LOCUS       NM_001170327            8446 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus SON DNA and RNA binding protein (Son), transcript
            variant 1, mRNA.
ACCESSION   NM_001170327 XM_001068992 XM_001069321 XM_221656
VERSION     NM_001170327.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8446)
  AUTHORS   Wen,K., Wang,H., Chen,Y., Yang,H., Zheng,Z., Yan,Y., Realivazquez
            Pena,A. and Zeng,M.
  TITLE     A new self-attenuated therapeutic influenza vaccine that uses host
            cell-restricted attenuation by artificial microRNAs
  JOURNAL   Int J Pharm 612, 121325 (2022)
   PUBMED   34883209
REFERENCE   2  (bases 1 to 8446)
  AUTHORS   Slezak,R., Smigiel,R., Rydzanicz,M., Pollak,A., Kosinska,J.,
            Stawinski,P., Malgorzata Sasiadek,M. and Ploski,R.
  TITLE     Phenotypic expansion in Zhu-Tokita-Takenouchi-Kim syndrome caused
            by de novo variants in the SON gene
  JOURNAL   Mol Genet Genomic Med 8 (10), e1432 (2020)
   PUBMED   32705777
REFERENCE   3  (bases 1 to 8446)
  AUTHORS   Kim,J.H., Park,E.Y., Chitayat,D., Stachura,D.L., Schaper,J.,
            Lindstrom,K., Jewett,T., Wieczorek,D., Draaisma,J.M., Sinnema,M.,
            Hoeberigs,C., Hempel,M., Bachman,K.K., Seeley,A.H., Stone,J.K.,
            Kong,H.K., Vukadin,L., Richard,A., Shinde,D.N., McWalter,K.,
            Si,Y.C., Douglas,G., Lim,S.T., Vissers,L.E.L.M., Lemaire,M. and
            Ahn,E.E.
  TITLE     SON haploinsufficiency causes impaired pre-mRNA splicing of CAKUT
            genes and heterogeneous renal phenotypes
  JOURNAL   Kidney Int 95 (6), 1494-1504 (2019)
   PUBMED   31005274
REFERENCE   4  (bases 1 to 8446)
  AUTHORS   Kim,J.H., Shinde,D.N., Reijnders,M.R.F., Hauser,N.S.,
            Belmonte,R.L., Wilson,G.R., Bosch,D.G.M., Bubulya,P.A., Shashi,V.,
            Petrovski,S., Stone,J.K., Park,E.Y., Veltman,J.A., Sinnema,M.,
            Stumpel,C.T.R.M., Draaisma,J.M., Nicolai,J., Yntema,H.G.,
            Lindstrom,K., de Vries,B.B.A., Jewett,T., Santoro,S.L., Vogt,J.,
            Bachman,K.K., Seeley,A.H., Krokosky,A., Turner,C., Rohena,L.,
            Hempel,M., Kortum,F., Lessel,D., Neu,A., Strom,T.M., Wieczorek,D.,
            Bramswig,N., Laccone,F.A., Behunova,J., Rehder,H., Gordon,C.T.,
            Rio,M., Romana,S., Tang,S., El-Khechen,D., Cho,M.T., McWalter,K.,
            Douglas,G., Baskin,B., Begtrup,A., Funari,T., Schoch,K.,
            Stegmann,A.P.A., Stevens,S.J.C., Zhang,D.E., Traver,D., Yao,X.,
            MacArthur,D.G., Brunner,H.G., Mancini,G.M., Myers,R.M., Owen,L.B.,
            Lim,S.T., Stachura,D.L., Vissers,L.E.L.M. and Ahn,E.Y.E.
  CONSRTM   University of Washington Center for Mendelian Genomics; Deciphering
            Developmental Disorders Study
  TITLE     De Novo Mutations in SON Disrupt RNA Splicing of Genes Essential
            for Brain Development and Metabolism, Causing an
            Intellectual-Disability Syndrome
  JOURNAL   Am J Hum Genet 99 (3), 711-719 (2016)
   PUBMED   27545680
REFERENCE   5  (bases 1 to 8446)
  AUTHORS   Tokita,M.J., Braxton,A.A., Shao,Y., Lewis,A.M., Vincent,M.,
            Kury,S., Besnard,T., Isidor,B., Latypova,X., Bezieau,S., Liu,P.,
            Motter,C.S., Melver,C.W., Robin,N.H., Infante,E.M., McGuire,M.,
            El-Gharbawy,A., Littlejohn,R.O., McLean,S.D., Bi,W., Bacino,C.A.,
            Lalani,S.R., Scott,D.A., Eng,C.M., Yang,Y., Schaaf,C.P. and
            Walkiewicz,M.A.
