LOCUS       NM_001013085            1423 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus sorting nexin 10 (Snx10), mRNA.
ACCESSION   NM_001013085 XM_216145
VERSION     NM_001013085.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1423)
  AUTHORS   Cervantes-Anaya N, Ponciano-Gomez A, Lopez-Alvarez GS,
            Gonzalez-Reyes C, Hernandez-Garcia S, Cabanas-Cortes MA,
            Garrido-Guerrero JE and Villa-Trevino S.
  TITLE     Downregulation of sorting nexin 10 is associated with
            overexpression of miR-30d during liver cancer progression in rats
  JOURNAL   Tumour Biol 39 (4), 1010428317695932 (2017)
   PUBMED   28381192
  REMARK    GeneRIF: the binomial miRNA 30d- SNX10 acts as a potential tumor
            oncogene suppressor by behaving as a dual tumor marker and a dual
            therapeutic target in liver cancer.
REFERENCE   2  (bases 1 to 1423)
  AUTHORS   Ye L, Morse LR, Zhang L, Sasaki H, Mills JC, Odgren PR, Sibbel G,
            Stanley JR, Wong G, Zamarioli A and Battaglino RA.
  TITLE     Osteopetrorickets due to Snx10 deficiency in mice results from both
            failed osteoclast activity and loss of gastric acid-dependent
            calcium absorption
  JOURNAL   PLoS Genet 11 (3), e1005057 (2015)
   PUBMED   25811986
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1423)
  AUTHORS   Zhu CH, Morse LR and Battaglino RA.
  TITLE     SNX10 is required for osteoclast formation and resorption activity
  JOURNAL   J Cell Biochem 113 (5), 1608-1615 (2012)
   PUBMED   22174188
REFERENCE   4  (bases 1 to 1423)
  AUTHORS   Chen Y, Wu B, Xu L, Li H, Xia J, Yin W, Li Z, Shi D, Li S, Lin S,
            Shu X and Pei D.
  TITLE     A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in
            vivo
  JOURNAL   Cell Res 22 (2), 333-345 (2012)
   PUBMED   21844891
REFERENCE   5  (bases 1 to 1423)
  AUTHORS   Tarantino C, Paolella G, Cozzuto L, Minopoli G, Pastore L, Parisi S
            and Russo T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   6  (bases 1 to 1423)
  AUTHORS   Qin B, He M, Chen X and Pei D.
  TITLE     Sorting nexin 10 induces giant vacuoles in mammalian cells
  JOURNAL   J Biol Chem 281 (48), 36891-36896 (2006)
   PUBMED   17012226
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091290.1.
            
            On Apr 20, 2005 this sequence version replaced XM_216145.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091290.1, CO405807.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1423
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1423
                     /gene="Snx10"
                     /note="sorting nexin 10"
                     /db_xref="GeneID:297096"
                     /db_xref="RGD:1305782"
     exon            1..50
                     /gene="Snx10"
                     /inference="alignment:Splign:2.1.0"
     exon            51..97
                     /gene="Snx10"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..679
                     /gene="Snx10"
                     /codon_start=1
                     /product="sorting nexin-10"
                     /protein_id="NP_001013103.1"
                     /db_xref="GeneID:297096"
                     /db_xref="RGD:1305782"
                     /translation="MFPEQQKEEFVSVWVRDPRIQKEDFWHSYIDYEICIHTNSMCFT
                     MKTSCVRRRYREFVWLRQRLQSNALLVQLPELPSKNLFFNMNNRQHVDQRRQGLEDFL
                     RKVLQNALLLSDSSLHLFLQSHLNSEDIEACVSGQTKYSVEEAIHKFALMNRRFPEEE
                     EEGKKDTDVEYDSESSSSGLGHSSDDSSSHGCKTSPALQES"
     exon            98..184
                     /gene="Snx10"
                     /inference="alignment:Splign:2.1.0"
     exon            185..285
                     /gene="Snx10"
                     /inference="alignment:Splign:2.1.0"
     exon            286..384
                     /gene="Snx10"
                     /inference="alignment:Splign:2.1.0"
     exon            385..597
                     /gene="Snx10"
                     /inference="alignment:Splign:2.1.0"
     exon            598..1400
                     /gene="Snx10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcaaactc cgccgggctc cgggccggac ccagccgtcc aggaccgcgc gttgatcgtg
       61 tcctgagccg aagatgttcc cagaacagca gaaagaggag ttcgtgagtg tctgggtccg
      121 agaccccagg attcagaagg aggacttttg gcattcttac atcgactatg agatatgtat
      181 tcacacgaat agcatgtgtt ttacgatgaa gacgtcttgc gtacgaagaa ggtatagaga
      241 gttcgtgtgg ctgaggcaga gactccaaag caacgcattg ctggtacaat taccagaact
      301 tccatctaaa aacctatttt tcaacatgaa caatcgccag catgtcgacc agcgccgcca
      361 gggcttggaa gatttcctca gaaaagtcct gcagaatgca ctcttgcttt ccgatagcag
      421 cctgcacctc ttcctgcaga gccatctgaa ctccgaggac attgaagcat gtgtttctgg
      481 gcagaccaag tactcggtag aagaggcaat tcacaagttt gccttgatga acagacggtt
      541 ccccgaagaa gaagaggaag gcaagaaaga caccgacgtg gagtatgatt cagaaagttc
      601 atcctctggg cttggacaca gtagtgatga cagcagctct catggatgta aaacgagccc
      661 ggctctgcag gagtcctgag aaggaactct agggctacca ccttaggaac gaaaattgtg
      721 cccagccaga aagaacgctt gctcataata gattcttacc taacgccact gtcagtatcc
      781 taggtggtta aattcttaga gtggtgggtt attagtagta gtagttttat gttgtctaat
      841 tctagccaag cttctgtatg aagctgtaag gtctgtgaat gccgtacaaa cctttattgc
      901 tagtacttgt aaatatgatc ctgctctcaa gtgaaatgag ttatgtgctc tatatattat
      961 acagttggtc ttaactgcac tttaaagagc taggtgtatt agtagcattt aaagcccaga
     1021 cagagcctcc ttgctgtatc aatgaggaag ttactgtaac acagtgtgac tggagtcaga
     1081 gtacggagtc acggcacagg agactgcttc tctgactcgt ggctcttgct ttgtggggac
     1141 ttcttctctg gaaaatactt tgccttcagg tattcgattg aaatatttaa gagtatttaa
     1201 gcttcccagc atatcgcatc atgtgtaaat gggaaaatac gtcttacaaa tagagatgta
     1261 ctgaaaaaaa aaatgtttac atcttaggag ggagagaaac agaagtcttg gtaactttgc
     1321 ttaaatttgc catacataga tttagaagta cattctcact gccccaaatc agcttaaata
     1381 aacaaggctt ctggtgacaa aaaaaaaaaa aaaaaaaaaa aaa
//
