LOCUS       NP_112379                240 aa            linear   ROD 19-AUG-2024
DEFINITION  small nuclear ribonucleoprotein-associated protein N [Rattus
            norvegicus].
ACCESSION   NP_112379
VERSION     NP_112379.1
DBSOURCE    REFSEQ: accession NM_031117.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 240)
  AUTHORS   Timalsina,B., Choi,H.J. and Moon,I.S.
  TITLE     N-Acetylglucosamine Kinase-Small Nuclear Ribonucleoprotein
            Polypeptide N Interaction Promotes Axodendritic Branching in
            Neurons via Dynein-Mediated Microtubule Transport
  JOURNAL   Int J Mol Sci 24 (14), 11672 (2023)
   PUBMED   37511433
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 240)
  AUTHORS   Zhang,Q., Zhang,F., Gao,H.H. and Zhang,J.M.
  TITLE     Effects of varicocele on DNA methylation pattern of H19 and Snrpn
            gene in spermatozoa and behavioural characteristics of adult rat
            offspring
  JOURNAL   Andrologia 49 (1) (2017)
   PUBMED   27071665
  REMARK    GeneRIF: Varicocele does not alter the methylation profiles of H19
            and Snrpn gene, but exerts depressant-like effect on the adult rat
            offspring.
REFERENCE   3  (residues 1 to 240)
  AUTHORS   Meng,F., Xu,L., Huang,S., Liu,Y., Hou,Y., Wang,K., Jiang,X. and
            Li,G.
  TITLE     Small nuclear ribonucleoprotein polypeptide N (Sm51) promotes
            osteogenic differentiation of bone marrow mesenchymal stem cells by
            regulating Runx2
  JOURNAL   Cell Tissue Res 366 (1), 155-162 (2016)
   PUBMED   27184949
  REMARK    GeneRIF: Sm51 plays an important role in regulating osteogenic
            differentiation of mesenchymal stem cells through increasing Runx2
            expression
REFERENCE   4  (residues 1 to 240)
  AUTHORS   Ishikawa,T., Kibe,T. and Wada,Y.
  TITLE     Deletion of small nuclear ribonucleoprotein polypeptide N (SNRPN)
            in Prader-Willi syndrome detected by fluorescence in situ
            hybridization: two sibs with the typical phenotype without a
            cytogenetic deletion in chromosome 15q
  JOURNAL   Am J Med Genet 62 (4), 350-352 (1996)
   PUBMED   8723064
REFERENCE   5  (residues 1 to 240)
  AUTHORS   Huntriss,J.D., Latchman,D.S. and Williams,D.G.
  TITLE     The snRNP core protein SmB and tissue-specific SmN protein are
            differentially distributed between snRNP particles
  JOURNAL   Nucleic Acids Res 21 (17), 4047-4053 (1993)
   PUBMED   8371979
REFERENCE   6  (residues 1 to 240)
  AUTHORS   Schmauss,C. and Lerner,M.R.
  TITLE     The closely related small nuclear ribonucleoprotein polypeptides N
            and B/B' are distinguishable by antibodies as well as by
            differences in their mRNAs and gene structures
  JOURNAL   J Biol Chem 265 (18), 10733-10739 (1990)
   PUBMED   1693924
REFERENCE   7  (residues 1 to 240)
  AUTHORS   Esposito,F., Ammendola,R., Duilio,A., Costanzo,F., Giordano,M.,
            Zambrano,N., D'Agostino,P., Russo,T. and Cimino,F.
  TITLE     Isolation of cDNA fragments hybridizing to rat brain-specific mRNAs
  JOURNAL   Dev Neurosci 12 (6), 373-381 (1990)
   PUBMED   1981744
REFERENCE   8  (residues 1 to 240)
  AUTHORS   Li,S., Klein,E.S., Russo,A.F., Simmons,D.M. and Rosenfeld,M.G.
