LOCUS       NM_001106367            5767 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus sortilin-related VPS10 domain containing receptor
            3 (Sorcs3), mRNA.
ACCESSION   NM_001106367 XM_001060421 XM_219998
VERSION     NM_001106367.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5767)
  AUTHORS   Breiderhoff,T., Christiansen,G.B., Pallesen,L.T., Vaegter,C.,
            Nykjaer,A., Holm,M.M., Glerup,S. and Willnow,T.E.
  TITLE     Sortilin-related receptor SORCS3 is a postsynaptic modulator of
            synaptic depression and fear extinction
  JOURNAL   PLoS One 8 (9), e75006 (2013)
   PUBMED   24069373
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jul 6, 2012 this sequence version replaced NM_001106367.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.8482.1,
                                           SRR26360194.2530162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-848               JAXUCZ010000001.1  257040442-257041289
            849-916             JAXUCZ010000001.1  257245290-257245357
            917-1016            JAXUCZ010000001.1  257347399-257347498
            1017-1175           JAXUCZ010000001.1  257395415-257395573
            1176-1249           JAXUCZ010000001.1  257462742-257462815
            1250-1314           JAXUCZ010000001.1  257503621-257503685
            1315-1433           JAXUCZ010000001.1  257511565-257511683
            1434-1523           JAXUCZ010000001.1  257551769-257551858
            1524-1703           JAXUCZ010000001.1  257562320-257562499
            1704-1850           JAXUCZ010000001.1  257572490-257572636
            1851-1953           JAXUCZ010000001.1  257574148-257574250
            1954-2030           JAXUCZ010000001.1  257578750-257578826
            2031-2122           JAXUCZ010000001.1  257581986-257582077
            2123-2230           JAXUCZ010000001.1  257591383-257591490
            2231-2348           JAXUCZ010000001.1  257615712-257615829
            2349-2482           JAXUCZ010000001.1  257616858-257616991
            2483-2596           JAXUCZ010000001.1  257628167-257628280
            2597-2768           JAXUCZ010000001.1  257633532-257633703
            2769-2955           JAXUCZ010000001.1  257636283-257636469
            2956-3089           JAXUCZ010000001.1  257641455-257641588
            3090-3213           JAXUCZ010000001.1  257656616-257656739
            3214-3326           JAXUCZ010000001.1  257659681-257659793
            3327-3458           JAXUCZ010000001.1  257663696-257663827
            3459-3558           JAXUCZ010000001.1  257665494-257665593
            3559-3664           JAXUCZ010000001.1  257666576-257666681
            3665-3825           JAXUCZ010000001.1  257672538-257672698
            3826-5767           JAXUCZ010000001.1  257673318-257675259
FEATURES             Location/Qualifiers
     source          1..5767
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..5767
                     /gene="Sorcs3"
                     /note="sortilin-related VPS10 domain containing receptor
                     3"
                     /db_xref="GeneID:294043"
                     /db_xref="RGD:1310974"
     exon            1..848
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..3890
                     /gene="Sorcs3"
                     /note="VPS10 domain-containing receptor SorCS3"
                     /codon_start=1
                     /product="VPS10 domain-containing receptor SorCS3
                     precursor"
                     /protein_id="NP_001099837.2"
                     /db_xref="GeneID:294043"
