LOCUS       NM_001399641            1691 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus small nuclear ribonucleoprotein U1 subunit 70
            (Snrnp70), mRNA.
ACCESSION   NM_001399641 XM_006229101
VERSION     NM_001399641.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1691)
  AUTHORS   Kondo,Y., Oubridge,C., van Roon,A.M. and Nagai,K.
  TITLE     Crystal structure of human U1 snRNP, a small nuclear
            ribonucleoprotein particle, reveals the mechanism of 5' splice site
            recognition
  JOURNAL   Elife 4, e04986 (2015)
   PUBMED   25555158
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1691)
  AUTHORS   Bai,B., Hales,C.M., Chen,P.C., Gozal,Y., Dammer,E.B., Fritz,J.J.,
            Wang,X., Xia,Q., Duong,D.M., Street,C., Cantero,G., Cheng,D.,
            Jones,D.R., Wu,Z., Li,Y., Diner,I., Heilman,C.J., Rees,H.D., Wu,H.,
            Lin,L., Szulwach,K.E., Gearing,M., Mufson,E.J., Bennett,D.A.,
            Montine,T.J., Seyfried,N.T., Wingo,T.S., Sun,Y.E., Jin,P.,
            Hanfelt,J., Willcock,D.M., Levey,A., Lah,J.J. and Peng,J.
  TITLE     U1 small nuclear ribonucleoprotein complex and RNA splicing
            alterations in Alzheimer's disease
  JOURNAL   Proc Natl Acad Sci U S A 110 (41), 16562-16567 (2013)
   PUBMED   24023061
REFERENCE   3  (bases 1 to 1691)
  AUTHORS   Pabis,M., Neufeld,N., Steiner,M.C., Bojic,T., Shav-Tal,Y. and
            Neugebauer,K.M.
  TITLE     The nuclear cap-binding complex interacts with the U4/U6.U5
            tri-snRNP and promotes spliceosome assembly in mammalian cells
  JOURNAL   RNA 19 (8), 1054-1063 (2013)
   PUBMED   23793891
REFERENCE   4  (bases 1 to 1691)
  AUTHORS   Zheng,S., Damoiseaux,R., Chen,L. and Black,D.L.
  TITLE     A broadly applicable high-throughput screening strategy identifies
            new regulators of Dlg4 (Psd-95) alternative splicing
  JOURNAL   Genome Res 23 (6), 998-1007 (2013)
   PUBMED   23636947
REFERENCE   5  (bases 1 to 1691)
  AUTHORS   Zhang,L., Li,X. and Zhao,R.
  TITLE     Structural analyses of the pre-mRNA splicing machinery
  JOURNAL   Protein Sci 22 (6), 677-692 (2013)
   PUBMED   23592432
  REMARK    Review article
REFERENCE   6  (bases 1 to 1691)
  AUTHORS   Monneaux,F., Briand,J.P. and Muller,S.
  TITLE     B and T cell immune response to small nuclear ribonucleoprotein
            particles in lupus mice: autoreactive CD4(+) T cells recognize a T
            cell epitope located within the RNP80 motif of the 70K protein
  JOURNAL   Eur J Immunol 30 (8), 2191-2200 (2000)
   PUBMED   10940910
REFERENCE   7  (bases 1 to 1691)
  AUTHORS   Manji,S.S., Pearson,R.B., Pardee,M., Paspaliaris,V., d'Apice,A.,
            Martin,T.J. and Ng,K.W.
  TITLE     Dual posttranscriptional targets of retinoic acid-induced gene
            expression
  JOURNAL   J Cell Biochem 72 (3), 411-422 (1999)
   PUBMED   10022522
REFERENCE   8  (bases 1 to 1691)
  AUTHORS   Neubauer,G., King,A., Rappsilber,J., Calvio,C., Watson,M., Ajuh,P.,
            Sleeman,J., Lamond,A. and Mann,M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
REFERENCE   9  (bases 1 to 1691)
  AUTHORS   Blencowe,B.J., Issner,R., Nickerson,J.A. and Sharp,P.A.
