LOCUS       NM_001393685            3122 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus sorting nexin 14 (Snx14), transcript variant 2,
            mRNA.
ACCESSION   NM_001393685 XM_039081535
VERSION     NM_001393685.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3122)
  AUTHORS   Akizu,N., Cantagrel,V., Zaki,M.S., Al-Gazali,L., Wang,X.,
            Rosti,R.O., Dikoglu,E., Gelot,A.B., Rosti,B., Vaux,K.K.,
            Scott,E.M., Silhavy,J.L., Schroth,J., Copeland,B., Schaffer,A.E.,
            Gordts,P.L., Esko,J.D., Buschman,M.D., Field,S.J., Napolitano,G.,
            Abdel-Salam,G.M., Ozgul,R.K., Sagiroglu,M.S., Azam,M., Ismail,S.,
            Aglan,M., Selim,L., Mahmoud,I.G., Abdel-Hadi,S., Badawy,A.E.,
            Sadek,A.A., Mojahedi,F., Kayserili,H., Masri,A., Bastaki,L.,
            Temtamy,S., Muller,U., Desguerre,I., Casanova,J.L., Dursun,A.,
            Gunel,M., Gabriel,S.B., de Lonlay,P. and Gleeson,J.G.
  TITLE     Biallelic mutations in SNX14 cause a syndromic form of cerebellar
            atrophy and lysosome-autophagosome dysfunction
  JOURNAL   Nat Genet 47 (5), 528-534 (2015)
   PUBMED   25848753
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 2, 2021 this sequence version replaced XM_039081535.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1184548.1,
                                           SRR26360194.2146701.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               JAXUCZ010000008.1  98270180-98270451   c
            273-393             JAXUCZ010000008.1  98255056-98255176   c
            394-470             JAXUCZ010000008.1  98253500-98253576   c
            471-549             JAXUCZ010000008.1  98253172-98253250   c
            550-593             JAXUCZ010000008.1  98249953-98249996   c
            594-681             JAXUCZ010000008.1  98246742-98246829   c
            682-766             JAXUCZ010000008.1  98240071-98240155   c
            767-923             JAXUCZ010000008.1  98237063-98237219   c
            924-999             JAXUCZ010000008.1  98235151-98235226   c
            1000-1044           JAXUCZ010000008.1  98234590-98234634   c
            1045-1125           JAXUCZ010000008.1  98234420-98234500   c
            1126-1240           JAXUCZ010000008.1  98234215-98234329   c
            1241-1396           JAXUCZ010000008.1  98233124-98233279   c
            1397-1521           JAXUCZ010000008.1  98232035-98232159   c
            1522-1580           JAXUCZ010000008.1  98231797-98231855   c
            1581-1607           JAXUCZ010000008.1  98230665-98230691   c
            1608-1740           JAXUCZ010000008.1  98228267-98228399   c
            1741-1942           JAXUCZ010000008.1  98220983-98221184   c
            1943-2026           JAXUCZ010000008.1  98218585-98218668   c
            2027-2127           JAXUCZ010000008.1  98215300-98215400   c
            2128-2239           JAXUCZ010000008.1  98213824-98213935   c
            2240-2280           JAXUCZ010000008.1  98211998-98212038   c
            2281-2400           JAXUCZ010000008.1  98211767-98211886   c
            2401-2524           JAXUCZ010000008.1  98208659-98208782   c
            2525-2689           JAXUCZ010000008.1  98208333-98208497   c
            2690-2785           JAXUCZ010000008.1  98205461-98205556   c
            2786-2877           JAXUCZ010000008.1  98204360-98204451   c
            2878-2934           JAXUCZ010000008.1  98203703-98203759   c
            2935-3122           JAXUCZ010000008.1  98201009-98201196   c
FEATURES             Location/Qualifiers
     source          1..3122
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..3122
                     /gene="Snx14"
                     /note="sorting nexin 14"
