LOCUS       NM_001271040            1072 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus small nuclear ribonucleoprotein polypeptide C
            (Snrpc), mRNA.
ACCESSION   NM_001271040 XM_001078182 XM_002725843 XM_002728920 XM_342101
VERSION     NM_001271040.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1072)
  AUTHORS   Zhang,L., Li,X. and Zhao,R.
  TITLE     Structural analyses of the pre-mRNA splicing machinery
  JOURNAL   Protein Sci 22 (6), 677-692 (2013)
   PUBMED   23592432
  REMARK    Review article
REFERENCE   2  (bases 1 to 1072)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1072)
  AUTHORS   Weber,G., Trowitzsch,S., Kastner,B., Luhrmann,R. and Wahl,M.C.
  TITLE     Functional organization of the Sm core in the crystal structure of
            human U1 snRNP
  JOURNAL   EMBO J 29 (24), 4172-4184 (2010)
   PUBMED   21113136
REFERENCE   4  (bases 1 to 1072)
  AUTHORS   Novakova,Z., Man,P., Novak,P., Hozak,P. and Hodny,Z.
  TITLE     Separation of nuclear protein complexes by blue native
            polyacrylamide gel electrophoresis
  JOURNAL   Electrophoresis 27 (7), 1277-1287 (2006)
   PUBMED   16502463
REFERENCE   5  (bases 1 to 1072)
  AUTHORS   Hochleitner,E.O., Kastner,B., Frohlich,T., Schmidt,A., Luhrmann,R.,
            Arnold,G. and Lottspeich,F.
  TITLE     Protein stoichiometry of a multiprotein complex, the human
            spliceosomal U1 small nuclear ribonucleoprotein: absolute
            quantification using isotope-coded tags and mass spectrometry
  JOURNAL   J Biol Chem 280 (4), 2536-2542 (2005)
   PUBMED   15525645
REFERENCE   6  (bases 1 to 1072)
  AUTHORS   Rossi,F., Forne,T., Antoine,E., Tazi,J., Brunel,C. and Cathala,G.
  TITLE     Involvement of U1 small nuclear ribonucleoproteins (snRNP) in 5'
            splice site-U1 snRNP interaction
  JOURNAL   J Biol Chem 271 (39), 23985-23991 (1996)
   PUBMED   8798632
REFERENCE   7  (bases 1 to 1072)
  AUTHORS   Satoh,M., Langdon,J.J., Hamilton,K.J., Richards,H.B., Panka,D.,
            Eisenberg,R.A. and Reeves,W.H.
  TITLE     Distinctive immune response patterns of human and murine autoimmune
            sera to U1 small nuclear ribonucleoprotein C protein
  JOURNAL   J Clin Invest 97 (11), 2619-2626 (1996)
   PUBMED   8647956
REFERENCE   8  (bases 1 to 1072)
  AUTHORS   Gunnewiek,J.M., van Aarssen,Y., Wassenaar,R., Legrain,P., van
            Venrooij,W.J. and Nelissen,R.L.
  TITLE     Homodimerization of the human U1 snRNP-specific protein C
  JOURNAL   Nucleic Acids Res 23 (23), 4864-4871 (1995)
   PUBMED   8532530
REFERENCE   9  (bases 1 to 1072)
  AUTHORS   Nelissen,R.L., Heinrichs,V., Habets,W.J., Simons,F., Luhrmann,R.
            and van Venrooij,W.J.
  TITLE     Zinc finger-like structure in U1-specific protein C is essential
            for specific binding to U1 snRNP
  JOURNAL   Nucleic Acids Res 19 (3), 449-454 (1991)
   PUBMED   1826349
REFERENCE   10 (bases 1 to 1072)
  AUTHORS   Craft,J., Mimori,T., Olsen,T.L. and Hardin,J.A.
  TITLE     The U2 small nuclear ribonucleoprotein particle as an autoantigen.