  TITLE     A coactivator of pre-mRNA splicing
  JOURNAL   Genes Dev 12 (7), 996-1009 (1998)
   PUBMED   9531537
REFERENCE   10 (bases 1 to 1691)
  AUTHORS   Query,C.C., Bentley,R.C. and Keene,J.D.
  TITLE     A common RNA recognition motif identified within a defined U1 RNA
            binding domain of the 70K U1 snRNP protein
  JOURNAL   Cell 57 (1), 89-101 (1989)
   PUBMED   2467746
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 12, 2022 this sequence version replaced XM_006229101.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC167051.1, SRR26643287.1142.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000001.1  105012668-105012851 c
            185-341             JAXUCZ010000001.1  105011834-105011990 c
            342-404             JAXUCZ010000001.1  105009464-105009526 c
            405-459             JAXUCZ010000001.1  105009236-105009290 c
            460-524             JAXUCZ010000001.1  105004277-105004341 c
            525-587             JAXUCZ010000001.1  105004092-105004154 c
            588-669             JAXUCZ010000001.1  104999874-104999955 c
            670-771             JAXUCZ010000001.1  104996784-104996885 c
            772-859             JAXUCZ010000001.1  104993428-104993515 c
            860-1691            JAXUCZ010000001.1  104992518-104993349 c
FEATURES             Location/Qualifiers
     source          1..1691
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1691
                     /gene="Snrnp70"
                     /gene_synonym="Snrp70"
                     /note="small nuclear ribonucleoprotein U1 subunit 70"
                     /db_xref="GeneID:361574"
                     /db_xref="RGD:1307120"
     exon            1..184
                     /gene="Snrnp70"
                     /gene_synonym="Snrp70"
                     /inference="alignment:Splign:2.1.0"
     exon            185..341
                     /gene="Snrnp70"
                     /gene_synonym="Snrp70"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1550
                     /gene="Snrnp70"
                     /gene_synonym="Snrp70"
                     /note="small nuclear ribonucleoprotein 70 (U1); U1 small
                     nuclear ribonucleoprotein polypeptide A"
                     /codon_start=1
                     /product="U1 small nuclear ribonucleoprotein 70 kDa"
                     /protein_id="NP_001386570.1"
                     /db_xref="GeneID:361574"
                     /db_xref="RGD:1307120"
                     /translation="MTQFLPPNLLALFAPRDPIPYLPPLEKLPHEKHHNQPYCGIAPY
                     IREFEDPRDAPPPTRAETREERMERKRREKIERRQQEVETELKMWDPHNDPNAQGDAF
                     KTLFVARVNYDTTESKLRREFEVYGPIKRIHMVYSKRSGKPRGYAFIEYEHERDMHSA
                     YKHADGKKIDGRRVLVDVERGRTVKGWRPRRLGGGLGGTRRGGADVNIRHSGRDDTSR
                     YDERPGPSPLPHRDRDRDRERERRERSRERDKERERRRSRSRDRRRRSRSRDKDERRR
                     SRERSKDKDRDRKRRSSRSRERARRERERKEELRGGGGGGGGGGGGGGGGGGGDMAEP
                     SEAGDGAPDDGPPGELGPEGPDGPEEKGRDRDRERRRSHRSERERRRDRDRDRDREHK
                     RGERGSERGRDEARGGGGSGQDNGLEGLGSDGRDMYMEAEGGDGYMAPENGYLMEAAP
                     E"
     exon            342..404
                     /gene="Snrnp70"
                     /gene_synonym="Snrp70"
                     /inference="alignment:Splign:2.1.0"