                     /db_xref="RGD:1310974"
                     /translation="MESAGTERPAGWPGAPLARTGLLLLSTWVLAGAEITWGATGGPG
                     RLVSPASRPPALPPLLPRAAENRWPEELASARRAAAPRRRSRLELLSQASRGEIPTEA
                     AGTSPEGARWVRGIPAPSQAGSARRTRRAQPPSTLERGDAWATAPADGAKGNRPQTKG
                     SREEVKATLTGGSATEELRLPSTSFALTGDSAHNQAMVHWFGHNSSVILILTKLYDFN
                     LGSVTESSLWRSVDYGATYEKLNDKVGLKTVLSYLYVNPTNKRKIMLLSDPEMESSIL
                     ISSDEGTTYQKYRLTFYIQSLLFHPKQEDWVLAYSLDQKLYSSMDFGRRWQLMHERIT
                     PNRFYWSVSGLDKEADLVHMEVRSADGYAHYLTCRIQECTETTRSGPFARSIDISSLV
                     VQDEYIFIQVTIGGRASYYVSYRREAFAQIKLPKYSLPKDMHIISTDENQVFAAVQEW
                     NQNDTYNLYISDTRGIYFTLAMENIKSSRSLMGNIIIELYEVAGIKGIFLANKKVDDQ
                     VKTYITYNKGRDWRLLQAPDVDLRGSPVHCLLPFCSLHLHLQLSENPYSSGRISSKDT
                     APGLVVATGNIGSELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHTP
                     LPVRHLWVSFDEGHSWDKYGFTLLPLFVDGALVEAGIETHIMTVFGHFNLRSEWQLVK
                     VDYKSIFSRRCTKEDFETWHLLNQGEPCVMGERKIFKKRKPGAQCALGREYSGSVTSE
                     PCVCADWDFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQSYLNSTGYRRIVSNNC
                     TDGLRDKYSAKTQLCPGKAPRGLHVVTTDGRLVAEQGHNATFIILMEEGDLQRTNIQL
                     DFGDGVAVSYANFSPIEDGIRHVYKSAGIFQVTAYAENNLGSDTAFLFLHVVCPVEHV
                     HLQVPFVAIRNKDVNISAVVWPSQLGTLTYFWWFGNSTKPLITLDSSISFTFLAEGTN
                     TITVQVAAGNALIQDTKEIAVHEYFQSQLLSFSPNLDYHNPDIPEWRQDIGNVIKRAL
                     IKVTSVPEDQILVAVFPGLPTSAELFILPPKNLTERRKGHEGDLEQIVETLFNALNQN
                     LVQFELKPGVQVIVYVTQLTLAPLVDSSAGHSSSAMLMLLSVVFVGLAVFLIYKFKRK
                     IPWINIYAQVQHDKEQEMIGSVSQSENAPKITLSDFTEPEELMDKELDTRVIGSIATI
                     ASSESTKEIPNCTSV"
     exon            849..916
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1016
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1175
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1249
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1314
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1433
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1523
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1703
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1850
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1953
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2030
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2122
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2230
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2348
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2482
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2596
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2768
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2955
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3089
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            3090..3213
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3326
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            3327..3458
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            3459..3558
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            3559..3664
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            3665..3825
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            3826..5767
                     /gene="Sorcs3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcaccctct ggacctggga gcaagcgatc cagagaggga agagtacagg ggacaggcga
       61 cgcgctccag ccggagccac ctccttcccg gccgccccct cctcactccc ctgacacact
