LOCUS       NM_138833               3004 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus SNF related kinase (Snrk), mRNA.
ACCESSION   NM_138833 XM_237743
VERSION     NM_138833.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3004)
  AUTHORS   Wang,Z.Y., Liu,X.X. and Deng,Y.F.
  TITLE     Negative feedback of SNRK to circ-SNRK regulates cardiac function
            post-myocardial infarction
  JOURNAL   Cell Death Differ 29 (4), 709-721 (2022)
   PUBMED   34621049
  REMARK    GeneRIF: Negative feedback of SNRK to circ-SNRK regulates cardiac
            function post-myocardial infarction.
REFERENCE   2  (bases 1 to 3004)
  AUTHORS   Kertesz,N., Samson,J., Debacker,C., Wu,H. and Labastie,M.C.
  TITLE     Cloning and characterization of human and mouse SNRK sucrose
            non-fermenting protein (SNF-1)-related kinases
  JOURNAL   Gene 294 (1-2), 13-24 (2002)
   PUBMED   12234663
REFERENCE   3  (bases 1 to 3004)
  AUTHORS   Lefebvre,D.L., Bai,Y., Shahmolky,N., Sharma,M., Poon,R.,
            Drucker,D.J. and Rosen,C.F.
  TITLE     Identification and characterization of a novel
            sucrose-non-fermenting protein kinase/AMP-activated protein
            kinase-related protein kinase, SNARK
  JOURNAL   Biochem J 355 (Pt 2), 297-305 (2001)
   PUBMED   11284715
REFERENCE   4  (bases 1 to 3004)
  AUTHORS   Yoshida,K., Yamada,M., Nishio,C., Konishi,A. and Hatanaka,H.
  TITLE     SNRK, a member of the SNF1 family, is related to low K(+)-induced
            apoptosis of cultured rat cerebellar granule neurons
  JOURNAL   Brain Res 873 (2), 274-282 (2000)
   PUBMED   10930554
REFERENCE   5  (bases 1 to 3004)
  AUTHORS   Becker,W., Heukelbach,J., Kentrup,H. and Joost,H.G.
  TITLE     Molecular cloning and characterization of a novel mammalian protein
            kinase harboring a homology domain that defines a subfamily of
            serine/threonine kinases
  JOURNAL   Eur J Biochem 235 (3), 736-743 (1996)
   PUBMED   8654423
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X89383.1.
            
            On Dec 17, 2003 this sequence version replaced XM_237743.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X89383.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3004
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3004
                     /gene="Snrk"
                     /note="SNF related kinase"
                     /db_xref="GeneID:170837"
                     /db_xref="RGD:69653"
     exon            1..42
                     /gene="Snrk"
                     /inference="alignment:Splign:2.1.0"
     exon            43..738
                     /gene="Snrk"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..2390
                     /gene="Snrk"
                     /EC_number="2.7.11.1"
                     /note="SNF1-related kinase"
                     /codon_start=1
                     /product="SNF-related serine/threonine-protein kinase"
                     /protein_id="NP_620188.1"
                     /db_xref="GeneID:170837"
                     /db_xref="RGD:69653"
                     /translation="MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAV
                     KVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFD
                     YIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFG
                     FSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEA
                     NDSETLTMIMDCKYTVPPRVSAGCRDLITRMLQRDPKRRASLEEIESHPWLQGVDPSP
                     ATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAE
                     RILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQDLEDDLTATPLSHATVPQSPA
                     RAGDSVLNGHRSKGLCDPAKKDELPELAGPALSTVPPASLKPAASGRKCLFRVEEDEE
                     EDEEDKKPVSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEEGESDDEFDMDENLPPK
                     LSRLKMNIASPGTVHKRYHRRKSQGRGSSCSSSETSDDDSESRRRLDKDSGLAYSWHR
                     RDSSEGPPGSEGDGGGQSKPSGGGGVDKASPGEQGTGGSGQGGSGGTPSGTAGSSRRC
                     AGPDSSSSSPASAAPRGAELVQSLKLVSLCLGSQLHGAKYILDPQKALLSSVKVQERS
                     TWKMCISAPGPGPSADLDPVRTKKLRNNVLQLPLCEKTISVNIQRSRKEGLLCASSPA
                     SCCHVI"
