LOCUS       NM_001191563            3940 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus sortilin-related VPS10 domain containing receptor
            1 (Sorcs1), mRNA.
ACCESSION   NM_001191563 XM_002728894
VERSION     NM_001191563.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3940)
  AUTHORS   Yau,B., Blood,Z., An,Y., Su,Z. and Kebede,M.A.
  TITLE     Type 2 diabetes-associated single nucleotide polymorphism in Sorcs1
            gene results in alternative processing of the Sorcs1 protein in
            INS1 beta-cells
  JOURNAL   Sci Rep 9 (1), 19466 (2019)
   PUBMED   31857633
  REMARK    GeneRIF: Type 2 diabetes-associated single nucleotide polymorphism
            in Sorcs1 gene results in alternative processing of the Sorcs1
            protein in INS1 beta-cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3940)
  AUTHORS   Ribeiro,L.F., Verpoort,B., Nys,J., Vennekens,K.M., Wierda,K.D. and
            de Wit,J.
  TITLE     SorCS1-mediated sorting in dendrites maintains neurexin axonal
            surface polarization required for synaptic function
  JOURNAL   PLoS Biol 17 (10), e3000466 (2019)
   PUBMED   31658245
  REMARK    GeneRIF: SorCS1-mediated sorting in dendritic endosomes controls
            Nrxn axonal surface polarization required for proper synapse
            development and function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3940)
  AUTHORS   Lazar,J., O'Meara,C.C., Sarkis,A.B., Prisco,S.Z., Xu,H., Fox,C.S.,
            Chen,M.H., Broeckel,U., Arnett,D.K., Moreno,C., Provoost,A.P. and
            Jacob,H.J.
  TITLE     SORCS1 contributes to the development of renal disease in rats and
            humans
  JOURNAL   Physiol Genomics 45 (16), 720-728 (2013)
   PUBMED   23780848
  REMARK    GeneRIF: The experimental data from the rat combined with
            association results from different ethnic groups indicates a role
            for SORCS1 in maintaining proper renal function.
REFERENCE   4  (bases 1 to 3940)
  AUTHORS   Hermey,G., Keat,S.J., Madsen,P., Jacobsen,C., Petersen,C.M. and
            Gliemann,J.
  TITLE     Characterization of sorCS1, an alternatively spliced receptor with
            completely different cytoplasmic domains that mediate different
            trafficking in cells
  JOURNAL   J Biol Chem 278 (9), 7390-7396 (2003)
   PUBMED   12482870
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jul 17, 2010 this sequence version replaced XM_002728894.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-558               JAXUCZ010000001.1  259534929-259535486 c
            559-626             JAXUCZ010000001.1  259355251-259355318 c
            627-726             JAXUCZ010000001.1  259269929-259270028 c
            727-885             JAXUCZ010000001.1  259220306-259220464 c
            886-959             JAXUCZ010000001.1  259199649-259199722 c
            960-1024            JAXUCZ010000001.1  259175137-259175201 c
            1025-1143           JAXUCZ010000001.1  259148966-259149084 c
            1144-1233           JAXUCZ010000001.1  259146699-259146788 c
            1234-1413           JAXUCZ010000001.1  259140159-259140338 c
            1414-1560           JAXUCZ010000001.1  259128292-259128438 c
            1561-1663           JAXUCZ010000001.1  259112543-259112645 c
            1664-1740           JAXUCZ010000001.1  259112203-259112279 c
            1741-1832           JAXUCZ010000001.1  259110150-259110241 c
            1833-1940           JAXUCZ010000001.1  259107925-259108032 c
            1941-2058           JAXUCZ010000001.1  259106215-259106332 c
            2059-2189           JAXUCZ010000001.1  259104606-259104736 c
            2190-2303           JAXUCZ010000001.1  259101597-259101710 c
            2304-2475           JAXUCZ010000001.1  259088686-259088857 c
            2476-2662           JAXUCZ010000001.1  259067695-259067881 c
            2663-2796           JAXUCZ010000001.1  259059499-259059632 c
            2797-2920           JAXUCZ010000001.1  259057964-259058087 c
            2921-3033           JAXUCZ010000001.1  259052351-259052463 c
            3034-3165           JAXUCZ010000001.1  259051331-259051462 c
            3166-3265           JAXUCZ010000001.1  259044613-259044712 c
            3266-3371           JAXUCZ010000001.1  259031690-259031795 c
            3372-3940           JAXUCZ010000001.1  259029432-259030000 c
FEATURES             Location/Qualifiers
     source          1..3940
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..3940
