LOCUS       NM_001005762            2634 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus sorbin and SH3 domain containing 3 (Sorbs3),
            mRNA.
ACCESSION   NM_001005762 XM_341350
VERSION     NM_001005762.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2634)
  AUTHORS   Li,M., Guo,S., Zhang,P., Gong,J., Zheng,A., Zhang,Y. and Li,H.
  TITLE     Vinexin-beta deficiency protects against cerebral
            ischaemia/reperfusion injury by inhibiting neuronal apoptosis
  JOURNAL   J Neurochem 134 (2), 211-221 (2015)
   PUBMED   25824575
  REMARK    GeneRIF: Our findings revealed that Vinexin-beta acts as a novel
            modulator of ischaemic injury
REFERENCE   2  (bases 1 to 2634)
  AUTHORS   Yamauchi,M., Sudo,K., Ito,H., Iwamoto,I., Morishita,R., Murai,T.,
            Kajita,K., Ishizuka,T. and Nagata,K.
  TITLE     Localization of multidomain adaptor proteins, p140Cap and vinexin,
            in the pancreatic islet of a spontaneous diabetes mellitus model,
            Otsuka Long-Evans Tokushima Fatty rats
  JOURNAL   Med Mol Morphol 46 (1), 41-48 (2013)
   PUBMED   23325552
  REMARK    GeneRIF: Vvinexin was highly enriched in pancreatic alpha cells but
            not in beta cells.
REFERENCE   3  (bases 1 to 2634)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   4  (bases 1 to 2634)
  AUTHORS   Mitsushima,M., Takahashi,H., Shishido,T., Ueda,K. and Kioka,N.
  TITLE     Abl kinase interacts with and phosphorylates vinexin
  JOURNAL   FEBS Lett 580 (17), 4288-4295 (2006)
   PUBMED   16831423
  REMARK    GeneRIF: vinexin alpha is a novel substrate for Abl.
REFERENCE   5  (bases 1 to 2634)
  AUTHORS   Matsuyama,M., Mizusaki,H., Shimono,A., Mukai,T., Okumura,K.,
            Abe,K., Shimada,K. and Morohashi,K.
  TITLE     A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene
            expression through activation of MAPK cascade in mouse fetal gonad
  JOURNAL   Genes Cells 10 (5), 421-434 (2005)
   PUBMED   15836771
REFERENCE   6  (bases 1 to 2634)
  AUTHORS   Bour,G., Plassat,J.L., Bauer,A., Lalevee,S. and Rochette-Egly,C.
  TITLE     Vinexin beta interacts with the non-phosphorylated AF-1 domain of
            retinoid receptor gamma (RARgamma) and represses RARgamma-mediated
            transcription
  JOURNAL   J Biol Chem 280 (17), 17027-17037 (2005)
   PUBMED   15734736
REFERENCE   7  (bases 1 to 2634)
  AUTHORS   Mitsushima,M., Suwa,A., Amachi,T., Ueda,K. and Kioka,N.
  TITLE     Extracellular signal-regulated kinase activated by epidermal growth
            factor and cell adhesion interacts with and phosphorylates vinexin
  JOURNAL   J Biol Chem 279 (33), 34570-34577 (2004)
   PUBMED   15184391
REFERENCE   8  (bases 1 to 2634)
  AUTHORS   Tujague,M., Thomsen,J.S., Mizuki,K., Sadek,C.M. and Gustafsson,J.A.
  TITLE     The focal adhesion protein vinexin alpha regulates the
            phosphorylation and activity of estrogen receptor alpha
  JOURNAL   J Biol Chem 279 (10), 9255-9263 (2004)
   PUBMED   14625289
REFERENCE   9  (bases 1 to 2634)
  AUTHORS   Kioka,N., Sakata,S., Kawauchi,T., Amachi,T., Akiyama,S.K.,
            Okazaki,K., Yaen,C., Yamada,K.M. and Aota,S.
  TITLE     Vinexin: a novel vinculin-binding protein with multiple SH3 domains
            enhances actin cytoskeletal organization
  JOURNAL   J Cell Biol 144 (1), 59-69 (1999)
   PUBMED   9885244
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083666.1.