  TITLE     De Novo Truncating Variants in SON Cause Intellectual Disability,
            Congenital Malformations, and Failure to Thrive
  JOURNAL   Am J Hum Genet 99 (3), 720-727 (2016)
   PUBMED   27545676
REFERENCE   6  (bases 1 to 8446)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 8446)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 8446)
  AUTHORS   Ahn,E.Y., DeKelver,R.C., Lo,M.C., Nguyen,T.A., Matsuura,S.,
            Boyapati,A., Pandit,S., Fu,X.D. and Zhang,D.E.
  TITLE     SON controls cell-cycle progression by coordinated regulation of
            RNA splicing
  JOURNAL   Mol Cell 42 (2), 185-198 (2011)
   PUBMED   21504830
REFERENCE   9  (bases 1 to 8446)
  AUTHORS   Cazalla,D., Newton,K. and Caceres,J.F.
  TITLE     A novel SR-related protein is required for the second step of
            Pre-mRNA splicing
  JOURNAL   Mol Cell Biol 25 (8), 2969-2980 (2005)
   PUBMED   15798186
REFERENCE   10 (bases 1 to 8446)
  AUTHORS   Greenhalf,W., Lee,J. and Chaudhuri,B.
  TITLE     A selection system for human apoptosis inhibitors using yeast
  JOURNAL   Yeast 15 (13), 1307-1321 (1999)
   PUBMED   10509013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On or before Dec 18, 2009 this sequence version replaced
            XM_221656.4, XM_001069321.1, XM_001068992.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. The extent of this transcript is supported
            by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.37544.1,
                                           SRR26643287.26620.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               JAXUCZ010000011.1  44377976-44378105
            131-297             JAXUCZ010000011.1  44381628-44381794
            298-6273            JAXUCZ010000011.1  44384037-44390012
            6274-6434           JAXUCZ010000011.1  44391537-44391697
            6435-6581           JAXUCZ010000011.1  44393597-44393743
            6582-6770           JAXUCZ010000011.1  44394030-44394218
            6771-6881           JAXUCZ010000011.1  44400450-44400560
            6882-6998           JAXUCZ010000011.1  44401308-44401424
            6999-7146           JAXUCZ010000011.1  44405311-44405458
            7147-7218           JAXUCZ010000011.1  44407319-44407390
            7219-7334           JAXUCZ010000011.1  44407498-44407613
            7335-8446           JAXUCZ010000011.1  44408016-44409127
FEATURES             Location/Qualifiers
     source          1..8446
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..8446
                     /gene="Son"
                     /note="SON DNA and RNA binding protein"
                     /db_xref="GeneID:304092"
                     /db_xref="RGD:1309013"
     exon            1..130
                     /gene="Son"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..7394
                     /gene="Son"
                     /note="isoform 1 is encoded by transcript variant 1; Son
                     cell proliferation protein; SON DNA-binding protein; Son
                     DNA binding protein"
                     /codon_start=1
                     /product="protein SON isoform 1"
