LOCUS       NM_001109274            4233 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus suppressor of cytokine signaling 5 (Socs5), mRNA.
ACCESSION   NM_001109274 XM_001058928 XM_575987
VERSION     NM_001109274.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4233)
  AUTHORS   Loyer X, Potteaux S, Vion AC, Guerin CL, Boulkroun S, Rautou PE,
            Ramkhelawon B, Esposito B, Dalloz M, Paul JL, Julia P, Maccario J,
            Boulanger CM, Mallat Z and Tedgui A.
  TITLE     Inhibition of microRNA-92a prevents endothelial dysfunction and
            atherosclerosis in mice
  JOURNAL   Circ Res 114 (3), 434-443 (2014)
   PUBMED   24255059
REFERENCE   2  (bases 1 to 4233)
  AUTHORS   Wang H, Zhou ZC, Peng XY and Zhao M.
  TITLE     [Expression of suppressor of cytokine signaling in retina of
            experimental autoimmune uveoretinitis]
  JOURNAL   Zhonghua Yan Ke Za Zhi 44 (10), 876-882 (2008)
   PUBMED   19176113
  REMARK    GeneRIF: Up-regulation of SOCS5 may have protective functions in
            experimental autoimmune uveoretinitis.
REFERENCE   3  (bases 1 to 4233)
  AUTHORS   Hwang MN, Kim KS, Choi YW, Jou I and Yoon S.
  TITLE     PMA activates Stat3 in the Jak/Stat pathway and induces SOCS5 in
            rat brain astrocytes
  JOURNAL   Mol Cells 23 (1), 94-99 (2007)
   PUBMED   17464217
  REMARK    GeneRIF: These results suggest that activated Stat3 binds to SOCS
            promoters and leads to their transcriptional induction.
REFERENCE   4  (bases 1 to 4233)
  AUTHORS   Kario E, Marmor MD, Adamsky K, Citri A, Amit I, Amariglio N,
            Rechavi G and Yarden Y.
  TITLE     Suppressors of cytokine signaling 4 and 5 regulate epidermal growth
            factor receptor signaling
  JOURNAL   J Biol Chem 280 (8), 7038-7048 (2005)
   PUBMED   15590694
REFERENCE   5  (bases 1 to 4233)
  AUTHORS   Nicholson SE, Metcalf D, Sprigg NS, Columbus R, Walker F, Silva A,
            Cary D, Willson TA, Zhang JG, Hilton DJ, Alexander WS and Nicola
            NA.
  TITLE     Suppressor of cytokine signaling (SOCS)-5 is a potential negative
            regulator of epidermal growth factor signaling
  JOURNAL   Proc Natl Acad Sci U S A 102 (7), 2328-2333 (2005)
   PUBMED   15695332
REFERENCE   6  (bases 1 to 4233)
  AUTHORS   Wormald S and Hilton DJ.
  TITLE     Inhibitors of cytokine signal transduction
  JOURNAL   J Biol Chem 279 (2), 821-824 (2004)
   PUBMED   14607831
  REMARK    Review article
REFERENCE   7  (bases 1 to 4233)
  AUTHORS   Seki Y, Hayashi K, Matsumoto A, Seki N, Tsukada J, Ransom J, Naka
            T, Kishimoto T, Yoshimura A and Kubo M.
