LOCUS       NM_053770               6302 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus sorbin and SH3 domain containing 2 (Sorbs2),
            mRNA.
ACCESSION   NM_053770
VERSION     NM_053770.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6302)
  AUTHORS   Lee,S.E., Kim,Y., Han,J.K., Park,H., Lee,U., Na,M., Jeong,S.,
            Chung,C., Cestra,G. and Chang,S.
  TITLE     nArgBP2 regulates excitatory synapse formation by controlling
            dendritic spine morphology
  JOURNAL   Proc Natl Acad Sci U S A 113 (24), 6749-6754 (2016)
   PUBMED   27226294
  REMARK    GeneRIF: results suggest that nArgBP2 functions to regulate spine
            morphogenesis and subsequent spine-synapse formation at
            glutamatergic synapses.
REFERENCE   2  (bases 1 to 6302)
  AUTHORS   Hallock,P.T., Chin,S., Blais,S., Neubert,T.A. and Glass,D.J.
  TITLE     Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine
            Receptor Cluster Formation
  JOURNAL   Mol Cell Biol 36 (2), 262-270 (2015)
   PUBMED   26527617
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6302)
  AUTHORS   Bang,C., Batkai,S., Dangwal,S., Gupta,S.K., Foinquinos,A.,
            Holzmann,A., Just,A., Remke,J., Zimmer,K., Zeug,A., Ponimaskin,E.,
            Schmiedl,A., Yin,X., Mayr,M., Halder,R., Fischer,A., Engelhardt,S.,
            Wei,Y., Schober,A., Fiedler,J. and Thum,T.
  TITLE     Cardiac fibroblast-derived microRNA passenger strand-enriched
            exosomes mediate cardiomyocyte hypertrophy
  JOURNAL   J Clin Invest 124 (5), 2136-2146 (2014)
   PUBMED   24743145
REFERENCE   4  (bases 1 to 6302)
  AUTHORS   Fouillade,C., Baron-Menguy,C., Domenga-Denier,V., Thibault,C.,
            Takamiya,K., Huganir,R. and Joutel,A.
  TITLE     Transcriptome analysis for Notch3 target genes identifies Grip2 as
            a novel regulator of myogenic response in the cerebrovasculature
  JOURNAL   Arterioscler Thromb Vasc Biol 33 (1), 76-86 (2013)
   PUBMED   23117660
REFERENCE   5  (bases 1 to 6302)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 6302)
  AUTHORS   Lamberti,A., Sanges,C., Chambery,A., Migliaccio,N., Rosso,F., Di
            Maro,A., Papale,F., Marra,M., Parente,A., Caraglia,M.,
            Abbruzzese,A. and Arcari,P.
  TITLE     Analysis of interaction partners for eukaryotic translation
            elongation factor 1A M-domain by functional proteomics
  JOURNAL   Biochimie 93 (10), 1738-1746 (2011)
   PUBMED   21689717
REFERENCE   7  (bases 1 to 6302)
  AUTHORS   Nakatani,S., Kakehashi,A., Ishimura,E., Yamano,S., Mori,K., Wei,M.,
            Inaba,M. and Wanibuchi,H.
  TITLE     Targeted proteomics of isolated glomeruli from the kidneys of
            diabetic rats: sorbin and SH3 domain containing 2 is a novel
            protein associated with diabetic nephropathy
  JOURNAL   Exp Diabetes Res 2011, 979354 (2011)
   PUBMED   22007191
  REMARK    GeneRIF: Data suggest that SORBS2 is up-regulated in podocytes of
            glomeruli and may be associated with development and progression of
            diabetic nephropathy in a model of type 2 diabetes, possibly
            through reorganization of actin filaments.
REFERENCE   8  (bases 1 to 6302)
  AUTHORS   Tosoni,D. and Cestra,G.
  TITLE     CAP (Cbl associated protein) regulates receptor-mediated
            endocytosis
  JOURNAL   FEBS Lett 583 (2), 293-300 (2009)
   PUBMED   19116150
REFERENCE   9  (bases 1 to 6302)
  AUTHORS   Cestra,G., Toomre,D., Chang,S. and De Camilli,P.
  TITLE     The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of
            multiple regulatory mechanisms converging on the actin cytoskeleton
  JOURNAL   Proc Natl Acad Sci U S A 102 (5), 1731-1736 (2005)
   PUBMED   15659545
  REMARK    GeneRIF: ArgBP2 is a scaffold protein that control the balance
            between adhesion and motility by coordinating the function of
            multiple signaling pathways converging on the actin cytoskeleton.
