LOCUS       NM_001037766            6789 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus small nuclear ribonucleoprotein U5 subunit 200
            (Snrnp200), mRNA.
ACCESSION   NM_001037766 XM_215831
VERSION     NM_001037766.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6789)
  AUTHORS   Zhan,X., Yan,C., Zhang,X., Lei,J. and Shi,Y.
  TITLE     Structure of a human catalytic step I spliceosome
  JOURNAL   Science 359 (6375), 537-545 (2018)
   PUBMED   29301961
REFERENCE   2  (bases 1 to 6789)
  AUTHORS   Haselbach,D., Komarov,I., Agafonov,D.E., Hartmuth,K., Graf,B.,
            Dybkov,O., Urlaub,H., Kastner,B., Luhrmann,R. and Stark,H.
  TITLE     Structure and Conformational Dynamics of the Human Spliceosomal
            Bact Complex
  JOURNAL   Cell 172 (3), 454-464 (2018)
   PUBMED   29361316
REFERENCE   3  (bases 1 to 6789)
  AUTHORS   Pabis,M., Neufeld,N., Steiner,M.C., Bojic,T., Shav-Tal,Y. and
            Neugebauer,K.M.
  TITLE     The nuclear cap-binding complex interacts with the U4/U6.U5
            tri-snRNP and promotes spliceosome assembly in mammalian cells
  JOURNAL   RNA 19 (8), 1054-1063 (2013)
   PUBMED   23793891
REFERENCE   4  (bases 1 to 6789)
  AUTHORS   Chang,T.H., Tung,L., Yeh,F.L., Chen,J.H. and Chang,S.L.
  TITLE     Functions of the DExD/H-box proteins in nuclear pre-mRNA splicing
  JOURNAL   Biochim Biophys Acta 1829 (8), 764-774 (2013)
   PUBMED   23454554
  REMARK    Review article
REFERENCE   5  (bases 1 to 6789)
  AUTHORS   Zhang,L., Li,X. and Zhao,R.
  TITLE     Structural analyses of the pre-mRNA splicing machinery
  JOURNAL   Protein Sci 22 (6), 677-692 (2013)
   PUBMED   23592432
  REMARK    Review article
REFERENCE   6  (bases 1 to 6789)
  AUTHORS   Li,N., Mei,H., MacDonald,I.M., Jiao,X. and Hejtmancik,J.F.
  TITLE     Mutations in ASCC3L1 on 2q11.2 are associated with autosomal
            dominant retinitis pigmentosa in a Chinese family
  JOURNAL   Invest Ophthalmol Vis Sci 51 (2), 1036-1043 (2010)
   PUBMED   19710410
REFERENCE   7  (bases 1 to 6789)
  AUTHORS   Foster,L.J., Zeemann,P.A., Li,C., Mann,M., Jensen,O.N. and
            Kassem,M.
  TITLE     Differential expression profiling of membrane proteins by
            quantitative proteomics in a human mesenchymal stem cell line
            undergoing osteoblast differentiation
  JOURNAL   Stem Cells 23 (9), 1367-1377 (2005)
   PUBMED   16210410
REFERENCE   8  (bases 1 to 6789)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   9  (bases 1 to 6789)
  AUTHORS   Laggerbauer,B., Achsel,T. and Luhrmann,R.
  TITLE     The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in
            vitro
  JOURNAL   Proc Natl Acad Sci U S A 95 (8), 4188-4192 (1998)
   PUBMED   9539711
REFERENCE   10 (bases 1 to 6789)
  AUTHORS   Lauber,J., Fabrizio,P., Teigelkamp,S., Lane,W.S., Hartmann,E. and
            Luhrmann,R.
  TITLE     The HeLa 200 kDa U5 snRNP-specific protein and its homologue in
            Saccharomyces cerevisiae are members of the DEXH-box protein family
            of putative RNA helicases
  JOURNAL   EMBO J 15 (15), 4001-4015 (1996)
   PUBMED   8670905
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000003.1.
