LOCUS       NM_001271323            1040 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus small nuclear ribonucleoprotein polypeptide A'
            (Snrpa1), mRNA.
ACCESSION   NM_001271323 XM_002728764 XM_003753290
VERSION     NM_001271323.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1040)
  AUTHORS   Bertram,K., Agafonov,D.E., Dybkov,O., Haselbach,D., Leelaram,M.N.,
            Will,C.L., Urlaub,H., Kastner,B., Luhrmann,R. and Stark,H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   2  (bases 1 to 1040)
  AUTHORS   Bertram,K., Agafonov,D.E., Liu,W.T., Dybkov,O., Will,C.L.,
            Hartmuth,K., Urlaub,H., Kastner,B., Stark,H. and Luhrmann,R.
  TITLE     Cryo-EM structure of a human spliceosome activated for step 2 of
            splicing
  JOURNAL   Nature 542 (7641), 318-323 (2017)
   PUBMED   28076346
REFERENCE   3  (bases 1 to 1040)
  AUTHORS   Wu,H., Sun,L., Wen,Y., Liu,Y., Yu,J., Mao,F., Wang,Y., Tong,C.,
            Guo,X., Hu,Z., Sha,J., Liu,M. and Xia,L.
  TITLE     Major spliceosome defects cause male infertility and are associated
            with nonobstructive azoospermia in humans
  JOURNAL   Proc Natl Acad Sci U S A 113 (15), 4134-4139 (2016)
   PUBMED   27035939
REFERENCE   4  (bases 1 to 1040)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 1040)
  AUTHORS   Chen,Y.I., Moore,R.E., Ge,H.Y., Young,M.K., Lee,T.D. and
            Stevens,S.W.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   6  (bases 1 to 1040)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   7  (bases 1 to 1040)
  AUTHORS   Neubauer,G., King,A., Rappsilber,J., Calvio,C., Watson,M., Ajuh,P.,
            Sleeman,J., Lamond,A. and Mann,M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
REFERENCE   8  (bases 1 to 1040)
  AUTHORS   Craft,J., Mimori,T., Olsen,T.L. and Hardin,J.A.
  TITLE     The U2 small nuclear ribonucleoprotein particle as an autoantigen.
            Analysis with sera from patients with overlap syndromes
  JOURNAL   J Clin Invest 81 (6), 1716-1724 (1988)
   PUBMED   2968364
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1 and FM044635.1.
            
            On or before Sep 16, 2012 this sequence version replaced
            XM_002728764.2, XM_003753290.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ232647.1, SRR26643429.2142.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                JAXUCZ010000001.1  129052050-129052065
            17-581              FM044635.1         1-565
            582-609             JAXUCZ010000001.1  129061296-129061323
            610-674             JAXUCZ010000001.1  129061707-129061771
            675-685             JAXUCZ010000001.1  129061772-129061782
            686-779             JAXUCZ010000001.1  129062387-129062480
            780-1040            JAXUCZ010000001.1  129064854-129065114
FEATURES             Location/Qualifiers
     source          1..1040
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1040
                     /gene="Snrpa1"
                     /note="small nuclear ribonucleoprotein polypeptide A'"
                     /db_xref="GeneID:100361269"
                     /db_xref="RGD:2320494"
     exon            1..152
                     /gene="Snrpa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..838
                     /gene="Snrpa1"
                     /note="U2 small nuclear ribonucleoprotein polypeptide A'"
                     /codon_start=1
                     /product="U2 small nuclear ribonucleoprotein A'"
                     /protein_id="NP_001258252.1"
                     /db_xref="GeneID:100361269"
                     /db_xref="RGD:2320494"
                     /translation="MVKLTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQF
                     DAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVE
                     LGDLDPLASLKSLTYLSILRNPVTNKKHYRLYVIYKVPQVRVLDFQKVKLKERQEAEK
                     MFKGKRGAQLAKDIARRSKTFNPGAGLPTDKKKGGPSAGDVEAIKNAIANASTLAEVE
                     RLKGLLQSGQIPGRERRSGPSDEGEEEMEDGTVTNGS"
     exon            153..300
                     /gene="Snrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            301..379
                     /gene="Snrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            380..426
                     /gene="Snrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            427..529
                     /gene="Snrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..609
                     /gene="Snrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            610..685
                     /gene="Snrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..779
                     /gene="Snrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..1040
                     /gene="Snrpa1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accctgggac acggcactgg cgggaggcac aggccggtgt ctgaggtgag ggtacgcggg
       61 cggcgacaga atggtgaagc tgacggcgga gctgatcgag caggcggcac agtacaccaa
      121 tgctgtgcgg gaccgtgagc tggacctccg cggatataaa attcctgtta ttgaaaatct
      181 gggtgccacc ttagaccagt ttgatgctat tgatttttct gacaatgaga tcaggaaact
      241 ggatggcttt ccgttgttga gaagactgaa aacattatta gtgaacaaca acagaatttg
      301 ccgtataggt gagggtctcg atcaggctct tccctgcctg acagaactca ttctcaccaa
      361 caacagtcta gtggaactgg gtgatctgga cccattggca tctctcaaat cactgacata
      421 tctaagcatc ctaagaaacc ctgtgaccaa taagaagcat tatcgactct atgtgattta
      481 taaggttcca caagtcagag tactggactt tcagaaagtg aaactaaaag agcgtcagga
      541 agcagagaaa atgttcaagg gcaaacgggg tgcacagctt gcaaaggata ttgccaggag
      601 aagcaaaact tttaatccag gtgctggttt gccaactgac aaaaagaaag gtgggccatc
      661 tgcaggggat gtggaagcaa tcaagaatgc catagcaaac gcgtcaacac tggctgaagt
      721 tgagaggctg aagggcttgc tgcagtctgg ccagattcct ggcagagagc gcagatcagg
      781 gccgagtgat gagggtgaag aggagatgga agacggcaca gtcacaaatg ggtcctgagc
      841 tctggcaggt gctctgataa gctcgtggga tgtcttgcat ttgagcattg agtaacagcc
      901 ttgcttgtgt cagcaacgtg gaatctgcag ctttgctgaa tgatcagaac tactgctgat
      961 aattttttaa tagaaacctt gaaatggcaa tgccaatttt ctacaaatgg taaataaagg
     1021 caacctactg tgctgccaaa
//
