LOCUS       NM_001127488            3949 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus sorting nexin 33 (Snx33), mRNA.
ACCESSION   NM_001127488 XM_001073948 XM_236271
VERSION     NM_001127488.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3949)
  AUTHORS   van Weering,J.R., Sessions,R.B., Traer,C.J., Kloer,D.P.,
            Bhatia,V.K., Stamou,D., Carlsson,S.R., Hurley,J.H. and Cullen,P.J.
  TITLE     Molecular basis for SNX-BAR-mediated assembly of distinct endosomal
            sorting tubules
  JOURNAL   EMBO J 31 (23), 4466-4480 (2012)
   PUBMED   23085988
REFERENCE   2  (bases 1 to 3949)
  AUTHORS   Ma,M.P. and Chircop,M.
  TITLE     SNX9, SNX18 and SNX33 are required for progression through and
            completion of mitosis
  JOURNAL   J Cell Sci 125 (Pt 18), 4372-4382 (2012)
   PUBMED   22718350
REFERENCE   3  (bases 1 to 3949)
  AUTHORS   Dislich,B., Than,M.E. and Lichtenthaler,S.F.
  TITLE     Specific amino acids in the BAR domain allow homodimerization and
            prevent heterodimerization of sorting nexin 33
  JOURNAL   Biochem J 433 (1), 75-83 (2011)
   PUBMED   20964629
REFERENCE   4  (bases 1 to 3949)
  AUTHORS   Wang,J.T., Kerr,M.C., Karunaratne,S., Jeanes,A., Yap,A.S. and
            Teasdale,R.D.
  TITLE     The SNX-PX-BAR family in macropinocytosis: the regulation of
            macropinosome formation by SNX-PX-BAR proteins
  JOURNAL   PLoS One 5 (10), e13763 (2010)
   PUBMED   21048941
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3949)
  AUTHORS   Zhang,J., Zhang,X., Guo,Y., Xu,L. and Pei,D.
  TITLE     Sorting nexin 33 induces mammalian cell micronucleated phenotype
            and actin polymerization by interacting with Wiskott-Aldrich
            syndrome protein
  JOURNAL   J Biol Chem 284 (32), 21659-21669 (2009)
   PUBMED   19487689
REFERENCE   6  (bases 1 to 3949)
  AUTHORS   Heiseke,A., Schobel,S., Lichtenthaler,S.F., Vorberg,I.,
            Groschup,M.H., Kretzschmar,H., Schatzl,H.M. and Nunziante,M.
  TITLE     The novel sorting nexin SNX33 interferes with cellular PrP
            formation by modulation of PrP shedding
  JOURNAL   Traffic 9 (7), 1116-1129 (2008)
   PUBMED   18419754
REFERENCE   7  (bases 1 to 3949)
  AUTHORS   Schobel,S., Neumann,S., Hertweck,M., Dislich,B., Kuhn,P.H.,
            Kremmer,E., Seed,B., Baumeister,R., Haass,C. and Lichtenthaler,S.F.
  TITLE     A novel sorting nexin modulates endocytic trafficking and
            alpha-secretase cleavage of the amyloid precursor protein
  JOURNAL   J Biol Chem 283 (21), 14257-14268 (2008)
   PUBMED   18353773
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            [WARNING] On Apr 15, 2024 this sequence was replaced by
            NM_001127488.2.
