LOCUS       NM_001108711            1934 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus sorting nexin 6 (Snx6), mRNA.
ACCESSION   NM_001108711 XM_001075611 XM_343062
VERSION     NM_001108711.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1934)
  AUTHORS   Li Q, Li X, Wang L, Zhang Y and Chen L.
  TITLE     miR-98-5p Acts as a Target for Alzheimer's Disease by Regulating
            Abeta Production Through Modulating SNX6 Expression
  JOURNAL   J Mol Neurosci 60 (4), 413-420 (2016)
   PUBMED   27541017
REFERENCE   2  (bases 1 to 1934)
  AUTHORS   Gallon M and Cullen PJ.
  TITLE     Retromer and sorting nexins in endosomal sorting
  JOURNAL   Biochem Soc Trans 43 (1), 33-47 (2015)
   PUBMED   25619244
  REMARK    Review article
REFERENCE   3  (bases 1 to 1934)
  AUTHORS   Hao X, Wang Y, Ren F, Zhu S, Ren Y, Jia B, Li YP, Shi Y and Chang
            Z.
  TITLE     SNX25 regulates TGF-beta signaling by enhancing the receptor
            degradation
  JOURNAL   Cell Signal 23 (5), 935-946 (2011)
   PUBMED   21266196
REFERENCE   4  (bases 1 to 1934)
  AUTHORS   Rivera J, Megias D and Bravo J.
  TITLE     Sorting nexin 6 interacts with breast cancer metastasis
            suppressor-1 and promotes transcriptional repression
  JOURNAL   J Cell Biochem 111 (6), 1464-1472 (2010)
   PUBMED   20830743
REFERENCE   5  (bases 1 to 1934)
  AUTHORS   Hong Z, Yang Y, Zhang C, Niu Y, Li K, Zhao X and Liu JJ.
  TITLE     The retromer component SNX6 interacts with dynactin p150(Glued) and
            mediates endosome-to-TGN transport
  JOURNAL   Cell Res 19 (12), 1334-1349 (2009)
   PUBMED   19935774
REFERENCE   6  (bases 1 to 1934)
  AUTHORS   Wassmer T, Attar N, Harterink M, van Weering JR, Traer CJ, Oakley
            J, Goud B, Stephens DJ, Verkade P, Korswagen HC and Cullen PJ.
  TITLE     The retromer coat complex coordinates endosomal sorting and
            dynein-mediated transport, with carrier recognition by the
            trans-Golgi network
  JOURNAL   Dev Cell 17 (1), 110-122 (2009)
   PUBMED   19619496
REFERENCE   7  (bases 1 to 1934)
  AUTHORS   Cavet ME, Pang J, Yin G and Berk BC.
  TITLE     An epidermal growth factor (EGF) -dependent interaction between
            GIT1 and sorting nexin 6 promotes degradation of the EGF receptor
  JOURNAL   FASEB J 22 (10), 3607-3616 (2008)
   PUBMED   18523162
REFERENCE   8  (bases 1 to 1934)
  AUTHORS   Sander LE, Frank SP, Bolat S, Blank U, Galli T, Bigalke H, Bischoff
            SC and Lorentz A.
  TITLE     Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not
            VAMP-2 or VAMP-3, are required for activation-induced degranulation
            of mature human mast cells
  JOURNAL   Eur J Immunol 38 (3), 855-863 (2008)
   PUBMED   18253931
REFERENCE   9  (bases 1 to 1934)
  AUTHORS   Parks WT, Frank DB, Huff C, Renfrew Haft C, Martin J, Meng X, de
            Caestecker MP, McNally JG, Reddi A, Taylor SI, Roberts AB, Wang T
            and Lechleider RJ.
