LOCUS       NM_001110151            5409 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus sorting nexin 27 (Snx27), transcript variant 1,
            mRNA.
ACCESSION   NM_001110151
VERSION     NM_001110151.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5409)
  AUTHORS   Yong,X.L.H., Zhang,L., Yang,L., Chen,X., Tan,J.Z.A., Yu,X.,
            Chandra,M., Livingstone,E., Widagdo,J., Vieira,M.M., Roche,K.W.,
            Lynch,J.W., Keramidas,A., Collins,B.M. and Anggono,V.
  TITLE     Regulation of NMDA receptor trafficking and gating by
            activity-dependent CaMKIIalpha phosphorylation of the GluN2A
            subunit
  JOURNAL   Cell Rep 36 (1), 109338 (2021)
   PUBMED   34233182
REFERENCE   2  (bases 1 to 5409)
  AUTHORS   Choi,H.J., Jang,H.J., Park,E., Tingskov,S.J., Norregaard,R.,
            Jung,H.J. and Kwon,T.H.
  TITLE     Sorting Nexin 27 Regulates the Lysosomal Degradation of Aquaporin-2
            Protein in the Kidney Collecting Duct
  JOURNAL   Cells 9 (5), 1208 (2020)
   PUBMED   32413996
  REMARK    GeneRIF: Sorting Nexin 27 Regulates the Lysosomal Degradation of
            Aquaporin-2 Protein in the Kidney Collecting Duct.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5409)
  AUTHORS   Halff,E.F., Szulc,B.R., Lesept,F. and Kittler,J.T.
  TITLE     SNX27-Mediated Recycling of Neuroligin-2 Regulates Inhibitory
            Signaling
  JOURNAL   Cell Rep 29 (9), 2599-2607 (2019)
   PUBMED   31775031
  REMARK    GeneRIF: SNX27-Mediated Recycling of Neuroligin-2 Regulates
            Inhibitory Signaling.
REFERENCE   4  (bases 1 to 5409)
  AUTHORS   Binda,C.S., Nakamura,Y., Henley,J.M. and Wilkinson,K.A.
  TITLE     Sorting nexin 27 rescues neuroligin 2 from lysosomal degradation to
            control inhibitory synapse number
  JOURNAL   Biochem J 476 (2), 293-306 (2019)
   PUBMED   30602588
  REMARK    GeneRIF: these data indicate that NLGs are SNX27-retromer cargoes
            and suggest that SNX27-retromer controls inhibitory synapse number,
            at least in part through trafficking of NLG2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5409)
  AUTHORS   Lin,T.B., Lai,C.Y., Hsieh,M.C., Wang,H.H., Cheng,J.K., Chau,Y.P.,
            Chen,G.D. and Peng,H.Y.
  TITLE     VPS26A-SNX27 Interaction-Dependent mGluR5 Recycling in Dorsal Horn
            Neurons Mediates Neuropathic Pain in Rats
  JOURNAL   J Neurosci 35 (44), 14943-14955 (2015)
   PUBMED   26538661
  REMARK    GeneRIF: The regulation of the VPS26A-SNX27 interaction modifies
            mGluR5 trafficking which mediates neuropathic pain.
REFERENCE   6  (bases 1 to 5409)
  AUTHORS   Lunn,M.L., Nassirpour,R., Arrabit,C., Tan,J., McLeod,I.,
            Arias,C.M., Sawchenko,P.E., Yates,J.R. 3rd and Slesinger,P.A.
  TITLE     A unique sorting nexin regulates trafficking of potassium channels
            via a PDZ domain interaction
  JOURNAL   Nat Neurosci 10 (10), 1249-1259 (2007)
   PUBMED   17828261
  REMARK    GeneRIF: SNX27 promotes the endosomal movement of Kir3 (GIRK)
            channels, leading to reduced surface expression, increased
            degradation and smaller Kir3 potassium currents.
REFERENCE   7  (bases 1 to 5409)
  AUTHORS   MacNeil,A.J. and Pohajdak,B.
  TITLE     Polarization of endosomal SNX27 in migrating and tumor-engaged
            natural killer cells
  JOURNAL   Biochem Biophys Res Commun 361 (1), 146-150 (2007)
   PUBMED   17644068
REFERENCE   8  (bases 1 to 5409)
  AUTHORS   Lee,K.H., Ryu,C.J., Hong,H.J., Kim,J. and Lee,E.H.
  TITLE     CDNA microarray analysis of nerve growth factor-regulated gene
            expression profile in rat PC12 cells
  JOURNAL   Neurochem Res 30 (4), 533-540 (2005)
   PUBMED   16076023
REFERENCE   9  (bases 1 to 5409)
  AUTHORS   Fujiyama,K., Kajii,Y., Hiraoka,S. and Nishikawa,T.
