LOCUS       NM_001011981            1944 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus sorting nexin 17 (Snx17), mRNA.
ACCESSION   NM_001011981 XM_216651
VERSION     NM_001011981.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1944)
  AUTHORS   Zhao,D., Li,X., Liang,H., Zheng,N., Pan,Z., Zhou,Y., Liu,X.,
            Qian,M., Xu,B., Zhang,Y., Feng,Y., Qili,M., Wu,Q., Yang,B. and
            Shan,H.
  TITLE     SNX17 produces anti-arrhythmic effects by preserving functional
            SERCA2a protein in myocardial infarction
  JOURNAL   Int J Cardiol 272, 298-305 (2018)
   PUBMED   30025651
  REMARK    GeneRIF: Abnormal down-regulation of SNX17 contributes to ischemic
            damages of cardiac electrophysiology and contractile function.
REFERENCE   2  (bases 1 to 1944)
  AUTHORS   McNally,K.E., Faulkner,R., Steinberg,F., Gallon,M., Ghai,R.,
            Pim,D., Langton,P., Pearson,N., Danson,C.M., Nagele,H.,
            Morris,L.L., Singla,A., Overlee,B.L., Heesom,K.J., Sessions,R.,
            Banks,L., Collins,B.M., Berger,I., Billadeau,D.D., Burstein,E. and
            Cullen,P.J.
  TITLE     Retriever is a multiprotein complex for retromer-independent
            endosomal cargo recycling
  JOURNAL   Nat Cell Biol 19 (10), 1214-1225 (2017)
   PUBMED   28892079
REFERENCE   3  (bases 1 to 1944)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   4  (bases 1 to 1944)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   5  (bases 1 to 1944)
  AUTHORS   Czubayko,M., Knauth,P., Schluter,T., Florian,V. and Bohnensack,R.
  TITLE     Sorting nexin 17, a non-self-assembling and a PtdIns(3)P high class
            affinity protein, interacts with the cerebral cavernous
            malformation related protein KRIT1
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1264-1272 (2006)
   PUBMED   16712798
REFERENCE   6  (bases 1 to 1944)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
REFERENCE   7  (bases 1 to 1944)
  AUTHORS   Stockinger,W., Sailler,B., Strasser,V., Recheis,B., Fasching,D.,
            Kahr,L., Schneider,W.J. and Nimpf,J.
  TITLE     The PX-domain protein SNX17 interacts with members of the LDL
            receptor family and modulates endocytosis of the LDL receptor
  JOURNAL   EMBO J 21 (16), 4259-4267 (2002)
   PUBMED   12169628
REFERENCE   8  (bases 1 to 1944)
  AUTHORS   Florian,V., Schluter,T. and Bohnensack,R.
  TITLE     A new member of the sorting nexin family interacts with the
            C-terminus of P-selectin
  JOURNAL   Biochem Biophys Res Commun 281 (4), 1045-1050 (2001)
   PUBMED   11237770
REFERENCE   9  (bases 1 to 1944)
  AUTHORS   Hoja,M.R., Wahlestedt,C. and Hoog,C.
  TITLE     A visual intracellular classification strategy for uncharacterized
            human proteins
  JOURNAL   Exp Cell Res 259 (1), 239-246 (2000)
   PUBMED   10942595
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078931.1.