                     /db_xref="GeneID:315871"
                     /db_xref="RGD:1310921"
     exon            1..272
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..2973
                     /gene="Snx14"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="sorting nexin-14 isoform 2"
                     /protein_id="NP_001380614.1"
                     /db_xref="GeneID:315871"
                     /db_xref="RGD:1310921"
                     /translation="MGSWVRTIGERLKQRLRLDVGREICRQYPLFCFLLLCLSAASLL
                     LNRYLHVLMIFWSFVAGVVTFYCSLGPDSLLPNIFFTIKYKPKQLGLQELFPQGHSCA
                     VCGKVKCKRHRPSLLLENYQPWLDLKVSSKVDASLSEVLELVLENFVYPWYRDVTDDE
                     SFVDELRITLRFFASVLVRRIHKVDIPSIITKKLLKAAMKHIEVIVKARQKVKNTEYL
                     QQAALEEYGPDLHVALRSRRDELQYLRKLTELLFPYILPPKATDCRSLTLLIREILSG
                     SVFLPSLDFLADPDTVNHLLIIFIDDSPPEKATEPASPLVPFLQKFAEPRNKKPSVLK
                     LELKQIREQQDLLFRFMNFLKQEGAVHVLQFCLTVEEFNDRILRPELSNDEMLSLHEE
                     LQKIYKTYCLDESIDKIRFDPFIVEEIQRIAEGPYIDVVKLQTMRCLFEAYEHVLSLL
                     ENVFTPMFCHSDEYFRQLLRGAESPTRNSKFNRGSLSLDDFRSTQKRGESFGISRIGS
                     KIKGVFKSTTMEGAVLPSYGVAEGEDDFIEEGIVVLEDDSPVEAVSTPNTPRNLAAWK
                     ISIPYVDFFEDPSSERKEKKERIPVFCIDVERNDRRAVGHEPEHWSVYRRYLEFYVLE
                     SKLTEFHGTFPDAQLPSKRIIGPKNYEFLKSKREEFQEYLQKLVQHPELSNSQLLADF
                     LSPNGGETQFLDKILPDVNLGKIIKSVPGKLMKEKGQHLEPFIMSFINSCESPKPKPS
                     RPELTILSPTSENNKKLFNDLFKNNANRAENTERKQNQNYFMEVMTVDGVYDYLMYVG
                     RVVFQVPDWLHHLLMGTRILFKNTLEMYTDYYLQCKLEQLFQEHRLVSLITLLRDAIF
                     CENTEPRSLQDKQKGAKQTFEEMMNYIPDLIVKCIGEETKYESIRLLFDGLQQPVLNK
                     QLTYVLLDIVIQELFPELNKVQKEATSTASWM"
     exon            273..393
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            394..470
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            471..549
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            550..593
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            594..681
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            682..766
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            767..923
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            924..999
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1044
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1125
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1240
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1396
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1521
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1580
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1607
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1740
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1942
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2026
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2127
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2239
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2280
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2400
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2524
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2689
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2785
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2877
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..2934
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..3122
                     /gene="Snx14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggggcctt gtgcggctgc gcctagctgt gaagctgggt ggtgggtggc tatgtggctc
       61 cgccgccggg gattgggggt gccttccgcc tcagcctctg agggcggcaa gtcctccgct
      121 tcgtggactg agatggggtc ttgggtgcgg acgatcggcg agaggctgaa gcagcggctg
