LOCUS       NM_001106135            2049 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus sorting nexin 2 (Snx2), mRNA.
ACCESSION   NM_001106135 XM_001057944 XM_214539
VERSION     NM_001106135.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2049)
  AUTHORS   Gallon,M. and Cullen,P.J.
  TITLE     Retromer and sorting nexins in endosomal sorting
  JOURNAL   Biochem Soc Trans 43 (1), 33-47 (2015)
   PUBMED   25619244
  REMARK    Review article
REFERENCE   2  (bases 1 to 2049)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2049)
  AUTHORS   Kim,Y., Ha,C.M. and Chang,S.
  TITLE     SNX26, a GTPase-activating protein for Cdc42, interacts with PSD-95
            protein and is involved in activity-dependent dendritic spine
            formation in mature neurons
  JOURNAL   J Biol Chem 288 (41), 29453-29466 (2013)
   PUBMED   24003235
REFERENCE   4  (bases 1 to 2049)
  AUTHORS   Prosser,D.C., Tran,D., Schooley,A., Wendland,B. and Ngsee,J.K.
  TITLE     A novel, retromer-independent role for sorting nexins 1 and 2 in
            RhoG-dependent membrane remodeling
  JOURNAL   Traffic 11 (10), 1347-1362 (2010)
   PUBMED   20604901
REFERENCE   5  (bases 1 to 2049)
  AUTHORS   Lieu,Z.Z. and Gleeson,P.A.
  TITLE     Identification of different itineraries and retromer components for
            endosome-to-Golgi transport of TGN38 and Shiga toxin
  JOURNAL   Eur J Cell Biol 89 (5), 379-393 (2010)
   PUBMED   20138391
REFERENCE   6  (bases 1 to 2049)
  AUTHORS   Wassmer,T., Attar,N., Harterink,M., van Weering,J.R., Traer,C.J.,
            Oakley,J., Goud,B., Stephens,D.J., Verkade,P., Korswagen,H.C. and
            Cullen,P.J.
  TITLE     The retromer coat complex coordinates endosomal sorting and
            dynein-mediated transport, with carrier recognition by the
            trans-Golgi network
  JOURNAL   Dev Cell 17 (1), 110-122 (2009)
   PUBMED   19619496
REFERENCE   7  (bases 1 to 2049)
  AUTHORS   Zhong,Q., Watson,M.J., Lazar,C.S., Hounslow,A.M., Waltho,J.P. and
            Gill,G.N.
  TITLE     Determinants of the endosomal localization of sorting nexin 1
  JOURNAL   Mol Biol Cell 16 (4), 2049-2057 (2005)
   PUBMED   15673616
REFERENCE   8  (bases 1 to 2049)
  AUTHORS   Parks,W.T., Frank,D.B., Huff,C., Renfrew Haft,C., Martin,J.,
            Meng,X., de Caestecker,M.P., McNally,J.G., Reddi,A., Taylor,S.I.,
            Roberts,A.B., Wang,T. and Lechleider,R.J.
  TITLE     Sorting nexin 6, a novel SNX, interacts with the transforming
            growth factor-beta family of receptor serine-threonine kinases
  JOURNAL   J Biol Chem 276 (22), 19332-19339 (2001)
   PUBMED   11279102
REFERENCE   9  (bases 1 to 2049)
  AUTHORS   Haft,C.R., de la Luz Sierra,M., Bafford,R., Lesniak,M.A., Barr,V.A.
            and Taylor,S.I.
  TITLE     Human orthologs of yeast vacuolar protein sorting proteins Vps26,
            29, and 35: assembly into multimeric complexes
  JOURNAL   Mol Biol Cell 11 (12), 4105-4116 (2000)
   PUBMED   11102511
REFERENCE   10 (bases 1 to 2049)
  AUTHORS   Haft,C.R., de la Luz Sierra,M., Barr,V.A., Haft,D.H. and
            Taylor,S.I.
  TITLE     Identification of a family of sorting nexin molecules and
            characterization of their association with receptors
  JOURNAL   Mol Cell Biol 18 (12), 7278-7287 (1998)
   PUBMED   9819414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO565239.1, CB557295.1, CO567837.1, DV723418.1 and AI146078.1.
