LOCUS       NM_001107225            5714 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus sortilin-related VPS10 domain containing receptor
            2 (Sorcs2), mRNA.
ACCESSION   NM_001107225 XM_001063684 XM_223522
VERSION     NM_001107225.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5714)
  AUTHORS   Malik,A.R., Szydlowska,K., Nizinska,K., Asaro,A., van Vliet,E.A.,
            Popp,O., Dittmar,G., Fritsche-Guenther,R., Kirwan,J.A., Nykjaer,A.,
            Lukasiuk,K., Aronica,E. and Willnow,T.E.
  TITLE     SorCS2 Controls Functional Expression of Amino Acid Transporter
            EAAT3 and Protects Neurons from Oxidative Stress and
            Epilepsy-Induced Pathology
  JOURNAL   Cell Rep 26 (10), 2792-2804 (2019)
   PUBMED   30840898
REFERENCE   2  (bases 1 to 5714)
  AUTHORS   Glerup,S., Bolcho,U., Molgaard,S., Boggild,S., Vaegter,C.B.,
            Smith,A.H., Nieto-Gonzalez,J.L., Ovesen,P.L., Pedersen,L.F.,
            Fjorback,A.N., Kjolby,M., Login,H., Holm,M.M., Andersen,O.M.,
            Nyengaard,J.R., Willnow,T.E., Jensen,K. and Nykjaer,A.
  TITLE     SorCS2 is required for BDNF-dependent plasticity in the hippocampus
  JOURNAL   Mol Psychiatry 21 (12), 1740-1751 (2016)
   PUBMED   27457814
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 15, 2008 this sequence version replaced NM_001107225.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.54875.1,
                                           SRR26643298.54793.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-574               JAXUCZ010000014.1  78596087-78596660
            575-642             JAXUCZ010000014.1  78747442-78747509
            643-742             JAXUCZ010000014.1  78822454-78822553
            743-907             JAXUCZ010000014.1  78898403-78898567
            908-981             JAXUCZ010000014.1  78905110-78905183
            982-1046            JAXUCZ010000014.1  78907618-78907682
            1047-1165           JAXUCZ010000014.1  78910286-78910404
            1166-1255           JAXUCZ010000014.1  78913474-78913563
            1256-1435           JAXUCZ010000014.1  78920299-78920478
            1436-1582           JAXUCZ010000014.1  78925729-78925875
            1583-1685           JAXUCZ010000014.1  78928594-78928696
            1686-1762           JAXUCZ010000014.1  78929998-78930074
            1763-1854           JAXUCZ010000014.1  78932116-78932207
            1855-1962           JAXUCZ010000014.1  78933132-78933239
            1963-2083           JAXUCZ010000014.1  78935810-78935930
            2084-2217           JAXUCZ010000014.1  78936912-78937045
            2218-2346           JAXUCZ010000014.1  78937632-78937760
            2347-2518           JAXUCZ010000014.1  78940281-78940452
            2519-2705           JAXUCZ010000014.1  78946056-78946242
            2706-2839           JAXUCZ010000014.1  78948447-78948580
            2840-2963           JAXUCZ010000014.1  78949672-78949795
            2964-3076           JAXUCZ010000014.1  78950862-78950974
            3077-3202           JAXUCZ010000014.1  78951688-78951813
            3203-3302           JAXUCZ010000014.1  78953012-78953111
            3303-3405           JAXUCZ010000014.1  78953602-78953704
            3406-3509           JAXUCZ010000014.1  78956338-78956441
            3510-5714           JAXUCZ010000014.1  78958378-78960582
FEATURES             Location/Qualifiers
     source          1..5714
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..5714
                     /gene="Sorcs2"
                     /note="sortilin-related VPS10 domain containing receptor
                     2"
                     /db_xref="GeneID:305438"
