LOCUS       NM_001399298            1990 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus sorting nexin 5 (Snx5), mRNA.
ACCESSION   NM_001399298 XM_006235119
VERSION     NM_001399298.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1990)
  AUTHORS   Si,W., Huang,Z., Li,X., Zhao,L., Ji,Y., Li,H., Liu,X., Ye,S.,
            Chen,D., Liu,H., Kuang,W. and Zhu,M.
  TITLE     Super-enhancer-driven Sorting Nexin 5 expression promotes
            dopaminergic neuronal ferroptosis in Parkinson's disease models
  JOURNAL   Biochem Biophys Res Commun 567, 35-41 (2021)
   PUBMED   34134000
  REMARK    GeneRIF: Super-enhancer-driven Sorting Nexin 5 expression promotes
            dopaminergic neuronal ferroptosis in Parkinson's disease models.
REFERENCE   2  (bases 1 to 1990)
  AUTHORS   Li,F., Yang,J., Jones,J.E., Villar,V.A., Yu,P., Armando,I.,
            Felder,R.A. and Jose,P.A.
  TITLE     Sorting nexin 5 and dopamine d1 receptor regulate the expression of
            the insulin receptor in human renal proximal tubule cells
  JOURNAL   Endocrinology 156 (6), 2211-2221 (2015)
   PUBMED   25825816
REFERENCE   3  (bases 1 to 1990)
  AUTHORS   Gallon,M. and Cullen,P.J.
  TITLE     Retromer and sorting nexins in endosomal sorting
  JOURNAL   Biochem Soc Trans 43 (1), 33-47 (2015)
   PUBMED   25619244
  REMARK    Review article
REFERENCE   4  (bases 1 to 1990)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1990)
  AUTHORS   Villar,V.A., Armando,I., Sanada,H., Frazer,L.C., Russo,C.M.,
            Notario,P.M., Lee,H., Comisky,L., Russell,H.A., Yang,Y.,
            Jurgens,J.A., Jose,P.A. and Jones,J.E.
  TITLE     Novel role of sorting nexin 5 in renal D(1) dopamine receptor
            trafficking and function: implications for hypertension
  JOURNAL   FASEB J 27 (5), 1808-1819 (2013)
   PUBMED   23195037
REFERENCE   6  (bases 1 to 1990)
  AUTHORS   Koharudin,L.M., Furey,W., Liu,H., Liu,Y.J. and Gronenborn,A.M.
  TITLE     The phox domain of sorting nexin 5 lacks phosphatidylinositol
            3-phosphate (PtdIns(3)P) specificity and preferentially binds to
            phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)
  JOURNAL   J Biol Chem 284 (35), 23697-23707 (2009)
   PUBMED   19553671
  REMARK    GeneRIF: The phox domain of SNX5 preferentially binds to
            phosphatidylinositol 4,5-bisphosphate.
REFERENCE   7  (bases 1 to 1990)
  AUTHORS   Lim,J.P., Wang,J.T., Kerr,M.C., Teasdale,R.D. and Gleeson,P.A.
  TITLE     A role for SNX5 in the regulation of macropinocytosis
  JOURNAL   BMC Cell Biol 9, 58 (2008)
   PUBMED   18854019
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1990)
  AUTHORS   Wassmer,T., Attar,N., Bujny,M.V., Oakley,J., Traer,C.J. and
            Cullen,P.J.
  TITLE     A loss-of-function screen reveals SNX5 and SNX6 as potential
            components of the mammalian retromer
  JOURNAL   J Cell Sci 120 (Pt 1), 45-54 (2007)
   PUBMED   17148574
REFERENCE   9  (bases 1 to 1990)
  AUTHORS   Liu,H., Liu,Z.Q., Chen,C.X., Magill,S., Jiang,Y. and Liu,Y.J.
  TITLE     Inhibitory regulation of EGF receptor degradation by sorting nexin
            5
  JOURNAL   Biochem Biophys Res Commun 342 (2), 537-546 (2006)
   PUBMED   16487940
  REMARK    GeneRIF: Overexpression of SNX5 inhibits the degradation of
            epidermal growth factor (EGF) receptor.
REFERENCE   10 (bases 1 to 1990)
  AUTHORS   Merino-Trigo,A., Kerr,M.C., Houghton,F., Lindberg,A., Mitchell,C.,
            Teasdale,R.D. and Gleeson,P.A.
