LOCUS       NP_001102181             406 aa            linear   ROD 26-FEB-2024
DEFINITION  sorting nexin-6 [Rattus norvegicus].
ACCESSION   NP_001102181 XP_001075611 XP_343063
VERSION     NP_001102181.1
DBSOURCE    REFSEQ: accession NM_001108711.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 406)
  AUTHORS   Li Q, Li X, Wang L, Zhang Y and Chen L.
  TITLE     miR-98-5p Acts as a Target for Alzheimer's Disease by Regulating
            Abeta Production Through Modulating SNX6 Expression
  JOURNAL   J Mol Neurosci 60 (4), 413-420 (2016)
   PUBMED   27541017
REFERENCE   2  (residues 1 to 406)
  AUTHORS   Gallon M and Cullen PJ.
  TITLE     Retromer and sorting nexins in endosomal sorting
  JOURNAL   Biochem Soc Trans 43 (1), 33-47 (2015)
   PUBMED   25619244
  REMARK    Review article
REFERENCE   3  (residues 1 to 406)
  AUTHORS   Hao X, Wang Y, Ren F, Zhu S, Ren Y, Jia B, Li YP, Shi Y and Chang
            Z.
  TITLE     SNX25 regulates TGF-beta signaling by enhancing the receptor
            degradation
  JOURNAL   Cell Signal 23 (5), 935-946 (2011)
   PUBMED   21266196
REFERENCE   4  (residues 1 to 406)
  AUTHORS   Rivera J, Megias D and Bravo J.
  TITLE     Sorting nexin 6 interacts with breast cancer metastasis
            suppressor-1 and promotes transcriptional repression
  JOURNAL   J Cell Biochem 111 (6), 1464-1472 (2010)
   PUBMED   20830743
REFERENCE   5  (residues 1 to 406)
  AUTHORS   Hong Z, Yang Y, Zhang C, Niu Y, Li K, Zhao X and Liu JJ.
  TITLE     The retromer component SNX6 interacts with dynactin p150(Glued) and
            mediates endosome-to-TGN transport
  JOURNAL   Cell Res 19 (12), 1334-1349 (2009)
   PUBMED   19935774
REFERENCE   6  (residues 1 to 406)
  AUTHORS   Wassmer T, Attar N, Harterink M, van Weering JR, Traer CJ, Oakley
            J, Goud B, Stephens DJ, Verkade P, Korswagen HC and Cullen PJ.
  TITLE     The retromer coat complex coordinates endosomal sorting and
            dynein-mediated transport, with carrier recognition by the
            trans-Golgi network
  JOURNAL   Dev Cell 17 (1), 110-122 (2009)
   PUBMED   19619496
REFERENCE   7  (residues 1 to 406)
  AUTHORS   Cavet ME, Pang J, Yin G and Berk BC.
  TITLE     An epidermal growth factor (EGF) -dependent interaction between
            GIT1 and sorting nexin 6 promotes degradation of the EGF receptor
  JOURNAL   FASEB J 22 (10), 3607-3616 (2008)
   PUBMED   18523162
REFERENCE   8  (residues 1 to 406)
  AUTHORS   Sander LE, Frank SP, Bolat S, Blank U, Galli T, Bigalke H, Bischoff
            SC and Lorentz A.
  TITLE     Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not
            VAMP-2 or VAMP-3, are required for activation-induced degranulation
            of mature human mast cells
  JOURNAL   Eur J Immunol 38 (3), 855-863 (2008)
   PUBMED   18253931
REFERENCE   9  (residues 1 to 406)
  AUTHORS   Parks WT, Frank DB, Huff C, Renfrew Haft C, Martin J, Meng X, de
            Caestecker MP, McNally JG, Reddi A, Taylor SI, Roberts AB, Wang T
            and Lechleider RJ.
  TITLE     Sorting nexin 6, a novel SNX, interacts with the transforming
            growth factor-beta family of receptor serine-threonine kinases
  JOURNAL   J Biol Chem 276 (22), 19332-19339 (2001)
   PUBMED   11279102
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473947.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_343063.2, XP_001075611.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168856.1, SRR8487227.119521.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q23"
     Protein         1..406
                     /product="sorting nexin-6"
                     /calculated_mol_wt=46506
     Region          30..170
                     /region_name="PX_SNX6"
                     /note="The phosphoinositide binding Phox Homology domain
                     of Sorting Nexin 6; cd07292"
                     /db_xref="CDD:132825"
     Site            order(69..71,96..97,140)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:132825"
     Region          186..403
                     /region_name="BAR_SNX6"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain of Sorting
                     Nexin 6; cd07662"
                     /db_xref="CDD:153346"
     Site            order(216,219..220,223..224,226..227,230,233..234,237,
                     244..245,247..248,251,254..255,258..259,274,363,366..367,
                     369..371,374,377..378,380..382,384..385,388..389,391..392,
                     395..396,398..399)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153346"
     CDS             1..406
                     /gene="Snx6"
                     /coded_by="NM_001108711.1:49..1269"
                     /db_xref="GeneID:362738"
                     /db_xref="RGD:1304647"
ORIGIN      
        1 mmeglddgpd flseedrglk sinvdlqsda alqvdisdal serdkvkftv htksslpnfk
       61 qnefsvvrqh eefiwlhdsf venedyagyi ippapprpdf dasreklqkl gegegsmtke
      121 eftkmkqele aeylaifkkt vamhevflcr vaahpilrkd lnfhvfleyn qdlsvrgknk
      181 kekledffkn mvksadgviv sgvkdvddff ehertflley hnrvkdasak sdrmtrshks
      241 aaddynrigs slyalgtqds tdickfflkv selfdktrki earvsadedl klsdllkyyl
      301 resqaakdll yrrsrslvdy enankaldka raknkdvlqa etsqqlccqk fekisesakq
      361 elidfktrrv aafrknlvel aelelkhakg nlqllqncla vlngdt
//