REFERENCE   10 (bases 1 to 6302)
  AUTHORS   Kawabe,H., Hata,Y., Takeuchi,M., Ide,N., Mizoguchi,A. and Takai,Y.
  TITLE     nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that
            interacts with synapse-associated protein 90/postsynaptic
            density-95-associated protein (SAPAP)
  JOURNAL   J Biol Chem 274 (43), 30914-30918 (1999)
   PUBMED   10521485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Feb 11, 2021 this sequence version replaced NM_053770.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF026505.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-489               JAXUCZ010000016.1  53358495-53358983   c
            490-626             JAXUCZ010000016.1  53328360-53328496   c
            627-676             JAXUCZ010000016.1  53254586-53254635   c
            677-769             JAXUCZ010000016.1  53249314-53249406   c
            770-796             JAXUCZ010000016.1  53245523-53245549   c
            797-921             JAXUCZ010000016.1  53245114-53245238   c
            922-1060            JAXUCZ010000016.1  53235086-53235224   c
            1061-1233           JAXUCZ010000016.1  53230526-53230698   c
            1234-1300           JAXUCZ010000016.1  53224084-53224150   c
            1301-1345           JAXUCZ010000016.1  53223352-53223396   c
            1346-1520           JAXUCZ010000016.1  53221259-53221433   c
            1521-1635           JAXUCZ010000016.1  53218359-53218473   c
            1636-1685           JAXUCZ010000016.1  53204813-53204862   c
            1686-1873           JAXUCZ010000016.1  53202042-53202229   c
            1874-3454           JAXUCZ010000016.1  53199139-53200719   c
            3455-3546           JAXUCZ010000016.1  53196261-53196352   c
            3547-3593           JAXUCZ010000016.1  53195104-53195150   c
            3594-3708           JAXUCZ010000016.1  53192423-53192537   c
            3709-3837           JAXUCZ010000016.1  53192208-53192336   c
            3838-4038           JAXUCZ010000016.1  53190099-53190299   c
            4039-4088           JAXUCZ010000016.1  53175752-53175801   c
            4089-4195           JAXUCZ010000016.1  53171792-53171898   c
            4196-6302           JAXUCZ010000016.1  53167827-53169933   c
FEATURES             Location/Qualifiers
     source          1..6302
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..6302
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /note="sorbin and SH3 domain containing 2"
                     /db_xref="GeneID:114901"
                     /db_xref="RGD:620061"
     exon            1..489
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            490..626
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            627..676
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             667..4257
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /note="nArgBP2; neural ArgBP2; arg/Abl-interacting protein
                     2; Arg/Abl-interacting protein ArgBP2; arg-binding protein
                     2"
                     /codon_start=1
                     /product="sorbin and SH3 domain-containing protein 2"
                     /protein_id="NP_446222.3"
                     /db_xref="GeneID:114901"
                     /db_xref="RGD:620061"
                     /translation="MNTDSGGCARKRAAMSVTLTSVKRVQSSPNLLAAGRESHSPDSA
                     WRSYNGRNPETLNGDATYSSLAAKGFRSVRPNLQDKKSPTQSHITINGNSGGAVSPVS
                     YYQRPFSPSAYSLPASLNSSIIMPHGRSLDSAETYSQHAQSLDGTMGSSIPLYRSSEE
                     EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDEDTDMY
