 aaactgcttc caatagtaaa ttctgtcgct ggtgttgaaa aaaaaaaaaa aaaaaaaaaa
     2161 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
