LOCUS       NM_017050                650 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Rattus norvegicus superoxide dismutase 1 (Sod1), mRNA.
ACCESSION   NM_017050
VERSION     NM_017050.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 650)
  AUTHORS   Mao,Z., Wang,C., Liu,J., Li,X., Duan,H., Ye,Y., Liu,H., Lv,L.,
            Xue,G., He,Z., Wuren,T. and Wang,H.
  TITLE     Superoxide dismutase 1-modified dental pulp stem cells alleviate
            high-altitude pulmonary edema by inhibiting oxidative stress
            through the Nrf2/HO-1 pathway
  JOURNAL   Gene Ther 31 (7-8), 422-433 (2024)
   PUBMED   38834681
  REMARK    GeneRIF: Superoxide dismutase 1-modified dental pulp stem cells
            alleviate high-altitude pulmonary edema by inhibiting oxidative
            stress through the Nrf2/HO-1 pathway.
REFERENCE   2  (bases 1 to 650)
  AUTHORS   Dong,N. and Liu,W.Y.
  TITLE     Regulatory mechanism of downregulation of SOD1 expression on
            cardiomyocyte function
  JOURNAL   Sleep Breath 27 (1), 399-410 (2023)
   PUBMED   35307768
  REMARK    GeneRIF: Regulatory mechanism of downregulation of SOD1 expression
            on cardiomyocyte function.
REFERENCE   3  (bases 1 to 650)
  AUTHORS   Bi,D., Shi,M., Zheng,D., Hu,Q., Wang,H., Peng,L., Lou,D., Zhang,A.
            and Hu,Y.
  TITLE     Mechanism underlying the targeted regulation of the SOD1 3'UTR by
            the AUF1/Dicer1/miR-155/SOD1 pathway in sodium arsenite-induced
            liver injury
  JOURNAL   Ecotoxicol Environ Saf 243, 113990 (2022)
   PUBMED   35998476
  REMARK    GeneRIF: Mechanism underlying the targeted regulation of the SOD1
            3'UTR by the AUF1/Dicer1/miR-155/SOD1 pathway in sodium
            arsenite-induced liver injury.
REFERENCE   4  (bases 1 to 650)
  AUTHORS   Petrozziello,T., Boscia,F., Tedeschi,V., Pannaccione,A., de
            Rosa,V., Corvino,A., Severino,B., Annunziato,L. and Secondo,A.
  TITLE     Na+/Ca2+ exchanger isoform 1 takes part to the Ca2+-related
            prosurvival pathway of SOD1 in primary motor neurons exposed to
            beta-methylamino-L-alanine
  JOURNAL   Cell Commun Signal 20 (1), 8 (2022)
   PUBMED   35022040
  REMARK    GeneRIF: Na(+)/Ca(2+) exchanger isoform 1 takes part to the
            Ca(2+)-related prosurvival pathway of SOD1 in primary motor neurons
            exposed to beta-methylamino-L-alanine.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 650)
  AUTHORS   Ramadan,W.S. and Alkarim,S.
  TITLE     Ellagic Acid Modulates the Amyloid Precursor Protein Gene via
            Superoxide Dismutase Regulation in the Entorhinal Cortex in an
            Experimental Alzheimer's Model
  JOURNAL   Cells 10 (12), 3511 (2021)
   PUBMED   34944019
  REMARK    GeneRIF: Ellagic Acid Modulates the Amyloid Precursor Protein Gene
            via Superoxide Dismutase Regulation in the Entorhinal Cortex in an
            Experimental Alzheimer's Model.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 650)
  AUTHORS   Crapo,J.D., Oury,T., Rabouille,C., Slot,J.W. and Chang,L.Y.
  TITLE     Copper,zinc superoxide dismutase is primarily a cytosolic protein
            in human cells
  JOURNAL   Proc Natl Acad Sci U S A 89 (21), 10405-10409 (1992)
   PUBMED   1332049
REFERENCE   7  (bases 1 to 650)
  AUTHORS   Hsu,J.L., Visner,G.A., Burr,I.A. and Nick,H.S.
