LOCUS       NM_058208                922 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus suppressor of cytokine signaling 2 (Socs2), mRNA.
ACCESSION   NM_058208
VERSION     NM_058208.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 922)
  AUTHORS   Sheng,M., Huang,Z., Pan,L., Yu,M., Yi,C., Teng,L., He,L., Gu,C.,
            Xu,C. and Li,J.
  TITLE     SOCS2 exacerbates myocardial injury induced by ischemia/reperfusion
            in diabetic mice and H9c2 cells through inhibiting the
            JAK-STAT-IGF-1 pathway
  JOURNAL   Life Sci 188, 101-109 (2017)
   PUBMED   28867579
  REMARK    GeneRIF: research suggests that overexpressed SOCS2 might
            exacerbate myocardial ischemia/reperfusion injury in type 2
            diabetes mellitus by inhibiting the expression of Insulin-like
            Growth Factor-1 via the Janus kinase-signal transducer and
            activator of transcription signaling pathway.
REFERENCE   2  (bases 1 to 922)
  AUTHORS   Choi,J.S., Shin,Y.J., Lee,J.Y., Choi,J.Y., Cha,J.H., Chun,M.H. and
            Lee,M.Y.
  TITLE     Enhanced expression of SOCS-2 in the rat hippocampus after
            transient forebrain ischemia
  JOURNAL   J Neurotrauma 26 (11), 2097-2106 (2009)
   PUBMED   19469688
  REMARK    GeneRIF: SOCS-2 may be involved in glial reactions, and possibly
            adult hippocampal neurogenesis during ischemic insults.
REFERENCE   3  (bases 1 to 922)
  AUTHORS   Isshiki,K., He,Z., Maeno,Y., Ma,R.C., Yasuda,Y., Kuroki,T.,
            White,G.S., Patti,M.E., Weir,G.C. and King,G.L.
  TITLE     Insulin regulates SOCS2 expression and the mitogenic effect of
            IGF-1 in mesangial cells
  JOURNAL   Kidney Int 74 (11), 1434-1443 (2008)
   PUBMED   19008912
  REMARK    GeneRIF: insulin can inhibit the mitogenic action of IGF-1 in
            mesangial cells by regulating STAT5/SOCS2 expression.
REFERENCE   4  (bases 1 to 922)
  AUTHORS   Hamilton,K.L., Lin,L., Wang,Y. and Knowlton,A.A.
  TITLE     Effect of ovariectomy on cardiac gene expression: inflammation and
            changes in SOCS gene expression
  JOURNAL   Physiol Genomics 32 (2), 254-263 (2008)
   PUBMED   17986523
  REMARK    GeneRIF: Data show that althhough we observed OVX-related increases
            in SOCS2 and SOCS3 mRNA, SOCS2 and SOCS3 protein did not differ
            among groups.
REFERENCE   5  (bases 1 to 922)
  AUTHORS   Haffner,M.C., Petridou,B., Peyrat,J.P., Revillion,F.,
            Muller-Holzner,E., Daxenbichler,G., Marth,C. and Doppler,W.
  TITLE     Favorable prognostic value of SOCS2 and IGF-I in breast cancer
  JOURNAL   BMC Cancer 7, 136 (2007)
   PUBMED   17651480
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 922)
  AUTHORS   Lindeman,G.J., Wittlin,S., Lada,H., Naylor,M.J., Santamaria,M.,
            Zhang,J.G., Starr,R., Hilton,D.J., Alexander,W.S., Ormandy,C.J. and
            Visvader,J.
  TITLE     SOCS1 deficiency results in accelerated mammary gland development
            and rescues lactation in prolactin receptor-deficient mice
  JOURNAL   Genes Dev 15 (13), 1631-1636 (2001)
   PUBMED   11445538
REFERENCE   7  (bases 1 to 922)
  AUTHORS   Johnson,T.S., O'Leary,M., Justice,S.K., Maamra,M.,
            Zarkesh-Esfahani,S.H., Furlanetto,R., Preedy,V.R., Hinds,C.J., El
            Nahas,A.M. and Ross,R.J.