  TITLE     Expression of the suppressor of cytokine signaling-5 (SOCS5)
            negatively regulates IL-4-dependent STAT6 activation and Th2
            differentiation
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 13003-13008 (2002)
   PUBMED   12242343
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473947.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_575987.2, XM_001058928.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: CO573422.1, EV769921.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMD00132292, SAMD00132300 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4233
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..4233
                     /gene="Socs5"
                     /gene_synonym="RGD1564914"
                     /note="suppressor of cytokine signaling 5"
                     /db_xref="GeneID:500616"
                     /db_xref="RGD:1564914"
     exon            1..360
                     /gene="Socs5"
                     /gene_synonym="RGD1564914"
                     /inference="alignment:Splign:2.1.0"
     exon            361..4233
                     /gene="Socs5"
                     /gene_synonym="RGD1564914"
                     /inference="alignment:Splign:2.1.0"
     CDS             373..1983
                     /gene="Socs5"
                     /gene_synonym="RGD1564914"
                     /codon_start=1
                     /product="suppressor of cytokine signaling 5"
                     /protein_id="NP_001102744.1"
                     /db_xref="GeneID:500616"
                     /db_xref="RGD:1564914"
                     /translation="MDKVGKMWNNFKYRCQNLFSHEGGSRSENVDMNANRCLSVKEKS
                     VSLGEAAPRQQSSPLRENIALQLGLSPSKTFSRRNQNCAAEIPQVVEISIEKDSDSSA
                     TPGTRLARRDSYSRHAPWGGKKKHSCSTKTQSSLDTEKKFGRTRSGLQRRERRYGVSS
                     MHDMDSVSSRAVGSRSLRQRLQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKC
                     PFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGV
                     DPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDGSAIPQTNCDSEEDSTTLCLQ
                     SRRQKQRQVSGDSHSHISRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAE
                     ALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSS
                     TVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPS
                     MLQDFLKEYHYKQKVRVRWLEREPVKAK"
ORIGIN      
        1 cgccggccgg gcaggagcgg aggacgggac gcgcgggcgg tcgccctcgc cctgtcgctg
       61 actgcgccgc cccggcccat cctgcctggc cgcaggtgcc ctggatgagg ccgccgcgcg
      121 tgtcccggcc gctgagtgtc cccgcggtcg cccggcgctg gtccgcaagc cgccgcctct
      181 ccacgccccg gtccctgtgc ccggcgcagt cttcctcggg cgggcgcctc cgcacctcgg
      241 cgcaggcggc acggcccttg ggccgggatg gatccgccgg gaagaggaag accagccggg
      301 gcgttgagcc cctgcgcccg gtgccgcgcg tagtgggagc ttacgcgcag taggctctcg
      361 ctcttctaat caatggataa agtggggaaa atgtggaaca acttcaaata caggtgccag
      421 aatctcttca gccatgaagg aggaagccga agtgagaatg tggacatgaa cgccaacaga
      481 tgtctgtctg tcaaagagaa aagcgtcagt ctgggcgagg cagctcctcg gcagcagagc
      541 agtccgttaa gagaaaatat tgccttacag ctgggactga gcccttcaaa gaccttttca
      601 agacggaacc aaaactgtgc cgcagagatt cctcaggttg ttgaaataag cattgagaag
      661 gacagcgact cgagcgctac cccaggaacg aggcttgcgc gaagagactc ctattcccga
      721 cacgccccgt ggggaggcaa gaagaagcat tcctgttcca caaagaccca gagttcactg
      781 gatactgaga aaaagttcgg tagaactcgc agcggccttc agaggcggga gcggcgctat
      841 ggagtcagct ccatgcacga catggacagt gtatccagcc gcgcggtcgg gagccgctct
      901 ctgaggcaga ggctccagga cactgttggt ttgtgcttcc ccatgagaac ttacagcaag
      961 cagtcaaagc ctctcttttc caataaaaga aaaatacatc tttctgaatt aatgctggag
     1021 aaatgccctt ttcctgctgg ctcagattta gcacaaaagt ggcatttgat taaacagcat
     1081 accgctcccg tgagcccaca ttcaacattt tttgatacat ttgatccatc actggtgtct
