LOCUS       NM_001421361            8087 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus sorbin and SH3 domain containing 1 (Sorbs1),
            mRNA.
ACCESSION   NM_001421361
VERSION     NM_001421361.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8087)
  AUTHORS   Hallock,P.T., Chin,S., Blais,S., Neubert,T.A. and Glass,D.J.
  TITLE     Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine
            Receptor Cluster Formation
  JOURNAL   Mol Cell Biol 36 (2), 262-270 (2015)
   PUBMED   26527617
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8087)
  AUTHORS   Satoh,T.
  TITLE     Rho GTPases in insulin-stimulated glucose uptake
  JOURNAL   Small GTPases 5, e28102 (2014)
   PUBMED   24613967
  REMARK    Review article
REFERENCE   3  (bases 1 to 8087)
  AUTHORS   Saito,M., Lessard,S.J., Rivas,D.A., Reeder,D.W., Hawley,J.A. and
            Yaspelkis,B.B. 3rd.
  TITLE     Activation of atypical protein kinase Czeta toward TC10 is
            regulated by high-fat diet and aerobic exercise in skeletal muscle
  JOURNAL   Metabolism 57 (9), 1173-1180 (2008)
   PUBMED   18702941
REFERENCE   4  (bases 1 to 8087)
  AUTHORS   Bernard,J.R., Saito,M., Liao,Y.H., Yaspelkis,B.B. 3rd and Ivy,J.L.
  TITLE     Exercise training increases components of the c-Cbl-associated
            protein/c-Cbl signaling cascade in muscle of obese Zucker rats
  JOURNAL   Metabolism 57 (6), 858-866 (2008)
   PUBMED   18502271
REFERENCE   5  (bases 1 to 8087)
  AUTHORS   Lesniewski,L.A., Hosch,S.E., Neels,J.G., de Luca,C.,
            Pashmforoush,M., Lumeng,C.N., Chiang,S.H., Scadeng,M., Saltiel,A.R.
            and Olefsky,J.M.
  TITLE     Bone marrow-specific Cap gene deletion protects against high-fat
            diet-induced insulin resistance
  JOURNAL   Nat Med 13 (4), 455-462 (2007)
   PUBMED   17351624
REFERENCE   6  (bases 1 to 8087)
  AUTHORS   Lebre,A.S., Jamot,L., Takahashi,J., Spassky,N., Leprince,C.,
            Ravise,N., Zander,C., Fujigasaki,H., Kussel-Andermann,P.,
            Duyckaerts,C., Camonis,J.H. and Brice,A.
  TITLE     Ataxin-7 interacts with a Cbl-associated protein that it recruits
            into neuronal intranuclear inclusions
  JOURNAL   Hum Mol Genet 10 (11), 1201-1213 (2001)
   PUBMED   11371513
REFERENCE   7  (bases 1 to 8087)
  AUTHORS   Baumann,C.A., Ribon,V., Kanzaki,M., Thurmond,D.C., Mora,S.,
            Shigematsu,S., Bickel,P.E., Pessin,J.E. and Saltiel,A.R.
  TITLE     CAP defines a second signalling pathway required for
            insulin-stimulated glucose transport
  JOURNAL   Nature 407 (6801), 202-207 (2000)
   PUBMED   11001060
REFERENCE   8  (bases 1 to 8087)
  AUTHORS   Mandai,K., Nakanishi,H., Satoh,A., Takahashi,K., Satoh,K.,
            Nishioka,H., Mizoguchi,A. and Takai,Y.
  TITLE     Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized
            at cell-cell and cell-matrix adherens junctions
  JOURNAL   J Cell Biol 144 (5), 1001-1017 (1999)
   PUBMED   10085297
REFERENCE   9  (bases 1 to 8087)
  AUTHORS   Ribon,V., Herrera,R., Kay,B.K. and Saltiel,A.R.
  TITLE     A role for CAP, a novel, multifunctional Src homology 3
            domain-containing protein in formation of actin stress fibers and
            focal adhesions
  JOURNAL   J Biol Chem 273 (7), 4073-4080 (1998)
   PUBMED   9461600
REFERENCE   10 (bases 1 to 8087)
  AUTHORS   Ribon,V., Printen,J.A., Hoffman,N.G., Kay,B.K. and Saltiel,A.R.
