LOCUS       NM_145879               1190 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus suppressor of cytokine signaling 1 (Socs1), mRNA.
ACCESSION   NM_145879
VERSION     NM_145879.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1190)
  AUTHORS   Wu,L., Ning,P., Liang,Y., Wang,T., Chen,L., Lu,D. and Tang,H.
  TITLE     Methyltransferase METTL3 regulates neuropathic pain through m6A
            methylation modification of SOCS1
  JOURNAL   Neuropharmacology 261, 110176 (2024)
   PUBMED   39357736
  REMARK    GeneRIF: Methyltransferase METTL3 regulates neuropathic pain
            through m6A methylation modification of SOCS1.
REFERENCE   2  (bases 1 to 1190)
  AUTHORS   Shao,Y., Li,Y., Jiang,Y., Li,H., Wang,J. and Zhang,D.
  TITLE     Circulating exosomal miR-155-5p contributes to severe acute
            pancreatitis-associated intestinal barrier injury by targeting
            SOCS1 to activate NLRP3 inflammasome-mediated pyroptosis
  JOURNAL   FASEB J 37 (6), e23003 (2023)
   PUBMED   37219532
  REMARK    GeneRIF: Circulating exosomal miR-155-5p contributes to severe
            acute pancreatitis-associated intestinal barrier injury by
            targeting SOCS1 to activate NLRP3 inflammasome-mediated pyroptosis.
REFERENCE   3  (bases 1 to 1190)
  AUTHORS   Chen,X., Li,P., Huang,R., Zhang,J., Ouyang,X. and Tan,D.
  TITLE     Ulinastatin affects focal cerebral ischemia-reperfusion injury via
            SOCS1-mediated JAK2/STAT3 signalling pathway
  JOURNAL   Clin Exp Pharmacol Physiol 50 (1), 107-116 (2023)
   PUBMED   36222378
  REMARK    GeneRIF: Ulinastatin affects focal cerebral ischemia-reperfusion
            injury via SOCS1-mediated JAK2/STAT3 signalling pathway.
REFERENCE   4  (bases 1 to 1190)
  AUTHORS   Zhang,Y., Jing,Z., Cao,X., Wei,Q., He,W., Zhang,N., Liu,Y.,
            Yuan,Q., Zhuang,Z., Dong,Y., Hong,Z., Li,J., Li,P., Zhang,L.,
            Wang,H. and Li,W.
  TITLE     SOCS1, the feedback regulator of STAT1/3, inhibits the osteogenic
            differentiation of rat bone marrow mesenchymal stem cells
  JOURNAL   Gene 821, 146190 (2022)
   PUBMED   35124149
  REMARK    GeneRIF: SOCS1, the feedback regulator of STAT1/3, inhibits the
            osteogenic differentiation of rat bone marrow mesenchymal stem
            cells.
REFERENCE   5  (bases 1 to 1190)
  AUTHORS   Yang,J., Zhu,X., Hu,H. and Lin,X.
  TITLE     The inhibitory effect of Gualou Guizhi Decoction on post-ischemic
            neuroinflammation via miR-155 in MCAO rats
  JOURNAL   Ann Palliat Med 10 (2), 1370-1379 (2021)
   PUBMED   33081480
REFERENCE   6  (bases 1 to 1190)
  AUTHORS   Schluter,G., Boinska,D. and Nieman-Seyde,S.C.
  TITLE     Evidence for translational repression of the SOCS-1 major open
            reading frame by an upstream open reading frame
  JOURNAL   Biochem Biophys Res Commun 268 (2), 255-261 (2000)
   PUBMED   10679190
REFERENCE   7  (bases 1 to 1190)
  AUTHORS   Dey,B.R., Spence,S.L., Nissley,P. and Furlanetto,R.W.
  TITLE     Interaction of human suppressor of cytokine signaling (SOCS)-2 with
            the insulin-like growth factor-I receptor
  JOURNAL   J Biol Chem 273 (37), 24095-24101 (1998)
   PUBMED   9727029
REFERENCE   8  (bases 1 to 1190)
  AUTHORS   Naka,T., Narazaki,M., Hirata,M., Matsumoto,T., Minamoto,S.,
            Aono,A., Nishimoto,N., Kajita,T., Taga,T., Yoshizaki,K., Akira,S.
            and Kishimoto,T.
  TITLE     Structure and function of a new STAT-induced STAT inhibitor
  JOURNAL   Nature 387 (6636), 924-929 (1997)
   PUBMED   9202127
REFERENCE   9  (bases 1 to 1190)
  AUTHORS   Endo,T.A., Masuhara,M., Yokouchi,M., Suzuki,R., Sakamoto,H.,
            Mitsui,K., Matsumoto,A., Tanimura,S., Ohtsubo,M., Misawa,H.,
            Miyazaki,T., Leonor,N., Taniguchi,T., Fujita,T., Kanakura,Y.,
            Komiya,S. and Yoshimura,A.