                     NTPYTYNAGLYNSPYSAQSHPAAKTQTYRPLSKSHSDNGTDAFKEAPSPVPPPHVPPR
                     PRDQSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPVSVYQSSIDRS
                     LERPSSSASMAGDFRKRRKSEPAVGPPRGLGDHSSSRTSPGRADLPGSSSTFTTSFIS
                     SSPSSPSRAQGGDDSKMCPPLCSYSGLNGSPSSELECCGAYRRHLDVPQDSQRAITFK
                     NGWQMARQNAEIWSSTEEAVSPKIKSRSCDDLLNDDCGSFPDPKTKSESMGSLLCDEG
                     SKESDPMTWTSPYIPEVCGNSRSRLKHRSAHNAPGFLKMYKKMHRINRKDLMNSEVIC
                     SVKSRILQYEKEQQHRGLLHGWSQSSTEEVPRDVVPTRISEFEKLIQKSKSMPNLGDE
                     MLSPVTLEPPQNGLCPKRRFSIESLLEEETQVRHPSQGQRSCKSNTLVPIHIEVTSDE
                     QPRTHMEFSDSDQDGVVSDHSDYVHVEGSSFCSESDFDHFSFTSSESFYGSSHHHHHH
                     HHHHRHLISSCKGRCPASYTRFTTMLKHERAKHENIDRPRRQDMDPGLSKLAFLVSPV
                     PFRRKKVLTPQKQTEQAKCKASVVEALDSALKDICDQIKAEKRRGSLPDNSILHRLIS
                     ELLPQIPERNSSLNALKRSPMHQPFHPLPQDGAIHCPLYQNDCGRMPHSASFPDVDTT
                     SSYHAQDYGSVLSLQDHESPRSYSSTLTDLGRSVSRERRGTPEKEVKLPAKAVYDFKA
                     QTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPP
                     VQPGEIGEAIAKYNFNADTNVELSLRKGDRIILLKRVDQNWYEGKIPGTNRQGIFPVS
                     YVEVVKRNTKGSEDYPDPPLPHSYSSDRIYSLSSNKPQRPVFSHENIQGGGEPFQALY
                     NYTPRNEDELELRESDVVDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL"
     exon            677..769
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..796
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            797..921
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1060
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1233
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1300
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1345
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1520
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1635
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1685
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1873
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..3454
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..3546
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3593
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3594..3708
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3709..3837
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3838..4038
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4039..4088
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4089..4195
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4196..6302
                     /gene="Sorbs2"
                     /gene_synonym="Argbp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaaatcttt ggagagaaga gagccacagt gagcacgcta gtgcacaatt attgcagcca
       61 cgtgtgcccg caagctggcc ctgcgacaag ctgttgagtg ctgttgcaat tagctgattg
      121 gagaacgggg actgcagggt gataatgctg cgtctccgct cgcgggcacc aggaaagggt
      181 tttgtctcgg gaaggcaagt cttccctgca cagttatctc agcagctccc tagctgaaga
      241 gaactggggg ctctaaaggg agggggtcgc actgtgcgag cacagattct gtgccaggct
      301 gttgcttatg agccgcaggt ctgggaaagc aggtgtgtgc tcggacgggc actgggctgg
      361 aacgcaggcg gcggctctcg ggttcacctg cttcctgtta acagactgtt ggctcacaga
      421 gcatctgctc ttacacgctg aagctgcggc tgagaaaggg gttcccggca tcccacttga
      481 ctgacggagg cacttggatt ggacttaatc ttaaacctct ggaggtcaag accttttaaa
      541 aagggctaaa taaacaatct acatgtaaaa ggccagcgac tcctacttcc tctgttggag
      601 caactgtgaa gtccagcctc ttctaggaaa actgaagact ttaataacac accgttcaag