  TITLE     Differential regulation by stimulants of neocortical expression of
            mrt1, arc, and homer1a mRNA in the rats treated with repeated
            methamphetamine
  JOURNAL   Synapse 49 (3), 143-149 (2003)
   PUBMED   12774298
  REMARK    GeneRIF: These findings suggest the differential regulation by
            stimulant of neocortical mrt1 expression and supports the view that
            stimulant induction of mrt1 may be involved in the early molecular
            signalings for stimulant sensitization.
REFERENCE   10 (bases 1 to 5409)
  AUTHORS   Kajii,Y., Muraoka,S., Hiraoka,S., Fujiyama,K., Umino,A. and
            Nishikawa,T.
  TITLE     A developmentally regulated and psychostimulant-inducible novel rat
            gene mrt1 encoding PDZ-PX proteins isolated in the neocortex
  JOURNAL   Mol Psychiatry 8 (4), 434-444 (2003)
   PUBMED   12740601
  REMARK    GeneRIF: Gene is developmentally regulated and stimulated by
            methamphetamine in the neocortex.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB051816.1, BF524912.1 and AC133978.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AB051816.1         1-156
            157-457             BF524912.1         50-350
            458-1692            AB051816.1         458-1692
            1693-5409           AC133978.2         88813-92529
FEATURES             Location/Qualifiers
     source          1..5409
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..5409
                     /gene="Snx27"
                     /gene_synonym="Mrt1"
                     /note="sorting nexin 27"
                     /db_xref="GeneID:260323"
                     /db_xref="RGD:628705"
     exon            1..425
                     /gene="Snx27"
                     /gene_synonym="Mrt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1740
                     /gene="Snx27"
                     /gene_synonym="Mrt1"
                     /note="isoform a is encoded by transcript variant 1;
                     PDZ-protein Mrt1; MAP-responsive gene protein;
                     methamphetamine-responsive transcript 1 protein;
                     methamphetamine (MAP) responsive transcript 1; sorting
                     nexin family member 27"
                     /codon_start=1
                     /product="sorting nexin-27 isoform a"
                     /protein_id="NP_001103621.1"
                     /db_xref="GeneID:260323"
                     /db_xref="RGD:628705"
                     /translation="MADEDGEGIHPSAPHRNGGGGGGSGLHCAGNGGGGGGGPRVVRI
                     VKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEV
                     NGVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEKQA
                     VPISVPTYKHVEQNGEKFVVYNVYMAGRQLCSKRYREFAILHQNLKREFANFTFPRLP
                     GKWPFSLSEQQLDARRRGLEEYLEKVCSIRVIGESDIMQEFLSESDENYNGVSDVELR
                     VALPDGATVTVRVKKNSTTDQVYQAIAAKVGMDSTTVNYFALFEVINHSFVRKLAPNE
                     FPHKLYVQNYTSAVPGTCLTIRKWLFTTEEEVLLNDNDLAVTYFFHQAVDDVKKGYIK
                     AEEKSYQLQKLYEQRKMVMYLNMLRTCEGYNEIIFPHCACDSRRKGHVITAISITHFK
                     LHACTEEGQLENQVIAFEWDEMQRWDTDEEGMAFCFEYARGEKKPRWVKIFTPYFNYM
                     HECFERVFCELKWRKENIFQMARSQQRDVAT"
     exon            426..657
                     /gene="Snx27"
                     /gene_synonym="Mrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..850
                     /gene="Snx27"
                     /gene_synonym="Mrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..915
                     /gene="Snx27"
                     /gene_synonym="Mrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1020
                     /gene="Snx27"
                     /gene_synonym="Mrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1099
                     /gene="Snx27"
