LOCUS       NM_012880               1731 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus superoxide dismutase 3 (Sod3), mRNA.
ACCESSION   NM_012880
VERSION     NM_012880.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1731)
  AUTHORS   Jindarojanakul,P., Kobayashi,Y., Kamimoto,H., Niki,Y., Chan Myo,A.,
            Satrawaha,S. and Moriyama,K.
  TITLE     Changes in superoxide dismutase 3 (SOD3) expression in periodontal
            tissue during orthodontic tooth movement of rat molars and the
            effect of SOD3 on in vitro hypoxia-exposed rat periodontal ligament
            cells
  JOURNAL   Eur J Orthod 45 (4), 430-437 (2023)
   PUBMED   36989187
  REMARK    GeneRIF: Changes in superoxide dismutase 3 (SOD3) expression in
            periodontal tissue during orthodontic tooth movement of rat molars
            and the effect of SOD3 on in vitro hypoxia-exposed rat periodontal
            ligament cells.
REFERENCE   2  (bases 1 to 1731)
  AUTHORS   Assmann,A., Schmidt,V., Lepke,C., Sugimura,Y., Assmann,A.K.,
            Barth,M., Lichtenberg,A. and Akhyari,P.
  TITLE     Degeneration of biological heart valve grafts in a rat model of
            superoxide dismutase-3 deficiency
  JOURNAL   FASEB J 36 (11), e22591 (2022)
   PUBMED   36251410
  REMARK    GeneRIF: Degeneration of biological heart valve grafts in a rat
            model of superoxide dismutase-3 deficiency.
REFERENCE   3  (bases 1 to 1731)
  AUTHORS   Guo,H., Xu,D., Kuroki,M., Lu,Z., Xu,X., Geurts,A., Osborn,J.W. and
            Chen,Y.
  TITLE     Kidney failure, arterial hypertension and left ventricular
            hypertrophy in rats with loss of function mutation of SOD3
  JOURNAL   Free Radic Biol Med 152, 787-796 (2020)
   PUBMED   31972339
  REMARK    GeneRIF: Kidney failure, arterial hypertension and left ventricular
            hypertrophy in rats with loss of function mutation of SOD3.
REFERENCE   4  (bases 1 to 1731)
  AUTHORS   Kobayashi,T., Sasaki,H., Asami,Y., Mori,G., Yoshinari,M. and
            Yajima,Y.
  TITLE     The characteristic regulation of gene expression Lbp and Sod3 in
            peri-implant connective tissue of rats
  JOURNAL   J Biomed Mater Res A 108 (3), 592-600 (2020)
   PUBMED   31714656
  REMARK    GeneRIF: The characteristic regulation of gene expression Lbp and
            Sod3 in peri-implant connective tissue of rats.
REFERENCE   5  (bases 1 to 1731)
  AUTHORS   Decharatchakul,N., Settasatian,C., Settasatian,N., Komanasin,N.,
            Kukongviriyapan,U., Intharaphet,P. and Senthong,V.
  TITLE     Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1
            with hypertriglyceridemia and low HDL-C level in subjects with high
            risk of coronary artery disease
  JOURNAL   PeerJ 7, e7407 (2019)
   PUBMED   31396447
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1731)
  AUTHORS   Landmesser,U., Merten,R., Spiekermann,S., Buttner,K., Drexler,H.
            and Hornig,B.
  TITLE     Vascular extracellular superoxide dismutase activity in patients
            with coronary artery disease: relation to endothelium-dependent
            vasodilation
  JOURNAL   Circulation 101 (19), 2264-2270 (2000)
   PUBMED   10811593
REFERENCE   7  (bases 1 to 1731)
  AUTHORS   Boggess,K.A., Oury,T.D., Kay,H.H. and Crapo,J.D.
  TITLE     Extracellular superoxide dismutase localization and activity within
            the human placenta
  JOURNAL   Placenta 19 (5-6), 417-422 (1998)
   PUBMED   9699963
REFERENCE   8  (bases 1 to 1731)
  AUTHORS   Carlsson,L.M., Marklund,S.L. and Edlund,T.
  TITLE     The rat extracellular superoxide dismutase dimer is converted to a
            tetramer by the exchange of a single amino acid
  JOURNAL   Proc Natl Acad Sci U S A 93 (11), 5219-5222 (1996)
   PUBMED   8643556
REFERENCE   9  (bases 1 to 1731)
  AUTHORS   Willems,J., Zwijsen,A., Slegers,H., Nicolai,S., Bettadapura,J.,
            Raymackers,J. and Scarcez,T.
  TITLE     Purification and sequence of rat extracellular superoxide dismutase
            B secreted by C6 glioma
  JOURNAL   J Biol Chem 268 (33), 24614-24621 (1993)
   PUBMED   8227019
REFERENCE   10 (bases 1 to 1731)
  AUTHORS   Perry,A.C., Jones,R. and Hall,L.