      661 gtgaaaatga atacagatag cggtgggtgt gctcgcaaac gtgccgccat gtctgtcacg
      721 ttaacatctg tgaagagagt tcaaagttct ccaaacctat tggctgcagg gcgtgagtct
      781 cactctccag actcagcttg gagatcttac aatggtcgaa atccagagac actgaacgga
      841 gatgccacat attcctctct tgcagcaaaa ggttttagaa gcgttcgacc aaacctgcaa
      901 gacaaaaagt caccaaccca gagccatatc actatcaacg gcaactctgg tggcgccgtg
      961 agtccagtga gttactatca gaggccattc tccccttctg catactccct cccagcctca
     1021 ctcaactcca gcattatcat gccacacggc aggtcgcttg attctgcgga gacatattcc
     1081 cagcatgccc agtcgctaga cggcaccatg ggaagctcca tcccactcta cagatcctcc
     1141 gaggaagaga agagggtcac agtcatcaaa gccccgcatt acccagggat cggccctgtg
     1201 gatgagtctg gaatccccac agccattaga acgacagttg accggccgaa ggactggtac
     1261 aagacaatgt ttaaacaaat tcacatggta cacaagccgg atgaggacac agacatgtat
     1321 aatactcctt acacatacaa tgcaggtctg tacaactcgc cctacagtgc tcagtcacat
     1381 cctgctgcaa agacccagac ctacagacct ctttccaaaa gccactcgga caatggcacc
     1441 gatgctttta aggaggcacc ctcaccagtg cctcccccac acgttccacc acgaccaaga
     1501 gatcagtctt caacagaaaa gcatgactgg gatcccccag acagaaaggt ggacaccagg
     1561 aaatttcgat cggagccaag gagtattttt gaatacgagc ctgggaagtc atccatcctg
     1621 cagcacgaaa gacccgtctc cgtctaccag tcttccatag acagaagctt ggaaagaccc
     1681 agcagctctg caagcatggc gggtgacttt agaaaacgga ggaagagtga acctgcagtg
     1741 ggcccgccca ggggcttggg ggatcacagt tcaagcagga ccagccccgg ccgggcagac
     1801 ctcccaggat caagttccac ctttaccacg tctttcatta gttcttctcc ttcctctccc
     1861 tcgagagcac aaggtgggga tgatagcaaa atgtgtccgc ccctttgcag ttactcgggg
     1921 ctcaatggct cgccctctag tgagttagag tgctgcggcg cttatagaag gcacttggac
     1981 gtcccccagg actctcaaag ggccatcact ttcaagaacg gctggcaaat ggcccggcaa
     2041 aatgcagaga tctggagtag cactgaagag gcggtttccc ccaaaatcaa atcacgaagc
     2101 tgtgacgatc tcctgaatga tgactgcggc agcttcccag accctaaaac caagtcagaa
     2161 agcatgggtt ctctgttatg tgacgaaggc tccaaagaga gcgaccccat gacgtggact
     2221 tccccctaca tcccggaagt gtgcgggaac agcagatcta ggctcaaaca taggtcagcc
     2281 cataacgccc caggcttcct caaaatgtac aagaaaatgc accgcatcaa ccgcaaggat
     2341 ttgatgaact cggaggtcat ttgctctgtg aaatccagga tccttcagta cgagaaggaa
     2401 cagcagcaca gggggctgct ccatggatgg agccagtcgt ccaccgagga ggtgcccagg
     2461 gacgtggtac ccactcgcat ctcggagttt gagaagctga ttcagaagtc aaagtctatg
     2521 cccaatctag gagatgaaat gttatctcct gtaaccctag aacccccaca aaatggtttg
     2581 tgccccaaga ggcgattttc tattgagtct ctgctggagg aggaaactca ggtccgacac
     2641 ccttctcagg gtcagcgaag ctgcaagtcg aacaccctgg tacccatcca catcgaggtc
     2701 accagcgatg agcaacctag aacacatatg gagttttccg acagtgacca agatggggtt
     2761 gtgtctgacc acagcgacta cgtccacgtc gaagggtcgt ccttttgtag tgaaagtgac
     2821 ttcgaccact tttcattcac atcctctgaa agtttctacg gatccagcca tcaccaccac
     2881 catcaccacc accatcaccg acacctcatc agttcctgca aaggccgatg ccccgcttct
     2941 tacactcgat ttaccacgat gttaaaacac gaaagagcta agcatgaaaa tattgaccga
     3001 cccagaaggc aagacatgga tcctggccta tctaaactcg cgtttctagt cagccctgtg
     3061 cctttccgaa ggaaaaaagt tttgactccc caaaaacaaa ctgagcaggc aaaatgcaaa
     3121 gcctcggtag ttgaggctct ggactctgcc cttaaagaca tttgcgacca aataaaagct
     3181 gaaaagcgga gaggaagctt gccggacaac agcatcctgc acaggcttat tagtgaactg
     3241 ctgccacaga ttcctgaaag gaattcatct cttaatgctc taaaaaggag ccccatgcac
     3301 cagcctttcc acccactgcc tcaagatggt gctattcatt gtcccctgta ccaaaatgat
     3361 tgtgggagaa tgcctcacag tgcctctttc ccagacgtgg acacgaccag cagctaccac
     3421 gcacaggact atggtagtgt gctgagtctc caagatcacg agtcccctag aagttactcg