      121 cgctagctcg cttgccggcg cgcgcatccc tccagccccc ccctccgccg gacccgcacc
      181 tcggcgggcg ccacacactc ggcagcccga gccgcggtag ccgcagcggg atggagtcgg
      241 caggcactga gcgcccggca ggctggcccg gggcgcccct cgcccggacc gggctgctgc
      301 tcttgtcaac gtgggtcctg gctggcgccg agatcacttg gggcgcaacc ggaggtcccg
      361 ggcgcttggt gtccccggct tcgcgaccac cagcgttgcc tcctctcttg cctcgggcag
      421 cggagaaccg gtggcctgag gagctggcat ctgcacggag agcggctgca ccgaggcgcc
      481 ggtccaggct cgagctactg tcccaggcga gccgcgggga gattccgaca gaagctgcgg
      541 gaacgtcgcc tgaaggcgcg aggtgggtcc ggggcatccc agctcctagc caggcgggca
      601 gcgctaggag gactcgccgg gctcagccgc ccagcactct ggagcgcggg gacgcttggg
      661 ctactgctcc cgcagatggt gccaaaggaa accgtcctca gaccaagggt tcccgggagg
      721 aggtgaaggc gacgctgacc ggaggatcgg cgactgagga gctccgattg cccagcacgt
      781 cttttgcact gacaggggac tcagctcaca accaagccat ggtgcactgg ttcggacata
      841 acagcagtgt catactgatc ctgacaaagc tctacgactt caacctgggg agtgtgactg
      901 agagttctct gtggaggtca gtagattatg gtgccaccta tgaaaagcta aatgacaaag
      961 tgggcttgaa gaccgtcctc agttacctct atgtcaaccc caccaacaag aggaagatca
     1021 tgcttcttag cgatcctgaa atggagagca gtatattgat cagctcagat gaagggacaa
     1081 cctatcaaaa gtatcggctt acattctaca tccagagcct tctcttccac cccaagcagg
     1141 aggactgggt gctggcctac agcttggacc aaaagcttta tagctccatg gacttcggca
     1201 ggcgatggca actcatgcat gagcgcatca cgcccaacag gttttactgg tcggtgtccg
     1261 gattggataa agaagcagac ctggttcaca tggaagtgag gtcggcagat ggatacgctc
     1321 actacctcac ctgcagaatc caagaatgta ctgagacaac tcggagtggc ccctttgccc
     1381 gctccattga catcagttcc ctggtcgtcc aggatgaata catcttcatt caggtaacga
     1441 tcggtggaag agccagctat tacgtgtcct atcgaagaga agcctttgcc cagataaagc
     1501 tgcccaagta ctccttgcca aaggacatgc acatcatcag tacagatgag aaccaagtgt
     1561 ttgcagccgt ccaagaatgg aaccaaaatg acacctacaa cctctacatc tcagacacac
     1621 gcgggatcta cttcacattg gctatggaga acattaagag cagccgaagt ctaatgggga
     1681 acatcattat tgagttatat gaggtagcag gtatcaaggg catattcctg gcaaacaaga
     1741 aggtggatga ccaggtgaag acgtacatca cttacaacaa aggcagggat tggcgtctac
     1801 tgcaagctcc agatgtggac ctgagaggaa gcccagtgca ctgtttgctg cccttctgtt
     1861 ccctacacct gcatctgcag ctctctgaaa acccatattc ttctggaaga atctccagca
     1921 aggatacagc tcctggactt gtggttgcca caggcaatat tggctcagaa ctctcttata
     1981 cggatatcgg tgtgttcatc tcctctgatg ggggcaacac atggagacag atctttgatg
     2041 aagaatacaa tgtgtggttc ctagactggg gtggtgctct ggtggccatg aaacacacac
     2101 ctctgccagt caggcatttg tgggtgagtt ttgatgaggg ccattcctgg gacaagtatg
     2161 gtttcacatt gctgcctctt ttcgtggatg gtgcgttggt ggaggcagga atagagaccc
     2221 acatcatgac agtctttggc cacttcaacc tgcgctccga atggcagttg gtgaaagtgg
     2281 actacaagtc tatcttcagc cggcgctgta ccaaggagga ctttgagact tggcacctgc
     2341 tcaatcaggg agagccttgt gtcatggggg aaaggaaaat attcaagaaa cgcaagccag
     2401 gtgctcagtg tgccctgggc agagaatact ctgggtcggt gacatcagaa ccctgtgtct
     2461 gtgcggactg ggacttcgaa tgtgactatg gctatgagag acatggagag agccagtgtg
     2521 tcccagcttt ctggtacaac ccagcttccc cttcaaagga ctgcagcctt ggtcaaagct
     2581 accttaacag cactgggtac cgaaggattg tatccaacaa ctgcactgat ggcttaaggg
     2641 ataaatattc tgccaagact cagttatgtc ctggaaaagc tcctcggggc ctccatgtgg
     2701 tgaccactga tgggcgcctg gtggcagaac agggacataa cgcaaccttc atcattctaa
     2761 tggaggaggg tgacctccaa aggacaaaca tccagcttga ctttggggat ggggttgctg
     2821 tgtcttatgc caacttcagc cccattgagg atggcatcag gcatgtgtat aagagcgcgg
     2881 ggatcttcca ggtgacagcc tatgcagaga acaaccttgg ctctgacaca gctttcctct
