LOCUS       NM_001168674            1698 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus syntrophin, beta 2 (Sntb2), mRNA.
ACCESSION   NM_001168674 XM_001071003 XM_001071043
VERSION     NM_001168674.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1698)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   2  (bases 1 to 1698)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   3  (bases 1 to 1698)
  AUTHORS   Schubert,S., Knoch,K.P., Ouwendijk,J., Mohammed,S., Bodrov,Y.,
            Jager,M., Altkruger,A., Wegbrod,C., Adams,M.E., Kim,Y.,
            Froehner,S.C., Jensen,O.N., Kalaidzidis,Y. and Solimena,M.
  TITLE     beta2-Syntrophin is a Cdk5 substrate that restrains the motility of
            insulin secretory granules
  JOURNAL   PLoS One 5 (9), e12929 (2010)
   PUBMED   20886068
  REMARK    GeneRIF: beta2-Syntrophin is a Cdk5 substrate that restrains the
            motility of insulin secretory granules.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1698)
  AUTHORS   Costantini,J.L., Cheung,S.M., Hou,S., Li,H., Kung,S.K.,
            Johnston,J.B., Wilkins,J.A., Gibson,S.B. and Marshall,A.J.
  TITLE     TAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion
            through interaction with the cytoskeletal protein utrophin:
            expression of a novel cell adhesion-promoting complex in B-cell
            leukemia
  JOURNAL   Blood 114 (21), 4703-4712 (2009)
   PUBMED   19786618
REFERENCE   5  (bases 1 to 1698)
  AUTHORS   Lyssand,J.S., DeFino,M.C., Tang,X.B., Hertz,A.L., Feller,D.B.,
            Wacker,J.L., Adams,M.E. and Hague,C.
  TITLE     Blood pressure is regulated by an alpha1D-adrenergic
            receptor/dystrophin signalosome
  JOURNAL   J Biol Chem 283 (27), 18792-18800 (2008)
   PUBMED   18468998
REFERENCE   6  (bases 1 to 1698)
  AUTHORS   Leonoudakis,D., Conti,L.R., Anderson,S., Radeke,C.M., McGuire,L.M.,
            Adams,M.E., Froehner,S.C., Yates,J.R. 3rd and Vandenberg,C.A.
  TITLE     Protein trafficking and anchoring complexes revealed by proteomic
            analysis of inward rectifier potassium channel (Kir2.x)-associated
            proteins
  JOURNAL   J Biol Chem 279 (21), 22331-22346 (2004)
   PUBMED   15024025
REFERENCE   7  (bases 1 to 1698)
  AUTHORS   Adams,M.E., Kramarcy,N., Krall,S.P., Rossi,S.G., Rotundo,R.L.,
            Sealock,R. and Froehner,S.C.
  TITLE     Absence of alpha-syntrophin leads to structurally aberrant
            neuromuscular synapses deficient in utrophin
  JOURNAL   J Cell Biol 150 (6), 1385-1398 (2000)
   PUBMED   10995443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On or before Dec 13, 2009 this sequence version replaced
            XM_001071043.1, XM_001071003.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.79749.1,
                                           SRR26643297.51612.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-609               JAXUCZ010000019.1  51741428-51742036
            610-823             JAXUCZ010000019.1  51791379-51791592
            824-1034            JAXUCZ010000019.1  51801677-51801887
            1035-1177           JAXUCZ010000019.1  51809716-51809858
            1178-1374           JAXUCZ010000019.1  51814326-51814522
            1375-1559           JAXUCZ010000019.1  51822149-51822333
            1560-1698           JAXUCZ010000019.1  51823734-51823872
FEATURES             Location/Qualifiers
     source          1..1698
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1698
                     /gene="Sntb2"
                     /note="syntrophin, beta 2"
                     /db_xref="GeneID:689421"
                     /db_xref="RGD:1592340"
     exon            1..609
                     /gene="Sntb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1652
