LOCUS       NM_017051               2090 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Rattus norvegicus superoxide dismutase 2 (Sod2), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_017051
VERSION     NM_017051.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2090)
  AUTHORS   Qiu,W., Sun,Q., Li,N., Chen,Z., Wu,H., Chen,Z., Guo,X. and Fang,F.
  TITLE     Superoxide dismutase 2 scavenges ROS to promote osteogenic
            differentiation of human periodontal ligament stem cells by
            regulating Smad3 in alveolar bone-defective rats
  JOURNAL   J Periodontol 95 (5), 469-482 (2024)
   PUBMED   37921754
  REMARK    GeneRIF: Superoxide dismutase 2 scavenges ROS to promote osteogenic
            differentiation of human periodontal ligament stem cells by
            regulating Smad3 in alveolar bone-defective rats.
REFERENCE   2  (bases 1 to 2090)
  AUTHORS   Chen,F., Xing,Y., Chen,Z., Chen,X., Li,J., Gong,S., Luo,F. and
            Cai,Q.
  TITLE     Competitive adsorption of microRNA-532-3p by circular RNA SOD2
            activates Thioredoxin Interacting Protein/NLR family pyrin domain
            containing 3 pathway and promotes pyroptosis of non-alcoholic fatty
            hepatocytes
  JOURNAL   Eur J Med Res 29 (1), 250 (2024)
   PUBMED   38659023
  REMARK    GeneRIF: Competitive adsorption of microRNA-532-3p by circular RNA
            SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin
            domain containing 3 pathway and promotes pyroptosis of
            non-alcoholic fatty hepatocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2090)
  AUTHORS   Anamika, Roy,A. and Trigun,S.K.
  TITLE     Hippocampus mitochondrial MnSOD activation by a SIRT3 activator,
            honokiol, correlates with its deacetylation and upregulation of
            FoxO3a and PGC1alpha in a rat model of ammonia neurotoxicity
  JOURNAL   J Cell Biochem 124 (4), 606-618 (2023)
   PUBMED   36922709
  REMARK    GeneRIF: Hippocampus mitochondrial MnSOD activation by a SIRT3
            activator, honokiol, correlates with its deacetylation and
            upregulation of FoxO3a and PGC1alpha in a rat model of ammonia
            neurotoxicity.
REFERENCE   4  (bases 1 to 2090)
  AUTHORS   Wang,K.X., Liang,F.X., Wu,S., Chen,S., Luo,Z.H., Han,Y.L., Chen,J.,
            Chen,B., Chen,Z.Q., Zhang,Y.L., Zhou,T. and Gu,X.L.
  TITLE     [Electroacupuncture preconditioning alleviates renal injury and
            oxidative stress through Sirt3/MnSOD pathway in type 2 diabetic
            rats]
  JOURNAL   Zhen Ci Yan Jiu 47 (9), 793-800 (2022)
   PUBMED   36153454
  REMARK    GeneRIF: [Electroacupuncture preconditioning alleviates renal
            injury and oxidative stress through Sirt3/MnSOD pathway in type 2
            diabetic rats].
REFERENCE   5  (bases 1 to 2090)
  AUTHORS   Mei,X., Cui,X.B., Li,Y. and Chen,S.Y.
  TITLE     CircSOD2: A Novel Regulator for Smooth Muscle Proliferation and
            Neointima Formation
  JOURNAL   Arterioscler Thromb Vasc Biol 41 (12), 2961-2973 (2021)
   PUBMED   34670409
  REMARK    GeneRIF: CircSOD2: A Novel Regulator for Smooth Muscle
            Proliferation and Neointima Formation.
REFERENCE   6  (bases 1 to 2090)
  AUTHORS   Nishiura,T., Suzuki,K., Kawaguchi,T., Nakao,H., Kawamura,N.,
            Taniguchi,M., Kanayama,Y., Yonezawa,T., Iizuka,S. and Taniguchi,N.
