LOCUS       NP_001101122             615 aa            linear   ROD 20-MAR-2023
DEFINITION  sorting nexin-18 [Rattus norvegicus].
ACCESSION   NP_001101122 XP_001075253 XP_226769
VERSION     NP_001101122.1
DBSOURCE    REFSEQ: accession NM_001107652.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 615)
  AUTHORS   Knaevelsrud H, Soreng K, Raiborg C, Haberg K, Rasmuson F, Brech A,
            Liestol K, Rusten TE, Stenmark H, Neufeld TP, Carlsson SR and
            Simonsen A.
  TITLE     Membrane remodeling by the PX-BAR protein SNX18 promotes
            autophagosome formation
  JOURNAL   J Cell Biol 202 (2), 331-349 (2013)
   PUBMED   23878278
REFERENCE   2  (residues 1 to 615)
  AUTHORS   Ma MP and Chircop M.
  TITLE     SNX9, SNX18 and SNX33 are required for progression through and
            completion of mitosis
  JOURNAL   J Cell Sci 125 (Pt 18), 4372-4382 (2012)
   PUBMED   22718350
REFERENCE   3  (residues 1 to 615)
  AUTHORS   Nakazawa S, Gotoh N, Matsumoto H, Murayama C, Suzuki T and Yamamoto
            T.
  TITLE     Expression of sorting nexin 18 (SNX18) is dynamically regulated in
            developing spinal motor neurons
  JOURNAL   J Histochem Cytochem 59 (2), 202-213 (2011)
   PUBMED   21339182
REFERENCE   4  (residues 1 to 615)
  AUTHORS   Park J, Kim Y, Lee S, Park JJ, Park ZY, Sun W, Kim H and Chang S.
  TITLE     SNX18 shares a redundant role with SNX9 and modulates endocytic
            trafficking at the plasma membrane
  JOURNAL   J Cell Sci 123 (Pt 10), 1742-1750 (2010)
   PUBMED   20427313
REFERENCE   5  (residues 1 to 615)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (residues 1 to 615)
  AUTHORS   Pisitkun T, Shen RF and Knepper MA.
  TITLE     Identification and proteomic profiling of exosomes in human urine
  JOURNAL   Proc Natl Acad Sci U S A 101 (36), 13368-13373 (2004)
   PUBMED   15326289
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473955.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_226769.4, XP_001075253.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ105693.1, FQ113700.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..615
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     Protein         1..615
                     /product="sorting nexin-18"
                     /note="sorting nexin associated golgi protein 1"
                     /calculated_mol_wt=67736
     Region          4..58
                     /region_name="SH3_SNX18"
                     /note="Src Homology 3 domain of Sorting nexin 18; cd11897"
                     /db_xref="CDD:212830"
     Site            order(9,11,14,18,37..38,52,54..55)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212830"
     Region          267..394
                     /region_name="PX_SNX18"
                     /note="The phosphoinositide binding Phox Homology domain
                     of Sorting Nexin 18; cd07286"
                     /db_xref="CDD:132819"
     Site            order(303..305,329,343)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:132819"
     Region          406..612
                     /region_name="BAR_SNX18"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain of Sorting
                     Nexin 18; cd07670"
                     /db_xref="CDD:153354"
     Site            order(425,428..429,432..433,435..436,439,442..443,446,
                     454..455,457..458,461,464..465,468..469,472,477,480,491,
                     573,576..577,579..581,584,587..588,590..592,594..595,
                     598..599,601..602,605..606,608..609,612)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153354"
     Site            order(427,445..446,453,457,531,536,542,548)
                     /site_type="other"
                     /note="putative membrane interaction site"
                     /db_xref="CDD:153354"
     CDS             1..615
                     /gene="Snx18"
                     /gene_synonym="Snag1"
                     /coded_by="NM_001107652.1:167..2014"
                     /db_xref="GeneID:310097"
                     /db_xref="RGD:1310367"
ORIGIN      
        1 malraralyd frsenpgeis lrehevlslc seqdiegwle ginsrgdrgl fpasyvqvir
       61 apepgppadg gpgaparyan vppggfeplp aappaafqpl lqpqaspgsf qspgagftyg
      121 ggapqpspqq lygayqaslg sdddwddewd dsstvadepg algsgaypdl dgsssaggga
      181 agryrlstrs dlslgsrgvs appphqasga kssatvsrnl nrfstfvksg geafvlgeas
      241 gfvkdgdklc vvlgpygpew qenpypfqct iddptkqtkf kgmksyisyk lvpthtqvpv
      301 hrrykhfdwl yarlaekfpv isvphlpekq atgrfeedfi skrrkgliww mnhmashpvl
      361 aqcdvfqhfl tcpsstdeka wkqgkrkaek demvganffl tlstppaaal dlqeveskid
      421 gfkcftkkmd dsalqlnhta nefarkqvtg fkkeyqkvgq sfrglsqafe ldqqafsvgl
      481 nqaiaftgda ydaigelfae qprqdldpvm dllalyqghl anfpdiihvq kgaltkvkes
      541 rrhveegkme vqkadgiqdr cntisfatla eihhfhqirv rdfksqmqhf lqqqiiffqk
      601 vtqkleealh kydsv
//