                     /gene_synonym="Mrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1263
                     /gene="Snx27"
                     /gene_synonym="Mrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1353
                     /gene="Snx27"
                     /gene_synonym="Mrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1503
                     /gene="Snx27"
                     /gene_synonym="Mrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1632
                     /gene="Snx27"
                     /gene_synonym="Mrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1692
                     /gene="Snx27"
                     /gene_synonym="Mrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..5409
                     /gene="Snx27"
                     /gene_synonym="Mrt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctagctcctg cggtcggccg gccgggcgcg cgctggggtc gcgcggctgc tgaagggggc
       61 gggcgcgcgc aggaggagtg gaggcgtagg ggggcggggg accgctcgct tactcgcaag
      121 atggcggacg aggacgggga agggattcac ccctcagccc cgcaccggaa tggaggcggc
      181 ggcggggggt ctgggctcca ctgcgccggg aacggtggcg ggggaggcgg cggcccgcgg
      241 gtcgtgcgca ttgtcaagtc cgaatccggc tacggcttca acgtgcgggg ccaagtgagc
      301 gagggcgggc aactgcggag catcaacggg gagctgtacg cgccgctgca gcatgtgagc
      361 gccgtgctgc ccgggggggc ggccgaccgg gccggggtgc gcaaggggga ccgcatcctg
      421 gaggtgaacg gcgtgaatgt tgagggggcg acacacaagc aggtggtgga cctgatccga
      481 gcaggcgaga aggaattgat cttgacagtg ttgtctgtac ctcctcatga ggctgataac
      541 ctagacccca gtgacgactc cttgggacaa tcattttatg attacacaga aaagcaagca
      601 gtgcccatat cggtccccac atacaaacat gtggagcaga atggtgagaa atttgtggta
      661 tacaatgttt atatggccgg gaggcagctg tgttctaagc ggtaccggga gtttgccatt
      721 ctgcaccaaa acctgaagag agagtttgcc aactttacat ttcctcgact tccaggaaag
      781 tggccattct cattatcaga gcaacagtta gatgcccggc gtcgggggtt ggaagaatat
      841 ctagaaaagg tgtgctccat ccgagtcatt ggtgagagcg acatcatgca ggagttcctg
      901 tcagaatctg atgagaatta caatggtgtg tctgatgtgg agctgagagt agcattacca
      961 gatggagcaa ctgttactgt cagagttaaa aagaacagca ccacagacca agtgtaccag
     1021 gctattgcag caaaggttgg catggacagt acaacagtga actactttgc cttatttgaa
     1081 gtcatcaatc attcctttgt acgtaagctg gcccctaatg aatttcctca taaactgtac
     1141 gtccagaatt acacatcagc tgtgccaggc acctgcctga ccattcgcaa gtggctcttt
     1201 accacagaag aagaagtcct cttaaatgac aatgaccttg ctgtcacgta cttctttcat
     1261 caggctgttg atgatgtaaa gaaaggttac attaaagcgg aggagaagtc ttaccagtta
     1321 cagaagctgt atgaacaaag gaagatggtc atgtacctca acatgctaag gacctgtgag
     1381 ggctacaatg aaatcatctt ccctcactgt gcctgcgact ccaggaggaa ggggcatgtt
     1441 atcacagcca tcagcatcac gcactttaaa cttcatgcct gcactgaaga agggcagctg
     1501 gagaaccagg taatagcgtt tgaatgggat gagatgcagc gatgggacac agacgaagaa
     1561 ggaatggcct tctgttttga atatgcacga ggagagaaga agcctcgatg ggttaaaatc
     1621 ttcacaccat atttcaatta catgcatgag tgctttgaga gggtgttctg cgagctcaag
     1681 tggagaaaag agaatatttt ccagatggcg aggtcacaac agagggatgt ggccacctag
     1741 cctttcctca tcccttcccc ttccctttgc cctcagcctc ttagcctttt catctttcat
     1801 gtcagacagt aaccattaac acaaaagaag aaaaaaggaa aaaagtcatt atatcccaaa
     1861 gtcctaagct aaatattatt aataacctcc tgtgaatttt acacctctgg acctgagctg
     1921 gtagcgagca gcaggttgat agtgccagaa gtccactgag atcagacaga aacaagccca
     1981 gcacctcgcc aaagtcatcc ttgtcctttt acccggggcc tcataacaac agactctcct
     2041 tgtactatat ttttaaaact ggaactatga actccatcca tttgcactgt tcaagcatat
     2101 atatgtatgt atgtaaaaat tatatataca caaattagct gcacgtatat acatatatat
     2161 ttctttttaa atttcatatt gatggcagaa ccttttttag cttgtgtttt tacacacctt
     2221 tcactgaatt catgacctct ctcttgctct ctttattttg aaacaaactt taaaaaggaa
     2281 aaaaaaaata cagggaaaat acctctcctc atgaaggact cgaaaagttt acaacctgct