            
            On Oct 12, 2007 this sequence version replaced NM_001106135.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166853.1, SRR8487231.66744.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-481               CO565239.1         1-481
            482-746             CB557295.1         86-350
            747-1365            CO567837.1         13-631
            1366-1901           DV723418.1         182-717
            1902-2049           AI146078.1         1-148               c
FEATURES             Location/Qualifiers
     source          1..2049
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..2049
                     /gene="Snx2"
                     /note="sorting nexin 2"
                     /db_xref="GeneID:291464"
                     /db_xref="RGD:1310291"
     exon            1..144
                     /gene="Snx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1596
                     /gene="Snx2"
                     /codon_start=1
                     /product="sorting nexin-2"
                     /protein_id="NP_001099605.2"
                     /db_xref="GeneID:291464"
                     /db_xref="RGD:1310291"
                     /translation="MAAEREPPPLGDVKPTDFEELEDGEDLFTSTVSTLESSPSSPEP
                     ASLPAEDISANSNGSRPVEVTLDDDREDLFAEATEEVSLDSPEREPIMSSEPSPAVTP
                     ITPTTLIAPRIESKSISAPVIFDRSREEIEEEANGDIFDIEIGVSDPEKVGDGMNAYM
                     AYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTK
                     VKVGKEDSSSTEFVEKRRAALERYLQRTVKHPTLLQDPDLRQFLESSELPRAVNTQAL
                     SGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKLHASVEALVCHR
                     KELSANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFADFYMFSEL
                     LSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKRETEAKMMVANKPDKIQQAKNEI
                     REWEAKVQQGERDFEQISKTIRKEVGRFEKERVKDFKAVIIKYLESLVQTQQQLIKYW
                     EAFLPEAKAIA"
     exon            145..262
                     /gene="Snx2"
                     /inference="alignment:Splign:2.1.0"
     exon            263..426
                     /gene="Snx2"
                     /inference="alignment:Splign:2.1.0"
     exon            427..493
                     /gene="Snx2"
                     /inference="alignment:Splign:2.1.0"
     exon            494..537
                     /gene="Snx2"
                     /inference="alignment:Splign:2.1.0"
     exon            538..679
                     /gene="Snx2"
                     /inference="alignment:Splign:2.1.0"
     exon            680..758
                     /gene="Snx2"
                     /inference="alignment:Splign:2.1.0"
     exon            759..834
                     /gene="Snx2"
                     /inference="alignment:Splign:2.1.0"
     exon            835..948
                     /gene="Snx2"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1042
                     /gene="Snx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1248
                     /gene="Snx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1392
                     /gene="Snx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1473
                     /gene="Snx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1545
                     /gene="Snx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..2037
                     /gene="Snx2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggcccggc tcttgcagac gtccaggcta gcgaagatgg cggctgagag ggaacctcct
       61 ccgctgggag acgtgaagcc caccgacttt gaggagctgg aggacggaga ggacctgttc
      121 accagcactg tctccacact tgagtcaagt ccatcatctc ctgaaccagc cagtcttcct
      181 gcagaagata ttagtgcaaa ctctaacggc tccagacctg tagaagtcac actagacgat
      241 gacagagaag atcttttcgc agaagccaca gaagaggtgt ctctggacag tccagaaaga
      301 gagcctatca tgtcctccga gccatctcct gcagtcactc ctatcactcc caccacactc
      361 attgctccta gaattgaatc aaagagtatt tctgctccag tcatctttga cagatccagg
      421 gaagagattg aagaagaagc aaatggagat atttttgata tagaaattgg tgtgtcagat
      481 ccggaaaaag ttggtgatgg catgaatgct tacatggcat atagagtaac aaccaagact
      541 tctctttcca tgttcagtaa gagtgaattt tcagtcaaaa gaagattcag tgactttctt
      601 ggtttgcata gcaaattagc aagcaaatat ttacatgttg gttacattgt gccaccagct
      661 ccagaaaaga gcatagtagg tatgaccaag gtcaaagtag gtaaagaaga ctcatcgtcc
      721 actgagtttg tagaaaaacg aagagcagca ctggagaggt atcttcaaag aacagtaaag
      781 catccaacat tgcttcagga tcctgactta aggcagttct tggaaagctc agagctgccg
      841 agagcagtta atacacaggc tctgagtgga gcaggaatat tgaggatggt gaacaaggct
      901 gccgacgctg tcaacaaaat gacaatcaag atgaatgaat cggatgcatg gtttgaagaa
      961 aagcaacagc aatttgagaa tcttgaccag caacttcgga aacttcatgc cagtgtcgaa
     1021 gccttggtct gtcatagaaa agaactttca gccaacacag ctgcctttgc taagagtgct
     1081 gccatgctag gtaattctga ggaccatact gctctctcta gagctttgtc tcagctcgca
     1141 gaggttgagg agaagataga ccagttacat caagagcaag cgtttgctga cttttacatg
     1201 ttctcagaac ttcttagtga ctacattcgt ctcattgctg cagtgaaagg tgtgtttgac
     1261 catcggatga aatgctggca gaaatgggaa gatgctcaaa ttactttgct caaaaaacgt
     1321 gaaactgagg caaaaatgat ggtcgctaac aaaccagata aaattcaaca agctaaaaat
     1381 gaaataagag agtgggaggc aaaagtacaa caaggagaga gagattttga gcagatctct
     1441 aaaacaattc gaaaagaagt gggaagattt gagaaagaac gagtgaaaga ttttaaagct
     1501 gttatcatca agtacttgga atcattagta caaacacagc aacagctgat aaagtactgg
     1561 gaggcattcc tacctgaagc caaagccatt gcctagcgtt atccccgtta aggagacatt
     1621 ggattcctca gtgagatcat ctaaaaaaca tctaaataaa ccactatata ttttatgaat
     1681 tacatgtggg ttttttatat ataaaaacat atgcgctgac attttattac aagctgcatg
     1741 tcctgacctt cttggaatta agtggactgt ggcatgacat tctgcaatat tttgctgaat
     1801 tgaacactat tgtgtcttaa atacttgcac taaaaggtgc attgcaaggc cagaaaattt
     1861 tacaatcttt tttctttatg ttctgtagtg tgtttaccct cattatgaaa caaattagca
     1921 atgcattgat taatgttcac ttatacattc ctgtacagaa attatgattt ttgtgattat
     1981 agtaataaaa tgatattact tgtgaaatat tagtaataaa ttatttgagt atataaaaaa
     2041 aaaaaaaaa
//