  TITLE     A novel, multifuntional c-Cbl binding protein in insulin receptor
            signaling in 3T3-L1 adipocytes
  JOURNAL   Mol Cell Biol 18 (2), 872-879 (1998)
   PUBMED   9447983
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                JAXUCZ010000001.1  249279536-249279608 c
            74-159              JAXUCZ010000001.1  249219017-249219102 c
            160-213             JAXUCZ010000001.1  249171678-249171731 c
            214-282             JAXUCZ010000001.1  249167896-249167964 c
            283-372             JAXUCZ010000001.1  249164998-249165087 c
            373-501             JAXUCZ010000001.1  249162733-249162861 c
            502-528             JAXUCZ010000001.1  249152778-249152804 c
            529-641             JAXUCZ010000001.1  249152542-249152654 c
            642-783             JAXUCZ010000001.1  249142805-249142946 c
            784-813             JAXUCZ010000001.1  249139144-249139173 c
            814-986             JAXUCZ010000001.1  249134079-249134251 c
            987-1050            JAXUCZ010000001.1  249131855-249131918 c
            1051-1098           JAXUCZ010000001.1  249120829-249120876 c
            1099-1228           JAXUCZ010000001.1  249120595-249120724 c
            1229-1343           JAXUCZ010000001.1  249118169-249118283 c
            1344-1427           JAXUCZ010000001.1  249112766-249112849 c
            1428-1493           JAXUCZ010000001.1  249109028-249109093 c
            1494-1595           JAXUCZ010000001.1  249108398-249108499 c
            1596-1645           JAXUCZ010000001.1  249104436-249104485 c
            1646-1818           JAXUCZ010000001.1  249095885-249096057 c
            1819-3285           JAXUCZ010000001.1  249093929-249095395 c
            3286-3371           JAXUCZ010000001.1  249093215-249093300 c
            3372-3539           JAXUCZ010000001.1  249089981-249090148 c
            3540-3586           JAXUCZ010000001.1  249086195-249086241 c
            3587-3701           JAXUCZ010000001.1  249082693-249082807 c
            3702-3827           JAXUCZ010000001.1  249082432-249082557 c
            3828-4022           JAXUCZ010000001.1  249079676-249079870 c
            4023-4775           JAXUCZ010000001.1  249077566-249078318 c
            4776-4835           JAXUCZ010000001.1  249066392-249066451 c
            4836-4894           JAXUCZ010000001.1  249065622-249065680 c
            4895-5007           JAXUCZ010000001.1  249062407-249062519 c
            5008-8087           JAXUCZ010000001.1  249057324-249060403 c
FEATURES             Location/Qualifiers
     source          1..8087
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..8087
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /note="sorbin and SH3 domain containing 1"
                     /db_xref="GeneID:686098"
                     /db_xref="RGD:1586598"
     exon            1..73
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            74..159
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            160..213
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..5075
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /note="ponsin; Cbl associated protein"
                     /codon_start=1
                     /product="sorbin and SH3 domain-containing protein 1"
                     /protein_id="NP_001408290.1"
                     /db_xref="GeneID:686098"
                     /db_xref="RGD:1586598"
                     /translation="MSSECDVGSSKAVVNGLAPGSHGPDKADPLRARTISAVKIIPVK
                     TVKSPSGLVLPPDMDPTKICTGKGTVTLRASSSYRETPSSSPVSPQESPKHENKSGLE