     1141 acagaggatg aagaagatag acttcgtgag agaagacggc ttagtatcga agaaggcgtg
     1201 gatccccctc ccaacgcaca aatccacacc tttgaagcta ctgcacaggt caatccattg
     1261 tataaactgg gaccaaagtt agcccctggg atgacggaaa taagcggaga tggttctgca
     1321 attccacaga cgaattgtga ctcagaagag gattcaacca ccctgtgtct gcagtcacgg
     1381 aggcagaagc agcgccaggt gtccggggac agccactcac acattagcag acagggagct
     1441 tggaaagttc atacgcagat cgattacata cactgccttg taccagattt gcttcagatc
     1501 acagggaatc cctgttactg gggcgtgatg gaccgctacg aagcagaagc cctcctagaa
     1561 gggaaaccgg aaggcacgtt tttgctcagg gactctgcgc aggaggacta cctcttctct
     1621 gtgagcttcc gccgctacaa caggtccctg cacgcccgga tcgagcagtg gaaccacaac
     1681 ttcagcttcg atgcccacga cccttgcgtg tttcactcct ccactgtcac gggactcctc
     1741 gaacattata aagaccctag ctcttgcatg ttctttgaac cgttgcttac gatatcgctg
     1801 aataggactt tccctttcag cctgcagtac atctgccgcg cagtgatctg caggtgcact
     1861 acatacgacg ggattgatgg gctccctcta ccgtccatgt tacaggattt tttaaaagag
     1921 tatcattata agcaaaaagt tagggttcgc tggttagaac gagagccagt caaggcaaag
     1981 taacccctgt tcccaaaggg cactaactag gtctgctctc atgcatcaga cagcacccat
     2041 aggaggcaga gtcagctgct ggggttttcc acccagaatg ggagcttagt cattagcttc
     2101 tgcccgatgg ggtcagctgt tactctgaca aaggtgccta gggacagcag ggtggtttgc
     2161 aggcgttcgg tgggctgtaa caactgaggg aaacaactct ggggcatttg ctacgaagaa
     2221 ttctatttct tactgaagaa caaattatta atattggatg ggtatttcaa cagtgtgact
     2281 aatgtttgaa attatttttt ctaagaattt ttctataacc ttccaaaaaa tagtggtttg
     2341 tagttactat aattcaagct ttgaaagtcc aaaacaagta aataaaagac tgccttcctt
     2401 ttagagaaaa acaaatgcag tttttctggc cacagggcat tgtgcagtgt cagtgtggtt
     2461 tagagtcagt ctcttttctc ctcagagaag gaggctctaa aataaaccag gcttttctaa
     2521 gatagttctt aaacctcgag attcaagctt agcgtggcgt tctgtacaaa acccccagcg
     2581 tccacttggg atgagctcgg agcatgcagt cggagtctct ggtggggcgt tttcctagcc
     2641 tgacacatgc agtccacaca ctgtctcatt acacttggaa tcttttcctg tgccctggac
     2701 tttgtgaacc cagaggaaag cgagactggg agatgcccag acacatcaga cagtagtaac
     2761 tccactggct gacgaagctg agctgtgtta aactctaact aatcatttgg atggcagtat
     2821 ttatctgttg taagctcata gctgacttac ttaagtacag tttatattat acaattttag
     2881 tgcagttaat tctgaacaga aaacctgaag tctacattgc agatttaaaa ggtactgtac
     2941 acccatgatg cctgtagata atttacttgg caccttttgt cacttagagt agtacgtaat
     3001 acaacttgag tgagcgcttt gggacgtgtc cttgagttct agtgttgctt cttagtgttg
     3061 gactgtgttc tcagttttgt cctagacctt tgcactacag tagccaaatc cattctcgtg
     3121 tctgttaccg tgctctgtga ctgctgccga gaacccctca ctcggtcttc acgccggcgg
     3181 ctgcaggagg ttactttatg tccctatggc cattgccagg gcttccggaa agaaatgcta
     3241 catctgtatg cagcactaac cctttgaccg ctaacgtatg tttctgcttg ctgtgccttg
     3301 ttctggctgc tttttcgtgc taataaagtc tgtttggtgt tctccctgta tatctgctgt
     3361 tttctacatt tgccacagtt tctcttgtac gtggaatggt ttggggtttt aaaatgagca
     3421 ttaacctgac aactttctgc agctaacgca gactcacctg cagcctaatc ctgtcagagt
     3481 aagccgagtg ctctttagct ttctaacccc tctcacgtcc ttcgaatcag tgtctcagag
     3541 aagcgattgc tctgctctgt agtgaggctg aaaccagcgg cagtgttagc agatgagcgt
     3601 tagagcgtcg ggctgcacca gaaacaggtg actcggagtc tgcgcccaga accgtcagct
     3661 ccgcttagtg gtttggggac cattttaatt gaagataaat gcctgaaatg tggaccttta
     3721 accaaagact tgttcatttt aatgcagaat ggggatgaaa ggaacttaga tctttctgtt
     3781 actgtagtag acgtccctga ggaacatata ccaaagtgtt tgagaacttc atccaaacct
     3841 actttcaaag cataatgtgc aattaagttg ttgtgacgta attatattgc ataattgttg
     3901 ggtctgtttt cttgagctta caatgtacct gggaaatgag cgtcgtcagg aaggaggagt
     3961 ccacgctgag gactggagga agactgagca ggagatgctg tgacaagaac ttgaaacacg
     4021 gagagagcat tggtgtttta tacgcttata gcaaattggt gttctcacta tagttttatg
     4081 aagatattaa tgcttttatg tatttcagaa cttttcctgt gttaatgcaa attgttttaa
     4141 gtgtaactat tgagtttatg tgagcatgtg tccactgtgc taaaggcacc ttgtttcagt
     4201 ttgtgtacaa tataaatatg caactttggg ggt
//