            Analysis with sera from patients with overlap syndromes
  JOURNAL   J Clin Invest 81 (6), 1716-1724 (1988)
   PUBMED   2968364
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On or before Aug 30, 2012 this sequence version replaced
            XM_001078182.2, XM_342101.4, XM_002725843.2, XM_002728920.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ209526.1, SRR26643287.36758.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               JAXUCZ010000020.1  5890229-5890395
            168-393             JAXUCZ010000020.1  5897641-5897866
            394-436             JAXUCZ010000020.1  5898164-5898206
            437-545             JAXUCZ010000020.1  5899737-5899845
            546-635             JAXUCZ010000020.1  5902775-5902864
            636-740             JAXUCZ010000020.1  5904389-5904493
            741-1072            JAXUCZ010000020.1  5908079-5908410
FEATURES             Location/Qualifiers
     source          1..1072
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1072
                     /gene="Snrpc"
                     /gene_synonym="Snrp1c; U1-C; U1C"
                     /note="small nuclear ribonucleoprotein polypeptide C"
                     /db_xref="GeneID:361808"
                     /db_xref="RGD:1306065"
     exon            1..167
                     /gene="Snrpc"
                     /gene_synonym="Snrp1c; U1-C; U1C"
                     /inference="alignment:Splign:2.1.0"
     exon            168..393
                     /gene="Snrpc"
                     /gene_synonym="Snrp1c; U1-C; U1C"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..865
                     /gene="Snrpc"
                     /gene_synonym="Snrp1c; U1-C; U1C"
                     /note="U1 snRNP C"
                     /codon_start=1
                     /product="U1 small nuclear ribonucleoprotein C"
                     /protein_id="NP_001257969.1"
                     /db_xref="GeneID:361808"
                     /db_xref="RGD:1306065"
                     /translation="MPKFYCDYCDTYLTHDSPSVRKTHCSGRKHKENVKDYYQKWMEE
                     QAQSLIDKTTAAFQQGKIPPAPFSAPPPAGAMIPPPPSLPGPPRPGMMPAPHMGGPPM
                     MPMMGPPPPGMMPVGPAPGMRPPMGGHMPMMPGPPMMRPPARPMMVPTRPGMTRPDR"
     exon            394..436
                     /gene="Snrpc"
                     /gene_synonym="Snrp1c; U1-C; U1C"
                     /inference="alignment:Splign:2.1.0"
     exon            437..545
                     /gene="Snrpc"
                     /gene_synonym="Snrp1c; U1-C; U1C"
                     /inference="alignment:Splign:2.1.0"
     exon            546..635
                     /gene="Snrpc"
                     /gene_synonym="Snrp1c; U1-C; U1C"
                     /inference="alignment:Splign:2.1.0"
     exon            636..740
                     /gene="Snrpc"
                     /gene_synonym="Snrp1c; U1-C; U1C"
                     /inference="alignment:Splign:2.1.0"
     exon            741..1072
                     /gene="Snrpc"
                     /gene_synonym="Snrp1c; U1-C; U1C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attacccttg agtttgcttc agaccatcac acaactggaa gatgttttgc acactcctgt
       61 gcctgggaac tttcatctct cttgcttaca tttcattcaa gagtgctgtg tgcaccggag
      121 cacgcttgtg aagccggcat ctgggagaca aagcacagag atcacagaga actaagtaac
      181 gcacttccga gagggaataa ccaatcacga gtaagtgagc gcgggttgaa cctccgaggc
      241 acccatagcc cacttcctgg ccgtcctcag taaagaccgg aagcagaagt cctattcttc
      301 gcgtttgcat ccctgcgtcg gcgcagcctg tgtgcgtcag ttcctggcgg cggggaccgg
      361 gatagccaac ggcctgtgga gcaacatgcc caagttttat tgtgactact gtgatacgta
      421 tcttacccac gattctccgt ctgtgaggaa gacacactgc agtggtcgga aacacaaaga
      481 gaatgtgaaa gactattacc agaaatggat ggaagaacag gcccagagcc tgattgacaa
      541 aacaacggct gcatttcaac aaggaaagat ccctccagct ccgttctctg ctcctccgcc
      601 tgcaggggcc atgatcccgc ctccccccag tctcccgggt cctcctcggc ctggcatgat
      661 gcctgcaccc cacatgggag gccctcccat gatgccaatg atgggccccc ctcctcctgg
      721 gatgatgcct gtgggaccag ctcctgggat gagaccaccc atgggaggcc atatgcccat
      781 gatgcccggg cctccaatga tgagacctcc cgcccgccct atgatggtgc ccacacggcc
      841 tggcatgacc cggccagaca gataagagca gaagcgctct ttatcctttt gtatttcttg
      901 ttgtttcgcc aggagatctt ggtgctgacc ctgagtgttt cctaggtgca tgatgaggaa
      961 cttcccttcc taacagagag aacgcttctg gagggagaag tggtacaaaa aagtgcggtt
     1021 ttcacttaca ttgtgaaatg tgaaaataaa gtcgtcagct cttttagtta aa
//