            
            On Dec 18, 2009 this sequence version replaced NM_001037766.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2429982.1,
                                           SRR26360194.2390531.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               JAXUCZ010000003.1  134882173-134882327
            156-319             JAXUCZ010000003.1  134882743-134882906
            320-491             JAXUCZ010000003.1  134884677-134884848
            492-684             JAXUCZ010000003.1  134886242-134886434
            685-740             JAXUCZ010000003.1  134886997-134887052
            741-839             JAXUCZ010000003.1  134889076-134889174
            840-992             JAXUCZ010000003.1  134890248-134890400
            993-1092            JAXUCZ010000003.1  134890553-134890652
            1093-1229           JAXUCZ010000003.1  134890863-134890999
            1230-1313           JAXUCZ010000003.1  134891490-134891573
            1314-1487           JAXUCZ010000003.1  134891653-134891826
            1488-1625           JAXUCZ010000003.1  134892132-134892269
            1626-1781           JAXUCZ010000003.1  134892571-134892726
            1782-1952           JAXUCZ010000003.1  134893208-134893378
            1953-2146           JAXUCZ010000003.1  134895407-134895600
            2147-2270           JAXUCZ010000003.1  134895789-134895912
            2271-2420           JAXUCZ010000003.1  134897230-134897379
            2421-2531           JAXUCZ010000003.1  134897725-134897835
            2532-2663           JAXUCZ010000003.1  134898548-134898679
            2664-2852           JAXUCZ010000003.1  134898838-134899026
            2853-3050           JAXUCZ010000003.1  134899353-134899550
            3051-3203           JAXUCZ010000003.1  134900150-134900302
            3204-3284           JAXUCZ010000003.1  134900417-134900497
            3285-3368           JAXUCZ010000003.1  134900794-134900877
            3369-3475           JAXUCZ010000003.1  134901532-134901638
            3476-3594           JAXUCZ010000003.1  134901919-134902037
            3595-3749           JAXUCZ010000003.1  134902317-134902471
            3750-3939           JAXUCZ010000003.1  134902558-134902747
            3940-4113           JAXUCZ010000003.1  134902928-134903101
            4114-4274           JAXUCZ010000003.1  134903696-134903856
            4275-4502           JAXUCZ010000003.1  134904389-134904616
            4503-4694           JAXUCZ010000003.1  134904884-134905075
            4695-4873           JAXUCZ010000003.1  134905163-134905341
            4874-5025           JAXUCZ010000003.1  134905498-134905649
            5026-5134           JAXUCZ010000003.1  134906434-134906542
            5135-5243           JAXUCZ010000003.1  134907295-134907403
            5244-5433           JAXUCZ010000003.1  134907894-134908083
            5434-5598           JAXUCZ010000003.1  134908174-134908338
            5599-5720           JAXUCZ010000003.1  134908513-134908634
            5721-5864           JAXUCZ010000003.1  134908846-134908989
            5865-6041           JAXUCZ010000003.1  134909082-134909258
            6042-6202           JAXUCZ010000003.1  134909532-134909692
            6203-6284           JAXUCZ010000003.1  134909770-134909851
            6285-6377           JAXUCZ010000003.1  134910911-134911003
            6378-6789           JAXUCZ010000003.1  134911101-134911512
FEATURES             Location/Qualifiers
     source          1..6789
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..6789
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /note="small nuclear ribonucleoprotein U5 subunit 200"
                     /db_xref="GeneID:296126"
                     /db_xref="RGD:1561120"
     exon            1..155