  TITLE     Sorting nexin 5 is localized to a subdomain of the early endosomes
            and is recruited to the plasma membrane following EGF stimulation
  JOURNAL   J Cell Sci 117 (Pt 26), 6413-6424 (2004)
   PUBMED   15561769
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 6, 2022 this sequence version replaced XM_006235119.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC160883.1, SRR26643294.15394.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000003.1  152094416-152094508 c
            94-176              JAXUCZ010000003.1  152094100-152094182 c
            177-281             JAXUCZ010000003.1  152085700-152085804 c
            282-392             JAXUCZ010000003.1  152084875-152084985 c
            393-514             JAXUCZ010000003.1  152083808-152083929 c
            515-638             JAXUCZ010000003.1  152082465-152082588 c
            639-734             JAXUCZ010000003.1  152081515-152081610 c
            735-840             JAXUCZ010000003.1  152079951-152080056 c
            841-916             JAXUCZ010000003.1  152079787-152079862 c
            917-956             JAXUCZ010000003.1  152078815-152078854 c
            957-1043            JAXUCZ010000003.1  152078634-152078720 c
            1044-1203           JAXUCZ010000003.1  152077472-152077631 c
            1204-1289           JAXUCZ010000003.1  152076556-152076641 c
            1290-1990           JAXUCZ010000003.1  152075258-152075958 c
FEATURES             Location/Qualifiers
     source          1..1990
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1990
                     /gene="Snx5"
                     /note="sorting nexin 5"
                     /db_xref="GeneID:296199"
                     /db_xref="RGD:1310190"
     exon            1..93
                     /gene="Snx5"
                     /inference="alignment:Splign:2.1.0"
     exon            94..176
                     /gene="Snx5"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1340
                     /gene="Snx5"
                     /codon_start=1
                     /product="sorting nexin-5"
                     /protein_id="NP_001386227.1"
                     /db_xref="GeneID:296199"
                     /db_xref="RGD:1310190"
                     /translation="MAAVPELLEQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDK
                     VKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLTETTDYAGLIIPPAPTKPDFDGP
                     REKMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDR
                     NFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFSGVKEVDDFFEQEKNFLIN
                     YYNRIKDSCAKADKMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKL
                     RKVEGRVSSDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSK
                     DVKLAETHQQECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIKHARNNVS
                     LLQSCIDLFKNN"
     exon            177..281
                     /gene="Snx5"
                     /inference="alignment:Splign:2.1.0"
     exon            282..392
                     /gene="Snx5"
                     /inference="alignment:Splign:2.1.0"
     exon            393..514
                     /gene="Snx5"
                     /inference="alignment:Splign:2.1.0"
     exon            515..638
                     /gene="Snx5"
                     /inference="alignment:Splign:2.1.0"
     exon            639..734
                     /gene="Snx5"
                     /inference="alignment:Splign:2.1.0"
     exon            735..840
                     /gene="Snx5"
                     /inference="alignment:Splign:2.1.0"
     exon            841..916
                     /gene="Snx5"
                     /inference="alignment:Splign:2.1.0"
     exon            917..956
                     /gene="Snx5"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1043
                     /gene="Snx5"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1203
                     /gene="Snx5"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1289
                     /gene="Snx5"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1990
                     /gene="Snx5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttctcgag gcgtgcctcg ctgggagagg gttcggaccc tgcgtccccg tcccggccct
       61 acagtgctgg tgtccgcgtg gcacggagcg aggccagacg gcccctgctc gaggcccgcg
      121 tcgccatggc cgcggttccc gagttactgg agcagcagga ggaggatcgc agcaagttga
      181 ggtctgtgtc tgtggacctg aatgttgacc catcgcttca gattgacata cctgatgcac
      241 tcagtgagag agataaggtc aagtttacag ttcacaccaa gaccacactg cccacatttc
      301 agagcccaga gttttctgtt acaaggcaac atgaagactt tgtgtggctg catgacactc
      361 ttactgaaac aacagattat gccgggctta tcatccctcc tgctcctaca aagccagact
      421 ttgatggccc tcgagagaag atgcagaaac tgggagaagg tgaaggatct atgacaaaag
      481 aagaatttgc caagatgaag caagaactgg aagctgagta tctcgctgtc tttaagaaga
      541 ctgtgtcctc acatgaagtc tttcttcagc ggctttcttc tcaccctgtt ctcagtaaag
      601 accgaaactt ccatgttttc ttggaatatg atcaggatct aagtgttagg cggaaaaata
      661 ccaaggagat gtttggaggc ttttttaaaa gtgttgtgaa gagcgctgat gaggtccttt
      721 tttctggagt taaggaggtg gatgacttct ttgagcaaga gaagaacttc cttattaact
      781 attacaacag gatcaaggac tcctgtgcta aagcggacaa gatgaccaga tctcacaaaa
      841 atgttgctga tgattacatc cacactgcag cctgcttgca tagcctggcc ttagaagagc
      901 ccacagtcat caaaaagtac ctgttgaaag ttgcagagct atttgaaaaa cttaggaaag
      961 tggaaggtcg agtctcatca gatgaagatt taaaactgac agagctcctc cgatactaca
     1021 tgctcaacat agaggctgca aaggatctcc tatacagacg cacaaaggcc ctaattgact
     1081 atgagaattc aaacaaagct ttggacaagg cccggttaaa aagcaaagat gtcaagttgg
     1141 cagagactca tcagcaggaa tgctgccaga agtttgaaca gctttctgaa tctgcaaaag
     1201 aagagctgat aaacttcaaa cggaagagag tggcagcatt tcgaaagaac ctaattgaaa
     1261 tgtctgaact ggaaataaag catgccagaa acaatgtctc cctgttgcag agctgcattg
     1321 atttattcaa gaacaactga cctgtcttta ctctggagga cgccaatgtg aaagccagca
     1381 tcacttgcac ttaaatcatt actgctaaag aaatagcttt gactagttta aaatcatgtg
     1441 aataaatatt ttgatttcta aaaatcttaa cacttaacca tgttggttta aaaatatttt
     1501 cattgcatgt tacttggaca taattaatcc ttttcttatg catttaatac ctcagagtag
     1561 gtagaatcta atgattctcc tatagatgtc aggaatgact gataactggt atagagatgt
     1621 gtgccttctg ggattgagaa gcaatagcct ggcccttgtc tgtctcaata tttcctgtgc
     1681 ccctacagac atgtcaggtt cgaattacaa cacatgggaa ctgtttgtgg gctggtggta
     1741 gacactctgt tctttaatta ggtagatttt gcgccctctt gtcaagatca cttcagatgc
     1801 ttgtacagta acaagcgaga agacctcatg tctttataca tccttacagc tccatttttg
     1861 taactgggat ataaataact tgagagaaaa ggagaatcta gggttcttaa cattccctga
     1921 tggtggggca tgtgtgtttg tgctttggat gtttttataa agtatgtaat aaaaataatc
     1981 catgttacca
//