                     /protein_id="NP_001163798.1"
                     /db_xref="GeneID:304092"
                     /db_xref="RGD:1309013"
                     /translation="MAADIEQVFRSFVVSKFREIQQELSSGRSEGQLNGETNAPIEGN
                     QAGDTAASARSLPNEEIVQKIEEVLSGVLDTELRYKPDLKEASRKSRCVSVQTDPTDE
                     VPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKLKSHHDGNVDLESDSFLKFDS
                     EPSALALEHPVRAFGLSEASETPLVLEPPVVSMEVQEPHALETLKPATKPAALSAVST
                     SVISEQPEQPVPVMLEPSMTKILDSFAAAPVPMSTAVLRSPEPVVTMSVEYQKSVLKS
                     LETVPPEISKTTLVELPIAKVLEPSETLTIVSETPTEVHPEPSPSTMDFPESSTTDVQ
                     RLPEQPVEAPPEIADSSMTRPQESLELPKTTAVELQESSVASALELPGPPATSMLELQ
                     GPPVTPVPELPGPSATTPVPELSGPLSTLVPELPGPPGTVVPELPGPSVTPVPQLSQE
                     LPGPSAPSMGLEPPQEVPEPPVMAQEVSGVPTVSAAIELTGQPAVTVAMELTEQPVTT
                     TEFEQPVAMTTVEHPGHPEVTTATGLLGQPEAAMVLELPGQPVATTALELSGQPSVTG
                     VPELSGLPSATRALELSGQSVATGALELPGQLMATGALEFSGQSGAAGALELLGQPLA
                     TGVLELPGQPGAPELPGQPVATVALEISVQSVVTTSELSTMTVSQSLEVPSTTALESY
                     NTVAQELPTTLVGETSVTVGVDPLMAQESHMLASNTMETHMLASNTMDSQMLASNTMD
                     SQMLASNTMDSQMLASSTMDSQILASSTMDSQMLATSSMDSQMLASSSMDSQMLATSS
                     MDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLAT
                     SSMDSQMLASGAMDSQMLASGTMDAQMLASGTMDAQMLASSTQDSAMMGSKSPDPYRL
                     AQDPYRLAQDPYRLGHDPYRLGHDAYRLGQDPYRLGHDPYRLTPDPYRMSPRPYRIAP
                     RSYRIAPRPYRLAPRPLMLASRRSMMMSYAAERSMMSSYERSMMSYERSMMSPMAERS
                     MMSAYERSMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMADRSMMSMGADR
                     SMMSSYSAADRSMMSSYSAADRSMMSSYTDRSMMSMAADSYTDSYTDSYTEAYMVPPL
                     PPEEPPTMPPLPPEEPPMTPPLPPEEPPEGAALSTEQSALTADNTWSTEVTLPTEESV
                     SQPEPPVSQSEISEPLVVPANYSASESETSMLASEAVMTVPEPAREPESSVTSTPVES
                     AVVAEHEMVPERPMTYMVSETTMAAEPSVLTSEASVMAETSETYDSMRPSGHAISEVS
                     MSLLEPAVTISQPAESSLELPSMAVPAPSTIATTESLVAVPELAAVADSEPPIMAVPE
                     PPTVAVPEPPVTTAPEPPPMITPELCSLSISESPVAVSELPALADPEHAVTAVSGVSS
                     LEPSVPVLEPSVSVLQPVMIVSEPCVSIQEPTVAVSEPAVIVSEHTQITSPEMAVESS
                     PVMVESSVVSSQIMKGMNLLSGDENLGSEVGTQETLLHPGEEPHDGGHLKSDLYEHEY
                     DRNTDLTVNSHLIAKEAEHSTACAAAIVPVGETSEEKILPISETKEMIELDTCPAVSE
                     ADVGRSLSSQLALELDTVGTSKGFEFVAASAPISESKYDVEVSVTTQDTEHDMVISTS
                     PSGGSEADIEGPLPAKDIHLDLPSTNLVCKDVEDSLPIKESDETVTVALSPKESSEDT
                     EGPLPNKEIVPDSGYSVSIDEINEADLVRPLLPKDMERLTSLRAGIEGPLLPSEVERD
                     KSVASPVVISIPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSL
                     RSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKS
                     RGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRR
                     RSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPS
                     RRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRSPKRLTDLD
                     KAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPTIEEKVAKKSGGATIEELTEKCKQI
                     AQSKEDDDVIVNKPHVSDEEEEEPPFYHHPFKLSEPKPIFFNLNIAAAKPTPPKSQVT
                     LTKEFPVSSGSQHRKKEADSVYGEWVPVEKNGEESKDDDNVFSSSLPSEPVDISTAMS
                     ERALAQKRLSENAFDLEAMSMLNRAQERIDAWAQLNSIPGQFTGSTGVQVLTQEQLAN
                     TGAQAWIKKDQFLRAAPVTGGMGAVLMRKMGWREGEGLGKNKEGNKEPILVDFKTDRK
                     GLVAVGERAQKRSGNFSAAMKDLSGKHPVSALMEICNKRRWQPPEFLLVHDSGPDHRK
                     HFLFRVLRNGSPYQPNCMFFLNRY"
     exon            131..297
                     /gene="Son"
                     /inference="alignment:Splign:2.1.0"
     exon            298..6273
                     /gene="Son"
                     /inference="alignment:Splign:2.1.0"
     exon            6274..6434
                     /gene="Son"
                     /inference="alignment:Splign:2.1.0"
     exon            6435..6581
                     /gene="Son"
                     /inference="alignment:Splign:2.1.0"
     exon            6582..6770
                     /gene="Son"
                     /inference="alignment:Splign:2.1.0"
     exon            6771..6881
                     /gene="Son"
                     /inference="alignment:Splign:2.1.0"
     exon            6882..6998
                     /gene="Son"
                     /inference="alignment:Splign:2.1.0"
     exon            6999..7146
                     /gene="Son"
                     /inference="alignment:Splign:2.1.0"
     exon            7147..7218
                     /gene="Son"
                     /inference="alignment:Splign:2.1.0"
     exon            7219..7334
                     /gene="Son"
                     /inference="alignment:Splign:2.1.0"
     exon            7335..8446
                     /gene="Son"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgggagcc tggaggacta gcgaggagga gttgagagaa cggagcggac gccatggcgg
       61 ccgacatcga gcaggttttt aggtctttcg tggtcagtaa attccgggaa atacaacagg
      121 agctttccag tggaaggagt gaaggccagc tgaatggtga aacgaatgca cccattgaag
      181 ggaaccaggc aggtgacaca gctgcctctg caaggagtct cccaaatgaa gagatagtgc
      241 agaagataga ggaggtcctc tctggggtcc tagacacaga actgcgatac aagccggact
      301 tgaaagaggc ctccagaaaa agtagatgtg tatctgtaca aacagatcct accgatgaag
      361 ttcccaccaa aaagtcaaag aagcataaaa agcacaaaaa caaaaagaag aaaaagaaga
      421 aagaaaagga aaaaaaatat aaaagacaac cagaagaatc tgaatccaag ctgaaatctc
      481 atcatgatgg gaatgttgat ctagaatctg attccttctt aaagtttgat tctgaacctt
      541 cagcattggc actggaacat cctgtaagag cattcggctt atctgaggcc agtgaaaccc
      601 ccttagtgct agagcctcca gtagtctcaa tggaggttca ggaaccacat gctttagaga
      661 ctctgaagcc agctacaaaa cctgcagcac tgtcagctgt gtctacatca gtaatctcgg
      721 agcagcctga gcaacctgtg ccagttatgc tggagccatc aatgacaaag attctggact
      781 ccttcgcagc agcaccagtg cctatgtcaa cagcagtgct gaggtcgcct gagcccgttg
      841 taacaatgtc agtggagtat cagaagtctg tgctgaaatc tttggagact gtgcctccag
      901 agatatcaaa gaccacgctg gtagagcttc ccatagcaaa agtgcttgag ccatcagaaa
      961 ccctcacaat agtatcagag acacctactg aggtgcaccc tgaaccaagc ccatcaacaa