                     /gene="Sntb2"
                     /note="syntrophin, basic 2"
                     /codon_start=1
                     /product="beta-2-syntrophin"
                     /protein_id="NP_001162145.1"
                     /db_xref="GeneID:689421"
                     /db_xref="RGD:1592340"
                     /translation="MAVWTRATKAGLVELLLRERWVRVVAELSGESLSLTGDAAAVEP
                     EPPAVAFNGLPNGGGGGGDSLPGSPNRGLGPPSPPAPPRGPAGEASASPPVRRVRVVK
                     QEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQ
                     AVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGASPQSPSFSGSEDSGSPKH
                     QNTTKDRKVIPLKMCFAARNLSMPDLENRLIELHSPDSRNTLILRCKDTATAHSWFVA
                     IHTNIMALLPQVLAELNAMLGATSTAGGSKEVKHIAWLAEQAKLDGGRQQWRPVLMAV
                     TEKDLLLYDCMPWTRDAWASPCHSYPLVATRLVHSGSGCRSPSLGSDLTFATRTGSRQ
                     GIEMHLFRVETHRDLSTWTRILVQGCHAAAELIKEVSLGCTLSGQDVRFTVHYEHGFT
                     ITRDNGGTSSILYRYPFERLKMSADDGIRNLYLDFGGPEGELTMDLHSCPKPIVFVLH
                     TFLSAKVTRMGLLV"
     exon            610..823
                     /gene="Sntb2"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1034
                     /gene="Sntb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1177
                     /gene="Sntb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1374
                     /gene="Sntb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1559
                     /gene="Sntb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1698
                     /gene="Sntb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcgggaag ggggaagcgc cgaggctgcc tgactggaat cgggggagct gcagcgacgg
       61 cggctgcggg agcagggctg gccatggcgg tgtggacgcg ggccaccaaa gcgggactgg
      121 tggagctgct tctgagggag cgctgggtgc gggtggtggc cgaactcagt ggcgagagcc
      181 tgagcctgac gggcgacgcc gcggcggtcg agcctgaacc gcccgcggtc gccttcaacg
      241 gtctcccgaa cggcggcggc ggcggcggag actcgctgcc ggggagcccg aaccgcggcc
      301 tggggccgcc cagccctccc gcgccgcccc gcggtccggc tggggaagcg agcgcctcgc
      361 cccccgtgcg ccgagtgcga gtggtgaagc aggaggcggg cggcctgggc atcagcatca
      421 agggcggccg agagaaccgg atgccgatcc tcatctccaa gatcttccca gggctggcgg
      481 ccgaccagag ccgggcgctg cggctaggcg acgccatcct gtcggtgaac ggcaccgacc
      541 tgcgccaggc cacccacgac caggccgtgc aggcgctgaa gcgcgcgggc aaggaggtgc
      601 tgctggaggt caagttcatc cgagaagtaa caccatatat caagaaacca tcattagtat
      661 cagatctgcc gtgggaaggt gcctctcccc agtcaccaag cttcagtggc agtgaagact
      721 ctggctctcc aaagcatcag aacaccacca aggacaggaa ggtcatccct ctcaaaatgt
      781 gctttgctgc tagaaaccta agcatgcccg atctggagaa cagattgata gagctacatt
      841 ctcctgatag caggaacacc ttgatcttac gctgcaagga tacggccaca gcacactcct
      901 ggttcgtagc tatccacacc aacataatgg ctctcctccc acaggtactg gctgagctca
      961 atgccatgct tggtgcaacc agtacagcgg gaggcagcaa ggaagtcaag catattgcct
     1021 ggctggcaga gcaggcaaaa ctagatggtg gaagacagca gtggaggcct gttctcatgg
     1081 ctgtgactga gaaggatttg ctactttatg actgtatgcc gtggacaaga gatgcctggg
     1141 catcgccgtg tcatagctac cctcttgttg ccacaaggtt ggttcattca ggttctggat
     1201 gtcggtcgcc ttcccttgga tctgacctta cctttgctac caggacgggc tctcggcagg
     1261 gcattgagat gcatctcttc agggttgaaa cgcatcggga tttgtcgacc tggaccagaa
     1321 tacttgtcca gggctgccat gctgctgctg agctgatcaa ggaagtctcc ctaggctgca
     1381 ccttaagtgg ccaagatgta agattcactg tccactatga gcacgggttc acgatcacca
     1441 gagacaatgg cggcaccagc agcatattgt accgctatcc ctttgaacgg ctgaagatgt
     1501 ctgctgatga tggaatcaga aatctctact tggattttgg tggtcctgag ggagaactga
     1561 ctatggatct gcattcttgt ccaaagccga ttgtgtttgt attgcacaca ttcttatctg
     1621 ccaaagtcac tcgcatggga ctgcttgtgt gagcagcaag agtggagaaa gactgccaca
     1681 agaagtattt ccacctca
//