            
            On Feb 11, 2005 this sequence version replaced XM_216651.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078931.1, SRR8487231.171283.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1944
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..1944
                     /gene="Snx17"
                     /note="sorting nexin 17"
                     /db_xref="GeneID:298836"
                     /db_xref="RGD:1306424"
     exon            1..168
                     /gene="Snx17"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1518
                     /gene="Snx17"
                     /codon_start=1
                     /product="sorting nexin-17"
                     /protein_id="NP_001011981.1"
                     /db_xref="GeneID:298836"
                     /db_xref="RGD:1306424"
                     /translation="MHFSIPETESRSGDSGGSTYVAYNIHVNGVLHCRVRYSQLLGLH
                     EQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFL
                     RRAQQETQQVPTEEVSLEVLLSDGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYF
                     SLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENR
                     VGLNLLYAQTVSDIEHGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDA
                     CVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGGT
                     STPSRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSI
                     RKMLRRRVGGNLRRSDSQQAVKSPPLLESPDASRESMVKLSSKLSAVSLRGIGSPSTD
                     ASASAVHGNFAFEGIGDEDL"
     exon            169..243
                     /gene="Snx17"
                     /inference="alignment:Splign:2.1.0"
     exon            244..361
                     /gene="Snx17"
                     /inference="alignment:Splign:2.1.0"
     exon            362..426
                     /gene="Snx17"
                     /inference="alignment:Splign:2.1.0"
     exon            427..537
                     /gene="Snx17"
                     /inference="alignment:Splign:2.1.0"
     exon            538..628
                     /gene="Snx17"
                     /inference="alignment:Splign:2.1.0"
     exon            629..716
                     /gene="Snx17"
                     /inference="alignment:Splign:2.1.0"
     exon            717..786
                     /gene="Snx17"
                     /inference="alignment:Splign:2.1.0"
     exon            787..879
                     /gene="Snx17"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1083
                     /gene="Snx17"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1209
                     /gene="Snx17"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1287
                     /gene="Snx17"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1362
                     /gene="Snx17"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1404
                     /gene="Snx17"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1910
                     /gene="Snx17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccccccaa aatggcgaac tgggctgcgg agacgcgctg agtggcggag gcaagcgagc
       61 agagccgctg aggccctggt agtacggagc tctgccttag ggaacatgca cttttccatt
      121 cctgaaaccg agtcccgcag cggggacagc ggcggctcca cctacgtggc ctataacatt
      181 cacgtgaatg gagtcctgca ctgtcgtgtg cgctacagcc agctcctggg gctgcacgag
      241 cagcttcgga aggagtatgg ggccaatgtg cttcctgcat tccccccaaa gaagcttttc
      301 tctttgacgc ctgcagaggt agaacagagg agggaacagt tagagaagta catgcaagct
      361 gttcggcaag atccattgct tgggagcagt gagaccttta atagctttct acgtcgggcc
      421 caacaggaga cacaacaggt ccccacagag gaggtttcct tggaagtgtt gctcagtgac
      481 ggacagaaag ttctggtcaa tgtgctaact tctgaccaga cggaagacgt cctggaggcc
      541 gtggctgcaa agctggatct tccagatgac ttgatcggat attttagtct cttccttgtt
      601 cgagaaaaag aagatggcgc cttttctttt gtacggaagc ttcaggagtt tgagctgcct
      661 tacgtatctg tcaccagtct tcggagtcaa gagtataaga tcgtgctcag aaagagttac
      721 tgggactctg cctatgacga cgatgtcatg gagaaccggg ttggcctgaa cctgctttat
      781 gcccagacgg tgtcagacat cgagcatggc tggatcctgg tcaccaagga gcagcaccga
      841 cagctcaaat ctctgcaaga gaaggtctcc aaaaaggagt tcttgcggct ggcccagact
      901 ctgcggcact atggctatct gcgctttgat gcctgtgtgg ctgactttcc ggagaaggac
      961 tgccctgttg tggtcagtgc aggcaacagt gagctcagtc tccagctgcg actcccaggc
     1021 cagcagctcc gtgaaggctc tttccgggtc acccgaatgc ggtgctggcg ggtcacctcc
     1081 tctgtgccac tccccagtgg gggtacaagc actccaagcc ggggtcgggg tgaggtacgc
     1141 ctggaactgg cttttgaata cctcatgagc aaggaccggc tacagtgggt caccatcacc
     1201 agcccacagg ctatcatgat gagcatctgc ctgcagtcca tggtagatga gctgatggtg
     1261 aagaagtctg ggggcagtat caggaagatg ctgcgtcgga gggtgggggg caacctgaga
     1321 cgttcagaca gccagcaagc agtgaagtcc ccaccattgc tcgaatcacc agatgccagc
     1381 cgggaatcca tggtcaaact ctcaagtaaa ctgagtgcgg tgagcttgcg gggaattggc
     1441 agtcccagca cagatgccag tgccagtgcc gtccacggca atttcgcctt cgagggcatt
     1501 ggagatgagg atctgtaatc tcagctgcct ggatgtctgc cctctaccca agaggagatt
     1561 tatacaaact taccctgtgc ctatgctccc aagttggagt cttttcctac ccccttccta
     1621 cttgttctgt tccctcttgg ccaggggcct cctaacgtac cttccctttc ttgggctggc
     1681 tgcacaaaag atcaccgtct ctgtgtcaga gctggccctt gatgccaaat tagcatttag
     1741 tattttgcac aaagtccaag ggactgtggc tgcctgcctt ggagaggagc tagagctctc
     1801 cgtggattgc ttctgacttt ttagggccag gccatgggca aagggtggac agaggtctct
     1861 gaatgctctg agcagctccc catcattaaa cacagcctga ttgccaccta aaaaaaaaaa
     1921 aaaaaaaaaa aaaaaaaaaa aaaa
//
