LOCUS       NM_053411               2028 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus sorting nexin 1 (Snx1), mRNA.
ACCESSION   NM_053411
VERSION     NM_053411.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2028)
  AUTHORS   Gallon,M. and Cullen,P.J.
  TITLE     Retromer and sorting nexins in endosomal sorting
  JOURNAL   Biochem Soc Trans 43 (1), 33-47 (2015)
   PUBMED   25619244
  REMARK    Review article
REFERENCE   2  (bases 1 to 2028)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2028)
  AUTHORS   Fukaya,M., Fukushima,D., Hara,Y. and Sakagami,H.
  TITLE     EFA6A, a guanine nucleotide exchange factor for Arf6, interacts
            with sorting nexin-1 and regulates neurite outgrowth
  JOURNAL   J Neurochem 129 (1), 21-36 (2014)
   PUBMED   24261326
REFERENCE   4  (bases 1 to 2028)
  AUTHORS   van Weering,J.R., Sessions,R.B., Traer,C.J., Kloer,D.P.,
            Bhatia,V.K., Stamou,D., Carlsson,S.R., Hurley,J.H. and Cullen,P.J.
  TITLE     Molecular basis for SNX-BAR-mediated assembly of distinct endosomal
            sorting tubules
  JOURNAL   EMBO J 31 (23), 4466-4480 (2012)
   PUBMED   23085988
REFERENCE   5  (bases 1 to 2028)
  AUTHORS   Mamo,A., Jules,F., Dumaresq-Doiron,K., Costantino,S. and
            Lefrancois,S.
  TITLE     The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in
            endosomal sorting
  JOURNAL   Mol Cell Biol 32 (10), 1855-1866 (2012)
   PUBMED   22431521
REFERENCE   6  (bases 1 to 2028)
  AUTHORS   Cozier,G.E., Carlton,J., McGregor,A.H., Gleeson,P.A.,
            Teasdale,R.D., Mellor,H. and Cullen,P.J.
  TITLE     The phox homology (PX) domain-dependent,
            3-phosphoinositide-mediated association of sorting nexin-1 with an
            early sorting endosomal compartment is required for its ability to
            regulate epidermal growth factor receptor degradation
  JOURNAL   J Biol Chem 277 (50), 48730-48736 (2002)
   PUBMED   12198132
  REMARK    GeneRIF: PX domain-dependent/early endosomal association of SNX1 is
            important for its ability to regulate the targeting of internalized
            epidermal growth factor receptor for lysosomal degradation
REFERENCE   7  (bases 1 to 2028)
  AUTHORS   Parks,W.T., Frank,D.B., Huff,C., Renfrew Haft,C., Martin,J.,
            Meng,X., de Caestecker,M.P., McNally,J.G., Reddi,A., Taylor,S.I.,
            Roberts,A.B., Wang,T. and Lechleider,R.J.
  TITLE     Sorting nexin 6, a novel SNX, interacts with the transforming
            growth factor-beta family of receptor serine-threonine kinases
  JOURNAL   J Biol Chem 276 (22), 19332-19339 (2001)
   PUBMED   11279102
REFERENCE   8  (bases 1 to 2028)
  AUTHORS   Chin,L.S., Raynor,M.C., Wei,X., Chen,H.Q. and Li,L.
  TITLE     Hrs interacts with sorting nexin 1 and regulates degradation of
            epidermal growth factor receptor
  JOURNAL   J Biol Chem 276 (10), 7069-7078 (2001)
   PUBMED   11110793
REFERENCE   9  (bases 1 to 2028)
  AUTHORS   Haft,C.R., de la Luz Sierra,M., Bafford,R., Lesniak,M.A., Barr,V.A.
            and Taylor,S.I.
  TITLE     Human orthologs of yeast vacuolar protein sorting proteins Vps26,
            29, and 35: assembly into multimeric complexes
  JOURNAL   Mol Biol Cell 11 (12), 4105-4116 (2000)
   PUBMED   11102511
REFERENCE   10 (bases 1 to 2028)
  AUTHORS   Haft,C.R., de la Luz Sierra,M., Barr,V.A., Haft,D.H. and
            Taylor,S.I.