     1021 tggattttcc agagtcatct acaactgacg tgcaaagatt gccagagcag cctgtagaag
     1081 caccgccgga gatcgcagat tcatctatga caagacctca ggagtcactg gagctgccta
     1141 agaccacagc ggtggagctg caggagtcgt cggtggcctc agccctggag ttgccggggc
     1201 cacctgcgac ctccatgctg gagttgcagg ggccccctgt gactccagtg ccggagttgc
     1261 ctgggccctc tgccaccacc ccagtgccag agttgtcagg gcccctttct accctagtgc
     1321 ctgagttgcc agggccccct gggacagtgg tccctgagtt gccggggccc tctgtgacac
     1381 cagtgccaca gttgtcacag gaattgccag ggccttcagc accatccatg gggttggagc
     1441 caccacagga ggtaccagag ccacctgtga tggcacagga ggtgtcaggg gtgcctacag
     1501 tgtcagcggc aatagagttg acagggcaac ctgcagtaac agtagcaatg gagttgaccg
     1561 aacaacctgt gacgacgaca gagttcgagc agcctgtggc gatgacgacg gtggaacatc
     1621 ctgggcatcc tgaggtgaca acagcaacag ggttgctggg gcagccagag gcagcaatgg
     1681 tgctggagtt gccaggacag ccagtggcaa ccacagcgct ggagttgtct gggcagcctt
     1741 cggtgactgg ggtgccagag ttgtcagggc tgccttcggc aactagggca ctggagttgt
     1801 cagggcagtc tgtggcaact ggggcattag agttgcctgg tcagctcatg gcaactgggg
     1861 cactggagtt ttcgggtcag tctggggcag ctggagcact ggagcttttg gggcagcccc
     1921 tggcaacggg ggtgctagag ttaccggggc agcctggagc gccagagttg cctgggcagc
     1981 ctgtggcaac tgtggcgctg gagatctctg ttcagtctgt ggtgacaaca tcggagctgt
     2041 cgacgatgac cgtgtcgcag tccctggagg tgccctcgac gacagcgctg gaatcctata
     2101 atacggtagc acaggagctg cctactacat tggtggggga gacttccgta acagtaggag
     2161 tggatccctt gatggcccaa gaatcccata tgttagcttc taacaccatg gagacccata
     2221 tgttagcatc caacaccatg gactcccaaa tgctagcatc caacactatg gattctcaga
     2281 tgctagcgtc caataccatg gattcccaga tgttagcctc tagtaccatg gattcccaga
     2341 tattagcctc tagcaccatg gattcccaga tgttagcaac tagctccatg gattcccaga
     2401 tgttagcatc tagctccatg gattcccaga tgttagcaac cagctccatg gactcccaga
     2461 tgttagcaac cagctccatg gactcgcaga tgttagcaac cagctccatg gactcgcaga
     2521 tgttagcaac cagcagtatg gactcgcaga tgttagcaac cagctccatg gactcgcaga
     2581 tgttagcaac cagttccatg gattcccaga tgttagcaac cagttccatg gattcccaga
     2641 tgttagcatc tggtgctatg gattctcaaa tgttagcttc tggcactatg gatgctcaga
     2701 tgttagcatc tggtaccatg gatgcccaaa tgttagcatc tagtacccag gattctgcta
     2761 tgatgggttc aaaatctcct gatccatata ggttagctca ggatccttac agattagctc
     2821 aggatcccta taggttgggt catgacccct ataggttagg ccatgatgct tacaggttag
     2881 gacaggaccc ttataggtta ggtcatgatc cctacagact aactcctgat ccctatagga
     2941 tgtcacccag gccctataga atagcaccca ggtcctatag aatagcacct aggccataca
     3001 ggttggcacc tagacccttg atgttagcat ctagacgttc tatgatgatg tcctatgctg
     3061 cagaacgttc catgatgtca tcttatgagc gctctatgat gtcttatgaa cgctctatga
     3121 tgtcccctat ggctgaacgc tctatgatgt cggcctatga gcgctccatg atgtcagctt
     3181 atgagcgctc tatgatgtct cctatggctg agcgttctat gatgtcagct tatgaacgct
     3241 ctatgatgtc agcttatgag cgctccatga tgtctcctat ggctgatcga tctatgatgt
     3301 ccatgggtgc cgaccggtct atgatgtcat cgtattctgc agctgaccgg tctatgatgt
     3361 catcgtactc tgcagctgat cgatcaatga tgtcatctta cactgatcga tcaatgatgt
     3421 ctatggcagc tgattcttat actgattctt acactgattc ctatacggag gcatatatgg