                     /gene="Sorcs1"
                     /note="sortilin-related VPS10 domain containing receptor
                     1"
                     /db_xref="GeneID:309533"
                     /db_xref="RGD:1305910"
     CDS             1..3507
                     /gene="Sorcs1"
                     /note="VPS10 domain-containing receptor SorCS1; VPS10
                     domain receptor protein SORCS 1"
                     /codon_start=1
                     /product="VPS10 domain-containing receptor SorCS1
                     precursor"
                     /protein_id="NP_001178492.1"
                     /db_xref="GeneID:309533"
                     /db_xref="RGD:1305910"
                     /translation="MGKVGAGDGSSAALSALLTGAGLLMLLAPGICSSLSCCPPQHPS
                     STPRWTLTPRGFSYPGPLGRAPATPPPLFMRPLFAVAPGDRALFLERAGGSRVSVATA
                     SRSGRRRRSGMDPEKTEPGEGTSRSRRDMLRDGGQQGPGTGARDPDKATRFRMEELRL
                     TSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYE
                     KLNDKVGLKTILSYLYVCPTNKRKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQS
                     LLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEAVVPNRFYWSVLGSNKEPDLVHL
                     EARTVDGHSIYLTCRMQNCTEANRNKPFPGYIDPDSLIVQDDYVFVQLTSGGRPHYYV
                     SYRRNPFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDTRGVYFTL
                     ALENVQSSRGPEGNVMIDLYEVAGIKGMFLANKKIDNQVKTFITYNKGRDWRLLQAPD
                     ADLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIASRDTAPSIIVASGNIGSELSDSDI
                     SMFVSSDAGNTWRQIFEEEHSILYLDQGGVLVAMKHTSLPIRHLWLSFDEGRSWSKYS
                     FTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQLVKVDYKSIFDRRCAEEDYRPWQ
                     LHSQGEACIMGAKRIYKKRKSERKCMQGTYAGAMESEPCVCTEADFDCDYGYERHSSG
                     QCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDGVREQYTAKPQKCPGKAPR
                     GLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDGIAVSYVNLSSMEDGIK
                     HVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFVTTKNKEVNATAVLW
                     PSQVGTLTYVWWYGNNTEPLITLEGSISFKFTSEGMNTITVQVSAGNAILQDTKTIAV
                     YEEFRSLRLAFSPNLDDYNPDIPEWRRDISRVIKKSLVEATGIPSQHILVAVLPGLPT
                     AAELFVLPYQDGARENKRSPEDLEQISEVLIHKLNQNLVHFELKPGVQVLVHAAHLTA
                     APLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALTSPPSPSTQPGDSSLRLQ
                     RPRQATPPSSPKRGSAGAQFAI"
     exon            1..558
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..626
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..726
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            727..885
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            886..959
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1024
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1143
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1233
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1413
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1560
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1663
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1740
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1832
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1940
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2058
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2189
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2303
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2475
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2662
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2796
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2920
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3033
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3034..3165
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3265
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..3371
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3372..3940
                     /gene="Sorcs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggaaaag ttggcgccgg ggacggctcc tcggccgcgc ttagcgcgct cctaacggga
       61 gccgggcttc tgatgctctt agcccctggc atctgcagca gcctttcttg ctgccctccg
      121 caacacccta gctcgacccc acgctggacc cttaccccaa gaggcttttc ttaccccgga
      181 ccgctgggtc gggctcctgc cacgcccccg cccctcttca tgagacccct gttcgcagtg
      241 gcccccgggg accgggcgct gtttctggag cgagctgggg gcagcagggt gtcagtggcg
      301 accgcttcac gctctggccg taggagacgg agtggaatgg atcctgagaa gactgaaccc
