LOCUS       NM_153728               2193 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus sterol O-acyltransferase 2 (Soat2), mRNA.
ACCESSION   NM_153728
VERSION     NM_153728.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2193)
  AUTHORS   Ichigo,Y., Takeshita,A., Hibino,M., Nakagawa,T., Hayakawa,T.,
            Patel,D., Field,C.J. and Shimada,M.
  TITLE     High-Fructose Diet-Induced Hypertriglyceridemia Is Associated With
            Enhanced Hepatic Expression of ACAT2 in Rats
  JOURNAL   Physiol Res 68 (6), 1021-1026 (2019)
   PUBMED   31647302
  REMARK    GeneRIF: Expression levels of hepatic ACAT2 (Soat2) were
            significantly increased following a high fructose diet.
REFERENCE   2  (bases 1 to 2193)
  AUTHORS   Nguyen,T.M., Sawyer,J.K., Kelley,K.L., Davis,M.A. and Rudel,L.L.
  TITLE     Cholesterol esterification by ACAT2 is essential for efficient
            intestinal cholesterol absorption: evidence from thoracic lymph
            duct cannulation
  JOURNAL   J Lipid Res 53 (1), 95-104 (2012)
   PUBMED   22045928
REFERENCE   3  (bases 1 to 2193)
  AUTHORS   Bell,T.A. 3rd, Kelley,K., Wilson,M.D., Sawyer,J.K. and Rudel,L.L.
  TITLE     Dietary fat-induced alterations in atherosclerosis are abolished by
            ACAT2-deficiency in ApoB100 only, LDLr-/- mice
  JOURNAL   Arterioscler Thromb Vasc Biol 27 (6), 1396-1402 (2007)
   PUBMED   17431188
REFERENCE   4  (bases 1 to 2193)
  AUTHORS   Waterham,H.R.
  TITLE     Defects of cholesterol biosynthesis
  JOURNAL   FEBS Lett 580 (23), 5442-5449 (2006)
   PUBMED   16876788
  REMARK    Review article
REFERENCE   5  (bases 1 to 2193)
  AUTHORS   Bell,T.A. 3rd, Brown,J.M., Graham,M.J., Lemonidis,K.M., Crooke,R.M.
            and Rudel,L.L.
  TITLE     Liver-specific inhibition of acyl-coenzyme a:cholesterol
            acyltransferase 2 with antisense oligonucleotides limits
            atherosclerosis development in apolipoprotein B100-only low-density
            lipoprotein receptor-/- mice
  JOURNAL   Arterioscler Thromb Vasc Biol 26 (8), 1814-1820 (2006)
   PUBMED   16675724
REFERENCE   6  (bases 1 to 2193)
  AUTHORS   Yen,C.L., Stone,S.J., Cases,S., Zhou,P. and Farese,R.V. Jr.
  TITLE     Identification of a gene encoding MGAT1, a monoacylglycerol
            acyltransferase
  JOURNAL   Proc Natl Acad Sci U S A 99 (13), 8512-8517 (2002)
   PUBMED   12077311
REFERENCE   7  (bases 1 to 2193)
  AUTHORS   Vaziri,N.D. and Liang,K.
  TITLE     Up-regulation of acyl-coenzyme A:cholesterol acyltransferase (ACAT)
            in nephrotic syndrome
  JOURNAL   Kidney Int 61 (5), 1769-1775 (2002)
   PUBMED   11967026
REFERENCE   8  (bases 1 to 2193)
  AUTHORS   Seo,T., Oelkers,P.M., Giattina,M.R., Worgall,T.S., Sturley,S.L. and
            Deckelbaum,R.J.
  TITLE     Differential modulation of ACAT1 and ACAT2 transcription and
            activity by long chain free fatty acids in cultured cells
  JOURNAL   Biochemistry 40 (15), 4756-4762 (2001)
   PUBMED   11294643
REFERENCE   9  (bases 1 to 2193)
  AUTHORS   Buhman,K.K., Accad,M., Novak,S., Choi,R.S., Wong,J.S.,
            Hamilton,R.L., Turley,S. and Farese,R.V. Jr.
  TITLE     Resistance to diet-induced hypercholesterolemia and gallstone
            formation in ACAT2-deficient mice
  JOURNAL   Nat Med 6 (12), 1341-1347 (2000)
   PUBMED   11100118
REFERENCE   10 (bases 1 to 2193)
  AUTHORS   Cases,S., Novak,S., Zheng,Y.W., Myers,H.M., Lear,S.R., Sande,E.,
            Welch,C.B., Lusis,A.J., Spencer,T.A., Krause,B.R., Erickson,S.K.
            and Farese,R.V. Jr.