  TITLE     Elevated serum manganese superoxide dismutase in acute leukemias
  JOURNAL   Cancer Lett 62 (3), 211-215 (1992)
   PUBMED   1596865
REFERENCE   7  (bases 1 to 2090)
  AUTHORS   Ono,M., Sekiya,C., Ohhira,M., Ohhira,M., Namiki,M., Endo,Y.,
            Suzuki,K., Matsuda,Y. and Taniguchi,N.
  TITLE     Elevated level of serum Mn-superoxide dismutase in patients with
            primary biliary cirrhosis: possible involvement of free radicals in
            the pathogenesis in primary biliary cirrhosis
  JOURNAL   J Lab Clin Med 118 (5), 476-483 (1991)
   PUBMED   1682406
REFERENCE   8  (bases 1 to 2090)
  AUTHORS   Ho,Y.S., Howard,A.J. and Crapo,J.D.
  TITLE     Molecular structure of a functional rat gene for
            manganese-containing superoxide dismutase
  JOURNAL   Am J Respir Cell Mol Biol 4 (3), 278-286 (1991)
   PUBMED   2001291
REFERENCE   9  (bases 1 to 2090)
  AUTHORS   Ho,Y.S. and Crapo,J.D.
  TITLE     Nucleotide sequences of cDNAs coding for rat manganese-containing
            superoxide dismutase
  JOURNAL   Nucleic Acids Res 15 (23), 10070 (1987)
   PUBMED   3697077
REFERENCE   10 (bases 1 to 2090)
  AUTHORS   Szymura,J.M., Wabl,M.R. and Klein,J.
  TITLE     Mouse mitochondrial superoxide dismutase locus is on chromosome 17
  JOURNAL   Immunogenetics 14 (3-4), 231-240 (1981)
   PUBMED   7333654
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070913.1.
            
            On May 24, 2004 this sequence version replaced NM_017051.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070913.1, Y00497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132292, SAMD00132304
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2090
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..2090
                     /gene="Sod2"
                     /gene_synonym="MnSOD"
                     /note="superoxide dismutase 2"
                     /db_xref="GeneID:24787"
                     /db_xref="RGD:3732"
     exon            1..106
                     /gene="Sod2"
                     /gene_synonym="MnSOD"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..752
                     /gene="Sod2"
                     /gene_synonym="MnSOD"
                     /EC_number="1.15.1.1"
                     /note="superoxide dismutase [Mn], mitochondrial;
                     Superoxide dimutase 2, mitochondrial; mitochondrial
                     superoxide dismutase 2; manganese superoxide dismutase;
                     superoxide dismutase 2, mitochondrial"
                     /codon_start=1
                     /product="superoxide dismutase [Mn], mitochondrial
                     precursor"
                     /protein_id="NP_058747.1"
                     /db_xref="GeneID:24787"
                     /db_xref="RGD:3732"
                     /translation="MLCRAACSAGRRLGPAASTAGSRHKHSLPDLPYDYGALEPHINA
                     QIMQLHHSKHHATYVNNLNVTEEKYHEALAKGDVTTQVALQPALKFNGGGHINHSIFW
                     TNLSPKGGGEPKGELLEAIKRDFGSFEKFKEKLTAVSVGVQGSGWGWLGFNKEQGRLQ
                     IAACSNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVSQRYI
                     VCKK"
     exon            107..309
                     /gene="Sod2"