     3481 tctactctga ctgacttggg aagaagtgta tcacgggaac gaagaggaac tccagaaaaa
     3541 gaggtaaaat tgcctgcaaa agctgtctat gatttcaaag ctcagacttc taaggagctg
     3601 tcatttaaga aaggagacac cgtctacatc ctcaggaaaa ttgaccagaa ctggtatgag
     3661 ggggagcacc acggaagagt gggcattttc ccaatctcat acgtagagaa actaacaccc
     3721 ccagaaaaag cgcagcccgc gagaccacca cccccagtcc agccgggaga gattggagaa
     3781 gccatagcca agtacaactt caatgcagac acaaatgtgg aactctccct gagaaagggt
     3841 gacaggatta ttcttctcaa aagagttgat caaaactggt atgaaggtaa aatcccagga
     3901 accaacagac aaggcatctt ccctgtctcc tacgtagaag ttgtcaagag gaacacgaaa
     3961 ggttctgagg attaccccga ccctcctcta ccccacagct actccagtga tagaatttac
     4021 agcctaagct ccaataagcc acagcgtcct gtgttctctc acgaaaacat tcaaggtgga
     4081 ggagaaccgt ttcaggctct gtataactat actcctagga atgaagatga gctggaactc
     4141 agagaaagtg atgtcgtaga tgtcatggaa aagtgtgatg acggatggtt cgtgggaact
     4201 tcaagaagaa ccaaattctt tggtactttt cctggaaact atgtcaaaag gctgtgactc
     4261 acctcactcc taatttatgc cacatttcag ccacacatct gcattaaccc acctgaaaca
     4321 tcccaggagg cctgttgctg cctcgcctta tggtttccaa taggccatta ccatctccat
     4381 ctgctgccac caaatcacca gcagagggac tgccgctgtg agccttaggg aggctgggag
     4441 ccttagagaa aagtggcaaa acttacaccc acataaatat tcagtctcct gctttctgcc
     4501 ctgaactttg aaatgcctgt atatggaatc agaatgaaaa tgatcatact ttcaaaaaag
     4561 tgaaataatt aaggaagaaa gaaagagaaa agaaatagag agactcttca ggaggctgtc
     4621 tggcctcatg gctgaatctc cacctctctg gaaggtgtac tgtcctcagg aagcctgaag
     4681 attgtttttt tctgaaatgc tatggttcca gttctcactc tcatctaggc ggtatatttt
     4741 cctttcacga gtttgcctag cgctcgggtt tacactacat gacaactata cttcggctgt
     4801 tgtttgcttg cacttattat tccttgtttc atgcacagtg atcacaaaat ccagagtgcc
     4861 tagggaaggt tcactggttc cactggttcg agtgtgattt ttgttgactg cattatattt
     4921 tcacacgggg agaggggtct ttcccctgcc cacttttttg tgcttattag aagtgcaaac
     4981 agtgagcaac tgagagctca gccacaccac aggacaaatc gtgttgtgaa ttcgcattgc
     5041 tgttttgtgt attaaggtgt aatcatcagc ttcatggaca acaagctatt agtgatttct
     5101 ttacctgtta aaacttacag gcagtgctag tgagttaggc agaaagatga cagtaatacc
     5161 agtaggtgag cttcactgcg tgcatgctca cacgtttgag attgtatgag gacatataat
     5221 tcatatgcta tgttgtacat tttatggaaa tataagagaa tcccacatta ttttatagag
     5281 tacttcagga gcatcctaag tgttaaggct ggctttagca aggattatga tcaatacaac
     5341 tatttttact acaataatta tttttcttct atgagaccca gaatcctgac tccacttgca
     5401 gacaggaata tatatgttga gcctgacttt tttttctggt atatgtaaaa tacttcccag
     5461 gaatacattg ggcacttttg ggaataatgg ttaaatcatt caggttgtgc ttcctgcccc
     5521 caaaacagat ctacaaaatg ataccaaacc tgaaagattt aacggattta cggtgcctgc
     5581 attccacaca acctcacact tagctttgta tttcaaatga atttgcataa aacctgttca
     5641 tctttagcac cttatagtca aaacttttta tggctttcct cccatgggca atgcttgatc
     5701 ttccacaaca tataaactct ggcatatttt gtacatatgt ttgttccttt ttggttgtac
     5761 agactattta cttgttcaga aaacatcgag atctcccaat ttgttcttta ccctgccctt
     5821 aaaaggaatt taaactcttt cagaagatcg cccttcacca catctccaca gatcacaagc
     5881 taaggtgaat ctggaatata tcgtctgcac aaaattttgt gactcagaaa gatctttgta
     5941 actactctga aatacatata ataacaatgt tccagttaca gaggaatatt gttggggcag
     6001 gaagtgaaga aacatcttca agaaacccac tttactctcc agttcacaac tagctttata
     6061 ttagaaaaac ttgggattgg aaagtcagcc agccagccgg ccacctgcag ccttgttgat
     6121 aaatgaatac tttttcacac catttatgaa aacaaatctt caactctgtt gcctgttata
     6181 tttaagaaaa attgctgttt ctactctctg tatctgattt taaaaggaaa aaaatattca
     6241 cgcctggctt tcaggacatt gactttgaat tcttacgagc aaaggtcgtt gtgtttttct
     6301 tg
//
