LOCUS       NM_001044283            1490 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus sorting nexin 3 (Snx3), mRNA.
ACCESSION   NM_001044283 XM_001068918
VERSION     NM_001044283.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1490)
  AUTHORS   Gallon,M. and Cullen,P.J.
  TITLE     Retromer and sorting nexins in endosomal sorting
  JOURNAL   Biochem Soc Trans 43 (1), 33-47 (2015)
   PUBMED   25619244
  REMARK    Review article
REFERENCE   2  (bases 1 to 1490)
  AUTHORS   Harrison,M.S., Hung,C.S., Liu,T.T., Christiano,R., Walther,T.C. and
            Burd,C.G.
  TITLE     A mechanism for retromer endosomal coat complex assembly with cargo
  JOURNAL   Proc Natl Acad Sci U S A 111 (1), 267-272 (2014)
   PUBMED   24344282
REFERENCE   3  (bases 1 to 1490)
  AUTHORS   Chua,R.Y. and Wong,S.H.
  TITLE     SNX3 recruits to phagosomes and negatively regulates phagocytosis
            in dendritic cells
  JOURNAL   Immunology 139 (1), 30-47 (2013)
   PUBMED   23237080
REFERENCE   4  (bases 1 to 1490)
  AUTHORS   Chen,C., Garcia-Santos,D., Ishikawa,Y., Seguin,A., Li,L.,
            Fegan,K.H., Hildick-Smith,G.J., Shah,D.I., Cooney,J.D., Chen,W.,
            King,M.J., Yien,Y.Y., Schultz,I.J., Anderson,H., Dalton,A.J.,
            Freedman,M.L., Kingsley,P.D., Palis,J., Hattangadi,S.M.,
            Lodish,H.F., Ward,D.M., Kaplan,J., Maeda,T., Ponka,P. and Paw,B.H.
  TITLE     Snx3 regulates recycling of the transferrin receptor and iron
            assimilation
  JOURNAL   Cell Metab 17 (3), 343-352 (2013)
   PUBMED   23416069
REFERENCE   5  (bases 1 to 1490)
  AUTHORS   Pons,V., Ustunel,C., Rolland,C., Torti,E., Parton,R.G. and
            Gruenberg,J.
  TITLE     SNX12 role in endosome membrane transport
  JOURNAL   PLoS One 7 (6), e38949 (2012)
   PUBMED   22719997
REFERENCE   6  (bases 1 to 1490)
  AUTHORS   Dong,H., Yuan,H., Jin,W., Shen,Y., Xu,X. and Wang,H.
  TITLE     Involvement of beta3A subunit of adaptor protein-3 in intracellular
            trafficking of receptor-like protein tyrosine phosphatase PCP-2
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 39 (7), 540-546 (2007)
   PUBMED   17622474
REFERENCE   7  (bases 1 to 1490)
  AUTHORS   Zhong,Q., Watson,M.J., Lazar,C.S., Hounslow,A.M., Waltho,J.P. and
            Gill,G.N.
  TITLE     Determinants of the endosomal localization of sorting nexin 1
  JOURNAL   Mol Biol Cell 16 (4), 2049-2057 (2005)
   PUBMED   15673616
REFERENCE   8  (bases 1 to 1490)
  AUTHORS   Xu,Y., Hortsman,H., Seet,L., Wong,S.H. and Hong,W.
  TITLE     SNX3 regulates endosomal function through its PX-domain-mediated
            interaction with PtdIns(3)P
  JOURNAL   Nat Cell Biol 3 (7), 658-666 (2001)
   PUBMED   11433298
REFERENCE   9  (bases 1 to 1490)
  AUTHORS   Parks,W.T., Frank,D.B., Huff,C., Renfrew Haft,C., Martin,J.,
            Meng,X., de Caestecker,M.P., McNally,J.G., Reddi,A., Taylor,S.I.,
            Roberts,A.B., Wang,T. and Lechleider,R.J.
  TITLE     Sorting nexin 6, a novel SNX, interacts with the transforming
            growth factor-beta family of receptor serine-threonine kinases
  JOURNAL   J Biol Chem 276 (22), 19332-19339 (2001)
   PUBMED   11279102
REFERENCE   10 (bases 1 to 1490)
  AUTHORS   Haft,C.R., de la Luz Sierra,M., Barr,V.A., Haft,D.H. and
            Taylor,S.I.