            
            On or before May 22, 2008 this sequence version replaced
            XM_236271.4, XM_001073948.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.28481.1,
                                           SRR26643293.45454.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2379              JAXUCZ010000008.1  66221131-66223509   c
            2380-3949           JAXUCZ010000008.1  66213133-66214702   c
FEATURES             Location/Qualifiers
     source          1..3949
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..3949
                     /gene="Snx33"
                     /gene_synonym="Sh3px3"
                     /note="sorting nexin 33"
                     /db_xref="GeneID:315696"
                     /db_xref="RGD:1307898"
     exon            1..2379
                     /gene="Snx33"
                     /gene_synonym="Sh3px3"
                     /inference="alignment:Splign:2.1.0"
     CDS             909..2633
                     /gene="Snx33"
                     /gene_synonym="Sh3px3"
                     /note="SH3 and PX domain containing 3"
                     /codon_start=1
                     /product="sorting nexin-33"
                     /protein_id="NP_001120960.1"
                     /db_xref="GeneID:315696"
                     /db_xref="RGD:1307898"
                     /translation="MALKGRALYDFHSENKEEISIQQDEDLVIFSETSLDGWLQGQNS
                     RGETGLFPASYVEIVRPGISTNHGDYSNSPAGSLGTQVSLYSSPSTASPARSSGGSGF
                     LSNQGSFEDDDDDDWDDWDDGCTVVEEPLAGGLGTNGHPPLNLSYPGAYPNQHMAFRP
                     KAPLERQDSLASAKRGSVVGRNLNRFSCFVRSGVEAFILGDVPMMAKIAETYSIEMGP
                     RGPQWKANPHPFACSIEDPTKQTKFKGIKSYISYKLTPTHAGSPVYRRYKHFDWLYNR
                     LLHKFTVISVPHLPEKQATGRFEEDFIEKRKRRLILWMDHMTSHPVLSQYEGFQHFLS
                     CLDDKQWKMGKRRAEKDEMVGASFLLTFQIPTEHQDLQDVEDRVDAFKAFSKKMDDSV
                     LQLSTVAAELVRKHVGGFRKEFQKLGSAFQAISHAFQMDPPFRSEALNNAISHTGRTY
                     ETVGEMFAGQPKHDLFQMLDTLSLYQGLLSNFPDIIHLQKGAFAKVKESQRMSDEGRM
                     AQEEADGIRRRCRVVGFALQAEMNHFHQRRELDFKHMMQSYLRQQILFYQRVGQQLEK
                     TLRMYDHL"
     exon            2380..3949
                     /gene="Snx33"
                     /gene_synonym="Sh3px3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaggggttc tgggtctccg atccgggtca gcttcgtact ctgaaactgc cgaggaatta
       61 ggcaaacaaa agaggcactg agagaaagag gccagaagtc ctctgcgccg cttgtcgcgc
      121 ccccttgtta tctgggggtg ggggctggcc atttgcaggg cgggaagagg gcaccagagc
      181 gggtgagacc gggtcgcacc ccctaggtcg agtagttatc ggctggttgt gcaagctttg
      241 gcccttgttt tcctggcctg gctcgtttgg aggccggaca catccaccct tggaattggt
      301 tcaggactct gctgttattc tccttgcccc tcttggattt tctggattct tgaagactcg
      361 gtggccgggg aggagagagg aaggaggaag gagcagatct tcagaggaat gtgagagcct
      421 cccaaagccg gagcagccag taggagcgga gagccaggag aggcagaacc ttgcctgcgt
      481 ttctgggacc gtggtctgag gttaattctc ttcctttgta caacattgtt ctagtagaaa
      541 gtgtctgtcc cgttcttgtt ctagcagagc tggtttctcc aagtcatttg acttttctgc
      601 ttggtgtgtg gggagggaga gactcgctcc ttttcatggg ctgcaaaggg agaggagaaa
      661 gactgcggcc atgaccaacc cctccctgca tacaggcaga taccccaagg ctgtttctgg
      721 accatggaca cttctttgac caagaggcag ttagacagca tctgtgcagc tgagaccctg
      781 tccaaggggc tcagtagggc gtactagact ttgagctgca agcacttttc ttttggactc
      841 cctgctggac aacctgggtc tgggcaaggc attttccttc cagtcttgac ctaacagata
      901 acttagccat ggcactgaaa ggccgagccc tctatgattt ccacagcgag aacaaggagg
      961 aaatcagcat ccagcaggac gaagacttgg ttatcttcag cgagacctca ctggacggct
     1021 ggctgcaggg acagaacagc cgtggggaga cagggctctt ccctgcttct tacgttgaga