                     PEDHSADEWKLSSSADANGNAQPSPLAAKGYRSVHPSLLADKPQGSPLLNEVSSSHID
                     TDSQVFPPTSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPASERRVGEQDPVP
                     TPAELTSPIRAAERRAKDDSRRVVRSAQDLSSVSMDEVGIPLRNTERSKDWYKTMFKQ
                     IHKLNRDDDSDLHSPRYSFSEDTKSPLSVPRSKSEMNYIDGEKVVKRSATLPLPARSS
                     SLKSSPERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLK
                     NEPWYKFFSELEFGRPPPKKIWDYTPGDCSILPRGDRKTNLEKDLNLCQAELEADLEK
                     VETVNKSPTAHVPQSSAVSPTPDITSEPPGYIYSSDFHAVKRESDGTPGGLASLENER
                     QIYKSVLEGGDIPLQGLSGLKRPSSSASTKVDRKGGNAHMISSSSVHSRTFHTSNALG
                     PGCKHKKPLSAAKACISEILPSKFKPRLSAPSALLQEQKSVLLTSEKAQSCENLCVSL
                     NDSKRGLPLRVGGSIENLLMRSRRDYDSKSSSTMSLQEYSTSSRRPCPLSRKAGLHFS
                     MFYRDMHQINRAGLSLGSISSSSVRDLASHFERSSLSLARGELGASQEGSEHIPKHTV
                     SSRITAFEQLIQRSRSMPSLDFSGRLSKSPTPVLSRSGLTSARSAESLLESTKLRPRE
                     MDGMDSGGVYSSPTCSNMADHALSFRSLAPSEPLSICSDELDHCSNISNDSREGSGGS
                     VHGDFPKHRLNKCKGTCPASYTRFTTIRKHEQQSSRQPDWRSDSRGDRNSLLRNIYLM
                     SPLPFRLKKPLQQHPRQPPHDDSSGCPAGQKADLPCQGPQDQPHSAGKPMVPTRLSSR
                     HTMARLSHNSEPPLDRSAGLEDCTRAVNNGNPVPYSDHALDRNNNPQSELAAAHGDSE
                     SPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQ
                     FITNERFGDLLNIDDTAKRKSGLEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQ
                     NWYEGEHHGRVGIFPRTYIELLPPAEKAQPRKLAPVQVLEYGEAIAKFNFNGDTQVEM
                     SFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVLKRPLVKTPVDYIDLPYSS
                     SPSRSATVSPQCTSHSKLIMPAPSSLPHPRRALSPEMHAITSEWISLTVGVPGRRSLA
                     MTPPLPPLPEASVYDMDRLALSARARPSLPLSLPYSSWSDHSTLRSVVSPVALPPPHK
                     ACSRAPSAQAPLHINGDGGIHIRQDGFSQPPLGNSDRVISELSDAFSSQSKRQPWRED
                     GPYDRKAESEAGERCPGGPKISKKSCLKPSDVVRCLSSEQRLSEFHTPEDSQSFKPLS
                     SPFPAWEAGPPELHRGVEADRKAAQSGVSQPSHHSLSAGPDLTESEKNYVQPQAQQRR
                     LTPDRSQPSQDLCSYQALYSYVPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTRQF
                     GTFPGNYVKPLYL"
     exon            214..282
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            283..372
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            373..501
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            502..528
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            529..641
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            642..783
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            784..813
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            814..986
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1050
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1098
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1228
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1343
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1427
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1493
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1595
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1645
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1818
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..3285
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            3286..3371
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            3372..3539
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..3586
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            3587..3701
