LOCUS       NM_001271237             429 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus small nuclear ribonucleoprotein polypeptide E
            (Snrpe), mRNA.
ACCESSION   NM_001271237 XM_002724889 XM_002728006
VERSION     NM_001271237.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 429)
  AUTHORS   Bertram,K., Agafonov,D.E., Dybkov,O., Haselbach,D., Leelaram,M.N.,
            Will,C.L., Urlaub,H., Kastner,B., Luhrmann,R. and Stark,H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   2  (bases 1 to 429)
  AUTHORS   Bertram,K., Agafonov,D.E., Liu,W.T., Dybkov,O., Will,C.L.,
            Hartmuth,K., Urlaub,H., Kastner,B., Stark,H. and Luhrmann,R.
  TITLE     Cryo-EM structure of a human spliceosome activated for step 2 of
            splicing
  JOURNAL   Nature 542 (7641), 318-323 (2017)
   PUBMED   28076346
REFERENCE   3  (bases 1 to 429)
  AUTHORS   Agafonov,D.E., Kastner,B., Dybkov,O., Hofele,R.V., Liu,W.T.,
            Urlaub,H., Luhrmann,R. and Stark,H.
  TITLE     Molecular architecture of the human U4/U6.U5 tri-snRNP
  JOURNAL   Science 351 (6280), 1416-1420 (2016)
   PUBMED   26912367
REFERENCE   4  (bases 1 to 429)
  AUTHORS   Kondo,Y., Oubridge,C., van Roon,A.M. and Nagai,K.
  TITLE     Crystal structure of human U1 snRNP, a small nuclear
            ribonucleoprotein particle, reveals the mechanism of 5' splice site
            recognition
  JOURNAL   Elife 4, e04986 (2015)
   PUBMED   25555158
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 429)
  AUTHORS   Lin,S.J., Chang,K.P., Hsu,C.W., Chi,L.M., Chien,K.Y., Liang,Y.,
            Tsai,M.H., Lin,Y.T. and Yu,J.S.
  TITLE     Low-molecular-mass secretome profiling identifies C-C motif
            chemokine 5 as a potential plasma biomarker and therapeutic target
            for nasopharyngeal carcinoma
  JOURNAL   J Proteomics 94, 186-201 (2013)
   PUBMED   24080422
REFERENCE   6  (bases 1 to 429)
  AUTHORS   Novakova,Z., Man,P., Novak,P., Hozak,P. and Hodny,Z.
  TITLE     Separation of nuclear protein complexes by blue native
            polyacrylamide gel electrophoresis
  JOURNAL   Electrophoresis 27 (7), 1277-1287 (2006)
   PUBMED   16502463
REFERENCE   7  (bases 1 to 429)
  AUTHORS   Riemekasten,G., Langnickel,D., Enghard,P., Undeutsch,R.,
            Humrich,J., Ebling,F.M., Hocher,B., Humaljoki,T., Neumayer,H.,
            Burmester,G.R., Hahn,B.H., Radbruch,A. and Hiepe,F.
  TITLE     Intravenous injection of a D1 protein of the Smith proteins
            postpones murine lupus and induces type 1 regulatory T cells
  JOURNAL   J Immunol 173 (9), 5835-5842 (2004)
   PUBMED   15494537
REFERENCE   8  (bases 1 to 429)
  AUTHORS   Will,C.L., Schneider,C., Hossbach,M., Urlaub,H., Rauhut,R.,
            Elbashir,S., Tuschl,T. and Luhrmann,R.
  TITLE     The human 18S U11/U12 snRNP contains a set of novel proteins not
            found in the U2-dependent spliceosome
  JOURNAL   RNA 10 (6), 929-941 (2004)
   PUBMED   15146077
REFERENCE   9  (bases 1 to 429)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   10 (bases 1 to 429)
  AUTHORS   Pillai,R.S., Will,C.L., Luhrmann,R., Schumperli,D. and Muller,B.
  TITLE     Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain
            Lsm10, a new 14 kDa Sm D1-like protein
  JOURNAL   EMBO J 20 (19), 5470-5479 (2001)
   PUBMED   11574479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ211122.1.
            
            On or before Sep 9, 2012 this sequence version replaced
            XM_002728006.2, XM_002724889.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211122.1, BF555033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-429               FQ211122.1         1-429
FEATURES             Location/Qualifiers
     source          1..429
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..429
                     /gene="Snrpe"
                     /note="small nuclear ribonucleoprotein polypeptide E"
                     /db_xref="GeneID:100360682"
                     /db_xref="RGD:2321675"
     exon            1..69
                     /gene="Snrpe"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..294
                     /gene="Snrpe"
                     /codon_start=1
                     /product="small nuclear ribonucleoprotein E"
                     /protein_id="NP_001258166.1"
                     /db_xref="GeneID:100360682"
                     /db_xref="RGD:2321675"
                     /translation="MAYRGQGQKVQKVMVQPINLIFRYLQNRSRIQVWLYEQVNMRIE
                     GCIIGFDEYMNLVLDDAEEIHSKTKSRKQLGRIMLKGDNITLLQSVSN"
     exon            70..96
                     /gene="Snrpe"
                     /inference="alignment:Splign:2.1.0"
     exon            97..159
                     /gene="Snrpe"
                     /inference="alignment:Splign:2.1.0"
     exon            160..238
                     /gene="Snrpe"
                     /inference="alignment:Splign:2.1.0"
     exon            239..420
                     /gene="Snrpe"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttgtgactt ccaccatggc gtaccgcggc cagggccaga aggtgcagaa ggtgatggtg
       61 cagcccatca accttatctt cagatacttg caaaatagat ctcgaattca ggtgtggctg
      121 tatgaacaag tgaatatgcg gatagagggt tgtattattg gctttgatga gtacatgaac
      181 ctcgtattag atgatgcaga agaaattcat tctaaaacaa agtcaagaaa acaactgggt
      241 cggatcatgc tcaaaggaga taatattact ctgctccaaa gcgtttccaa ctagcagtgg
      301 ccaagcatgg gagaggttga gaaggggctc aggggctgct ggtgactaca tttactcatc
      361 ctgtttcact tgtacattct cattggggta aaaataaatg tgagcttgtt tttgttacaa
      421 aaaaaaaaa
//
