LOCUS       NP_001101601             890 aa            linear   ROD 23-MAR-2023
DEFINITION  sorting nexin-19 [Rattus norvegicus].
ACCESSION   NP_001101601 XP_001055595 XP_235940
VERSION     NP_001101601.1
DBSOURCE    REFSEQ: accession NM_001108131.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 890)
  AUTHORS   Mas C, Norwood SJ, Bugarcic A, Kinna G, Leneva N, Kovtun O, Ghai R,
            Ona Yanez LE, Davis JL, Teasdale RD and Collins BM.
  TITLE     Structural basis for different phosphoinositide specificities of
            the PX domains of sorting nexins regulating G-protein signaling
  JOURNAL   J Biol Chem 289 (41), 28554-28568 (2014)
   PUBMED   25148684
REFERENCE   2  (residues 1 to 890)
  AUTHORS   Harashima S, Horiuchi T, Wang Y, Notkins AL, Seino Y and Inagaki N.
  TITLE     Sorting nexin 19 regulates the number of dense core vesicles in
            pancreatic beta-cells
  JOURNAL   J Diabetes Investig 3 (1), 52-61 (2012)
   PUBMED   24843546
REFERENCE   3  (residues 1 to 890)
  AUTHORS   Kan A, Ikeda T, Saito T, Yano F, Fukai A, Hojo H, Ogasawara T,
            Ogata N, Nakamura K, Chung UI and Kawaguchi H.
  TITLE     Screening of chondrogenic factors with a real-time
            fluorescence-monitoring cell line ATDC5-C2ER: identification of
            sorting nexin 19 as a novel factor
  JOURNAL   Arthritis Rheum 60 (11), 3314-3323 (2009)
   PUBMED   19877062
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474007.2.
            
            [WARNING] On Apr 29, 2024 this sequence was replaced by
            NP_001101601.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_235940.4, XP_001055595.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..890
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     Protein         1..890
                     /product="sorting nexin-19"
                     /calculated_mol_wt=97981
     Region          1..165
                     /region_name="PXA"
                     /note="PXA domain; cl02564"
                     /db_xref="CDD:470618"
     Region          430..557
                     /region_name="PX_SNX19"
                     /note="The phosphoinositide binding Phox Homology domain
                     of Sorting Nexin 19; cd06893"
                     /db_xref="CDD:132803"
     Site            order(480..482,516..517,527)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:132803"
     Region          736..843
                     /region_name="Nexin_C"
                     /note="Sorting nexin C terminal; pfam08628"
                     /db_xref="CDD:462541"
     CDS             1..890
                     /gene="Snx19"
                     /coded_by="NM_001108131.1:181..2853"
                     /db_xref="GeneID:315478"
                     /db_xref="RGD:1309857"
ORIGIN      
        1 miirdfvlsw yrsvshektf eaemeasmkg lvqelrrrms ivdshaltqr vltlcgchlq
       61 syiqakgata keqscpveps qlwdaycqvt tphpamscpt tevtyargiv nlilkelvpk
      121 phletrtgrh vvvelitcnv ilplisklsd pdwihlilvs ifskykqdaa qgtkppsspc
      181 vleqpsvpts lplmvevesl pvgkasspva apvhlassep apspeieegh eavegelpgm
      241 leerkvgnns shflqpdirg plflcedsel esplselgke timlmtpgnf lshriqdalc
      301 alddsqalep rdgegsecme gaeaeeapga etetgtlvsm lncpeiqidp adkeaeqgdd
      361 asltalleep ekpclqrpsc ldkglgsgac slepavppls lsssppgpls satfsfesls
      421 spdgpvviqn lritgtitar ehsgtgfhpy tlytvkyeta lsgenssglq qlayhtvnrr
      481 yreflnlqtr leekpdlrkf iknvkgpkkl fpdlpfgnmd sdrvearksl lesflrqlca
      541 ipeianseev qeflalntda riafvkkpfm vsridkmvvs aivdtlktaf prsepqspte
      601 elseaenesk pqtegkkask srlrfssski apalsiaeaq dkilyclqeg nsesevlsms
      661 gmesfiekqt kllqmqpaev pdkepqqvpk esvdsglldk avvsqelnks dpgtetelad
      721 tafdlillll meqwkwlcte nmqkflrlvf gtlvqrwlev qvanltcpqr waqylrllre
      781 siwpggvlpk fprpgrtqaq kaatekqalq slmgllpdfl veilgvhkcq lswslvlesf
      841 qqplinrhli yclgdiilef ldlsaaveec apttsasdsp gslkkmavst
//