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..6521
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /EC_number="3.6.4.13"
                     /note="activating signal cointegrator 1 complex subunit
                     3-like 1; BRR2 homolog; U5 snRNP-specific 200 kDa protein;
                     small nuclear ribonucleoprotein 200 (U5)"
                     /codon_start=1
                     /product="U5 small nuclear ribonucleoprotein 200 kDa
                     helicase"
                     /protein_id="NP_001032855.2"
                     /db_xref="GeneID:296126"
                     /db_xref="RGD:1561120"
                     /translation="MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLV
                     GKLEGTRMGDKAQRTKPQMQEERRAKRRKRDEDRHDINKMKGYTLLSEGIDEMVGIIY
                     KPKTKETRETYEVLLSFIQAALGDQPRDILCGAADEVLAVLKNEKLRDKERRREIDLL
                     LGQTDDTRYHVLVNLGKKITDYGGDKEIQNMDDNIDETYGVNVQFESDEEEGDEDVYG
                     EVREEASDDDMEGDEAVVRCTLSANLVASGELMSSKKKDLHPRDIDAFWLQRQLSRFY
                     DDAIVSQKKADEVLEILKTASDDRECENQLVLLLGFNTFDFIKVLRQHRMMILYCTLL
                     ASAQSEAEKERIMGKMEADPELSKFLYQLHETEKEDLIREERSRRERVRQSRMDTDLE
                     TMDLDQGGEALAPRQVLDLEDLVFTQGSHFMANKRCQLPDGSFRRQRKGYEEVHVPAL
                     KPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAG
                     KTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITV
                     AELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIVLDEIHLLHDDR
                     GPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRP
                     VPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRD
                     MCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVE
                     DLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRA
                     GRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAK
                     DAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKY
                     DKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVR
                     EEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSA
                     GRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKK
                     NFPFERLYDLNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTI
                     TPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFEPL
                     PPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESL
                     YQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVY
                     ITPMEALAEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILS
                     RRWKQRKNVQNINLFVVDEVHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSL
                     SNAKDVAHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYHAITK
                     HSPKKPVIVFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLK
                     ETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTQY
                     YNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVES
                     HLDHCMHDHFNAEIVTKTIENKQDAVDYLTWTFLYRRMTQNPNYYNLQGISHRHLSDH
                     LSELVEQTLSDLEQSKCISIEDEMDVAPLNLGMIAAYYYINYTTIELFSMSLNAKTKV
                     RGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVPHKLNNPKFNDPHVKTNLLLQAHLS
                     RMQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWSKDS
                     YLKQLPHFTSEHIKRCTDKGVESVFDIMEMEDEERNALLQLTDSQIADVARFCNRYPN
                     IELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLFPQKREEGWWVVIGDAKSN
                     SLISIKRLTLQQKAKVKLDFVAPATGGHNYTLYFMSDAYMGCDQEYKFSVDVKEAETD
                     SDSD"
     exon            156..319
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            320..491