     2941 tccttcacgt ggtttgtcca gtggagcacg ttcaccttca agttccattc gtcgccataa
     3001 gaaataagga tgttaacatc agtgccgtcg tgtggcccag tcagctcggg acccttacct
     3061 acttctggtg gtttggcaat agcacaaagc ccctcatcac cttggacagc agcatctctt
     3121 tcacattcct tgcagaggga accaatacca tcactgtcca ggtagctgct gggaatgccc
     3181 tcatccaaga cacaaaagag attgctgtac acgaatactt ccagtcacag ctcttatcat
     3241 tctctccaaa tctggattac cacaatcctg atatccctga gtggaggcaa gacattggca
     3301 acgtcatcaa gcgagctctg attaaagtga ccagtgtccc agaagaccag atccttgtgg
     3361 ccgtgttccc aggtctcccc acttcagcag agcttttcat cctcccacct aagaacttga
     3421 cagagaggag gaaaggccac gaaggggatc tagaacaaat tgtagagaca ctatttaatg
     3481 cgcttaatca aaacttggta cagtttgagc tgaaaccagg tgtccaggtc attgtttatg
     3541 tgacacagct gacattagct cccctggtgg actctagcgc cgggcacagc agctctgcca
     3601 tgctcatgct cctctcggtg gtttttgtcg gcttggctgt gtttctgatc tacaagttta
     3661 aaaggaaaat cccctggatt aacatctacg cccaagtcca acatgataag gaacaggaga
     3721 tgattgggtc agtgagccaa agtgaaaatg cccccaaaat cacactcagt gacttcaccg
     3781 agcccgagga gctgatggac aaggagctgg acacacgggt cataggaagc attgctacca
     3841 tcgcgagcag tgagagcaca aaggagatcc ccaactgtac tagtgtttaa caaagaagcc
     3901 acgtgggcca tcaccttcct gactttttat ttttgatgac tactattact attattatgg
     3961 aaaaatgaaa atgtcttttt ttttaccttt tgtttaccaa gggtcccttc ataattagtg
     4021 ggcagatgct tagctttggg aagcaaaaaa acaaaaacaa aaaaaacaaa aaacaaaaaa
     4081 aggcattctt agttgatcat aatgggatga aggaatatat ggttatattt gtgttaagaa
     4141 tgcttcttcc cacaggtttc ttgctttact ctgctgtcag tagaacgaag tttttctcat
     4201 gtcattctgt ctcttttgag ttgggttttt gttaacttca ccttcctcta cccctctcat
     4261 gctccacact cacgtacaca tacaacgtag accattcccc agttcaactg caggacgtag
     4321 gttgaggggg agtggacata gctgccaaag gcacgcacac cttttcgaaa gaggccctgc
     4381 ctcgtgcatg tcaaaactga ggctaaagat ggtgtattgt atataacaac aatgtaaata
     4441 gctttttatt tcctaagaaa taatttaatg tttagtaaaa aagaaaacag aaaaaaagaa
     4501 agatgtgtgt gttggcttct gcactcacct tcagagatga ccgcccccca gcctgcctgg
     4561 tgtgttggat tctgggtagt ctccagctgt ttgtcacact caactcttgt gtctcagtcc
     4621 acaccatagc tggtttctgc ttatgtatat aaagggagtg ggggagggct tcttcaggac
     4681 aattgacaaa ggaaagactt cagtgacact caagaaaaca ggggttgttt ttcttcctag
     4741 gaaaacatgg aggaagccac aaagactagt agagacttca aactgaaact catttgggga
     4801 gataagactt tctctcaaga aagaaaataa aagggcgggt attcatcagc ctgagaaagc
     4861 agtcctctct aaaggagcaa caaggaatct aaagatgctc gcactctgtt ttctaattgg
     4921 attttgtgga tatgtgcatt gcccataatg agccgcccag ctgttctgag ctcagaaccg
     4981 tctttgggca ttacatgagg tccagtgaac atcgactggc attacgagaa tcagagtggc
     5041 tggaaaggga ggtccatttg tggaatcctg agtttgtgaa aaccctgtag gccaaacaga
     5101 ggtctagtct ttaatgatat tagtcagaat gattttagca aagctgtgct atttgcttgt
     5161 cagatgtaca caacttcctt aaagtcagat gtcagccttc agttccctta aggtagttct
     5221 ctcgcctctg gggtgaatgg ctttcaaagc ctgtacttgc tttcttagca ccccagcccc
     5281 ctcacctgtt taacatgcca actcttttcc gtaggctcac ttcacaccat gctgcaagca
     5341 tccgtttcat tttcaggctc tgcctgtgca cacgtgtttc aaagaatgct atactgtata
     5401 tatatatatg aaaagaaagg ccacattttg tacccgtcaa ccttcatgag atgctgttca
     5461 tagtcctctt tgtgagatac agggagaatg tgatggagaa atctagctgg ttacaccaca
     5521 gatcagtatt agaagggttt ctaaagatcc ctctttttca tttcaaaggt taaatggagc
     5581 agacaattgc gatatgtgta ctaaacactg ggatacagtg catgagtcat atctatctat
     5641 atatatatac agtatatgta catatactgt tcttggtttt attgttccat ttgaatattt
     5701 ctactgtaaa aaaagacagt ggttttgaaa ttgttgaaaa taaatgtatt tttgtacatc
     5761 aaagcta
//