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            3702..3827
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            3828..4022
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            4023..4775
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            4776..4835
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            4836..4894
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            4895..5007
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            5008..8087
                     /gene="Sorbs1"
                     /gene_synonym="CAP; SH3P12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcggggc tgactgcagc gtggagcgcg agccgggcag gacgcgcgta agcccttgcc
       61 ggggacccgc gaggaggttg gcacccgttg gaagactctg agatcctctc tgcccagaac
      121 tccgggacca atgcatcttc ccaccacctt aaaacactga accctccgga gcagcggctg
      181 gagaagactt gcctgccacc agcatgagtt ctgaatgtga tgttggaagt tctaaagctg
      241 tggtgaatgg cttggcacct ggcagccatg gaccagacaa agccgaccct ttgcgtgctc
      301 gcactatatc tgctgttaaa ataattcccg tgaagacagt gaaaagccct tcaggcctag
      361 tactccctcc agacatggac cctacaaaaa tctgcacagg gaaagggaca gtgacccttc
      421 gggcctcgtc ttcctacagg gagaccccaa gcagcagccc tgtgagcccc caggaatctc
      481 cgaagcatga aaacaagtca ggcctggagc cagaggacca ttcagcagat gaatggaaac
      541 tttcttccag tgccgatgcc aatggcaacg cccagccctc cccactcgct gccaagggct
      601 atagaagtgt gcatcccagc cttttggctg acaagcccca gggcagtcct ttactaaatg
      661 aagtttcttc ttcccacatt gacactgatt cccaagtctt ccctccaaca agcaaacctt
      721 cgtctgccta cccttccacc acaattgtca accctaccat tgtgctcttg cagcacaacc
      781 gagaacagca aaaacgactc agtagtcttt cagatcccgc ctcagagaga agagtgggtg
      841 agcaggaccc agtgccaacc ccggcagaac tcacctcgcc catcagggct gcggaaagga
      901 gagccaagga tgacagcaga cgggtggtga ggagtgcaca ggacctaagc agtgtgtcta
      961 tggatgaagt gggcatccca ctccggaata ccgagagatc gaaagactgg tacaaaacta
     1021 tgtttaaaca gatccacaag ctgaacagag atgatgattc tgacctgcac tctcctcgat
     1081 actccttttc tgaagacaca aagtctcccc tttctgtgcc tcgctcaaaa agtgagatga
     1141 actacattga cggggagaaa gtggtcaaga ggtctgccac actccccctc ccagcccgct
     1201 cctcctcact caagtccagc ccagagagaa acgactggga gcccccagat aagaaagtgg
     1261 atacgagaaa ataccgagca gagcccaaaa gcatttatga gtatcagccc ggcaagtctt
     1321 ccgtcctgac caatgagaag atgagtcggg atataagccc agaagagata gatttaaaga
     1381 atgaaccttg gtataaattc ttttcggaat tggagtttgg gagaccgcct cctaaaaaga
     1441 tatgggacta tactcctgga gactgctcta tccttcctag aggggataga aagactaacc
     1501 tagaaaaaga tctcaacttg tgccaagcag agttagaggc agatttagag aaagtggaga
     1561 cggttaataa atcacccact gcacacgtgc cacagagctc agcagtcagc ccgactccag
     1621 acattacgtc agagcctcct ggatatatat actcctccga cttccatgca gtgaagagag
     1681 aatcagacgg gacccccggg ggtctcgcta gcttggagaa cgagaggcag atttataaaa
     1741 gtgtcttgga aggtggtgac atccctcttc aaggcctgag tgggctcaag cgaccttcca
     1801 gctcagcgtc tactaaagtg gatcgtaaag gcgggaatgc tcacatgatt tcttcatcat
     1861 cagttcatag ccgaacgttt cacactagca atgctttagg ccctgggtgt aagcacaaga
     1921 aacccctgtc ggctgcgaaa gcctgcattt cggagatcct tccttccaaa ttcaaaccca
     1981 ggctctctgc tcccagcgct cttttgcagg aacagaagag cgtcctgtta acctcagaga
     2041 aggctcagag ctgtgagaac ctttgtgttt ctttgaatga ttccaaaaga ggcctcccac
     2101 tccgtgttgg gggaagcatc gagaacctac tcatgcgctc ccggcgggat tacgacagca
     2161 agtccagcag caccatgagc ctacaggagt acagcaccag ctccaggagg ccttgccctc
     2221 tctccagaaa ggctggactg catttctcca tgttctaccg ggacatgcac cagatcaacc
     2281 gagctggcct ctccttaggc tccatctcct cctcgagtgt gcgagatctt gcctcccact