  TITLE     ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase.
            Its cloning, expression, and characterization
  JOURNAL   J Biol Chem 273 (41), 26755-26764 (1998)
   PUBMED   9756919
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_153728.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB101480.1, AB075946.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-360               JAXUCZ010000007.1  135160424-135160783
            361-416             JAXUCZ010000007.1  135161188-135161243
            417-553             JAXUCZ010000007.1  135163828-135163964
            554-613             JAXUCZ010000007.1  135164623-135164682
            614-721             JAXUCZ010000007.1  135164920-135165027
            722-998             JAXUCZ010000007.1  135167374-135167650
            999-1068            JAXUCZ010000007.1  135168153-135168222
            1069-1153           JAXUCZ010000007.1  135168620-135168704
            1154-1199           JAXUCZ010000007.1  135169106-135169151
            1200-1329           JAXUCZ010000007.1  135169266-135169395
            1330-1427           JAXUCZ010000007.1  135171001-135171098
            1428-1526           JAXUCZ010000007.1  135171510-135171608
            1527-1662           JAXUCZ010000007.1  135172272-135172407
            1663-1808           JAXUCZ010000007.1  135172802-135172947
            1809-2193           JAXUCZ010000007.1  135173137-135173521
FEATURES             Location/Qualifiers
     source          1..2193
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2193
                     /gene="Soat2"
                     /gene_synonym="Acat-2"
                     /note="sterol O-acyltransferase 2"
                     /db_xref="GeneID:266770"
                     /db_xref="RGD:628865"
     exon            1..360
                     /gene="Soat2"
                     /gene_synonym="Acat-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..1859
                     /gene="Soat2"
                     /gene_synonym="Acat-2"
                     /EC_number="2.3.1.26"
                     /note="cholesterol acyltransferase 2; acyl-coenzyme
                     A:cholesterol acyltransferase 2; acyl-CoA:cholesterol
                     acyltransferase 2"
                     /codon_start=1
                     /product="sterol O-acyltransferase 2"
                     /protein_id="NP_714950.3"
                     /db_xref="GeneID:266770"
                     /db_xref="RGD:628865"
                     /translation="MEPKAPQLRRRERQGEEQENGACGEGNTRTHRAPDLVQWTRHME
                     AVKTQCLEQAQRELAELMDRAIWEAVQAYPKQDRPLPSTASDSTRKTQELHPGKRKVF
                     ITRKSLLDELMEVQHFRTIYHMFIAGLCVLIISTLAIDFIDEGRLMLEFDLLLFSFGQ
                     LPLALMMWVPMFLSTLLLPYQTLRLWARPRSGGAWTLGASLGCVLLAAHAAVLCVLPV
                     HVSVKHELPPASRCVLVFEQVRFLMKSYSFLRETVPGIFCVRGGKGICTPSFSSYLYF
                     LFCPTLIYRETYPRTPSIRWNYVAKNFAQALGCLLYACFILGRLCVPVFANMSREPFS
                     TRALLLSILHATGPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNY
                     YRTWNVVVHDWLYSYVYQDGLWLLGRQGRGAAMLGVFLVSALVHEYIFCFVLGFFYPV
                     MLILFLVVGGLLNFTMNDRHTGPAWNILMWTFLFLGQGIQVSLYCQEWYARRHCPLPQ
                     PTFWELVTPRSWSCHP"
     exon            361..416
                     /gene="Soat2"
                     /gene_synonym="Acat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            417..553
                     /gene="Soat2"
                     /gene_synonym="Acat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            554..613
                     /gene="Soat2"
                     /gene_synonym="Acat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            614..721
                     /gene="Soat2"
                     /gene_synonym="Acat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            722..998
                     /gene="Soat2"
                     /gene_synonym="Acat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1068