     3481 tgccaccttt gcctcctgaa gagcccccaa caatgccacc attgccacct gaggaaccac
     3541 caatgacacc cccattacct cctgaggaac caccagaggg tgcagcatta tcaacagagc
     3601 agtcagcatt aacagctgac aatacttggt ctacagaggt gacattacct actgaagaat
     3661 ctgtatcaca gcctgagcct cctgtgagtc aaagtgagat ttcagagcct ttggtggtac
     3721 ctgctaatta ttcagcgtca gaatcagaga cttcaatgtt agcatcagag gctgttatga
     3781 ctgttccaga acctgcacga gagcctgagt cttcagttac atcaacacca gttgagtctg
     3841 ctgtagtagc agaacacgaa atggttccag agagaccaat gacttacatg gtttctgaga
     3901 ctaccatggc agctgaacca tctgtgttaa catcagaggc ttctgttatg gcagagacat
     3961 cagaaacata tgattccatg agaccatcag ggcatgccat ctcagaggta tctatgtcac
     4021 tcttggagcc agcagtaact atttcacagc cagcagagag cagtctggag ctcccatcca
     4081 tggctgtccc agcaccttcc actattgcta ccacagaatc tcttgttgca gtcccagaac
     4141 ttgctgctgt ggctgactca gaacctccca ttatggctgt gccagaaccc cctactgtgg
     4201 ctgtcccaga accacctgtt acgaccgctc cggagccgcc tcctatgatt actcctgaac
     4261 tttgctcctt atctatctca gagtctcctg tggctgtctc agagcttccg gctttggctg
     4321 acccagagca tgctgtcact gcagtgtcgg gtgtttcttc cctggagcct tctgtgcctg
     4381 tcttggaacc atcagtgtca gtccttcaac ctgttatgat tgtttcagaa ccatgtgttt
     4441 ctatccagga acccactgtg gcagtttcag aacctgctgt catagtctca gagcacactc
     4501 aaataacatc acctgagatg gctgtagagt cttcaccagt aatggtggaa tctagtgttg
     4561 tgtcatcaca gattatgaaa ggaatgaatt tactttctgg ggatgaaaat ctcggttcag
     4621 aggttggcac tcaggagact ctgttgcatc caggtgaaga gccacatgat ggaggacact
     4681 tgaaaagtga cttgtatgaa catgagtatg atagaaatac agaccttact gtaaacagtc
     4741 atttaattgc taaagaagca gagcatagta cagcatgtgc tgctgccatt gttcctgttg
     4801 gtgaaacaag tgaagagaag attttgccta ttagtgagac taaggagatg atagaattgg
     4861 acacctgtcc tgctgttagt gaagctgatg taggaagaag tctgtcttct cagcttgctc
     4921 tggaactgga tacagtagga actagtaagg ggtttgaatt tgttgcagcg tctgcaccca
     4981 tttcagagag taaatatgat gttgaagtat ctgtaactac tcaagatact gagcatgaca
     5041 tggtaatttc caccagcccc agtggtggca gtgaagcaga catagaggga cctttgcctg
     5101 ctaaagacat tcatctcgat ttgccatcaa caaatcttgt ttgtaaggat gtggaagact
     5161 cattacctat aaaagagagt gatgagacag tgacagtggc tcttagccct aaagaaagca
     5221 gtgaagatac agaaggacct cttcccaata aagaaatagt tcctgattca ggttattctg
     5281 tcagcattga tgaaattaat gaagctgact tagtgagacc attacttcct aaggacatgg
     5341 agcgtcttac aagccttaga gctggcattg aaggaccttt acttcctagt gaggttgaac
     5401 gtgacaagtc agttgccagt ccagttgtaa ttagtatacc agaaagagct tcagagtcat
     5461 cttcagagga aaaggacgat tatgaaattt ttgtaaaagt taaggacaca catgagaaaa
     5521 gcaagaaaaa taaaaaccgt gacaaaggtg agaaagagaa aaaaagggac tcttcattaa
     5581 ggtctcggag taagcgttcc aagtcttctg aacataagtc acgtaagcgt accagtgagt
     5641 ctcgttctag ggcaaggaag agatcatcta agtccaagtc tcatcgttct caaacacggt
     5701 cacggtcacg gtcacgacgt aggaggagga gtagcagatc aagatctaag tctagaggaa
     5761 gacggtccgt atcaaaagag aaacgcaaaa gatctccaaa gcatagatcc aagtccaggg
     5821 aaaggaaaag gaaaagatca agctcccgag acaaccggaa aacagttcga gctcggagtc
     5881 gaactccaag tcgtcggagt aggagtcaca ctcctagtcg gaggagacgg tctagatctg
     5941 ttggtagaag gagaagtttt agcatttccc ctagccgaag gagcagaacc cccagccgca