     2341 ttgaaaggag cagtctgtcg ctagccaggg gtgagctggg cgctagccaa gagggctcag
     2401 aacatatccc caagcacaca gtgtcctccc gtatcacggc ctttgagcag ctcattcagc
     2461 ggtctcggtc catgccatcc ctggacttct ctggcaggct gagcaagtcc ccgacacctg
     2521 tgctctctag aagcggcctg acctcagctc gttcagcaga atccctcctc gagtctacca
     2581 agctccgtcc cagagagatg gacgggatgg actccggagg ggtctattcg tctcccacgt
     2641 gtagcaatat ggcggaccac gccttgagct tccggagcct tgcgccctct gagccccttt
     2701 ccatctgctc ggatgagcta gaccactgct caaatatttc taatgacagc agggagggca
     2761 gcgggggcag tgttcatggg gacttcccca aacatcgcct caacaagtgc aagggcacct
     2821 gcccggcttc atacacccgg ttcaccacta tccggaagca tgagcagcag tcctccaggc
     2881 agccagactg gcgctcggat tccagggggg acaggaacag tctcctcaga aacatctacc
     2941 tgatgagccc cctccctttt cgattgaaaa agccccttca acagcacccc agacagcctc
     3001 cccacgatga ctcctcaggg tgccctgctg gccagaaggc agaccttccc tgccagggcc
     3061 ctcaggacca gccccactct gcggggaaac ccatggtccc cactcgcctg tcttcccgac
     3121 acaccatggc caggcttagc cacaactcag agccccctct ggacagatcc gcaggcctgg
     3181 aggattgcac aagggctgtt aataacggga accccgtgcc ctactcagac catgccttgg
     3241 acaggaacaa caatccacaa agtgaactgg cagcagccca tggagattca gagtcaccaa
     3301 gacattttat accagctgat tacttggagt ccacagaaga atttatccgg agacggcacg
     3361 acgataaaga gaaactttta gcggaccaga gacgacttaa gcgcgagcaa gaagaggccg
     3421 atattgcagc tcgccgccac acaggtgtca tcccgactca tcatcagttt atcactaatg
     3481 agcgctttgg ggacctcctc aatatagatg acactgcaaa aaggaaatct gggttagaga
     3541 tgagacctgc ccgagccaaa tttgacttta aagctcagac actgaaggag ctgcctctgc
     3601 agaagggaga tattgtttac atctataaac agatcgatca gaactggtat gaaggtgaac
     3661 accatggccg ggtgggaatc ttcccacgca cctatatcga gcttcttcct ccagctgaga
     3721 aggctcagcc cagaaagttg gcgcccgtac aggttttgga atatggagaa gccattgcga
     3781 agtttaactt taatggtgat acacaagtag aaatgtcttt ccgaaagggg gagaggatca
     3841 cgctgctccg gcaggtggat gagaactggt acgaagggag gattcctggc acatcccgcc
     3901 aaggcatttt ccctatcacc tatgtagatg tgcttaagag gccattggtg aaaacccccg
     3961 tggattacat cgatctgcct tattcttctt ccccaagtcg cagtgccact gtgagcccac
     4021 agtgcactag tcacagcaag ctcatcatgc cagccccttc atctctaccc cacccccgcc
     4081 gagccctgtc ccccgagatg cacgccatca cctctgagtg gatctctctg actgttgggg
     4141 tcccgggcag gcgttctctg gccatgacac cacccttgcc tccactgcct gaggcttctg
     4201 tgtatgacat ggaccgtttg gccttgtcag cgagggcccg cccctccttg ccactcagtc
     4261 ttccctattc cagttggtca gatcactcca ccctgcgctc agtggtctcc ccggtggccc
     4321 tacctccacc ccacaaagcc tgctcacggg cacccagtgc ccaggctcct cttcacatca
     4381 atggagacgg tggtattcac attcgccaag atggcttctc ccagccacca cttgggaact
     4441 ccgatagggt catctcagag cttagtgacg cctttagcag ccagagcaag agacagccct
     4501 ggcgagaaga tggaccatat gacaggaaag cagagagcga ggcaggtgag agatgccctg
     4561 gtggacccaa gatctctaag aagagctgct tgaaaccttc agacgtggtc aggtgcctga
     4621 gttctgagca gagactctcg gagttccaca ctcctgagga cagccagtcc ttcaagcctc
     4681 tgagtagccc tttcccagca tgggaagctg ggccaccaga gcttcacaga ggtgtcgagg
     4741 ctgacaggaa agctgctcag agtggtgtaa gccagccttc tcatcattca ttgagcgcag
     4801 gacctgatct cacagaatct gaaaagaact atgtgcaacc tcaagcccag cagcgaagac
     4861 tcacccctga caggagtcag ccctcacagg atttatgtag ctaccaagcg ttatatagtt
     4921 acgtgccaca gaacgatgat gagttggaac tccgagatgg agatattgtc gatgtcatgg
     4981 aaaaatgtga cgatggctgg tttgttggca cttcgagaag gacgaggcag tttggcactt
     5041 ttccaggcaa ctatgtaaaa cctttatatc tataagaaga ctgaaaagca cagagattat
     5101 tttttatcag aagatgaagc atcattcatg aactggtctc tttatttaaa tatcgagtca
     5161 gtaggaaaac gaatttcagt tgataaagaa agaattcaaa gagaggaaca gagaagtgtg
