LOCUS       NM_053565                863 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus suppressor of cytokine signaling 3 (Socs3), mRNA.
ACCESSION   NM_053565
VERSION     NM_053565.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 863)
  AUTHORS   Gu,Q., Xiao,Y.B. and Wang,Y.
  TITLE     Silencing suppressor of cytokine signaling 3 induces apoptosis and
            activates the p-STAT3/NF-kappaB pathway in hypoxic cultivated H9c2
            cells
  JOURNAL   J Physiol Biochem 80 (1), 127-136 (2024)
   PUBMED   37856074
  REMARK    GeneRIF: Silencing suppressor of cytokine signaling 3 induces
            apoptosis and activates the p-STAT3/NF-kappaB pathway in hypoxic
            cultivated H9c2 cells.
REFERENCE   2  (bases 1 to 863)
  AUTHORS   Li,X., Hu,R., Wang,H. and Xu,W.
  TITLE     SOCS3 Silencing Promotes Activation of Vocal Fold Fibroblasts via
            JAK2/STAT3 Signaling Pathway
  JOURNAL   Inflammation 46 (4), 1318-1331 (2023)
   PUBMED   37154979
  REMARK    GeneRIF: SOCS3 Silencing Promotes Activation of Vocal Fold
            Fibroblasts via JAK2/STAT3 Signaling Pathway.
REFERENCE   3  (bases 1 to 863)
  AUTHORS   Zhou,Q., Zhou,L. and Li,J.
  TITLE     MiR-218-5p-dependent SOCS3 downregulation increases osteoblast
            differentiation inpostmenopausal osteoporosis
  JOURNAL   J Orthop Surg Res 18 (1), 109 (2023)
   PUBMED   36793115
  REMARK    GeneRIF: MiR-218-5p-dependent SOCS3 downregulation increases
            osteoblast differentiation inpostmenopausal osteoporosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 863)
  AUTHORS   Huang,S.T., Chen,B.B., Song,Z.J., Tang,H.L., Hua,R. and Zhang,Y.M.
  TITLE     Unraveling the role of Epac1-SOCS3 signaling in the development of
            neonatal-CRD-induced visceral hypersensitivity in rats
  JOURNAL   CNS Neurosci Ther 28 (9), 1393-1408 (2022)
   PUBMED   35702948
  REMARK    GeneRIF: Unraveling the role of Epac1-SOCS3 signaling in the
            development of neonatal-CRD-induced visceral hypersensitivity in
            rats.
REFERENCE   5  (bases 1 to 863)
  AUTHORS   Elhennawy,M.G., Abdelaleem,E.A., Zaki,A.A. and Mohamed,W.R.
  TITLE     Cinnamaldehyde and hesperetin attenuate TNBS-induced ulcerative
            colitis in rats through modulation of the JAk2/STAT3/SOCS3 pathway
  JOURNAL   J Biochem Mol Toxicol 35 (5), e22730 (2021)
   PUBMED   33522063
  REMARK    GeneRIF: Cinnamaldehyde and hesperetin attenuate TNBS-induced
            ulcerative colitis in rats through modulation of the
            JAk2/STAT3/SOCS3 pathway.
REFERENCE   6  (bases 1 to 863)
  AUTHORS   Eyckerman,S., Broekaert,D., Verhee,A., Vandekerckhove,J. and
            Tavernier,J.
  TITLE     Identification of the Y985 and Y1077 motifs as SOCS3 recruitment
            sites in the murine leptin receptor
  JOURNAL   FEBS Lett 486 (1), 33-37 (2000)
   PUBMED   11108838
REFERENCE   7  (bases 1 to 863)
  AUTHORS   Wang,Z., Zhou,Y.T., Kakuma,T., Lee,Y., Kalra,S.P., Kalra,P.S.,
            Pan,W. and Unger,R.H.
  TITLE     Leptin resistance of adipocytes in obesity: role of suppressors of
            cytokine signaling
  JOURNAL   Biochem Biophys Res Commun 277 (1), 20-26 (2000)
   PUBMED   11027633
REFERENCE   8  (bases 1 to 863)
  AUTHORS   Paul,C., Seiliez,I., Thissen,J.P. and Le Cam,A.