      361 ggagagggta cgagtcggag ccgccgggac atgctaaggg atggagggca gcaggggcct
      421 gggactggcg cgcgggaccc ggacaaagcc actcgcttcc ggatggagga gctgagattg
      481 accagcacca catttgcgct gactggagac tcggcacaca accaagctat ggtccactgg
      541 tctggccaca acagcagcgt gattctcatt ttgacaaagc tctatgacta taacctggga
      601 agcatcactg agagctcgct ttggaggtca accgattatg ggacaaccta cgagaagctg
      661 aatgataaag tggggttgaa gaccattttg agctatctct atgtgtgccc aaccaacaag
      721 cgtaagatta tgctactcac ggacccggag attgagagca gtttgttgat cagctcagat
      781 gaaggggcaa cctatcaaaa gtaccggctc aacttttaca tccagagttt gcttttccat
      841 ccgaagcaag aagactggat cctggcctac agtcaagacc aaaagttata cagctctgct
      901 gagtttggca gaagatggca gcttatccag gaagcagtgg tacccaatag gttttactgg
      961 tctgtgctgg ggtcgaacaa agaaccagac cttgtgcatc tcgaggccag gaccgtagat
     1021 ggtcactcca tatacttaac ttgtcggatg caaaactgca ctgaagccaa cagaaataaa
     1081 cctttcccag gatacattga cccggattct ttgattgttc aggatgatta tgtgtttgtt
     1141 cagctcacat caggaggaag accacattac tatgtgtcct accgaagaaa cccatttgca
     1201 caaatgaaac ttccgaaata tgctttgccc aaggatatgc atgtcatcag tacggatgag
     1261 aatcaggtgt ttgcagcagt tcaagaatgg aaccagaatg acacctacaa cctgtacatc
     1321 tcagacacac gcggggtcta cttcacgctg gccttggaga acgtgcagag cagcagaggc
     1381 cctgaaggca atgtcatgat tgacctttat gaggtagcag ggataaaggg aatgttcttg
     1441 gctaacaaga agattgacaa ccaagtgaag actttcatca cttacaacaa aggcagagac
     1501 tggcgtttgc tgcaggctcc agatgcagat ctaagggggg accctgtgca ctgtttgctg
     1561 ccctactgtt cactacacct tcatctcaaa gtttctgaga atccctacac atctgggatc
     1621 attgccagca gagacacagc cccaagtatt atagttgcat caggtaacat aggctctgag
     1681 ttgtcagaca gcgacatcag catgtttgta tcatcagatg cagggaacac ttggaggcag
     1741 atttttgaag aagagcacag cattttgtac cttgatcaag ggggagtcct ggttgctatg
     1801 aaacacacat ctctcccaat tcggcacctg tggttgagtt ttgatgaagg gaggtcttgg
     1861 agcaaataca gttttacatc cattccactt tttgtggatg gagtcctggg ggagcctgga
     1921 gaagagacac taatcatgac agtgtttgga cacttcagtc atcgttctga gtggcagctg
     1981 gtcaaagtgg attacaagtc catttttgac agacgctgtg ctgaagaaga ctacagaccc
     2041 tggcagttac atagccaggg ggaagcatgc atcatgggag ccaagaggat ctataagaag
     2101 cgaaaatctg agcgcaagtg tatgcaaggg acgtatgcag gagcgatgga gtctgagcct
     2161 tgtgtgtgta cagaggcgga ctttgactgt gactatggct acgagagaca tagtagtgga
     2221 caatgcctac cagcattttg gttcaacccg tcctcactgt caaaagactg cagcttggga
     2281 cagagttacc tcaacagcac tgggtacagg aaggtggtct ccaataactg cacggacgga
     2341 gtgagggaac agtacaccgc caaaccacag aagtgtccag ggaaggcccc tcgtgggcta
     2401 cggattgtca ctgcagatgg gaaactgaca gcagaacagg ggcacaatgt cactctcatg
     2461 gtgcagttgg aagaggggga tgtacagcgg acactcatcc aagtggactt tggagatggc
     2521 attgcggtgt cttatgtcaa cctcagctcg atggaagacg gaatcaagca tgtatatcag
     2581 aatgtgggca ttttccgagt gaccgtgcag gtggacaaca gtctggggtc tgacagcgcc
     2641 gtcctgtact tacatgtaac ttgtcccctg gaacatgtgc acctgtccct tccttttgtc
     2701 acaacaaaga acaaagaggt caacgcaact gccgtgctgt ggcccagcca agtgggcact
     2761 ctcacttacg tgtggtggta tgggaacaac acagagcccc tgatcacctt ggagggcagc
     2821 atatcattca agtttacttc tgaaggaatg aacactatca cggtacaggt ctcagctggg
     2881 aatgccatac tgcaagacac taagaccatt gcggtatacg aggaattccg ctctcttcgc
     2941 ttggcttttt ctccaaactt ggatgactac aaccctgaca tcccggagtg gaggagggac
     3001 atcagccgag taatcaaaaa gtctctggtg gaagccacag ggattcccag ccagcatatc
     3061 ctggtggcag tgttacctgg cttacccact gctgctgagc tctttgtttt gccctatcaa
     3121 gatggagcta gagaaaacaa aaggtcccca gaggacctgg agcagatatc tgaagttcta
     3181 atccacaaac tcaaccaaaa cttggtgcac tttgagctga agcctggggt ccaagttctt
     3241 gtccacgcag ctcacctaac agcagccccc ctggtggacc tcactcctac ccacagcgga
     3301 tctgccatgc tgatgttgct ctcagtggtg tttgtggggt tggccgtgtt cgtcatctac
     3361 aagtttaaaa ggagagtagc tttaacctcc cctccctccc cttctactca acctggggac
     3421 tcatctctcc gattgcaaag accaagacaa gccacaccac cttcatcgcc aaagcgggga
     3481 tctgctgggg cacaatttgc aatctaagga aaacccccaa aggctacagg agacctgctg
     3541 atcagaaaag aatttcgctc ttgtcaagta catcatcctt catgaccact aactttgttt
     3601 tttttttttt cttcttctgt tgttctgttt cctatttcgc caggaagtat ttccatagtt
     3661 gctgagaatc aaagcacaaa agaaatccct acctatgtaa atgtttgaat ggaggacgcc
     3721 agtaaaaaca aacaaacaaa aagtaaataa aaataaaaac aatcaaaatc caaaataaca
     3781 agtaaacact ctcactgcat cggaactttt aaattcttca gacacagaca acaagggttt
     3841 ttagctttaa gcctgtgcat gtggacaata ctttgagaac gtgtttggag gggcagtgta
     3901 caggtgctct attttaatgg aaaacactcc cctcctttct
//