     6001 ggagcagaac ccccagccgc aggagcagga cccccagccg caggagcagg acccccagcc
     6061 gcaggagcag aacccccagc cgcaggagca gaactcccag ccgtcggaga agatcaagat
     6121 ctgtggtaag aagacgaagc ttcagtatat caccagtcag attaaggcga tcaagaacac
     6181 ctttgagaag aaggtttagt agatctccca ttcgtcggaa aagatccagg tcttctgaaa
     6241 gaggcagatc acccaaacgt ctaacagatt tggataaggc tcaattactt gaaatagcca
     6301 aagctaatgc agctgccatg tgtgctaagg ctggtgttcc tttgccacca aacctaaagc
     6361 ctgcacctcc acctacaata gaagagaaag ttgctaaaaa gtctggagga gctaccatag
     6421 aagaactaac tgagaaatgc aaacagattg cacagagtaa agaagatgat gatgtaatag
     6481 tgaataaacc tcatgtttcg gatgaagagg aagaagagcc tcctttttat catcatccct
     6541 ttaaactcag tgaacccaag cccatttttt tcaatttgaa tattgctgca gcaaagccaa
     6601 ctccaccaaa aagccaagta acattaacaa aggagtttcc tgtgtcatct ggatctcaac
     6661 atcggaaaaa ggaagcggat agtgtttatg gagagtgggt tccagtagag aaaaatggcg
     6721 aagaaagcaa agatgacgat aatgtgttca gcagcagctt gccctcagag cctgtggaca
     6781 tttcaacagc aatgagtgaa cgggcacttg ctcagaagag actcagtgag aatgcatttg
     6841 accttgaagc catgagtatg ttaaatcgag ctcaagaacg gattgacgcc tgggctcagt
     6901 tgaactctat ccctgggcag ttcacaggaa gtacaggagt acaagtcctg acacaggaac
     6961 agctggctaa tactggtgcc caagcctgga ttaaaaagga tcagttctta agagcagccc
     7021 cagtaactgg aggaatggga gctgtgttga tgagaaaaat gggctggaga gaaggagaag
     7081 gactaggaaa gaacaaagaa ggaaataagg aacccatcct tgttgacttt aagacagacc
     7141 gaaaaggtct tgttgcagta ggagagagag cacaaaagag gtctgggaac ttctccgctg
     7201 caatgaaaga cttgtcaggc aaacatcctg tgtctgcctt gatggaaatc tgtaataaga
     7261 gaaggtggca accacctgaa tttctcttgg tccatgacag tggccctgac catcgcaaac
     7321 acttcctctt tagggtattg agaaatggaa gcccttacca gcccaattgt atgtttttct
     7381 tgaataggta ttgataaatg gaagcgctta ccagcccagc tttgccagcc ctaataagaa
     7441 gcatgctaaa gccacagcag ctactgtggt tcttcaagca atgggccttg taccaaagga
     7501 cctcatggct aatgccactt gcttcaggag tgcctcacgt agatagattg aggttttata
     7561 ttaatcattt cagataattt tactctgcat cacaatgtat ttcctcctta atgttgtaaa
     7621 tatttcacaa tttaagacat tgtgtaaaaa gcaatctgta caaacatctc caggctttgg
     7681 ttttgtacca tggaaattgt atttaaccac acagggtttt ggtatgttta tattgtttac
     7741 cttagtgatg tatttgttta agtggctaac atcaaaacaa ttgtttgagg gcatcagtaa
     7801 tattcagtgt ggaatgttaa ataacgcttt tatactgtat tttgtactat gatgtaactt
     7861 cccttccata cggctaggct gctgtaacac ttgcctgtaa tcagtgaagg gctgtgcacc
     7921 ttgtactatt tcacaatggg ttctgctgga cagatactgg gccagtgtta ttaaagtaat
     7981 gaagcaagat ctgtcccaca gggctaatgc caccatctcc ccctttttgt agagattatg
     8041 aaaagaaagt gatacgttgt gtcatgatca gtactaagtc ctgcattccc attaaagcca
     8101 cttgggtcat aagaaagaag tcaaaatgga agtccaacta gaattttact tcagaggcca
     8161 agtacatatt tagtatggct tgagttgtga tatagtttta ctttgatgtg cattttgaat
     8221 ttcagctaca cctagataga cgtaaataat aaaaatgctg taaccaactt atctaataaa
     8281 aattggcaac cagccgctat tttgttgact gagaaagttt aagtttatgt taatttttta
     8341 gggtctgata gaatattcat gtgtattaca gtggtattca tatgctatgt ctctaaactt
     8401 tattttcaaa agcttaaggc ccaaatacaa acttctctgg aataaa
//