                     /db_xref="RGD:1310621"
     exon            1..574
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..3574
                     /gene="Sorcs2"
                     /note="VPS10 domain receptor protein SORCS 2"
                     /codon_start=1
                     /product="VPS10 domain-containing receptor SorCS2"
                     /protein_id="NP_001100695.2"
                     /db_xref="GeneID:305438"
                     /db_xref="RGD:1310621"
                     /translation="MAHRGTPSAPKRPGLTAPDRSSQVLLPPCWPRSWPLLLLLLVLV
                     AACGAMGRSPQPGRWGPSVQVTRLLPAGRTESSNRQDPQTRESEPGVPGLRPGSASGP
                     STDGAPALGKGRRVRAAPVAGAASASRAQVSLISTSFVLKGDATHNQAMVHWTGENSS
                     VILILTKYYHADMGKVLESSLWRSSDFGTTYTKLTLQPGVTTVIDNFYICPANKRKII
                     LVSSSLGDREQSLFLSTDEGTTFQKYPVPFLVETLLFHPKEEDKVLAYTKDSKLYVSS
                     DLGKKWTLLQEQVTKDHVFWAVSGVDDDPNLVHMEARDLSGGYRYYTCLIHNCSAQPH
                     TAPFPGPTDRGSLTVQDEYIFLKATSTNRTKYYVSYRRSDFVLMKLPKYALPKDLQII
                     STDEQQVFVAVQEWNQVDTYNLYQSDLRGVRYSLVLENVRSSRQAEENVVIDILEVRG
                     VKGVFLANQKVDGKVTTVITYNKGRDWDYLRPPSTDMNGKPTNCQPPDCHLHLHLRWA
                     DNPYVSGTVHTKDTAPGLIMGAGNLGSQLVEYKEEMYITSDCGHTWRQVFEEEHHVLY
                     LDHGGVIAAIKDTSIPLKTLKFSVDEGHTWSTHNFTSTSVFVDGLLSEPGDETLVMTV
                     FGHISFRSDWELVKVDFRPSFPRPCVEDDYSSWDLTDLQGDHCIMGQQRSYRKRKSTS
                     WCVKGRSFTSALTSRVCKCRDSDFLCDYGFERSSSSESTVNKCSANFWFNPLSPPEDC
                     VLGQTYTSSLGYRKVVSNVCEGGVDLQQSPVQLQCPLQAPRGLQVSIRGEAVAVRPRE
                     DVLFVVRQEQGDVLTTKYQVDLGDGFKAMYVNLTLTGEPIRHHYESPGIYRVSVRAEN
                     MAGHDEAVLFVQVNSPLQALYLEVVPVIGINQEVNLTAVLLPLNPNLTVFYWWIGHSL
                     QPLLSLDNSVTTRFTDAGDVRVTVQAACGNSVLQDSRLVRVLDQFQVVPLQFSRDLDT
                     FNPNTPEWREDVGLVVTRLLSKETSIPEELLVTVVKPGLPTIADLYVLLPPPRPTRKR
                     SLTSDKRLAAVQQALNSHRISFILRGGLRVLVELRDTDAGPQRPGGSGGYWAVVVLFV
                     IGLFAVGAFILYKFKRKRPGRTVYAQMHNEKEQEMTSPVSHSEDAQSAMQGNHSGVVL
                     SINSREMHSYLVG"
     exon            575..642
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            643..742
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            743..907
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            908..981
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1046
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1165
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1255
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1435
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1582
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1685
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1762
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1854
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1962
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2083
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2217
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2346
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2518
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2705
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2839
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..2963
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3076
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3202
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            3203..3302
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3405
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3509
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