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            492..684
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            685..740
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            741..839
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            840..992
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1092
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1229
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1313
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1487
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1625
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1781
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1952
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2146
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2270
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2420
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2531
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2663
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..2852
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..3050
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3051..3203
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3284
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3368
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3369..3475
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3476..3594
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3595..3749
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3750..3939
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3940..4113
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            4114..4274
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            4275..4502
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            4503..4694
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            4695..4873
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            4874..5025
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5026..5134
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5135..5243
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5244..5433
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5434..5598
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5599..5720
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5721..5864
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5865..6041
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            6042..6202
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            6203..6284
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            6285..6377
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            6378..6789
                     /gene="Snrnp200"
                     /gene_synonym="Ascc3l1; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgtcccgta cgtttgtcct gcgtggtacc tgttgggcca gagcggtttg cacaggcggt
       61 tcgcaccgtg aggaagagtg gaaccctgag ttcccggagc accggcagcc atggcggatg
      121 tgactgcccg cagtttgcag tacgagtaca aagcgaactc aaatcttgtg ctccaagctg
      181 accgctctct cattgaccgg acccgccggg atgaaccgac aggagaggtt ctgtccctgg
      241 ttgggaaatt ggagggaact cgaatgggag ataaggctca aaggaccaaa ccacagatgc
      301 aggaggaaag acgggccaag aggagaaaac gtgatgagga ccgacacgac atcaacaaga
      361 tgaaaggcta tactctgctg tcagagggca ttgatgagat ggtgggcatc atctataagc
      421 ccaagacgaa ggagacccgg gagacctatg aggtgctgct cagtttcatc caggctgctc
      481 tcggggatca gcctcgagat attctttgtg gggcagccga tgaagttctg gctgttctga
      541 aaaatgaaaa gcttcgagac aaggagagaa gaagggagat tgacttgctg ctgggtcaga
      601 cagatgatac gagataccat gtgttagtaa acttgggcaa gaagatcaca gactatggtg
      661 gcgacaagga gatccagaat atggatgaca acattgatga gacttatggc gtgaatgtgc
      721 agtttgagtc tgatgaggag gaaggtgatg aagatgtgta tggggaagtc agagaagaag