     5221 tctaaaaacc tctgtgtatc agggactgac tatctgctga agacatctgt atttacatgg
     5281 ctgcttctgg agttgctcta gcccctgctg cttacagaat ctgatctgga gtagtgtccg
     5341 tgagcaacat tagccaaaaa atgtgtccgg tctttaccca ttcccatttc aaaagtggtc
     5401 cgttggggct ggataagtca gtccctgtcc atgttccaca ggtcccaagc ctgagcatca
     5461 ttggcaactc ctgcctctat tcctggctac cccagagcct gcagacctca agggacgcta
     5521 gaggccggtc tgggttgttg aagttttctt tcagaccttg atgaggtcca ggtaaagaaa
     5581 tggtgcagac caggtgccct agcccccagc ttctgggtga tatcaccctt tactgccctg
     5641 atgttcagac agaaaactgg ctgtcctaag cttgggagca ggtggccagg cagatgggtt
     5701 acgtttgtgt ttccacgtga tgaagccacc ttggggctct gcaagtcact tggagtgtgt
     5761 ccttccctgg tcactaccac tggctagcca gggttggctg tgcctttctt ctttggttta
     5821 gtatgggctt gatacacttg agcccatagg ctacagcctg gtctccagta gctctcttag
     5881 catgcgtaga tgcaagctgg ctgcagggcc accatgagta agacactccc agacccagga
     5941 ggggctctgt gcctcctgtg ttgcctgtgg agtttgaatg ccacccagaa cattgtcttc
     6001 tcttgtcctt cccctgcttc ctctccaccc caggcctggg agtcctggtg cacatagtga
     6061 ggcctccatt cagaactcaa gaattacaca ccggcctggg tatgaggcag caattctcct
     6121 cctggtggca gccgtgagtc tgtcctctgt gagccctggt tgtgaggagg ggaccctttg
     6181 acacctgggt gtttagtcac cactctgatt tctctgttag atccctagtt gacacaaaga
     6241 taagtgtggc ctcttcccaa agctgagcct gccagggcct cagctcagtg gacaacacag
     6301 gagaagaagc ccaatctaga gagactgtga tacgtgcaga gggtgtgagg aagggatgtt
     6361 tttctcctga ggggacacta gaaagcggtc aggtttcccg ctcccatagc tcacttctaa
     6421 acaactggga tgctgggaga accctcgtct gagggtagtt tgtgtctgga aatactgaga
     6481 attttttttc cagacccata aatacatgta caaggtcaca aataccaggg attgtgggtg
     6541 atggggtata cactggaacc ctgactctct gcatgtagtt cagagtcacc ctaagcacta
     6601 tcccaaagtc tggagtcggc aacatttgtc ttcagtgacc gcctactgcc gtagatagca
     6661 tgggacccta atttcccacc tctgccatca cccgtcagcc ataattctct gaggaggttc
     6721 ttatcctcgg gaaagaaacc gccacgcatt gattcgcact gaaatgtaaa tggctgatgg
     6781 ggaaataaat gtgttgcctc ttccggaaga caagacttta actgagacag agcagagcct
     6841 ttagtcccaa gggaaaatgg aatggaactg aaggggtagg agctgcctgg acagaaagac
     6901 ctattgcttt gcaagctcag tctcctcagc caactgcact gctttctttg ttttactttg
     6961 cccctctcga aggggacata ggaaaagtaa attacaatgc acacgtccgt tttactcatt
     7021 cagaatgcag ttgctctctc tcctagatgc caaccatgac tagcgcaatt gtatctaaat
     7081 ttcctgaggg gcgtttttgt tttttaatga agtaggtaat gttaaacacc cctttaaata
     7141 cagctagaaa ataaaaccat tttataaaag ccaccctcga atcccctgcg agcctcccac
     7201 agagcatctc tccaaatcca ggtataccca cccatcttta gtctgatctc tcccgcttcc
     7261 gacgtatgaa aaaaaaaaaa aaaccaggag aacggaggtt cccaattact cttttgtctt
     7321 cagacattta gtaatataaa atacctattt ttatgctgaa atgtttatac aggtttatta
     7381 acagcaagcg caactaactg gcggcgtgcc gtgcaaccca ttttgatata ttagccgtgc
     7441 ttccaggtaa aggcaagccc ccagctactc accttttgca gtctctctct ggaatcagta
     7501 aaaagaaaag aaaaaaaaaa atcacgtttg agaagtggga ctgtaaatat gtaatgtatg
     7561 tttaactttg tggagcccat gtacctacct tgtatagaag aaataatttt taaaagttga
     7621 gcagaaaggg agtaaaatga agtcacgaag ggtttccccc cccccaacac ttttatttaa
     7681 atgaaggaat ttcgaataat tcacctgcgg acctttagca caaaaatagt cctgggaaat
     7741 tgttaacata ttcactcgtt ctctggggaa gagaagacag ctatcatatc atatttgcag
     7801 ttttacgttt gcagtcctat ttatctgcag tagtattaag tcacattgct ggaataggtt
     7861 actaccaaaa aagaagacat tattgagaga aaaaaacaaa accgatctat gtaacctatt
     7921 agagtattgc atttaaattg cacaccaagc gcgtgtacta cgcagacaca ggtttttctg
     7981 ttcatttatt gtttttcctt actgccgtgg attgatttga tagacatgtt gaattactac
     8041 ttcgctgtac atattattta ataaacttta ttcggaattg cgtggca
//
