LOCUS       NP_001386227             404 aa            linear   ROD 31-MAR-2024
DEFINITION  sorting nexin-5 [Rattus norvegicus].
ACCESSION   NP_001386227 XP_006235181
VERSION     NP_001386227.1
DBSOURCE    REFSEQ: accession NM_001399298.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 404)
  AUTHORS   Si,W., Huang,Z., Li,X., Zhao,L., Ji,Y., Li,H., Liu,X., Ye,S.,
            Chen,D., Liu,H., Kuang,W. and Zhu,M.
  TITLE     Super-enhancer-driven Sorting Nexin 5 expression promotes
            dopaminergic neuronal ferroptosis in Parkinson's disease models
  JOURNAL   Biochem Biophys Res Commun 567, 35-41 (2021)
   PUBMED   34134000
  REMARK    GeneRIF: Super-enhancer-driven Sorting Nexin 5 expression promotes
            dopaminergic neuronal ferroptosis in Parkinson's disease models.
REFERENCE   2  (residues 1 to 404)
  AUTHORS   Li,F., Yang,J., Jones,J.E., Villar,V.A., Yu,P., Armando,I.,
            Felder,R.A. and Jose,P.A.
  TITLE     Sorting nexin 5 and dopamine d1 receptor regulate the expression of
            the insulin receptor in human renal proximal tubule cells
  JOURNAL   Endocrinology 156 (6), 2211-2221 (2015)
   PUBMED   25825816
REFERENCE   3  (residues 1 to 404)
  AUTHORS   Gallon,M. and Cullen,P.J.
  TITLE     Retromer and sorting nexins in endosomal sorting
  JOURNAL   Biochem Soc Trans 43 (1), 33-47 (2015)
   PUBMED   25619244
  REMARK    Review article
REFERENCE   4  (residues 1 to 404)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 404)
  AUTHORS   Villar,V.A., Armando,I., Sanada,H., Frazer,L.C., Russo,C.M.,
            Notario,P.M., Lee,H., Comisky,L., Russell,H.A., Yang,Y.,
            Jurgens,J.A., Jose,P.A. and Jones,J.E.
  TITLE     Novel role of sorting nexin 5 in renal D(1) dopamine receptor
            trafficking and function: implications for hypertension
  JOURNAL   FASEB J 27 (5), 1808-1819 (2013)
   PUBMED   23195037
REFERENCE   6  (residues 1 to 404)
  AUTHORS   Koharudin,L.M., Furey,W., Liu,H., Liu,Y.J. and Gronenborn,A.M.
  TITLE     The phox domain of sorting nexin 5 lacks phosphatidylinositol
            3-phosphate (PtdIns(3)P) specificity and preferentially binds to
            phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)
  JOURNAL   J Biol Chem 284 (35), 23697-23707 (2009)
   PUBMED   19553671
  REMARK    GeneRIF: The phox domain of SNX5 preferentially binds to
            phosphatidylinositol 4,5-bisphosphate.
REFERENCE   7  (residues 1 to 404)
  AUTHORS   Lim,J.P., Wang,J.T., Kerr,M.C., Teasdale,R.D. and Gleeson,P.A.
  TITLE     A role for SNX5 in the regulation of macropinocytosis
  JOURNAL   BMC Cell Biol 9, 58 (2008)
   PUBMED   18854019
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 404)
  AUTHORS   Wassmer,T., Attar,N., Bujny,M.V., Oakley,J., Traer,C.J. and
            Cullen,P.J.
  TITLE     A loss-of-function screen reveals SNX5 and SNX6 as potential
            components of the mammalian retromer
  JOURNAL   J Cell Sci 120 (Pt 1), 45-54 (2007)
   PUBMED   17148574
REFERENCE   9  (residues 1 to 404)
  AUTHORS   Liu,H., Liu,Z.Q., Chen,C.X., Magill,S., Jiang,Y. and Liu,Y.J.
  TITLE     Inhibitory regulation of EGF receptor degradation by sorting nexin
            5
  JOURNAL   Biochem Biophys Res Commun 342 (2), 537-546 (2006)
   PUBMED   16487940
  REMARK    GeneRIF: Overexpression of SNX5 inhibits the degradation of
            epidermal growth factor (EGF) receptor.
REFERENCE   10 (residues 1 to 404)
  AUTHORS   Merino-Trigo,A., Kerr,M.C., Houghton,F., Lindberg,A., Mitchell,C.,
            Teasdale,R.D. and Gleeson,P.A.
  TITLE     Sorting nexin 5 is localized to a subdomain of the early endosomes
            and is recruited to the plasma membrane following EGF stimulation
  JOURNAL   J Cell Sci 117 (Pt 26), 6413-6424 (2004)
   PUBMED   15561769
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 6, 2022 this sequence version replaced XP_006235181.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC160883.1, SRR26643294.15394.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..404
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     Protein         1..404
                     /product="sorting nexin-5"
                     /calculated_mol_wt=46662
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y5X3; propagated from
                     UniProtKB/Swiss-Prot (B1H267.1)"
     Region          29..169
                     /region_name="PX_SNX5"
                     /note="The phosphoinositide binding Phox Homology domain
                     of Sorting Nexin 5; cd07291"
                     /db_xref="CDD:132824"
     Site            order(68..70,95..96,139)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:132824"
     Region          169..261
                     /region_name="Interaction with DOCK1.
                     /evidence=ECO:0000250|UniProtKB:Q9Y5X3"
                     /note="propagated from UniProtKB/Swiss-Prot (B1H267.1)"
     Region          183..200
                     /region_name="Membrane-binding amphipathic helix.
                     /evidence=ECO:0000250|UniProtKB:Q9Y5X3"
                     /note="propagated from UniProtKB/Swiss-Prot (B1H267.1)"
     Region          185..402
                     /region_name="BAR_SNX5"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain of Sorting
                     Nexin 5; cd07663"
                     /db_xref="CDD:153347"
     Site            193
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y5X3; propagated from
                     UniProtKB/Swiss-Prot (B1H267.1)"
     Site            order(215,218..219,222..223,225..226,229,232..233,236,
                     243..244,246..247,250,253..254,257..258,273,362,365..366,
                     368..370,373,376..377,379..381,383..384,387..388,390..391,
                     394..395,397..398)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153347"
     Site            275
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y5X3; propagated from
                     UniProtKB/Swiss-Prot (B1H267.1)"
     CDS             1..404
                     /gene="Snx5"
                     /coded_by="NM_001399298.1:126..1340"
                     /db_xref="GeneID:296199"
                     /db_xref="RGD:1310190"
ORIGIN      
        1 maavpelleq qeedrsklrs vsvdlnvdps lqidipdals erdkvkftvh tkttlptfqs
       61 pefsvtrqhe dfvwlhdtlt ettdyaglii ppaptkpdfd gprekmqklg egegsmtkee
      121 fakmkqelea eylavfkktv sshevflqrl sshpvlskdr nfhvfleydq dlsvrrkntk
      181 emfggffksv vksadevlfs gvkevddffe qeknflinyy nrikdscaka dkmtrshknv
      241 addyihtaac lhslaleept vikkyllkva elfeklrkve grvssdedlk ltellryyml
      301 nieaakdlly rrtkalidye nsnkaldkar lkskdvklae thqqeccqkf eqlsesakee
      361 linfkrkrva afrknliems eleikharnn vsllqscidl fknn
//
