LOCUS       NM_001127637            2371 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus sorting nexin 9 (Snx9), mRNA.
ACCESSION   NM_001127637 XM_001067064
VERSION     NM_001127637.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2371)
  AUTHORS   Ganaie IA, Naqvi SH, Jain SK and Wajid S.
  TITLE     Reduced expression of SETD2 and SNX9 proteins in chemically induced
            mammary tumorigenesis in Wistar rats: a prognostic histological and
            proteomic study
  JOURNAL   Protoplasma 254 (3), 1451-1466 (2017)
   PUBMED   27766425
  REMARK    GeneRIF: The significance of this study lies in reporting the
            significantly reduced expression of two proteins: histone-lysine
            N-methyltransferase (SETD2) and sorting nexin-9 (SNX9) at very
            early stage (13 weeks) of tumorigenesis, while the full-fledged
            tumors developed after 6 months.
REFERENCE   2  (bases 1 to 2371)
  AUTHORS   Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S and Zaidel-Bar R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2371)
  AUTHORS   Cao H, Yin X, Cao Y, Jin Y, Wang S, Kong Y, Chen Y, Gao J, Heller S
            and Xu Z.
  TITLE     FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and
            cuticular plate and regulate actin polymerization in vitro
  JOURNAL   PLoS One 8 (2), e56516 (2013)
   PUBMED   23437151
REFERENCE   4  (bases 1 to 2371)
  AUTHORS   van Weering JR, Sessions RB, Traer CJ, Kloer DP, Bhatia VK, Stamou
            D, Carlsson SR, Hurley JH and Cullen PJ.
  TITLE     Molecular basis for SNX-BAR-mediated assembly of distinct endosomal
            sorting tubules
  JOURNAL   EMBO J 31 (23), 4466-4480 (2012)
   PUBMED   23085988
REFERENCE   5  (bases 1 to 2371)
  AUTHORS   Ma MP and Chircop M.
  TITLE     SNX9, SNX18 and SNX33 are required for progression through and
            completion of mitosis
  JOURNAL   J Cell Sci 125 (Pt 18), 4372-4382 (2012)
   PUBMED   22718350
REFERENCE   6  (bases 1 to 2371)
  AUTHORS   Schobel S, Neumann S, Hertweck M, Dislich B, Kuhn PH, Kremmer E,
            Seed B, Baumeister R, Haass C and Lichtenthaler SF.
  TITLE     A novel sorting nexin modulates endocytic trafficking and
            alpha-secretase cleavage of the amyloid precursor protein
  JOURNAL   J Biol Chem 283 (21), 14257-14268 (2008)
   PUBMED   18353773
REFERENCE   7  (bases 1 to 2371)
  AUTHORS   Pylypenko O, Lundmark R, Rasmuson E, Carlsson SR and Rak A.
  TITLE     The PX-BAR membrane-remodeling unit of sorting nexin 9
  JOURNAL   EMBO J 26 (22), 4788-4800 (2007)
   PUBMED   17948057
REFERENCE   8  (bases 1 to 2371)
  AUTHORS   Shin N, Lee S, Ahn N, Kim SA, Ahn SG, YongPark Z and Chang S.
  TITLE     Sorting nexin 9 interacts with dynamin 1 and N-WASP and coordinates
            synaptic vesicle endocytosis
  JOURNAL   J Biol Chem 282 (39), 28939-28950 (2007)
   PUBMED   17681954
REFERENCE   9  (bases 1 to 2371)
  AUTHORS   Soulet F, Yarar D, Leonard M and Schmid SL.
  TITLE     SNX9 regulates dynamin assembly and is required for efficient
            clathrin-mediated endocytosis
  JOURNAL   Mol Biol Cell 16 (4), 2058-2067 (2005)
   PUBMED   15703209
REFERENCE   10 (bases 1 to 2371)
  AUTHORS   MaCaulay SL, Stoichevska V, Grusovin J, Gough KH, Castelli LA and
            Ward CW.