     exon            3510..5714
                     /gene="Sorcs2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttctctg cgctcttgct caagcttcca gcgccctccc gctctcgcgg ccgcggtgtc
       61 gcccgtaccg ccccgccgct acctaccggc gaccatggcg caccggggaa ccccgagcgc
      121 cccgaagcgt cctggcctta ctgcgccgga tcggagctcc caggttctgc tgccgccgtg
      181 ctggccacgt tcgtggccgc tgctgctgct gctgctggtg ctggtggctg cctgcggagc
      241 gatggggcgc tccccccagc ccgggcgctg gggtcccagt gtgcaggtca ccaggctgct
      301 gcccgcggga cgcacggagt ccagcaatcg ccaggatccg cagacacgag aatcggagcc
      361 tggcgtcccg ggtctccgtc cgggttctgc ttcgggtccc agcactgatg gcgccccagc
      421 tctgggcaag gggcgcaggg ttcgggcggc gccggtggcc ggtgcagctt cggcttcgcg
      481 cgcacaggtc tcgctcatca gcacgtcgtt cgtgctcaag ggagacgcga cgcacaacca
      541 ggcgatggta cactggacag gagagaacag cagcgtcatc ctgatcctga cgaagtacta
      601 ccatgcagac atggggaagg ttctggaaag ttctctctgg aggtcctcag attttgggac
      661 aacctacacc aagcttactc tccaacctgg tgtcaccact gtcattgaca acttctatat
      721 ctgccctgct aacaaaagaa agatcatcct ggtgagctca tccctcggtg acagggaaca
      781 gagcctcttc ctcagcactg acgagggcac cacattccag aagtatcctg tccccttcct
      841 tgtggagact ctcctctttc acccaaagga ggaggacaag gttcttgcct acaccaagga
      901 cagcaagctg tatgtgtcgt ccgacctggg gaagaagtgg acactgctgc aggaacaggt
      961 gaccaaggac cacgtgttct gggctgtgtc tggggtggat gacgacccca acctggtcca
     1021 catggaagca cgggacctca gtggaggcta tcggtactac acgtgtctga tccacaactg
     1081 ctcagcccag ccacacacag cacccttccc tggccccact gaccgagggt ccctgaccgt
     1141 gcaggatgag tacatctttt tgaaggcgac atcaacaaac cgaaccaaat actatgtctc
     1201 ttatcgccgc agcgactttg tcctgatgaa gctgcccaag tatgccctgc ccaaggacct
     1261 acagatcatc agcacagatg agcagcaggt gttcgtggcc gtccaggagt ggaaccaggt
     1321 ggacacctac aacctgtacc agtcggacct gcgtggagtg cgctattcgc tggtgctgga
     1381 gaacgtgcgc agctcgaggc aggctgagga gaatgtggtc atcgacatcc ttgaggtcag
     1441 aggggtgaag ggagtcttct tggcaaacca gaaagtggat ggcaaggtga caacagtcat
     1501 aacctacaac aagggccgtg actgggatta cctgaggcca cccagcactg acatgaatgg
     1561 gaaacctacc aactgccagc caccggactg ccacctgcac ctgcacctgc gctgggcaga
     1621 caacccctat gtgtcaggca cggtacacac caaggacact gcccctggcc tcatcatggg
     1681 tgcaggtaac ctgggctcac agttggtgga gtataaagag gaaatgtaca tcacatctga
     1741 ctgcgggcac acctggagac aggtctttga ggaagagcac catgtcctgt acctggacca
     1801 cggtggtgtc attgctgcca tcaaggacac ctccatcccc ctgaagaccc tcaagttcag
     1861 cgtggacgag ggccacactt ggagtacaca caacttcacc agcacctcag tgttcgtgga
     1921 tgggctgctg agcgaaccag gggatgaaac gctggtcatg acggtctttg gtcacatcag
     1981 cttccgctct gactgggagc tggtcaaggt ggacttccgg ccctccttcc ccaggccatg
     2041 tgttgaggat gactatagct cctgggacct cactgacctc cagggtgacc actgtatcat
     2101 gggccagcag agaagttacc ggaagagaaa gtccacgtcc tggtgtgtca aggggaggag
     2161 cttcacgtca gcactcacat cccgtgtgtg caagtgccgg gactctgact tcctctgtga
     2221 ctacgggttt gagcgctcat cttcctcaga gtctactgtc aacaagtgct ctgccaactt
     2281 ctggttcaac cccctgtctc ctcctgaaga ctgtgtccta ggacagacct ataccagtag
     2341 ccttgggtac cggaaggtgg tgtccaatgt gtgcgaaggt ggtgtggacc tgcagcagag
     2401 cccagtgcag ctgcagtgcc ccctacaagc accgcggggc ctgcaggtga gcatccgagg
     2461 agaggcagtg gctgtgcgac ctagagaaga tgtgctgttt gtggtgcgac aggaacaggg
     2521 tgatgtcctg accactaagt atcaggtgga tcttggggac ggcttcaagg ccatgtacgt
     2581 gaacctcact ctgacaggcg agcccattcg gcaccactac gagagtcctg gcatctaccg
     2641 tgtgtctgtc agggctgaga acatggcagg ccacgatgag gctgtgctct ttgtccaggt
     2701 caactctccc ctgcaggccc tctacctcga agtagtccct gtcattggca tcaaccaaga
     2761 ggtgaacctc acagctgtgc tgttaccgct gaaccccaat ctcactgtct tctactggtg