  TITLE     A new protein containing an SH2 domain that inhibits JAK kinases
  JOURNAL   Nature 387 (6636), 921-924 (1997)
   PUBMED   9202126
REFERENCE   10 (bases 1 to 1190)
  AUTHORS   Schluter,G., Celik,A., Obata,R., Schlicker,M., Hofferbert,S.,
            Schlung,A., Adham,I.M. and Engel,W.
  TITLE     Sequence analysis of the conserved protamine gene cluster shows
            that it contains a fourth expressed gene
  JOURNAL   Mol Reprod Dev 43 (1), 1-6 (1996)
   PUBMED   8720108
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AW917497.1 and JAXUCZ010000010.1.
            
            On Mar 13, 2014 this sequence version replaced NM_145879.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW917497.1, CB557066.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            regulatory uORF        :: PMID: 10679190
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-524               AW917497.1         2-525
            525-1190            JAXUCZ010000010.1  5390600-5391265
FEATURES             Location/Qualifiers
     source          1..1190
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q11"
     gene            1..1190
                     /gene="Socs1"
                     /gene_synonym="Cish1; Socs-1"
                     /note="suppressor of cytokine signaling 1"
                     /db_xref="GeneID:252971"
                     /db_xref="RGD:69272"
     exon            1..82
                     /gene="Socs1"
                     /gene_synonym="Cish1; Socs-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      27..131
                     /regulatory_class="uORF"
                     /gene="Socs1"
                     /gene_synonym="Cish1; Socs-1"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:10679190]"
                     /note="this uORF is predicted to encode a 34 aa peptide
                     (PMID:10679190)"
     exon            83..1190
                     /gene="Socs1"
                     /gene_synonym="Cish1; Socs-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      99..131
                     /regulatory_class="uORF"
                     /gene="Socs1"
                     /gene_synonym="Cish1; Socs-1"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:10679190]"
                     /note="this uORF is predicted to encode a 10 aa peptide
                     (PMID:10679190)"
     CDS             133..771
                     /gene="Socs1"
                     /gene_synonym="Cish1; Socs-1"
                     /note="cytokine inducible SH2-containing protein 1"
                     /codon_start=1
                     /product="suppressor of cytokine signaling 1"
                     /protein_id="NP_665886.2"
                     /db_xref="GeneID:252971"
                     /db_xref="RGD:69272"
                     /translation="MVARNQVAADNAISPASEPRRRPEPSSSSSSSSPAAPARPRPCP
                     VVPAPAPGDTHFRTFRSHSDYRRITRTSALLDACGFYWGPLSVHGAHERLRAEPVGTF
                     LVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRETFDCLFELLEHYVAAPR
                     RMLGAPLRQRRVRPLQELCRQRIVAAVGRENLARIPLNPVLRDYLSSFPFQI"
ORIGIN      
        1 agcggcacgg ctcccggccc cggagcatgc gcgacagcag ccccggaacc cccagccgcg
       61 gcgccccgcg tcccgccgcc agcgcagccc cggacgctat ggcccacccc tccagctggc
      121 ccctcgagta ggatggtagc acgtaaccag gtggcagccg acaatgcgat ctccccggca
      181 tcagagcccc gacggcggcc agagccatcc tcgtcctcgt cttcgtcctc gccggcggcc
      241 ccggcgcgtc cccggccctg cccggtggtc ccggccccgg ctccgggcga cactcacttc
      301 cgcaccttcc gctcccactc tgattaccgg cgcatcacgc ggaccagcgc tctcctggac
      361 gcctgcggct tctactgggg acccctgagc gtgcatgggg cgcacgaacg gctgcgtgcc
      421 gagcccgtgg gcaccttctt ggtgcgcgac agtcgccagc ggaactgctt cttcgcgctc
      481 agcgtgaaga tggcttcggg ccccacgagc attcgtgtgc acttccaggc cggccgcttc
      541 cacctggacg gcagccgcga gaccttcgac tgcctcttcg agctgctgga gcactacgtg
      601 gcggcgccgc gccgcatgtt gggggcccca ctgcgccagc gccgcgtgcg gccgctgcag
      661 gagctgtgtc gccagcgcat cgtggccgcc gtgggtcgcg agaacctggc acgcatccct
      721 cttaacccgg tactccgtga ctacctgagt tccttcccct tccagatctg accggctgcc
      781 gccgtgcccg cagcattaag tgggagcgcc ttattatttc ttattattaa ttattattat
      841 ttttctggaa ccacgtggga gccctccccg cctaggtcgg agggagtggg tgtggagggt
      901 gagatgcctc ccacttctgg ctggagacct tatcccgcct ctcggggggc ctcccctcct
      961 ggtgctccct cccggtcccc ctggttgtag cagcttgtgt ctggggccag gacctgaact
     1021 ccacgcctac ctctccatgt ttacatgttc ccagtatctt tgcacaaacc aggggtgggg
     1081 gagggtctct ggcttcattt ttctgctgtg cagaatattc tattttatat ttttacatcc
     1141 agtttagata ataaacttta ttatgaaagt ttttttttta aagaaacaaa
//