      181 cggttggacg tgggacgcga gatttgccgt cagtatccgc tgttctgctt cctgctactc
      241 tgcctcagcg ccgcttcgct gctcctcaac aggtatcttc acgtcttaat gatcttctgg
      301 tcttttgttg cgggagttgt gacgttctac tgttcattag gacccgattc cctcttacca
      361 aatatattct tcacaataaa atacaaacct aagcaattag gacttcagga gttatttcca
      421 caaggacata gctgtgctgt ttgtggtaaa gtgaagtgta agcgacatag gccttccttg
      481 ctacttgaaa actatcagcc ctggctagac ctgaaagttt cttccaaggt tgatgcatct
      541 ctctcagagg tccttgaatt agtgttggaa aactttgtct atccatggta cagggatgtg
      601 acggatgacg agtcctttgt ggatgagctg aggatcacct tacggttttt tgcatctgtc
      661 ttagtgcgaa gaattcacaa ggtcgatatt ccatctatta taaccaagaa actattaaaa
      721 gcagcaatga aacatataga agtgattgtt aaagcaagac agaaagtaaa aaacacggag
      781 tatttacagc aagctgcttt agaagaatat ggtccagatc ttcatgtggc tttgagaagt
      841 cgaagagatg aattacagta tttaaggaaa cttactgagt tactttttcc ttatattttg
      901 cctcctaaag caacagactg cagatccctg acattactta taagagagat tctatctggt
      961 tctgtgtttc ttccttcttt ggatttccta gctgatccag ataccgtcaa tcatttgctt
     1021 atcatcttca tagatgacag ccctcctgaa aaagcaactg agccagcttc ccccttggtt
     1081 ccattcctgc agaaatttgc tgaacctaga aataaaaaac catctgtgct gaagttagaa
     1141 ttgaaacaaa tcagagaaca acaagatctt ttgtttcgct ttatgaactt cctgaaacaa
     1201 gaaggagccg tgcacgtcct gcagttctgt ctgactgttg aggaatttaa tgatagaatt
     1261 ttgcggccag agttatcaaa cgatgaaatg ctctctctgc atgaggaatt gcagaagatt
     1321 tataagacat actgcttgga cgaaagtatt gacaaaatcc ggtttgatcc cttcattgta
     1381 gaggagatcc aaagaattgc tgaaggccca tacatagatg ttgtgaagct gcaaactatg
     1441 cgatgtcttt ttgaagcata tgagcatgtt ctttccctct tggagaatgt gttcacccct
     1501 atgttctgcc acagcgacga gtatttcagg caactcttaa gaggtgcaga atcgcccaca
     1561 cgaaattcca aattcaatag aggtagccta agtttggatg atttccgaag cacacaaaaa
     1621 agaggagaat cgttcggaat cagcagaata ggcagcaaaa ttaaaggtgt attcaagagc
     1681 accaccatgg agggggcagt gctgcctagt tacggcgtgg ctgaaggcga agatgacttt
     1741 attgaagaag gaattgtggt actggaggat gactctcctg tagaagccgt gagcacacct
     1801 aacactcctc ggaacctcgc cgcgtggaaa attagcattc cgtatgtaga cttttttgag
     1861 gatccctcct ctgaaaggaa ggagaagaag gagagaattc ctgtgttttg tattgatgtt
     1921 gaaagaaacg ataggcgagc agttggacat gagcctgaac attggtctgt ctatagaaga
     1981 tatcttgaat tctatgtact tgaatcaaaa ctaacagaat ttcacggcac atttcccgat
     2041 gctcagctgc catccaaaag gatcattggc cccaagaact acgagttttt aaagtcgaag
     2101 agagaggagt ttcaggagta tctacagaaa cttgtgcagc acccagagct gagtaacagc
     2161 cagcttctgg ctgacttcct ctctcccaat ggtggggaga cacagtttct ggataagata
     2221 cttccagatg taaatcttgg aaaaattata aagtcggttc ctgggaaact aatgaaggag
     2281 aaaggtcagc atttggaacc tttcatcatg agtttcatta attcttgtga atccccaaaa
     2341 cctaaaccga gtcggccaga actgaccatt ctcagcccta cctctgaaaa caacaagaag
     2401 cttttcaacg atctatttaa gaataatgca aaccgcgctg aaaacacaga gcgaaaacaa
     2461 aatcagaact acttcatgga ggtgatgact gtggatggag tctacgatta cctgatgtat
     2521 gtagggcgag tagtttttca agttccagat tggcttcatc accttttaat gggcactcga
     2581 atcctcttta agaacacact ggaaatgtac actgactact atctccagtg caagctggag
     2641 cagctctttc aggagcatcg gctggtgtca ctcataaccc ttctcagaga tgctatattt
     2701 tgtgaaaata ctgaacctcg ctctctgcaa gataagcaaa aaggagcaaa acaaactttt
     2761 gaagaaatga tgaattacat tccagatctg atcgtcaagt gtattggtga agaaaccaag
     2821 tatgaaagca tcagacttct gtttgatggc ttgcagcagc cagtgctcaa caagcagctg
     2881 acctatgttt tgttggacat tgtgatacag gagctgtttc cagagctgaa taaggtacaa
     2941 aaggaagcta cctccacggc atcctggatg taaacacttg ctatagaata acataccagt
     3001 ataatggaat gtactttaca ctttgtatat ttttataaat atcatgtact ctagtgtttg
     3061 aaatatattt tttgttttaa taaagactta caaactaata gcaataaaaa gtgatttagg
     3121 ta
//