  TITLE     Identification of a family of sorting nexin molecules and
            characterization of their association with receptors
  JOURNAL   Mol Cell Biol 18 (12), 7278-7287 (1998)
   PUBMED   9819414
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF218916.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF218916.1, BC092201.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2028
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2028
                     /gene="Snx1"
                     /note="sorting nexin 1"
                     /db_xref="GeneID:84471"
                     /db_xref="RGD:68935"
     exon            1..236
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1646
                     /gene="Snx1"
                     /codon_start=1
                     /product="sorting nexin-1"
                     /protein_id="NP_445863.1"
                     /db_xref="GeneID:84471"
                     /db_xref="RGD:68935"
                     /translation="MASGGGGCSASERLPPPFPGMDPESEGAAGGSEPEAGDSDTEGE
                     DIFTGAAAASKPQSPKKTTSLFPIKNGSKENGIHEEQDQEPQDLFADATVELSLDSTQ
                     NNQKTMPGKTLIPHPTQEATNSPKPQPSYEELEEEEQEDQFDLTVGITDPEKIGDGMN
                     AYVAYKVTTQTSLPMFRSRQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIG
                     MTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGT
                     QALSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLV
                     NHRKELALNTALFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLL
                     AELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKRESEARLLWANKPDKLQQAK
                     DEITEWESRVTQYERDFERISTVVRKEVTRFEKEKSKDFKNHVIKYLETLLHSQQQLA
                     KYWEAFLPEARAIS"
     exon            237..348
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            349..476
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            477..543
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            544..587
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            588..729
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..808
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..884
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..998
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1092
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1298
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1442
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1523
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1595
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..2028
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcacacagc tggagcgctt tgctcgcggc actgtctata aagttgttgt tgctgcttcc
       61 gccacgggtg gaggaagatg gcgtcgggag gtggtggctg tagcgcttcg gagcgactcc
      121 ctccgccctt ccctggaatg gatccggagt ccgaaggggc tgccgggggg tcagaacccg
      181 aggctgggga cagcgacacc gagggggagg atattttcac tggcgccgcg gcagctagta
      241 agccccagtc tccaaagaaa accacatccc tttttcctat caaaaatggt tccaaagaaa
      301 atgggatcca tgaagaacaa gaccaagagc cacaggacct ctttgcagat gccacagtgg
      361 aactatccct ggacagcaca cagaataacc agaagacaat gccaggcaaa acacttattc
      421 ctcatcctac gcaagaagcc acaaattctc ctaagccaca gccaagctat gaagagctgg
      481 aggaagaaga acaggaggat cagtttgatt tgacagttgg tatcactgat cctgagaaga
      541 tcggggacgg tatgaatgcc tatgtagcct acaaagtcac cacacagaca agcttaccga
      601 tgttcagaag taggcagttt gcagtgaaaa gaagattcag tgactttctg ggtctttatg
      661 agaagctctc agagaagcac tcccagaatg gtttcattgt ccctcctcca cctgagaaga
      721 gcctaatagg aatgacaaag gtgaaggttg ggaaggaaga ttcttcttct gcagagtttc
      781 ttgagaaacg gagggctgct ttggaaaggt accttcaaag aattgtgaat catcctacca
      841 tgttacagga cccagatgtc agggagtttt tagaaaaaga agagctgcct cgagctgtag
      901 gtacgcaggc tctaagtggt gctggtctcc ttaagatgtt caacaaagct acagatgcag
      961 tcagcaaaat gaccatcaag atgaatgaat cagacatttg gttcgaggag aagctccagg
     1021 aggtggagtg tgaggaacag cgcctacgga agctgcacgc tgtggtggag actctagtca
     1081 accataggaa agaactagca ctgaatacag ccctgtttgc caagagtcta gccatgcttg
     1141 gcagctccga ggacaacaca gcactgtctc gagcactctc ccaactggct gaggtggaag
     1201 aaaagattga gcagctccac caggaacagg ccaacaatga cttcttcctc ctggctgaac
     1261 tcctgagtga ctatatccgc ctcctggcca ttgtccgagc cgccttcgac cagcgcatga
     1321 agacatggca gcgctggcag gatgctcaag ccacgctgca gaagaagcgg gagtctgagg
     1381 ctcggctgct gtgggccaac aagcctgaca aactgcagca ggctaaggat gagattacag
     1441 agtgggaatc tcgggtgact cagtatgaaa gggactttga aaggatttca acagttgtcc
     1501 gaaaggaggt gacacgattt gagaaagaga aatccaagga cttcaaaaac cacgtgatca
     1561 agtacctgga gacactcctg cattcccagc agcagctggc aaaatactgg gaagccttcc
     1621 ttcctgaggc cagggccatc tcctgaggga ccaaggagac cagagcctac cttcgtgacg
     1681 ctgccttttt atatactgtc ctcctcccct tgatggaccc caactgatgc ccctgccttg
     1741 gctggactta gcccttccac tctgccccac agacaaactg ttcccagtta ctctaaccaa
     1801 catttcattt agcttccaca tatattttct tacctaagag aatagtttcc tgctttaagc
     1861 aaaagaccta caataggtgg tggagttata ggttaggggt ggagcagtga tataaatata
     1921 taaatacaaa tgtatatttt tcaggatgtg gtttaggaac tgggaataac gttttctgtt
     1981 actcctgatg gtgccatgaa agattatgta ataaaatatt tgaaaatc
//