  TITLE     Regulation of expression of the rat SOCS-3 gene in hepatocytes by
            growth hormone, interleukin-6 and glucocorticoids mRNA analysis and
            promoter characterization
  JOURNAL   Eur J Biochem 267 (19), 5849-5857 (2000)
   PUBMED   10998044
REFERENCE   9  (bases 1 to 863)
  AUTHORS   Park,E.S., Kim,H., Suh,J.M., Park,S.J., Kwon,O.Y., Kim,Y.K.,
            Ro,H.K., Cho,B.Y., Chung,J. and Shong,M.
  TITLE     Thyrotropin induces SOCS-1 (suppressor of cytokine signaling-1) and
            SOCS-3 in FRTL-5 thyroid cells
  JOURNAL   Mol Endocrinol 14 (3), 440-448 (2000)
   PUBMED   10707961
REFERENCE   10 (bases 1 to 863)
  AUTHORS   Mao,Y., Ling,P.R., Fitzgibbons,T.P., McCowen,K.C., Frick,G.P.,
            Bistrian,B.R. and Smith,R.J.
  TITLE     Endotoxin-induced inhibition of growth hormone receptor signaling
            in rat liver in vivo
  JOURNAL   Endocrinology 140 (12), 5505-5515 (1999)
   PUBMED   10579313
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF075383.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF075383.1, MK957182.1 [ECO:0000345]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..863
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.2"
     gene            1..863
                     /gene="Socs3"
                     /gene_synonym="Cish3; Socs-3; Ssi-3"
                     /note="suppressor of cytokine signaling 3"
                     /db_xref="GeneID:89829"
                     /db_xref="RGD:621087"
     exon            1..863
                     /gene="Socs3"
                     /gene_synonym="Cish3; Socs-3; Ssi-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..695
                     /gene="Socs3"
                     /gene_synonym="Cish3; Socs-3; Ssi-3"
                     /note="cytokine-inducible SH2 protein 3; cytokine
                     inducible SH2-containing protein 3"
                     /codon_start=1
                     /product="suppressor of cytokine signaling 3"
                     /protein_id="NP_446017.1"
                     /db_xref="GeneID:89829"
                     /db_xref="RGD:621087"
                     /translation="MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQES
                     GFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVETQSGTKNLRIQCEGGSF
                     SLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSFSLPPTEPSFEVQEQPPAQALPGGT
                     PKRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFL
                     DQYDAPL"
ORIGIN      
        1 cgctggctcc gtgcgccatg gtcacccaca gcaagtttcc cgccgccggg atgagccgcc
       61 ccctggacac cagcctgcgc ctcaagacct tcagctccaa gagcgagtac cagctggtgg
      121 tgaacgccgt gcgcaagctg caggagagcg gattctactg gagtgccgta accggcggcg
      181 aggcgaacct gctgctcagc gccgagcccg cgggcacctt tcttatccgc gacagctcgg
      241 accagcgcca cttcttcaca ctgagcgtcg agacccagtc ggggaccaag aacctacgca
      301 tccagtgcga ggggggcagc ttttcgctgc agagtgaccc ccggagcacg cagccagtgc
      361 cccgctttga ctgtgtactc aagttggtgc accactacat gccgccccca ggggcccctt
      421 ccttttcttt accaccgacg gaaccttcct ttgaggttca ggagcagcca cctgcccagg
      481 cactccccgg gggtaccccc aagagagctt actacatcta ttctgggggc gagaagatcc
      541 cgctggtact gagccgacct ctctcctcca acgtggctac cctccagcat ctttgtcgga
      601 agactgtcaa cggtcacctg gactcctatg agaaagtgac ccagctgcct ggacccattc
      661 gggagttcct ggaccagtat gatgctccac tttaaagagc aaagaaaggg tcagaggggg
      721 cctggatcgg tcgcctctcc tccgaggcac atggcacaag cacaaaaatc cagccccaat
      781 ggtcggtagc tcccagttag cccagcagaa gataggcttc ttcctcaggc cctccactcc
      841 gcagagtaga gctggcagga cct
//