     2341 tgggttttcc tccctttctg tattgagtac ggtttctggc tgttggtttg ccatagagtc
     2401 tgaggagcga ggagtgtagt gtctttatct tcaagagggt gctgaggagg agaaaggctg
     2461 tttctcaaga gcggcgaggc tgccgagagt ctgaagacct atagtcttga ttgcaagtca
     2521 ttttcctgat ccatcctgca tctccttcct gttcctttag ggtcttttat ataaagcttc
     2581 cttgcaactg gcccaaacca gagttcaggg tcacatgagg aggctgttcc cacagaaact
     2641 gtgacacttc tcttcctgag acagacaggg atcgtatcag gagtaaagct tggcatctga
     2701 ggcaccaagg caggacatac ggaggggagg gagggaagaa agaaggaagg aaggaaagaa
     2761 ggaaggaagc agtgcctcat gtgtataagg gccttacctc ctccattcct gtccagtaac
     2821 catctatatt ttatatcctc tgtgagttct ttaaacagtt gtgtgtggag ggagtgcctt
     2881 gggtaaactt agccctgttc atgacagctg agggcccaag aagtgggaat atggtcggtt
     2941 ttagttgacc accaccattt ccttcaaagg agactgagga gaaaactctt agagttcttt
     3001 acctgggggt gggcctgggc cggttctgtt ggtagagtgc ttgcctaaca tgggtgaagc
     3061 cctaagttcc atctccagca ctacataaaa cttgggtgtt gtagtgcatc cctgtaatct
     3121 cagcacttgg gaggggaata caggaaactc agaattttca agtccacccc tctggtacct
     3181 aatgagttca aggctattct ggatcacata tctcaaaggt agaagagttt tttacctgct
     3241 cctgcactta ggcctcatag gacctcaaag caacatgtgg gacagagccc aggctggcac
     3301 tagagtaata ttcttaaacc ttgagttctt gtgtaaggaa tgctcaggtt aggtacaact
     3361 aaaacacatc tttgaaactc tttatctact ttaccttcaa tattgaaacc gccatcagct
     3421 gcatctttgg ctttctgagg ctgagaggca gctagaattg gatgtggtcg gcagtgctgg
     3481 acttggttta aagtttcttt caagccttgg ttttgcagag cattatgagg ccacttttct
     3541 gtctccataa ttctagcagc cattgtccca ggaaggtgtg aaccttttcc ctttcctatc
     3601 cctttcctct ccaagcctgt gggaccacaa ggttataaaa tatggtgagt gtttaaagtt
     3661 gaagagagcc gtacctgatt tgaaggcttt catcagtatc aacttgccct tttagcttta
     3721 ataatgagcc tgagtacctt aagagggggt gagttgattc tccctctcca agatgttctg
     3781 gaggccagct gtgtgcaaac tgtaaaacag cagcagtgca gcccatccat ccctcagtgg
     3841 gagagcctgt gctacagcct tccagagtag agacagggct ttgaaggtcc tgaagagttg
     3901 agccccagac gtgtggggac taacagatct gagtaggaac atgctacttc aggtagtctt
     3961 gctgccaaaa cacccagctg cagcagggag atgggaagaa ggaggtccca caggcccaca
     4021 gtggggctgc agtcatggag gaggaggtca ctatggccta gaggcccaca ggatcaagtt
     4081 cttttgcatg aagcagtgtt agatgtaaca tatccctccc ccaagcccct tgcgcttcct
     4141 ttctctaatc tgttctatgt ttcttagtct tggcttctgc ccagagaggc atctacagtt
     4201 ttcttggaca gtttgtctct aggaatggga tgtcccttcc cagcttcact ctggcaggat
     4261 cttcctggtc tccagctgtt gtttcctcca cgttgagttt ctgttctctg agacaaaaat
     4321 tcagagattt ttatggaaca ggaaaatact taggccctga gaaacctggc actctaggaa
     4381 gctttgcttg ggcagtactt tgagcttctg ctctttgtat ttttatcctg gtctccgttt
     4441 tctgccttcc ccttgccgag gcctaggctc agcccagcta cagatgtgtc agtgttcagg
     4501 gcagcgcccg gccttgacag agctctcagg gaggaacaag gtaaatgctc tagcatcctc
     4561 ttgcctggcc catttaattt tatcctttag ttaccagggc cagtagcttt gaattatcct
     4621 ttcattactc caaacccaat gcctgaagca gcaaaatagg acactgataa gagggaacac
     4681 ctctctcatc tcagaactcc cagcttaagt tccggctcct agaaagcagt tttcttaaag
     4741 ggacctacat gcatttgagt agagccagtc tctaggaatg gaggcccttt ctgccctcct
     4801 gcccattgtg ctgtctggag ggatggcctc agcacactgc tgctccttca ccagtttcat
     4861 gggctgcttt aacttctttt tggaggagca gcagtgtggc tgagtactta gagctggtgg
     4921 gagggagaat gcttctttag tcctccatct tgggctcctc ttatctaacc cccggcatat
     4981 gtaccaggcc tcctttacct ggataactgc agcttcctct cagcggtaac tgagggcgcg
     5041 taggcaccag gctctgggga ggaatgagac tgaagagggc agatcctggt aggagcactt
     5101 ggccagctgc tgaccatggg tgccgccttg ttattgtgcc cccttctaag ctggtgagct
     5161 gggcttcagt ttttcccagg ccatgcacac ttttaattta tttgagagaa actaattgta
     5221 ttttcactgc agtatcttgt acttttgttt gtgatttacg aatgtgaaga gaatgcagag
     5281 acccagtggc tccagtgctt ctccaggccc tgccctagag ctaaccactc taagactgtt
     5341 tggtaatgtc acttagtgta attaattgta acatattctt ttaaataaat tgatttattg
     5401 atgaaacaa
//