  TITLE     Isolation of cDNA clones encoding small nuclear
            ribonucleoparticle-associated proteins with different tissue
            specificities
  JOURNAL   Proc Natl Acad Sci U S A 86 (24), 9778-9782 (1989)
   PUBMED   2532363
REFERENCE   9  (residues 1 to 240)
  AUTHORS   McAllister,G., Roby-Shemkovitz,A., Amara,S.G. and Lerner,M.R.
  TITLE     cDNA sequence of the rat U snRNP-associated protein N: description
            of a potential Sm epitope
  JOURNAL   EMBO J 8 (4), 1177-1181 (1989)
   PUBMED   2526016
REFERENCE   10 (residues 1 to 240)
  AUTHORS   Schmauss,C., McAllister,G., Ohosone,Y., Hardin,J.A. and Lerner,M.R.
  TITLE     A comparison of snRNP-associated Sm-autoantigens: human N, rat N
            and human B/B'
  JOURNAL   Nucleic Acids Res 17 (4), 1733-1743 (1989)
   PUBMED   2522186
  REMARK    Erratum:[Nucleic Acids Res 1989 Aug 25;17(16):6777]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1, FM122235.1 and BC087671.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M29293.1, SRR26360190.1463453.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840110, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..240
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     Protein         1..240
                     /product="small nuclear ribonucleoprotein-associated
                     protein N"
                     /note="FE294 psi pseudogene; FE294 gene for
                     snRNP-associated polypeptide N; smN; sm-D; sm-N; snRNP-N;
                     sm protein N; sm protein D; small nuclear
                     ribonucleoparticle-associated protein (snRNP) mRNA, clone
                     Sm51; small nuclear ribonucleoprotein N"
                     /calculated_mol_wt=24483
     Region          5..83
                     /region_name="Sm_B"
                     /note="Sm protein B; cd01717"
                     /db_xref="CDD:212464"
     Site            order(8,14,22..23,32,36,43..44,69..82)
                     /site_type="other"
                     /note="heptamer interface [polypeptide binding]"
                     /db_xref="CDD:212464"
     Site            order(17..23,25..37,39..43)
                     /site_type="other"
                     /note="Sm1 motif"
                     /db_xref="CDD:212464"
     Site            order(20..25,27,33..34,37,39,41,60,65,67,69..79)
                     /site_type="other"
                     /note="putative hexamer interface [polypeptide binding]"
                     /db_xref="CDD:212464"
     Site            order(36..39,49,59..61,73,75)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:212464"
     Site            69..80
                     /site_type="other"
                     /note="Sm2 motif"
                     /db_xref="CDD:212464"
     Site            108
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P14678; Dimethylated
                     arginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P14678;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P63163; propagated from
                     UniProtKB/Swiss-Prot (P63164.1)"
     Site            112
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P14678; Dimethylated
                     arginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P14678;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P14678; propagated from
                     UniProtKB/Swiss-Prot (P63164.1)"
     Site            147
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:P14678; propagated from
                     UniProtKB/Swiss-Prot (P63164.1)"
     Region          163..240
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P63164.1)"
     Site            172
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:P63162; propagated from
                     UniProtKB/Swiss-Prot (P63164.1)"
     Region          175..236
                     /region_name="Repeat-rich region"
                     /note="propagated from UniProtKB/Swiss-Prot (P63164.1)"
     CDS             1..240
                     /gene="Snrpn"
                     /gene_synonym="FE 294; FE 294 psi; FE294; FE294 psi"
                     /coded_by="NM_031117.2:597..1319"
                     /db_xref="GeneID:81781"
                     /db_xref="RGD:621306"
ORIGIN      
        1 mtvgksskml qhidyrmrci lqdgrifigt fkafdkhmnl ilcdcdefrk ikpknakqpe
       61 reekrvlglv llrgenlvsm tvegpppkdt giarvplaga aggpgvgraa grgvpagvpi
      121 pqapaglagp vrgvggpsqq vmtpqgrgtv aaaavaatas iagaptqypp grgtppppvg
      181 ratpppgima pppgmrppmg ppiglpparg tpigmpppgm rppppgirgp pppgmrpprp
//