  TITLE     Identification of a family of sorting nexin molecules and
            characterization of their association with receptors
  JOURNAL   Mol Cell Biol 18 (12), 7278-7287 (1998)
   PUBMED   9819414
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC107918.1.
            
            On Aug 24, 2006 this sequence version replaced XM_001068918.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107918.1, FQ234595.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1490
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q13"
     gene            1..1490
                     /gene="Snx3"
                     /note="sorting nexin 3"
                     /db_xref="GeneID:684097"
                     /db_xref="RGD:1595151"
     exon            1..488
                     /gene="Snx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             327..815
                     /gene="Snx3"
                     /codon_start=1
                     /product="sorting nexin-3"
                     /protein_id="NP_001037748.1"
                     /db_xref="GeneID:684097"
                     /db_xref="RGD:1595151"
                     /translation="MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRG
                     RFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLP
                     FRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIR
                     HA"
     exon            489..584
                     /gene="Snx3"
                     /inference="alignment:Splign:2.1.0"
     exon            585..709
                     /gene="Snx3"
                     /inference="alignment:Splign:2.1.0"
     exon            710..1420
                     /gene="Snx3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcccggt atccttggcg cccaccgttc cgtgacgccg ccgcccctca gccccacccc
       61 gcagtgtccc tccggggccg ccgcggggcc tgcgaaccgg gcgcggcgtt caggccagtc
      121 agctgtttct ccttgggcaa agggcggaag cccgagcagc ctggggcgga gcttcgcgta
      181 gagcgaacgc ccacccgtcc tacgtgctcg ttcgcctctg ttcgctgcgc gcgagccggg
      241 agtcccccgc ggcgggcggc ggcggcggcg ttggcggaag gaggcggcgg tggagagaag
      301 cccgcggctg ccgcggcgat agcgaaatgg cggagaccgt agcggacacc cggcggctca
      361 tcaccaagcc gcagaacctg aatgacgcct acgggccgcc cagcaacttc ctcgagatcg
      421 acgtgagcaa tccgcagact gtgggggtcg gccggggccg cttcaccacc tacgagatca
      481 gggtcaagac caatcttcct atcttcaagc tgaaggaatc tactgttaga agaagataca
      541 gtgactttga gtggcttcga agtgaactag agagagagag caaggttgtc gttcccccac
      601 tcccggggaa agcatttttg cggcagcttc cttttagagg agacgatgga atatttgacg
      661 ataatttcat cgaggaaagg aagcaagggc tggaacagtt cataaacaag gtcgctggtc
      721 atcctctggc ccagaatgaa cgttgtcttc acatgttttt acaggatgaa atcatagata
      781 aaagctatac tccatctaaa ataagacatg cctgagtttg gcaagaagag gcaaacccca
      841 agaccatgaa tgattcgtcc gtaccaatga agacgttgta actaacttag catgctgcag
      901 acactgctgt aacaaacgcg cacgccctgg atgtactaac actcacgctc cctttcattc
      961 tgtctgtttg gcaagacgtt catttgcttt agtggaaact ccctcacttc tccagccttt
     1021 ctaagtagcc cttcccaccg tgtccctccg tgtgcactgt agcctcagcc ctgtagacct
     1081 gcagtgttct gactaaagct gccgacttgc tcgaatttgc agtttctgtg tcgtgtgctt
     1141 cttgaatctg attgactagg atatttctcc ccacccctga tgtgtgatgt caccacttgg
     1201 tcctaattta tgtgcaggag cacgacacca tttgtctcca gtgccacaca tacgaggtgt
     1261 actttgtgtg cagaatgtgt cttccttctg gcctgtaatc cccttcacat gagagattaa
     1321 tgagggaaat ctttatattc tgtataaaac aaaatcaaat ttatatacta aaatcatttg
     1381 tctaaaattt aagttgtttt caaataaaag ttgaaatgca aaaaaaaaaa aaaaaaaaaa
     1441 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