  TITLE     Sorting nexin 6, a novel SNX, interacts with the transforming
            growth factor-beta family of receptor serine-threonine kinases
  JOURNAL   J Biol Chem 276 (22), 19332-19339 (2001)
   PUBMED   11279102
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473947.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_343062.3, XM_001075611.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168856.1, SRR8487227.119521.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1934
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q23"
     gene            1..1934
                     /gene="Snx6"
                     /note="sorting nexin 6"
                     /db_xref="GeneID:362738"
                     /db_xref="RGD:1304647"
     exon            1..54
                     /gene="Snx6"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1269
                     /gene="Snx6"
                     /codon_start=1
                     /product="sorting nexin-6"
                     /protein_id="NP_001102181.1"
                     /db_xref="GeneID:362738"
                     /db_xref="RGD:1304647"
                     /translation="MMEGLDDGPDFLSEEDRGLKSINVDLQSDAALQVDISDALSERD
                     KVKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDA
                     SREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRKD
                     LNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLL
                     EYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDK
                     TRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKN
                     KDVLQAETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNL
                     QLLQNCLAVLNGDT"
     exon            55..102
                     /gene="Snx6"
                     /inference="alignment:Splign:2.1.0"
     exon            103..207
                     /gene="Snx6"
                     /inference="alignment:Splign:2.1.0"
     exon            208..318
                     /gene="Snx6"
                     /inference="alignment:Splign:2.1.0"
     exon            319..440
                     /gene="Snx6"
                     /inference="alignment:Splign:2.1.0"
     exon            441..564
                     /gene="Snx6"
                     /inference="alignment:Splign:2.1.0"
     exon            565..660
                     /gene="Snx6"
                     /inference="alignment:Splign:2.1.0"
     exon            661..766
                     /gene="Snx6"
                     /inference="alignment:Splign:2.1.0"
     exon            767..842
                     /gene="Snx6"
                     /inference="alignment:Splign:2.1.0"
     exon            843..882
                     /gene="Snx6"
                     /inference="alignment:Splign:2.1.0"
     exon            883..969
                     /gene="Snx6"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1129
                     /gene="Snx6"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1215
                     /gene="Snx6"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1934
                     /gene="Snx6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgtggcctt gcttgtgagt ctgcgcgaga cctggactcg aagcagccat gatggaaggc
       61 ctggatgacg gccccgactt cctctcggag gaagaccgcg gacttaaatc aataaatgta
      121 gatctccaaa gtgatgctgc tctacaagtg gacatttcgg acgctcttag tgaaagggat
      181 aaagtcaaat tcactgttca cacaaagagt tcattgccaa attttaagca aaatgagttt
      241 tcagtcgttc gacaacatga ggaatttatc tggcttcatg attcctttgt tgaaaatgaa
      301 gactatgcag gttacattat cccaccagca ccaccaagac ccgactttga tgcttcacgg
      361 gaaaaactgc agaagcttgg agaaggggaa gggtcaatga caaaggaaga attcacgaag
      421 atgaaacagg agctggaagc tgagtatctg gcaatcttca agaagacagt tgcgatgcat
      481 gaggtgttcc tgtgtcgtgt tgccgcgcat cccattttga gaaaagattt aaatttccac
      541 gtcttcttgg aatataatca agatttgagt gttcgaggaa aaaacaaaaa agaaaaactc
      601 gaggatttct ttaaaaacat ggttaagtca gcggatggag taattgtttc aggagtaaag
      661 gatgtagatg acttctttga acatgaacga acattccttc tagaatatca caaccgagtt
      721 aaggatgcat ctgctaagtc tgacagaatg acaagatctc acaaaagtgc tgctgatgat
      781 tacaatagaa ttgggtcttc actatatgct ttaggaactc aggactccac agatatatgc
      841 aagtttttcc tcaaagtttc agaactgttt gataaaacaa gaaaaataga agctcgggtg
      901 tctgctgatg aggacctcaa gctttctgac ctactaaagt actacttgcg ggagtctcaa
      961 gcagctaagg accttctcta tcgaaggtct aggtcgctgg tggactatga aaatgccaat
     1021 aaagcactgg acaaagcaag agcaaaaaac aaagatgtac tgcaggctga gacctcccaa
     1081 cagctgtgct gtcagaagtt tgaaaagata tccgaatctg caaaacaaga actgatagat
     1141 tttaagacaa gaagagttgc tgcattcaga aaaaatttag tggaacttgc agaactagaa
     1201 ctgaagcatg caaagggtaa cctccagcta ctgcagaact gccttgcggt tttaaatgga
     1261 gacacatagg cttcactcca ccttctgttg aaaagggctg ccttcagatc tggtttgttt
     1321 tcctgaggac ctccggcatc taagctcact gggaacaaaa gaaacagcgg gcacagtgca
     1381 tcggctcttc tgagagaccg tggagcagca gggctcaccc tgccacctcg cactccacct
     1441 tccaagaagc ccaaagttga accctctctt tctttaagta gcctgtctca actgtgttta
     1501 tctcgtatgt ggcgattctg tgcctgcagg ccttattacc taggaatcgc tcgtccagtt
     1561 ttaacattct cagtacattg ttcacgcaat ttaaaggttg cctttctgat tttttttaag
     1621 catcctgttc cttagttctt tcatgtattc gtgtaaagca tcttaatgag acttactttg
     1681 aattaatgaa cgtagaagtt atgggtcaga ctttatgtaa gctttatacg tatgatctct
     1741 gaagagaagc agatgcatta gtatgtttgc cttaaactcg tggactaaac caatattgta
     1801 aaccgccgag acaccagcgg catttttact ccgtgctcct tgtatcgctc tggaattcgg
     1861 ggtagccata ataaacctac tccgctagta tgctttacag tgcaggtctt ttttcttccc
     1921 ctcctacctt tctt
//