  TITLE     Insulin stimulates movement of sorting nexin 9 between cellular
            compartments: a putative role mediating cell surface receptor
            expression and insulin action
  JOURNAL   Biochem J 376 (Pt 1), 123-134 (2003)
   PUBMED   12917015
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158878.1.
            
            On May 25, 2008 this sequence version replaced XM_001067064.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2371
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..2371
                     /gene="Snx9"
                     /note="sorting nexin 9"
                     /db_xref="GeneID:683687"
                     /db_xref="RGD:1584466"
     exon            1..161
                     /gene="Snx9"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1937
                     /gene="Snx9"
                     /codon_start=1
                     /product="sorting nexin-9"
                     /protein_id="NP_001121109.1"
                     /db_xref="GeneID:683687"
                     /db_xref="RGD:1584466"
                     /translation="MATKARVMYDFAAEPGNNELTVNEGEIITITNPNVGGGWLEGKN
                     SKGEQGLVPTDYVEILPNDGKDPFSCGNSVADQAFLDSLSASTAQANSSSANSNNQVG
                     GGSDPWSAWNAPRSGNWDSSDAWGTRTDGAGAQRNSSANNWDTGFGHPQAYQGPATGD
                     DDEWDEDWDDPKSSSPYFKDSEPAEAGGIQRGNSRAGASSMKLPLNKFPGFAKPGMEQ
                     YLLAKQLAKPKEKIPIIVGDYGPMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTP
                     TNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAW
                     MTRMCRHPVVSESEVFQQFLNFRDEKEWKTGKRKAEKDELVGVMIFSTMEPEAPDLDL
                     IEIEQKCDAVGKFTKAMDDGVKELLTVGQEHWKRCTGPLPKEYQKIGKALQSLAAVFS
                     SSGYQGETDLNNAITEAGKTYEEIASLVAEQPKKDLHFLMECNHEYKGFLGCFPDIIG
                     AHKGAIEKVKESDKLVATSKITPQDKQTMVKRVGTMSYALQAEMNHFHSNRIYDYNSV
                     IRLYLEQQVQFYETIAEKLRQALGRFPVM"
     exon            162..248
                     /gene="Snx9"
                     /inference="alignment:Splign:2.1.0"
     exon            249..323
                     /gene="Snx9"
                     /inference="alignment:Splign:2.1.0"
     exon            324..449
                     /gene="Snx9"
                     /inference="alignment:Splign:2.1.0"
     exon            450..618
                     /gene="Snx9"
                     /inference="alignment:Splign:2.1.0"
     exon            619..769
                     /gene="Snx9"
                     /inference="alignment:Splign:2.1.0"
     exon            770..854
                     /gene="Snx9"
                     /inference="alignment:Splign:2.1.0"
     exon            855..980
                     /gene="Snx9"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1098
                     /gene="Snx9"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1229
                     /gene="Snx9"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1333
                     /gene="Snx9"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1437
                     /gene="Snx9"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1515
                     /gene="Snx9"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1592
                     /gene="Snx9"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1682