  TITLE     Isolation and characterization of a rat cDNA clone encoding a
            secreted superoxide dismutase reveals the epididymis to be a major
            site of its expression
  JOURNAL   Biochem J 293 (Pt 1) (Pt 1), 21-25 (1993)
   PUBMED   8328962
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012880.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z24721.1, BC061861.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMN16676784
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               JAXUCZ010000014.1  62828487-62828602   c
            117-1731            JAXUCZ010000014.1  62822865-62824479   c
FEATURES             Location/Qualifiers
     source          1..1731
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q11"
     gene            1..1731
                     /gene="Sod3"
                     /gene_synonym="ECSODPT"
                     /note="superoxide dismutase 3"
                     /db_xref="GeneID:25352"
                     /db_xref="RGD:3733"
     exon            1..116
                     /gene="Sod3"
                     /gene_synonym="ECSODPT"
                     /inference="alignment:Splign:2.1.0"
     exon            117..1731
                     /gene="Sod3"
                     /gene_synonym="ECSODPT"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..867
                     /gene="Sod3"
                     /gene_synonym="ECSODPT"
                     /EC_number="1.15.1.1"
                     /note="extracellular superoxide dismutase; EC-SOD;
                     superoxide dismutase B; Superoxide dimutase 3; superoxide
                     dismutase 3, extracellular"
                     /codon_start=1
                     /product="extracellular superoxide dismutase [Cu-Zn]
                     precursor"
                     /protein_id="NP_037012.1"
                     /db_xref="GeneID:25352"
                     /db_xref="RGD:3733"
                     /translation="MVAFLFCNLLLVACGSVTWTMSDTGESGVDLADRLDLVEKIGDT
                     HSKDLEIWMELGKQREADAREMHAVCRVQPSAMLPPDQPQITGLVLFRQLGPSSRLEA
                     SFNLEGFPAEQNTSNHAIHVHEFGDLSQGCESTGPHYNPLGVPHPQHPGDFGNFVVRD
                     GRLWKHRMGLATSLAGPHSILGRAVVVHAGEDDLGKGGNQASVQNGNAGRRLACCVVG
                     TSNSEAWESQTKERKKRRRESECKTT"
ORIGIN      
        1 gctcacaagc agctggccag ttctggggag gcagctcaga ggctctttct caggcctcta
       61 gctgggtctg tcctgtactt caccagagga aaaacgttct tgggagagct tgtcaggtgt
      121 ggaacctcag ccatggtggc cttcttgttc tgcaacctgc tactggtggc ctgtggctct
      181 gtcacctgga ccatgtcaga taccggagag tccggtgtcg acttagcaga ccggcttgac
      241 ctggttgaga agataggcga cacgcactcc aaagacctgg agatctggat ggagctagga
      301 aaacaacggg aggcggatgc cagggagatg cacgcagtct gcagggtaca gccctcagcc
      361 atgctgcctc ccgatcagcc acagatcaca ggcttggtcc tcttccggca gctggggccc
      421 agctccagac ttgaggcctc cttcaatctg gagggcttcc cagccgagca gaacacctcc
      481 aaccacgcca tccacgtgca tgagttcggg gacctgagcc agggctgcga gtccaccgga
      541 ccacactaca acccgctggg tgtgccgcac ccacagcacc cgggggactt cggcaacttc
      601 gtggtgcgcg atggccgcct ttggaagcat cgaatgggcc tggccacgtc actggccgga
      661 ccgcactcga tcttgggccg cgctgtggtg gtccacgctg gcgaggacga cctgggtaaa
      721 ggtggcaacc aggccagcgt gcagaacggc aacgcaggtc gccggctcgc ctgctgcgtg
      781 gtaggcacca gcaactcgga ggcctgggag agccagacaa aggagcgcaa gaagcggcgg
      841 cgggagagcg agtgcaagac cacttaagca tcacccaggg ccgcctagcc tagctgctgc
      901 gcgcatagat gcctccacac gcgcctctag acgcctccag tcatcctaga ggtctctggg
      961 tgtcctagac tgacgcttcc cagacacctc aatcgcctct gtgcgcccca cactcttcca
     1021 cataccccag acacctctgt atggctcaga tgccttcaag aacctcctcg gccacgtcca
     1081 cgagccccag atgttcccac gtgccctggg cactgttctc ggagaccagg acactttttg
     1141 taacctagga atcctttcac accctatgca cttccacaga cccaaactcc ttcgtgctct
     1201 aggtccacct cgaactactt tatgccccaa gacaatccca taagccccta gcatcccctt
     1261 tgaaacagtc tttgagtttg ctcccagaga attccccgct tacccccaga ggtcgaatgt
     1321 gcgcagataa ctctcctttt actctgagga catcccagtg gaccttctag agaactccct
     1381 tggggtgttc tgaaatatca ccaccccact tccttctgcc cccttttgtt ttctttctgt
     1441 cccctagcac ccgagacttc tctcttccct agagacctcg tttgtcttcc ccttgttcct
     1501 cctagggctc tgggaccacc ctgacacaca cacacacaca cacacacaca cacacacaca
     1561 cacacacaca cacacacaca tccctaagat tccatgttcc tgatcacctc ctgccgggcc
     1621 cctggttctg ttttcatctg tttcccatat ggtgcctgca ccccaaggag agcagctcct
     1681 ccgagagtat ttgacaacct ttatgctgct cattaaaacc acagcaattc a
//