     exon            739..880
                     /gene="Snrk"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1093
                     /gene="Snrk"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1228
                     /gene="Snrk"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..3004
                     /gene="Snrk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caactactgg taacagagtg atctgtcatg cagttttgca aggtatccat tatgatgttg
       61 acaataaagg ccttatctcc agcagatatg ctcatatgag aagacccact tcaagcactt
      121 tttaagtatt tccccttcat tgaaccagca tggcagggtt caagcgaggc tatgatggaa
      181 aaattgctgg attgtatgat ctggataaaa ccttgggtcg aggtcacttc gcagtggtca
      241 aactggccag gcatgtcttc acaggtgaga aggtggcagt gaaagtcatt gacaagacaa
      301 agctggacac tctagccact ggtcacctct tccaggaagt caggtgcatg aagctagtgc
      361 agcaccccaa catcgtgcgt ctctatgagg tcatagacac ccagaccaaa ctgtatctca
      421 ttctagaact tggagatgga ggagatatgt ttgactacat aatgaagcac gaggagggtc
      481 ttaatgaaga cttggcaaag aagtactttg ctcagatagt tcacgctata tcctattgcc
      541 ataaactcca tgtggttcac agagacttga aaccagagaa tgtagtcttt tttgaaaaac
      601 aaggtcttgt gaagttgaca gactttggct tcagcaacaa gtttcagcct ggaaagaagc
      661 tcactacaag ctgtggatct cttgcgtact ctgctccgga aatcctgctt ggcgatgagt
      721 acgatgcccc tgcagtagac atatggagcc tgggtgtgat ccttttcatg ctggtgtgtg
      781 ggcagccgcc cttccaagaa gccaacgaca gtgagacgct gaccatgatc atggactgca
      841 agtacactgt gccgccccgt gtgtctgcag ggtgcaggga cctcatcaca cggatgctgc
      901 agagagaccc caaaaggaga gcctctctgg aagagattga aagccaccct tggctccagg
      961 gagtggaccc ctcaccagcc accaagtata acattcccct cgtgtcctac aagaacctct
     1021 cggaagagga gcacaatagc atcatccagc gcatggtgct tggggacatc gcagatcgag
     1081 atgccatcgt agaagccctg gaaaccaaca ggtacaacca catcaccgcc acttacttct
     1141 tacttgctga aaggatcctg cgagaaaagc aagagaaaga aatacagacc aggtctgcaa
     1201 gccccagcaa catcaaggcc cagttcaggc agtcgtggcc aactaaaatt gatgttcccc
     1261 aagaccttga agatgatctc actgccaccc ctctgtcaca tgccacagtc ccgcagtctc
     1321 ctgctcgggc tggtgacagt gtcctcaatg gccacaggag caaaggcctg tgtgaccctg
     1381 ccaagaaaga tgagctcccg gagctggcgg ggccagcact gtccactgtt ccacccgcaa
     1441 gcctgaagcc cgcagccagt gggcggaagt gtctcttcag ggtggaagaa gatgaagagg
     1501 aagatgagga ggacaagaag cctgtgtccc tgtccacgca ggtggtgctg cgccggaagc
     1561 catcagtcac caaccgcctg acatctcgaa agagtgcccc ggtgctcaat cagatcttcg
     1621 aggaaggcga gtctgacgac gagtttgaca tggacgagaa cctaccaccc aagctgagcc
     1681 ggctgaagat gaacatcgcg tcaccaggca cagtgcacaa gcgctaccac cgcaggaaaa
     1741 gccagggccg tggctcgagc tgcagcagct ctgagaccag cgatgatgac tctgagagcc
     1801 gccggcggct ggacaaggac agtggcttgg cttactcgtg gcaccggcgt gacagcagtg
     1861 aggggccacc aggcagtgag ggcgatggtg gcggtcagag caaacctagc ggcggtggtg
     1921 gtgtggacaa ggcgagtcca ggagagcagg gcacgggcgg cagtggccag ggaggctcag
     1981 gtgggacccc atcgggtaca gcaggttcct ccaggcgctg tgcaggccct gactcctcct
     2041 catcctcccc cgcctctgcc gctccacgtg gtgcagagct tgtgcagagc ctcaaactcg
     2101 tgagcctgtg tctaggctcg cagctccatg gcgccaagta cattctggac ccgcagaagg
     2161 ccttgttgtc cagcgtgaag gtgcaggaga ggtccacttg gaagatgtgc atcagtgccc
     2221 caggccccgg cccctctgct gaccttgacc ctgtgaggac caagaagctg aggaacaacg
     2281 tgctccagct acctctgtgc gagaagacca tctccgtgaa catccaacgc agccgcaagg
     2341 aagggctgct ctgcgcctcc agccccgcca gctgctgcca cgtcatctga gctgtagcgt
     2401 gctcacttca tctgttctga cgtgacaatg catggtcttt gtgcatgctg ctacacgcta
     2461 cttttctttt ccagccgaaa agtctactgt gtgattttac attcatgatt ttcagtgtgg
     2521 atgaccagga tgaagttgtg tatctggaac ccaacgtaat ggagcgctta gaaattcatg
     2581 ttctgcactt aacctggagg gaaatgctct cgtttccttg tgaaaagccc aaattcctgt
     2641 cctgacctcc ggtgataggg aaactcgatg ctctgaggcc cactggtgcc cgagacagaa
     2701 ccaaagcaat aacgtggtga tgcgatgccc acaggccagc cgcccggggc ctgtgcaccg
     2761 agaaccttag agccacagtc tgagcgccca cacctgtttg tcttaaatga ctgtgaacgc
     2821 agttggggct ctcatatctt cattgacaga agtgttcttg tttgtagtag gtgagatcag
     2881 ctacttagtt tgtgaggcag cttaccccat agaattacaa ggagacaatc ttttgtgagg
     2941 cgatgaggtg aactcaagtc ttaactctat ttagagtgtg tatgtctgtc tgacagaaca
     3001 aaaa
//