      781 cttctgatga tgacatggaa ggggatgaag ctgttgtgcg ctgtaccctc tccgctaatc
      841 ttgtagcctc aggcgaactg atgagttcta agaagaagga tttgcaccct cgggatattg
      901 acgcgttctg gctgcagcga cagctcagtc gtttctatga tgatgccatt gtgtcgcaga
      961 agaaggcaga tgaggtgttg gagattttga agacagcaag tgatgaccga gaatgtgaga
     1021 accagctggt tctgctcctt ggcttcaaca cttttgactt catcaaagtg ttgcggcagc
     1081 acaggatgat gattttatac tgtaccttat tggccagtgc tcagagtgaa gctgaaaagg
     1141 agaggatcat gggaaagatg gaagctgatc cagagctttc caaattcctc tatcagctcc
     1201 atgaaactga gaaggaagac ctgatcaggg aagaaaggtc ccggagagag agagtccgtc
     1261 agtcccgaat ggacacagat ctggaaacca tggatttgga ccagggtgga gaggctctgg
     1321 ctccgaggca ggttctggat ttggaggacc ttgtttttac tcaaggaagc cacttcatgg
     1381 ccaataagcg ctgccagctt cccgacgggt ctttccgacg ccagcgtaag ggctatgaag
     1441 aggtgcacgt gcctgctttg aagcccaagc cctttggctc agaagaacaa ctgctcccag
     1501 tggagaagct gccaaagtat gcccaggcag gatttgaggg cttcaaaacg ctgaaccgga
     1561 tccagagtaa actctaccgt gctgccctgg agacagatga gaatctgctg ctgtgtgctc
     1621 ctactggtgc cggcaagacc aatgtggctc tgatgtgtat gctccgagag ataggaaaac
     1681 acatcaacat ggatggcact atcaacgtgg atgacttcaa gatcatctac atagctccta
     1741 tgcggtccct ggtacaggag atggtgggca gctttggaaa gcgcctggcc acatatggca
     1801 ttactgttgc tgagctgact ggggatcatc aactatgcaa ggaagaaatc agtgccacac
     1861 agatcattgt ctgcacccct gagaagtggg acatcatcac acgcaagggc ggggagcgca
     1921 cctacaccca gctggtgcgg ctcattgtct tggatgagat ccatcttcta catgatgaca
     1981 gaggtcctgt cttagaagct ttggtggcca gggccatccg aaacattgag atgacccaag
     2041 aagatgtccg actcattggt ctcagcgcta ccctccccaa ctatgaagat gtggccacct
     2101 ttctgcgcgt cgaccctgct aagggcctct tctactttga caacagcttc cgcccagtgc
     2161 ctctggaaca aacatatgtg ggcatcacag agaaaaaagc tatcaaacgt ttccagatca
     2221 tgaatgaaat agtctatgag aaaatcatgg agcatgctgg aaaaaaccag gtgctggtgt
     2281 ttgtccactc tcgaaaagaa actgggaaga cagcaagggc aatccgtgac atgtgtctgg
     2341 agaaggacac cttgggtctg tttcttcggg agggttctgc ctccactgaa gtccttcgta
     2401 cagaagcaga acagtgcaag aacttggaac tgaaggatct tttgccctat ggctttgcta
     2461 ttcatcatgc aggcatgact agagttgacc gaacacttgt agaagatctt tttgctgaca
     2521 aacatattca ggttttagtt tctactgcaa ctctggcttg gggtgtaaat cttcctgcac
     2581 acacagtcat cattaaaggt acccaagtgt acagtccaga gaaagggcgt tggacagagc
     2641 tgggagcact ggatattctg cagatgctgg gccgtgctgg acggccgcag tatgacacta
     2701 agggtgaagg tatactcatc acgtctcatg gcgagctcca gtactacctc tccctcctca
     2761 accagcagct tccaattgag agccagatgg tatcaaagct gcctgacatg ctcaatgcag
     2821 aaattgtgct ggggaacgtc cagaatgcaa aggatgcagt gaactggctg ggctatgcct
     2881 acctatacat ccgaatgctc cggtccccta ccctctatgg catctctcat gatgacctca
     2941 agggagatcc cttgctggac cagcgccgac tcgatcttgt tcacactgct gccttgatgc
     3001 ttgacaagaa caatctggtc aagtacgaca agaagacagg caacttccag gtgacagaac
     3061 ttggtcggat agcaagtcac tactatatca ccaatgatac tgtgcagaca tacaatcagc
     3121 tgctgaagcc tactctgagt gagattgagc ttttccgagt gttctccttg tcctcagagt
     3181 tcaagaacat cacagtgaga gaggaggaga agctagaact gcagaagttg cttgagagag
     3241 tgcccatccc tgtaaaggag agcattgaag aacccagtgc taagatcaat gtgcttctcc
     3301 aagccttcat ctcacagctg aaacttgaag gctttgcact gatggctgac atggtgtacg
     3361 tgacacagtc ggctggccgg ttgatgcgtg caatctttga aattgtcctg aatcgaggtt
     3421 gggcacagct tacagataag accctgaatc tctgcaagat gattgacaaa cgcatgtggc
     3481 agtccatgtg tcctcttcgc cagttccgaa aacttcctga ggaagtagtg aagaagattg
     3541 agaagaagaa cttccccttt gagcggctgt atgacttgaa tcataatgag ataggtgagc
     3601 ttattcgaat gccgaagatg gggaagacca tccacaagta tgtccatctt ttccccaagt
     3661 tggagttgtc ggttcacctg cagcctatta cacgctctac gctgaaagta gagctgacta
     3721 tcacaccgga tttccagtgg gatgaaaagg tccatggttc gtcagaggca ttttggattc