     2821 gatcggccac agcttgcagc ctctgctttc cttggacaac tccgtgacaa caaggtttac
     2881 agatgctggg gatgtgcgtg tgacagtgca agctgcctgt gggaactcgg tgctccagga
     2941 ctccaggctc gtccgtgtgc tcgatcagtt ccaggtggtg cctctgcagt tctccaggga
     3001 cctggacacc tttaacccca acacgcctga atggagggag gacgtgggat tggtggtcac
     3061 ccgacttctc tccaaggaga ccagcatccc agaggagcta ctagtgactg tggtcaagcc
     3121 agggctgccc accatagcgg atctgtatgt gcttctgcct cctcccaggc ccacaaggaa
     3181 gaggagcctc acaagtgaca agaggctggc agctgtgcag caggcactga actcccacag
     3241 gatcagcttc atccttcgag gagggcttcg tgtcctggtg gagctgaggg acacagatgc
     3301 aggtcctcag aggccgggtg gcagtggtgg ctactgggct gtggtggtcc tctttgtcat
     3361 cgggctcttt gcagtaggag cattcatcct ctacaagttc aaaaggaagc gcccaggcag
     3421 gacggtgtac gcccagatgc acaatgagaa ggaacaggag atgacaagtc ccgtgagcca
     3481 cagtgaggac gcccagagcg ccatgcaagg caaccactca ggtgtggtcc tgagcatcaa
     3541 ctctcgagag atgcatagct acctggtggg ctgatggcat cagctggcca ggacacgctc
     3601 ctcctgcttc cttcatagag ggcgcaggac cgcaagtaca gctggaacga cacaccctct
     3661 gagacctgtg gaaaggccaa ctcctctagc tgtccccact cagaggacag acacctctcc
     3721 ctgtcagccc cagctggccc atgggatcct gggacagccg actcatgacc cacctggaca
     3781 tgggcctgtg gtgccacaca aagtccccac ccttgactct gaggcatcac agtccttaga
     3841 cctgagcatg ctgccctggc tgctccaact tgccactgca gcccaggact ggcttctcct
     3901 gcctggggct ggaccagcct atttctgggg tgagcctgca gccaccccac cccacacact
     3961 ccagacttgt agacctgctc agccctggcc ccacagtccc tgtccctgca ggggacccca
     4021 gagccaggaa gtctatgggc cagacctgtc taacaccacc ttccaggcag ccactcttca
     4081 ctgcagtgta aatacctgcc cgggtagagc tatttgagtt tggggggctc tttcttttag
     4141 ctttctgttt tcaaggccag gcaatagaat ccatctacgt tctatcagaa tcccattctc
     4201 agaacccctc tttcagaatg cccagagctg ggcctagagg ggcaaataat ctctctgatt
     4261 ttccctcagg gctatggggt tggaggcaag aaagggagga acccttacat gcaattccag
     4321 ctatgtccag caggatgcac ccttccacag cttctaggct gatgactgct ttctggtcag
     4381 ggctgggctc tagaaatgtc tacaggcccc agaaaggcac attagctgaa tacatcaggc
     4441 tctgatgccc tatggtttga gggacccttg tggaaccaac caggagaggt gtgggagggc
     4501 agcgtctcct ggtgaaatga actagaggat ccagggactt gtggcccttt caaggtcgta
     4561 gaaagaaaag cagcagaggt agccctagag tcacctgctg tctgctccca ctgccaagtc
     4621 agggacccag cacaggttga cactgtgagc tggcacaatt caccttttgc cttgaactga
     4681 agtcagtatt cccttccctt cccctcctct tccctcctcc cacctcagac tcttgctgcc
     4741 ccaccagaaa gcccaggctg gcctggtgcc aggcctaggt gtctccccac ccgctgctgc
     4801 tgctgctgca cacccaccag cacccaccag ttctccctgg ggaagagctg tggtctatat
     4861 aggaggagag gtctaggaca gaccctcaca caggacagct cagcactcca gacactcatg
     4921 tcacagacca gggcagctat gtgggcacaa agccggtctg tgggaggatc tcaactgtac
     4981 cccaatatct ctcactttct gccactctct ggggctcagg ggtccctcca gaggtaactg
     5041 caggctgtcc tccctgtgag gggctaccaa tgggacccta gtgccaggga aggctgtgac
     5101 actctaaggc atttgcccca catggcttct tgctatctca aaagaaacct aagcagagac
     5161 ctttccccca tccatgtccc cacaacactg tatcatccag tcccacacag aaggagatgc
     5221 tcacacacca tagtctccac taggtccacg gtcagcacag aacccctgga tgtagcccat
     5281 cactttagcc caccagtgcc tggggtacca actgtaggtc tttgccttcc tggagcactg
     5341 tgttaccctc aaggacactt gggtaggctt tcccttgatg ttcaggtttt gtgttactat
     5401 ttctattaag aacatttgga gtgcatagac ccaggagcct ccctgttctc atctctgtaa
     5461 ctgcagacag ctatgcaggc acagagtttc cctgcttctc agccgaggtg ccatgcattg
     5521 tatagtcagg ggcaaaagcc ccacggacag cccagatgcc accagctcag gggctcacaa
     5581 gcactctcca ctgggacctg tgcatacctg gcatgtgggc atagctgagg tgataaattc
     5641 tttgtttttt cctttctaaa aaaaaaaaaa ccaataaatc atttgtgatg gttttaacaa
     5701 aggttaaatc gaca
//