  TITLE     Differential expression of suppressors of cytokine signalling genes
            in response to nutrition and growth hormone in the septic rat
  JOURNAL   J Endocrinol 169 (2), 409-415 (2001)
   PUBMED   11312157
REFERENCE   8  (bases 1 to 922)
  AUTHORS   Horvat,S. and Medrano,J.F.
  TITLE     Lack of Socs2 expression causes the high-growth phenotype in mice
  JOURNAL   Genomics 72 (2), 209-212 (2001)
   PUBMED   11401434
REFERENCE   9  (bases 1 to 922)
  AUTHORS   Mao,Y., Ling,P.R., Fitzgibbons,T.P., McCowen,K.C., Frick,G.P.,
            Bistrian,B.R. and Smith,R.J.
  TITLE     Endotoxin-induced inhibition of growth hormone receptor signaling
            in rat liver in vivo
  JOURNAL   Endocrinology 140 (12), 5505-5515 (1999)
   PUBMED   10579313
REFERENCE   10 (bases 1 to 922)
  AUTHORS   Dey,B.R., Spence,S.L., Nissley,P. and Furlanetto,R.W.
  TITLE     Interaction of human suppressor of cytokine signaling (SOCS)-2 with
            the insulin-like growth factor-I receptor
  JOURNAL   J Biol Chem 273 (37), 24095-24101 (1998)
   PUBMED   9727029
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_058208.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF075382.1, SRR26643429.26456.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840129, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-361               JAXUCZ010000007.1  31930063-31930423   c
            362-922             JAXUCZ010000007.1  31927814-31928374   c
FEATURES             Location/Qualifiers
     source          1..922
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..922
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /note="suppressor of cytokine signaling 2"
                     /db_xref="GeneID:84607"
                     /db_xref="RGD:69273"
     exon            1..361
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..819
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /note="cytokine-inducible SH2 protein 2; cytokine
                     inducible SH2-containing protein 2"
                     /codon_start=1
                     /product="suppressor of cytokine signaling 2"
                     /protein_id="NP_478115.1"
                     /db_xref="GeneID:84607"
                     /db_xref="RGD:69273"
                     /translation="MTLRCLEPSGNGADRTRSQWGTAGSPEDQSPEAARLAKALRELS
                     QTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDG
                     KFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSA
                     PTLQHFCRLSINKCTGTIRGLPLPTRLKDYLEEYKFQV"
     exon            362..922
                     /gene="Socs2"
                     /gene_synonym="Cish2; Socs-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgatctgtg ggtgaccgtg tctgcgagag actttgccat accattttgc gggaatttgg
       61 agagaaacaa ccagctgctt ccagtcccct ccccctccgc caccatttcg gacaccccgc
      121 acagactcgt tttggggtac cctgtgactt ccaggaagca cgcgaggtcc tttggcccca
      181 gctcgggcga ccacctgtct tggacgtgtt gactcatctc ccatgaccct gcggtgcctg
      241 gagccctctg ggaatggcgc ggacaggaca cggagccagt gggggacagc ggggtcgccg
      301 gaggatcagt ccccggaggc ggcgcgtctg gcgaaggccc tgcgtgagct cagtcaaaca
      361 ggatggtact ggggaagtat gactgttaat gaagccaaag agaaattaaa agaggcgcca
      421 gaaggaactt tcttgattag agatagctcc cactcagact acctattaac catatctgtt
      481 aagacatcag ccgggccgac taacctgcgg attgagtacc aagacgggaa attcagattg
      541 gattctatca tatgtgtcaa gtccaagctt aagcagtttg acagcgtggt tcatctgatt
      601 gactactacg ttcagatgtg caaggacaaa cggacaggcc ctgaagcccc ccggaatggg
      661 actgttcacc tttacctgac caaacctctg tatacatcag caccgacgct gcagcacttc
      721 tgccgactca gcattaacaa gtgtaccggt accatccggg gactaccttt accaacaaga
      781 ctgaaagatt acttggaaga gtataaattc caggtataag tatttctctc tctctctctc
      841 tctttttttt ttttttaaat gaatgcctca tatagagtat caccgaatgc agctatgtaa
      901 aagagaaaac ccggaggccc tc
//