                     /gene="Snx9"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1797
                     /gene="Snx9"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1889
                     /gene="Snx9"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2357
                     /gene="Snx9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcgccga gagcagggct gaggcggagc cgccgcgccc ggccggagcc gccgaaccgc
       61 agccggagcc gtcctgcccg cccgcctagg gccgaagctc cgcagcgcgg gagaccagcc
      121 ggcccgcagg ggccggggaa ccgcccgcca tggccaccaa ggctcgggtc atgtatgact
      181 ttgctgctga acctggaaac aatgaactga cagtcaatga aggggagatc atcacaatca
      241 caaacccgaa cgttggtgga ggatggctgg aaggaaaaaa cagcaaggga gagcaggggc
      301 tcgttcctac ggactacgtg gaaattttac ccaacgatgg aaaagacccg ttttcttgtg
      361 gaaattcggt ggccgaccaa gctttccttg attcgctgtc agccagcacg gctcaagcca
      421 actcatcttc tgccaacagc aataaccagg ttggtggtgg cagtgacccc tggtcagcct
      481 ggaatgctcc cagatctggg aactgggaca gctctgatgc ctggggcacc aggacagatg
      541 gggctggcgc tcagaggaac agcagtgcca acaactggga caccggcttc ggccatccgc
      601 aggcctacca aggaccagcg actggtgatg atgatgaatg ggatgaagat tgggacgacc
      661 ccaagtcctc ctcaccttac tttaaggatt cagaaccagc tgaagcaggg ggcatccagc
      721 ggggaaacag ccgtgcgggt gcctcttcca tgaagctgcc ccttaacaaa ttccctggat
      781 ttgcaaaacc tggcatggag cagtacctgt tggccaagca gctagcaaaa cccaaagaga
      841 aaatccccat cattgttgga gattatggcc ctatgtgggt ttatcctacc tctacgtttg
      901 actgtgtggt agctgatccc cggaaaggtt ccaaaatgta cggtctgaaa agctacattg
      961 agtatcagct aacacccact aacactaatc gatctgtaaa ccacagatat aagcactttg
     1021 actggttata tgaacgtctc ctggttaagt ttgggtccgc catcccgatc ccttctcttc
     1081 cagacaagca ggtcacaggt cgctttgaag aggagttcat caagatgcgc atggagcggc
     1141 tccaggcctg gatgaccagg atgtgccggc accccgtggt gtcagaaagt gaagttttcc
     1201 agcagttcct gaatttccga gatgagaagg aatggaagac tggcaagagg aaggctgaga
     1261 aagatgagct ggtgggagtt atgatatttt ccaccatgga accagaggct cctgacttgg
     1321 atttgataga aatagaacag aagtgtgacg cggtggggaa gttcaccaag gccatggacg
     1381 acggcgtgaa ggagctgctg accgtggggc aggagcactg gaagcgctgc acagggccct
     1441 tacccaagga gtatcagaag atcgggaagg ccctgcagag cctagcggcc gtcttcagct
     1501 ccagcggtta tcaaggagag acggacctta acaatgcaat cacagaagcc gggaagacat
     1561 acgaggagat tgccagcctt gtggcagagc agccaaagaa ggacctccac ttcctgatgg
     1621 agtgcaacca cgagtacaaa ggctttcttg gctgcttccc ggacatcatt ggtgcccaca
     1681 agggagcaat agaaaaagtg aaagaaagtg acaagctggt tgcaactagt aaaatcaccc
     1741 cccaggacaa gcagacgatg gtgaagcggg ttggcaccat gtcgtatgct ttgcaagctg
     1801 agatgaatca cttccacagt aaccggatct acgattacaa cagcgtcatc cgcctctacc
     1861 tggagcagca agtgcaattc tatgaaacaa tcgcagaaaa gctgaggcag gccctcggcc
     1921 gcttcccagt tatgtagacc agaacggaca caagagaact ccgaagtgct tctttttgac
     1981 ctgggacaat gcaattcagt tttctcccca ccccatcata agagagagag agagagaagg
     2041 aagaaaacca aaaagacaga agttgataaa actcgttttc gtcattagcc agcctaaagg
     2101 cgttgttgct taggatggcc ttccttgttc atttcgacat attagttacc caatggaaat
     2161 gtctattttt gaaaaatact taaatttatc aagatttttg aatgaagaaa taggggttcc
     2221 tcctcctggt attttacaca gaatcgtaat ttatatgtta cctatgatct tccagttctt
     2281 acccaatgtc agataattaa tactaattgc tttcttaaaa atatgaaaaa tgacagaata
     2341 aaaaatgtat ctttgtaaaa aaaaaaaaaa a
//
