LOCUS       NP_001037748             162 aa            linear   ROD 27-APR-2025
DEFINITION  sorting nexin-3 [Rattus norvegicus].
ACCESSION   NP_001037748 XP_001068918
VERSION     NP_001037748.1
DBSOURCE    REFSEQ: accession NM_001044283.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 162)
  AUTHORS   Gallon,M. and Cullen,P.J.
  TITLE     Retromer and sorting nexins in endosomal sorting
  JOURNAL   Biochem Soc Trans 43 (1), 33-47 (2015)
   PUBMED   25619244
  REMARK    Review article
REFERENCE   2  (residues 1 to 162)
  AUTHORS   Harrison,M.S., Hung,C.S., Liu,T.T., Christiano,R., Walther,T.C. and
            Burd,C.G.
  TITLE     A mechanism for retromer endosomal coat complex assembly with cargo
  JOURNAL   Proc Natl Acad Sci U S A 111 (1), 267-272 (2014)
   PUBMED   24344282
REFERENCE   3  (residues 1 to 162)
  AUTHORS   Chua,R.Y. and Wong,S.H.
  TITLE     SNX3 recruits to phagosomes and negatively regulates phagocytosis
            in dendritic cells
  JOURNAL   Immunology 139 (1), 30-47 (2013)
   PUBMED   23237080
REFERENCE   4  (residues 1 to 162)
  AUTHORS   Chen,C., Garcia-Santos,D., Ishikawa,Y., Seguin,A., Li,L.,
            Fegan,K.H., Hildick-Smith,G.J., Shah,D.I., Cooney,J.D., Chen,W.,
            King,M.J., Yien,Y.Y., Schultz,I.J., Anderson,H., Dalton,A.J.,
            Freedman,M.L., Kingsley,P.D., Palis,J., Hattangadi,S.M.,
            Lodish,H.F., Ward,D.M., Kaplan,J., Maeda,T., Ponka,P. and Paw,B.H.
  TITLE     Snx3 regulates recycling of the transferrin receptor and iron
            assimilation
  JOURNAL   Cell Metab 17 (3), 343-352 (2013)
   PUBMED   23416069
REFERENCE   5  (residues 1 to 162)
  AUTHORS   Pons,V., Ustunel,C., Rolland,C., Torti,E., Parton,R.G. and
            Gruenberg,J.
  TITLE     SNX12 role in endosome membrane transport
  JOURNAL   PLoS One 7 (6), e38949 (2012)
   PUBMED   22719997
REFERENCE   6  (residues 1 to 162)
  AUTHORS   Dong,H., Yuan,H., Jin,W., Shen,Y., Xu,X. and Wang,H.
  TITLE     Involvement of beta3A subunit of adaptor protein-3 in intracellular
            trafficking of receptor-like protein tyrosine phosphatase PCP-2
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 39 (7), 540-546 (2007)
   PUBMED   17622474
REFERENCE   7  (residues 1 to 162)
  AUTHORS   Zhong,Q., Watson,M.J., Lazar,C.S., Hounslow,A.M., Waltho,J.P. and
            Gill,G.N.
  TITLE     Determinants of the endosomal localization of sorting nexin 1
  JOURNAL   Mol Biol Cell 16 (4), 2049-2057 (2005)
   PUBMED   15673616
REFERENCE   8  (residues 1 to 162)
  AUTHORS   Xu,Y., Hortsman,H., Seet,L., Wong,S.H. and Hong,W.
  TITLE     SNX3 regulates endosomal function through its PX-domain-mediated
            interaction with PtdIns(3)P
  JOURNAL   Nat Cell Biol 3 (7), 658-666 (2001)
   PUBMED   11433298
REFERENCE   9  (residues 1 to 162)
  AUTHORS   Parks,W.T., Frank,D.B., Huff,C., Renfrew Haft,C., Martin,J.,
            Meng,X., de Caestecker,M.P., McNally,J.G., Reddi,A., Taylor,S.I.,
            Roberts,A.B., Wang,T. and Lechleider,R.J.
  TITLE     Sorting nexin 6, a novel SNX, interacts with the transforming
            growth factor-beta family of receptor serine-threonine kinases
  JOURNAL   J Biol Chem 276 (22), 19332-19339 (2001)
   PUBMED   11279102
REFERENCE   10 (residues 1 to 162)
  AUTHORS   Haft,C.R., de la Luz Sierra,M., Barr,V.A., Haft,D.H. and
            Taylor,S.I.
  TITLE     Identification of a family of sorting nexin molecules and
            characterization of their association with receptors
  JOURNAL   Mol Cell Biol 18 (12), 7278-7287 (1998)
   PUBMED   9819414
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC107918.1.
            
            On Aug 24, 2006 this sequence version replaced XP_001068918.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107918.1, FQ234595.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..162
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q13"
     Protein         1..162
                     /product="sorting nexin-3"
                     /calculated_mol_wt=18631
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:O60493; propagated from
                     UniProtKB/Swiss-Prot (Q5U211.1)"
     Region          28..150
                     /region_name="PX_SNX3"
                     /note="The phosphoinositide binding Phox Homology domain
                     of Sorting Nexin 3; cd07293"
                     /db_xref="CDD:132826"
     Site            43
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:O60493; propagated from
                     UniProtKB/Swiss-Prot (Q5U211.1)"
     Site            order(70,72,75,95..96,109,118)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:132826"
     Site            72
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5U211.1)"
     Region          147..162
                     /region_name="Binds predominantly to PtdIns(P5) and weaker
                     to PtdIns(P3) abd PtdIns(P4), involved in neurite
                     outgrowth regulation.
                     /evidence=ECO:0000250|UniProtKB:O70492"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U211.1)"
     CDS             1..162
                     /gene="Snx3"
                     /coded_by="NM_001044283.1:327..815"
                     /db_xref="GeneID:684097"
                     /db_xref="RGD:1595151"
ORIGIN      
        1 maetvadtrr litkpqnlnd aygppsnfle idvsnpqtvg vgrgrfttye irvktnlpif
       61 klkestvrrr ysdfewlrse lereskvvvp plpgkaflrq lpfrgddgif ddnfieerkq
      121 gleqfinkva ghplaqnerc lhmflqdeii dksytpskir ha
//