            
            On Oct 15, 2004 this sequence version replaced XM_341350.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083666.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2634
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p11"
     gene            1..2634
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /note="sorbin and SH3 domain containing 3"
                     /db_xref="GeneID:282843"
                     /db_xref="RGD:628900"
     exon            1..106
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     exon            107..253
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..2351
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /note="SH3 domain protein 4"
                     /codon_start=1
                     /product="vinexin"
                     /protein_id="NP_001005762.1"
                     /db_xref="GeneID:282843"
                     /db_xref="RGD:628900"
                     /translation="MARIPGVGRSSTSSLDNKEDSESDVALLSPKDPDRVHTKEQLAH
                     PVSSNLDPSMQGLPAGLSLDDFIPGHLRAHIGASSRGTRVPVIRNGGSNTLNFQFHDP
                     APRTVCNGCPPPRRDGSQHPDPAWYQTWPGPGSQPSVSPKQPAPQNAQNWSATWTKDS
                     KRRDKRWVKYEGIGPVDESGMPIAPRSSVDSPRDWYRRMFQQIHRKMPDLQLDWTLED
                     PPKVVSSRASSADPRHPGPQQRPASRPGTTGTSSGRNWNHSEETSRNTLNYNLGPSSR
                     LHASNQVPRHREKVENVWTEDSWNQFLHELETGHKPKKSLVDDPVEKPAQPIEVLLER
                     ELAKLSAELDKDLRAIETRLPSPKNSQAPRRPLEQPGPEQQPSARLSSAWRPNSPHAP
                     YFGSSRPLSPHRMADGGGSPFLGRRDFVYPSSAREPSASERGSSPARKEEKKRKAARL
                     KFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKP
                     IKPPTYQVLEYGDAVAQYTFKGDLDVELSFRKGERICLIRKVNEHWYEGRITGTGRQG
                     IFPASYVQINREPRLRLCDDSPQLPTSPHLTTTAHLGSHSQPSSIPVDPTDWGGRTSP
                     RRSAFPFPITLQEPRSQPQSLSTPGPTLSHPRGTSHPTNLGSSSLNTTEIHWTPYRAM
                     YQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV"
     exon            254..398
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     exon            399..516
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     exon            517..710
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     exon            711..774
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     exon            775..813
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     exon            814..907
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     exon            908..995
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1082
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1136
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1223
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1285
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1428
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1481
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1528
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1643
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1769
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..2078
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2182
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2289
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2598
                     /gene="Sorbs3"
                     /gene_synonym="Sh3d4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaatttcat gccaagtcta ggtggtttca gctcaagcag caaggacgtg aacatggagc
       61 atccctctgt gcagctctga agtagagcca agcactctgc ctgcctgtca gagccttaga
      121 gcctaagaag ttcactgctg gtgaggggga tggccaggat tcccggagtg ggaagatctt
      181 caacttcgtc tttggacaac aaagaagaca gtgaaagtga tgtggccctt cttagtccca
      241 aggaccctga cagagtacac acgaaggagc agctggcaca tcctgtgtcc tccaaccttg
      301 acccaagcat gcaaggcctc cctgctgggc tcagcctgga tgatttcatc cctggccacc
      361 tccgggccca tataggtgca tcttcccggg ggacaagggt gcctgtgatc cggaatggtg
      421 gctccaacac ccttaatttc cagtttcatg accctgcacc caggactgtg tgcaacggct
      481 gtcccccgcc caggagagat ggttcccagc atccagaccc agcatggtat cagacctggc
      541 caggccctgg gagtcagccc tctgtgagcc ctaagcagcc tgccccccag aatgcccaga
      601 actggtcagc cacatggacc aaggacagca agcggcggga caagcgctgg gtgaagtacg
      661 agggaatcgg gcccgtggat gagagcggca tgcccattgc cccccgatca agtgtcgaca
      721 gccccagaga ctggtatcgg agaatgttcc agcaaattca ccggaaaatg ccagacctgc
      781 agctggactg gaccttggaa gacccaccca aagtggtttc ctcacgtgcc tcttctgcag
      841 accccaggca tccagggccc caacaaagac ctgcctccag gcctggcaca actgggactt
      901 cgagcggaag aaactggaac cactctgaag agacatctag aaataccttg aactataatc
      961 ttggaccatc ctcaaggctt catgcctcaa atcaggtgcc tagacatcga gagaaagtag
     1021 agaatgtctg gacagaagac tcctggaacc agtttctgca cgaactagaa actgggcata
     1081 agcccaagaa atcactggtg gatgaccctg ttgagaaacc tgcacagccc attgaggtcc
     1141 tgctagagag agaactggcc aagctgagcg cagagctgga caaggacctg cgggccattg
     1201 agacccgcct gccatccccc aagaactctc aggctccacg acggcccctt gagcagcccg
     1261 gcccggagca gcagccctcc gcccgactgt cctcagcctg gaggcccaac tcaccgcatg
     1321 caccttactt cggttcctcc cgacccctga gcccccacag aatggcagat ggaggaggaa
     1381 gcccctttct gggacgtaga gattttgtct acccttcctc agcccgagag cctagtgcct
     1441 ctgaaagggg tagcagccct gcgaggaagg aggagaagaa gaggaaggct gcccggctca
     1501 agtttgactt ccaggcgcag tcccccaagg agctgactct gcagaagggt gacattgtct
     1561 atatccataa agaagtggac aagaactggc tggaggggga acaccatggc cgactgggca
     1621 tcttcccagc taattatgtg gaggttctgc ctgcagatga gattcccaag cccatcaagc
     1681 cgcccacata ccaggtgctg gagtatggag atgctgtagc ccagtatacc ttcaagggag
     1741 acctggatgt ggagctgtcc ttccgaaagg gggaacgcat ctgcctgatc cgcaaagtga
     1801 atgaacattg gtacgagggg cgcatcacgg gcacgggacg ccaaggcatc ttccctgcca
     1861 gctacgtgca gataaaccgg gagccccggc tcaggctctg cgacgatagt ccccagctcc
     1921 ctacatcacc tcacctgaca accactgctc atctaggcag ccactcccaa ccctcctcaa
     1981 tacctgtgga ccccactgac tggggaggtc ggacctcccc ccgacgctct gccttcccct
     2041 tccccatcac ccttcaggag cccagatccc aaccccagag tctcagtacc cctggaccaa
     2101 ccctgtccca tccacgaggc accagccatc ccacaaacct ggggtcctcc tccctaaaca
     2161 ccacagagat acactggact ccgtaccggg ccatgtacca gtacagaccc cagaatgaag
     2221 atgagctgga acttcgtgag ggagaccgtg tggatgtcat gcagcagtgt gatgatggct
     2281 ggtttgtggg tgtctcccgg agaactcaga aatttgggac attccctgga aattatgtag
     2341 ccccggtgtg aatggtctcc atggcagtat ggagccaacg aggatcgggt ggggagcagt
     2401 agcactatgg gagggagaga ggccctccat atcctcctcc cccaggacct atgctcccag
     2461 cttctgcaga aaccccagca acttttcctc caagcctcct tgaagtcccc tggactgatt
     2521 cccacccgca agtcacaggc attcctttga cagccccctt caccgcccct caaatacaga
     2581 catctgcttt catgtggaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