                     /gene_synonym="MnSOD"
                     /inference="alignment:Splign:2.1.0"
     exon            310..426
                     /gene="Sod2"
                     /gene_synonym="MnSOD"
                     /inference="alignment:Splign:2.1.0"
     exon            427..606
                     /gene="Sod2"
                     /gene_synonym="MnSOD"
                     /inference="alignment:Splign:2.1.0"
     exon            607..2065
                     /gene="Sod2"
                     /gene_synonym="MnSOD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggcggacg ccgcagagca gacgcgcggc tgctagcgaa cggccgtgtt ctgaggagag
       61 cagcggtcgt gggcgcctca gcaatgttgt gtcgggcggc gtgcagcgcg ggcagaagac
      121 tgggccccgc ggccagtacc gcgggctccc ggcacaagca cagcctccct gacctgcctt
      181 acgactatgg cgcgctggag ccgcacatta acgcgcagat catgcagctg caccacagca
      241 agcaccacgc gacctacgtg aacaatctga acgtcaccga ggagaagtac cacgaggcgc
      301 tggccaaggg agatgttaca actcaggttg ctcttcagcc tgcactgaag ttcaatggcg
      361 ggggccatat caatcacagc attttctgga caaacctgag ccctaagggt ggtggagaac
      421 ccaaaggaga gttgctggag gctatcaagc gtgactttgg gtcttttgag aagtttaagg
      481 agaaactgac agctgtgtct gtgggagtcc aaggttcagg ctggggctgg cttggcttca
      541 ataaggagca aggtcgctta cagattgccg cctgctctaa tcaggaccca ctgcaaggaa
      601 ccacaggcct tattccactg ctggggattg atgtgtggga gcacgcttac tatcttcagt
      661 ataaaaacgt cagacctgac tatctgaaag ccatttggaa tgtaatcaac tgggagaatg
      721 ttagccaaag atacatagtt tgcaagaagt gaagcccttc cgccaggctg tgtgtcaggc
      781 ccgtggtggg tgttttgtag tagtgtagag cattgcagca ctgtggctga gctgttgtaa
      841 tcttcattga tgcctatcca catatgtgta agcatacagt tatgataatt tcttaattaa
      901 atgtattgtt aggcaactgt ttgagaacag tacatacttg gtgtgagctg ctcttgattg
      961 aacattttca ttagaggctt gaattgcttg gacgctgtca ctgtcatcat aaggccatca
     1021 aagatattcc atctctgtgt tggggcctgt ggggaggctg taatcctgtt ctactgcagt
     1081 taggaaaaaa aatgagttac cccccccccc agaattgttg aataataaaa tagagaactg
     1141 aatagttctc ttttctgtta aaaattgcta tttttcataa gtaatccttt gtttagcgga
     1201 tatcacctag tggtctttat ttatggccac agtttcatag aaacatcatt ttttcacttg
     1261 aaacgtgtaa ctaggctaag gatggatgga gtggtagagc ctttgcctgt cttatgtgag
     1321 gccctgggct ctacctcact actgaacaaa tcaacagacc caagctaggc tcctgactga
     1381 caactgttaa ttcggagagg agtgacattg tgcctctggg tttttttata ggctgagatg
     1441 caaaaactgt taccttgtct attaaaaccg actgtgtatt gtatgaaagt gctcaagatg
     1501 gacaaagtat gcagggcctg tcccatgatg tcaacatggg gactaggcca cagggcattc
     1561 agggaagcca ttcagcacca ttaattgtgt atctcaggag aactggaccc tgggtgaggt
     1621 ggcacctttt tcagtagagg caaacgggtt tctgagtgag gtcagtaggg tgtcttgaga
     1681 acatcagttt tcagagacat gtattttcat tttttctgca gtctcaagaa cttatactca
     1741 caagagggcc tttgtattgt tattcaatag aaggacaccc tttccctgac aaggtacaca
     1801 gtgtttctga ttgtattcct gtgcagcatt tgggtgtaga gctgtgcact gttgaaatgc
     1861 ctttgtgaat ttgccttttc acatttcgtc tcaccatctt ccttgttttc tttactgact
     1921 atgtaatgtt ttatcagttg gatattactg aatagtttgt ttgtgtttaa ttgcctttta
     1981 ttaccaaaaa ggctgtggtc agcaacccca ggcatgcaca ttacttctta atggagtatt
     2041 ttttaaaggt ttattttaat tttaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