     3781 tggtggagga tgtggacagc gaggtgattc tgcaccacga atattttctc ctgaaggcca
     3841 aatatgccca ggatgagcac ctcatcacgt tctttgttcc ggtctttgaa ccactacctc
     3901 ctcagtactt cattcgagtg gtgtctgatc gctggctctc ttgtgagacc caactgcctg
     3961 tctctttccg gcacctgatc ctaccagaga agtacccacc tccaactgaa ctgttggatc
     4021 tgcagccatt gcctgtatct gctctgagaa acagtgcttt tgagagcctt taccaagata
     4081 aatttccttt cttcaatccc atccagactc aagtgtttaa taccgtgtac aacagtgatg
     4141 ataacgtgtt tgtgggggcc cccacgggca gcgggaagac tatttgtgca gagtttgcca
     4201 tcttacggat gctgctgcag aattctgagg ggcgctgtgt ctacattacc cctatggagg
     4261 ctctggcaga gcaggtgtac atggactggt atgagaagtt tcaggacagg ctcaataaga
     4321 aggtggtgct gctgacgggg gagaccagca cagacctgaa gctcctgggc aaaggcaaca
     4381 tcatcatcag tactcctgag aagtgggaca tcctctctcg gaggtggaag cagcgcaaga
     4441 atgtccagaa cattaacctc tttgtggtgg atgaggtcca ccttattggg ggcgagaatg
     4501 ggcctgtctt ggaagtgatc tgctcccgga tgcgctacat ctcctcccag atcgagcggc
     4561 ccattcgcat tgtggcactt agctcctcac tctccaatgc caaggatgtg gctcactggc
     4621 tgggctgtag tgccacctcc accttcaact tccaccctaa tgtgcgccct gtacctttgg
     4681 aactgcacat ccagggcttc aacatcagtc acacacagac tcgcctgctc tctatggcca
     4741 agcctgtgta ccatgctatc actaaacact cacccaagaa gcctgtcatt gtttttgtcc
     4801 catctcgcaa gcagacccgc ctcactgcca tagacatcct cactacctgt gcagcagaca
     4861 tccagcggca gaggttcctg cactgtaccg agaaggatct gatcccttac ctggagaagc
     4921 taagtgacag cacactcaaa gaaacattgt taaatggggt gggctaccta catgaagggc
     4981 tgagtcccat ggaaaggcgc ctggtagagc agctcttcag ctcaggggct atccaggtag
     5041 tggtggcttc tcgaagtctc tgctggggca tgaatgttgc tgctcatctt gtgatcatca
     5101 tggacactca atactacaat ggcaagatcc atgcctatgt ggattaccca atctatgatg
     5161 tgcttcagat ggtgggccat gccaaccgcc ccctgcagga tgacgagggg cgctgtgtca
     5221 tcatgtgtca gggctctaaa aaggattttt tcaaaaagtt tttatatgag ccattgccgg
     5281 tagagtctca cctggaccac tgtatgcatg accacttcaa tgctgagatt gtcaccaaga
     5341 ccatcgagaa caagcaggat gccgtggact acctcacctg gacctttctg tatcgccgaa
     5401 tgacacagaa ccccaattac tacaacctgc aggggatatc tcatcgtcat ttgtctgacc
     5461 atttgtcaga gctggtggag cagacgctca gtgacctgga gcagtccaag tgcatcagta
     5521 ttgaggacga gatggatgtg gcccctctga acctgggcat gattgctgcc tactattaca
     5581 taaactacac caccatcgag ctcttcagca tgtctctgaa tgccaaaacc aaggttcgag
     5641 ggcttataga gattatttcc aatgcagcag agtatgagaa cattcccatc aggcatcacg
     5701 aagacaacct cctgcgccag ttggctcaga aggttcccca caagctgaat aaccccaagt
     5761 tcaatgatcc ccatgtgaag accaatctgt tgctgcaggc tcacctgtcc cgcatgcagc
     5821 taagtgctga actacagtca gacacagagg agatcctaag taaggcaatc cggctcattc
     5881 aggcctgtgt ggatgtactc tccagcaatg ggtggcttag ccctgctctg gcagccatgg
     5941 aactggctca gatggtcacc caagccatgt ggtctaagga ctcttacctg aagcagctgc
     6001 cacacttcac ctcagagcat atcaaacgtt gcacagataa gggagtggag agtgtttttg
     6061 acatcatgga gatggaggat gaagaacgga atgcattgct tcagttgact gacagccaga
     6121 ttgcagatgt ggcccgcttc tgtaaccgct acccgaatat cgaactgtcc tatgaagtgg
     6181 tggataaaga cagcatccgc agtggcgggc cagtcgtggt gctggtgcaa ctagagcgag
     6241 aggaggaagt caccggccct gttattgcac ctctcttccc acagaaacgt gaagagggct
     6301 ggtgggttgt gattggagac gccaagtcca acagcctcat ctccatcaag aggctgacct
     6361 tgcagcagaa agccaaggtg aagctggact ttgtggcccc agccacaggc ggccacaact
     6421 ataccctgta cttcatgagt gacgcttaca tggggtgtga ccaggagtat aaattcagcg
     6481 tggacgtgaa agaagctgag acagacagtg actcagattg agtctgaggc atcaaacctg
     6541 agaacacgga tctggacagc cccggggatc tggttttaga gaccagatct gtcagcctga
     6601 ggtctggcca tcaggctgct gctgttccca gtccacatcc agttgctctc ccaccttgac
     6661 cttgcagttc aaggtctgca tccagtattt tcaagtgtct catcaaacac gaactgtaca
     6721 atatttggag gcatgttttt tagttccttg agtcagacat tctaataaat aatttggaaa
     6781 aaaaaaaaa
//