     1081 ttgttcgtcc tggcatcagc accaaccatg gggactattc caacagccct gcaggctccc
     1141 tgggcaccca ggtgagtttg tatagcagcc ctagtacggc cagtccagcc aggagtagtg
     1201 ggggcagtgg cttcctctca aaccaaggaa gctttgagga tgatgatgac gatgactggg
     1261 atgactggga tgatggatgc acagtggtag aagagccact ggctggtggc ctaggtacca
     1321 atggacaccc tccacttaac ctctcctacc cgggtgccta ccccaaccag catatggctt
     1381 tcagacccaa ggcacccctg gaaaggcagg acagtctagc gtctgccaag cggggcagtg
     1441 ttgtaggacg gaacctcaat cgtttctcat gctttgtacg ctctggagtg gaggccttca
     1501 tccttggtga tgtgcccatg atggccaaga ttgctgagac ctactccatt gagatgggcc
     1561 cacgtgggcc tcagtggaag gccaatcccc acccatttgc ctgctccata gaggacccca
     1621 ccaagcagac caagttcaaa ggcattaaaa gttacatctc ctacaagctt acgcccaccc
     1681 acgctggctc acctgtttac cgccgttaca aacactttga ctggctatac aaccgccttc
     1741 tgcacaagtt cacagtaatt tcagtgcccc acctgcctga gaagcaggcc acaggccgct
     1801 ttgaggagga cttcattgag aaacgtaagc gaaggctcat cctctggatg gaccacatga
     1861 ccagccaccc tgtgctctcc cagtatgagg gcttccagca cttcctcagc tgcctggatg
     1921 acaaacagtg gaagatgggg aaacgccgag cagagaagga tgagatggtg ggtgccagtt
     1981 tcctgctcac cttccagatc cccacagaac accaggatct gcaggatgta gaggatcggg
     2041 tggacgcatt caaggctttc agtaagaaga tggatgacag cgtcctacag cttagcactg
     2101 tagcagcaga attggtgcgg aaacatgtag gaggcttccg caaggaattc cagaagctcg
     2161 gaagtgcctt ccaggccatt agccatgcct tccagatgga ccctcccttt aggtctgagg
     2221 ctctcaacaa tgccatttct cacactggcc ggacctatga aaccgttgga gaaatgtttg
     2281 ctggacagcc caagcatgac ctcttccaaa tgctcgacac actgtctctc taccagggcc
     2341 tactctccaa cttccctgac attatccacc tgcagaaagg tgcctttgcc aaggtgaagg
     2401 agagccagcg catgagtgat gagggccgca tggctcagga agaggcagac ggtattcgca
     2461 ggcgctgccg tgtggtaggc tttgccctgc aggccgagat gaaccatttc caccagcgcc
     2521 gtgagctcga cttcaagcat atgatgcaaa gctacctgcg ccagcagatc cttttctacc
     2581 agcgggtggg ccagcagctg gagaagacgc tccgcatgta tgatcacctc tgacagactc
     2641 tgaccagcta tgcagggcct cttcccaccg gtccacccca ctcctgtcat tagcagcggc
     2701 tcaggtgcac agggcgggtg aggtaggcag cctgttcttt ctaggagaag ggactttgga
     2761 gaagtcctgg tatccttggc gtaatttccc ctgactttag agatggatga atggcagtag
     2821 ccctttgagc caaagcctgg gccgctggtc agtccctaaa gagcaacctt ctctggagcc
     2881 tatagtgcac tctcacccgg ccaccacact ctgttcattc cctggactct atagactgcc
     2941 gtggccttgg ctgagacatt ggtgaccaag gggctggaac ttgcctgtcc ccgaagagcc
     3001 acttttcaag atggttatta gacaatgcaa actggtaggt gacacctgaa gattcatggg
     3061 aactctcctc aaaggaccac agaactctgc tggtcagggg gacacttcat ggagtaggtg
     3121 acattccagc aatcatcttg aagaattcca aggacctaca aaggacagta aatggaaagg
     3181 acgacatttt gggcagaaga gcgatgtggt tccctcccct tacctttccc aaagcaagtt
     3241 tagtgtcctt tctgtgggtt gtgatctgtg tgacagaggg gagggacatg cttgctctgt
     3301 ggtccctggc tttccctgcc ctacccatgc ctttgcagga gggactgcag gccagctccc
     3361 tcctataggc cttggattcc tcaatgcttt ggttgaggga ccctgcccta cttttccttg
     3421 attaggggac catgcaacaa ctttcccttc tgtatgttca aggtgctcaa tctagggagc
     3481 actgggcccc cggtggtacc tttctggagg gaactctcaa gttaccagca gtgactcccc
     3541 attctcctag caggtccagg tcgagttccc aggcaccatt gtttctgtgg cttggtcttc
     3601 tcaagttact cccattgcac agtgggaaat ctgacagaaa gaaactggga actcccgacc
     3661 cccatgtgtg gccagaatca ctggtcagtt tgcgtagtca cccacctatg tttacattct
     3721 acagaaatta ctgctctgta accctcagtc ctgggtgcgg cccagcagcg tgttgttggg
     3781 aaatgaccct gcccctggcc tccctgggaa gccatgttct gctcctaggt cctgctgctg
     3841 gattcttttc ttcataaact tttacagtta actagtgtaa cagaatcaca gcctcttctt
     3901 tttgaatcct ggaagcaggg agagttgtgg gggtggggtg tgtttgaca
//