                     /gene="Soat2"
                     /gene_synonym="Acat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1153
                     /gene="Soat2"
                     /gene_synonym="Acat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1199
                     /gene="Soat2"
                     /gene_synonym="Acat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1329
                     /gene="Soat2"
                     /gene_synonym="Acat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1427
                     /gene="Soat2"
                     /gene_synonym="Acat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1526
                     /gene="Soat2"
                     /gene_synonym="Acat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1662
                     /gene="Soat2"
                     /gene_synonym="Acat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1808
                     /gene="Soat2"
                     /gene_synonym="Acat-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..2193
                     /gene="Soat2"
                     /gene_synonym="Acat-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggccatag tggttgagga tagaggggct gtgacatgcc acagaccggc cagagccagg
       61 atatgagaaa cgttgcctgt agataaccta tctgacacgc ggcgggctcc gctccggaaa
      121 ggactttagt ctctggagtt gtctctgagt gggacacacg agctccatag gtaggttgag
      181 agaggaagga aggaaggaag gaaggaagga aggaaggaag gaaggaagga aggaaggaag
      241 ggacagacaa cggcctgtgt gctgtcccgc tccacacggg caccatggag ccaaaggcgc
      301 cccagctgcg gaggagagaa aggcagggag aggagcagga gaacggagcc tgtggagaag
      361 ggaacacaag gacgcacaga gccccagacc tggtacaatg gacccgacat atggaggctg
      421 tgaagacaca gtgtctggag caagcacaga gagagttggc agagctgatg gatcgggcca
      481 tatgggaagc tgtgcaagcc taccccaaac aagacagacc tcttccttct accgcctcag
      541 attctacaag gaagacccaa gagttacacc ctgggaaacg gaaagttttc atcacccgca
      601 agtcactgct cgacgagcta atggaggtgc aacatttccg aaccatctac cacatgttca
      661 tagcaggcct ctgtgtcttg atcatcagta ccctggccat cgacttcatt gatgagggca
      721 ggttgatgct ggagtttgat ctactcctct tcagcttcgg acagctgccc ttggcgctga
      781 tgatgtgggt tcccatgttc ctgtccacgc tgcttctgcc ctaccagacc ttgcggctgt
      841 gggccaggcc acgctcaggg ggcgcctgga cgctgggtgc cagcctgggc tgtgttctgc
      901 tggctgccca cgccgcggtg ctctgcgtcc tgccggtgca cgtgtcagtg aagcatgaac
      961 ttccaccggc ctcgcgctgt gtgcttgtct ttgagcaggt cagattcctg atgaaaagct
     1021 actccttcct gagagagact gtgcctggga tcttttgtgt cagaggaggg aagggcatct
     1081 gcaccccgag tttctccagc tatctctact tcctcttctg ccctacactc atctacagag
     1141 aaacataccc caggacaccc agcatcaggt ggaattatgt ggccaagaac tttgcccagg
     1201 ctctgggctg tttgctctat gcctgcttca tcctgggccg cctctgtgtc cctgtctttg
     1261 ccaacatgag tcgagaaccc ttcagcaccc gggctctgct gctgtccatc ctgcacgcca
     1321 cggggccagg catcttcatg ctgctcctca tcttcttcgc cttcctgcac tgctggctca
     1381 acgccttcgc cgagatgctg cggtttggag acagaatgtt ctaccgggac tggtggaact
     1441 ctacttcctt ctccaactat taccgcacct ggaacgtggt ggtccatgac tggctgtaca
     1501 gctacgtgta tcaagatggg ctgtggctct taggaaggca gggtcgaggg gcagccatgc
     1561 tgggagtgtt cctagtgtct gccctggtac atgagtacat cttctgcttc gtcctggggt
     1621 tcttctaccc ggtcatgctg atcctctttc ttgtggttgg aggtctgctg aacttcacca
     1681 tgaacgacag gcacacaggt ccagcctgga acatcctgat gtggaccttt ctcttcctgg
     1741 gtcagggcat ccaggtcagc ctatactgcc aggagtggta cgctcggcga cactgtccct
     1801 tgccccagcc gacattttgg gagctggtga cacctcgctc ctggtcctgc cacccctaga
     1861 agtcaaggct tcacactgca cagatgatgg catcaagctc ttctctacca gcaaagccca
     1921 gagccagggc tcctcactac ctcacttgga gtcaaggacc tcccagcggg gtcataggga
     1981 ctcaggcaca cacctctgtg ggcagctggc cacaggctca gtacggtttg attcgagcac
     2041 caccctctgt ggactgtgca caggtcacct tctgatcctt ggctctccag gtgtggggag
     2101 actcagagga acaggggcca tcaaagtttg acaccactgg ttctgtttct cccaatgcag
     2161 caataaaatc ttaagtctcc cttttaattc act
//