  TITLE     Rat copper/zinc superoxide dismutase gene: isolation,
            characterization, and species comparison
  JOURNAL   Biochem Biophys Res Commun 186 (2), 936-943 (1992)
   PUBMED   1379810
REFERENCE   8  (bases 1 to 650)
  AUTHORS   Hass,M.A., Iqbal,J., Clerch,L.B., Frank,L. and Massaro,D.
  TITLE     Rat lung Cu,Zn superoxide dismutase. Isolation and sequence of a
            full-length cDNA and studies of enzyme induction
  JOURNAL   J Clin Invest 83 (4), 1241-1246 (1989)
   PUBMED   2703531
REFERENCE   9  (bases 1 to 650)
  AUTHORS   Puga,A. and Oates,E.L.
  TITLE     Isolation and nucleotide sequence of rat Cu/Zn superoxide dismutase
            cDNA clones
  JOURNAL   Free Radic Res Commun 3 (6), 337-346 (1987)
   PUBMED   3508449
REFERENCE   10 (bases 1 to 650)
  AUTHORS   Francke,U. and Taggart,R.T.
  TITLE     Assignment of the gene for cytoplasmic superoxide dismutase (Sod-1)
            to a region of chromosome 16 and of Hprt to a region of the X
            chromosome in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 76 (10), 5230-5233 (1979)
   PUBMED   291939
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from Y00404.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y00404.1, CA339871.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..650
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..650
                     /gene="Sod1"
                     /gene_synonym="CuZnSOD"
                     /note="superoxide dismutase 1"
                     /db_xref="GeneID:24786"
                     /db_xref="RGD:3731"
     exon            1..165
                     /gene="Sod1"
                     /gene_synonym="CuZnSOD"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..558
                     /gene="Sod1"
                     /gene_synonym="CuZnSOD"
                     /EC_number="1.15.1.1"
                     /note="superoxide dismutase 1, soluble"
                     /codon_start=1
                     /product="superoxide dismutase [Cu-Zn]"
                     /protein_id="NP_058746.1"
                     /db_xref="GeneID:24786"
                     /db_xref="RGD:3731"
                     /translation="MAMKAVCVLKGDGPVQGVIHFEQKASGEPVVVSGQITGLTEGEH
                     GFHVHQYGDNTQGCTTAGPHFNPHSKKHGGPADEERHVGDLGNVAAGKDGVANVSIED
                     RVISLSGEHSIIGRTMVVHEKQDDLGKGGNEESTKTGNAGSRLACGVIGIAQ"
     exon            166..262
                     /gene="Sod1"
                     /gene_synonym="CuZnSOD"
                     /inference="alignment:Splign:2.1.0"
     exon            263..332
                     /gene="Sod1"
                     /gene_synonym="CuZnSOD"
                     /inference="alignment:Splign:2.1.0"
     exon            333..450
                     /gene="Sod1"
                     /gene_synonym="CuZnSOD"
                     /inference="alignment:Splign:2.1.0"
     exon            451..650
                     /gene="Sod1"
                     /gene_synonym="CuZnSOD"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      650
                     /gene="Sod1"
                     /gene_synonym="CuZnSOD"
                     /note="polyA site"
ORIGIN      
        1 gttttgcacc ttcgtttcct gcggcggctt ctgtcgtctc cttgcttttt gctctcccag
       61 gttccgaggc cgccgcgcgt ctcccgggga agcatggcga tgaaggccgt gtgcgtgctg
      121 aagggcgacg gtccggtgca gggcgtcatt cacttcgagc agaaggcaag cggtgaacca
      181 gttgtggtgt caggacagat tacaggatta actgaaggcg agcatgggtt ccatgtccat
      241 caatatgggg acaatacaca aggctgtacc actgcaggac ctcattttaa tcctcactct
      301 aagaaacatg gcggtccagc ggatgaagag aggcatgttg gagacctggg caatgtggct
      361 gctggaaagg acggtgtggc caatgtgtcc attgaagatc gtgtgatctc actctcagga
      421 gagcattcca tcattggccg tactatggtg gtccacgaga aacaagatga cttgggcaaa
      481 ggtggaaatg aagaaagtac aaagactgga aatgctggaa gccgcttggc ttgtggtgtg
      541 attgggattg cccaataaac attccctatg tggtctgagt ctcagactca tctgctgtcc
      601 tgctaaactg tagaaaaaaa ccaaaccatt aaactgtaat cttaacagtt
//