     exon            405..459
                     /gene="Snrnp70"
                     /gene_synonym="Snrp70"
                     /inference="alignment:Splign:2.1.0"
     exon            460..524
                     /gene="Snrnp70"
                     /gene_synonym="Snrp70"
                     /inference="alignment:Splign:2.1.0"
     exon            525..587
                     /gene="Snrnp70"
                     /gene_synonym="Snrp70"
                     /inference="alignment:Splign:2.1.0"
     exon            588..669
                     /gene="Snrnp70"
                     /gene_synonym="Snrp70"
                     /inference="alignment:Splign:2.1.0"
     exon            670..771
                     /gene="Snrnp70"
                     /gene_synonym="Snrp70"
                     /inference="alignment:Splign:2.1.0"
     exon            772..859
                     /gene="Snrnp70"
                     /gene_synonym="Snrp70"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1691
                     /gene="Snrnp70"
                     /gene_synonym="Snrp70"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttctgatc gcgagctgag gccgcgcggg ttgcgaggag aggcctggtt tgcgcgcgct
       61 gcgcggacca cagtggatac ctgacgcggg caccgccgaa gtggaagcca gagcgggagt
      121 ttttgtttgt gaacggcggc cgcgaggcct gagactaacg tcaggccgag aagagcgccg
      181 cgcgatttgg gaagatgaca cagtttctgc ctcccaacct tctggccctt tttgcacccc
      241 gagaccccat cccatacctg ccacccctgg aaaagctgcc acatgaaaaa caccataacc
      301 aaccttactg tggcattgca ccatatatcc gagagtttga ggaccctcga gatgcccctc
      361 ctccaacaag ggcagaaacc cgggaagaac gcatggagag aaagagacgg gaaaaaattg
      421 aacggcgaca gcaggaagtg gagacagagc tgaaaatgtg ggaccctcac aatgatccca
      481 atgctcaggg cgatgccttc aagactctgt tcgtggctag agtgaactat gacacaacag
      541 aatctaagct gcgaagagag tttgaggtgt acggacccat caaaagaatc cacatggtct
      601 acagtaaacg ctctgggaaa ccccgtggtt atgccttcat cgagtatgag catgaacgag
      661 acatgcactc cgcttacaag cacgcagatg gcaagaagat agatggcagg agggtcctcg
      721 tggatgtgga gaggggccgg actgtgaagg gctggaggcc ccggcggcta ggaggtggcc
      781 ttggtggtac cagaagaggt ggggcagatg tgaatatcag gcattcaggc cgagatgaca
      841 cttcccgata tgatgagagg ccgggcccct ccccgcttcc acacagagac cgggaccggg
      901 accgcgagcg ggagcgcaga gaaagaagcc gagagcgaga caaggagaga gaaaggagac
      961 gctcccgctc tcgggaccgg aggaggcgct ctcggagtcg agacaaggat gagcggcgcc
     1021 gatccagaga gcgaagcaag gacaaagaca gagatcgaaa gcgtcgaagt agtcggagcc
     1081 gggagcgagc acgcagggag cgggagcgaa aagaggagct tcgaggcgga ggaggaggtg
     1141 gtggtggtgg tggtggtggc ggcggcggag gcggtggagg cgacatggct gaaccctctg
     1201 aagctggtga tggagctcct gatgatgggc ctcctggaga gcttggccct gaaggccctg
     1261 atggccctga ggagaagggt cgggatcgag accgggagag gcgtcgaagt caccgaagtg
     1321 agagggaacg ccgtcgggac cgagaccgtg accgggatag agagcacaag cgtggggagc
     1381 ggggcagtga gcggggcagg gatgaggccc ggggtggggg tggcagcggt caggacaatg
     1441 ggctggaagg gctaggtagt gatggtcgag acatgtacat ggaggccgag ggtggggatg
     1501 ggtacatggc cccagagaac ggatatctga tggaggcagc gcctgaatga agaggcctct
     1561 gttgtggaca tgctcctgcc ttgctgtctg ccttcctagc ctttccacct tggcttgccc
     1621 tctgagggca gaggtttttt gttctgatcc cttggattta agaataaaat taatttcctg
     1681 ttgatagtgg g
//
