LOCUS       NM_001106525            4694 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus syntaphilin (Snph), mRNA.
ACCESSION   NM_001106525 XM_001060677 XM_230716
VERSION     NM_001106525.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4694)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 4694)
  AUTHORS   Salam,S., Tacconelli,S., Smith,B.N., Mitchell,J.C., Glennon,E.,
            Nikolaou,N., Houart,C. and Vance,C.
  TITLE     Identification of a novel interaction of FUS and syntaphilin may
            explain synaptic and mitochondrial abnormalities caused by ALS
            mutations
  JOURNAL   Sci Rep 11 (1), 13613 (2021)
   PUBMED   34193962
  REMARK    GeneRIF: Identification of a novel interaction of FUS and
            syntaphilin may explain synaptic and mitochondrial abnormalities
            caused by ALS mutations.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4694)
  AUTHORS   Lin,M.Y., Cheng,X.T., Tammineni,P., Xie,Y., Zhou,B., Cai,Q. and
            Sheng,Z.H.
  TITLE     Releasing Syntaphilin Removes Stressed Mitochondria from Axons
            Independent of Mitophagy under Pathophysiological Conditions
  JOURNAL   Neuron 94 (3), 595-610 (2017)
   PUBMED   28472658
  REMARK    GeneRIF: Stressed mitochondria are removed from axons triggered by
            the bulk release of mitochondrial anchoring protein syntaphilin via
            a new class of mitochondria-derived cargos independent of Parkin,
            Drp1, and autophagy.
REFERENCE   4  (bases 1 to 4694)
  AUTHORS   Lin,M.Y. and Sheng,Z.H.
  TITLE     Regulation of mitochondrial transport in neurons
  JOURNAL   Exp Cell Res 334 (1), 35-44 (2015)
   PUBMED   25612908
  REMARK    Review article
REFERENCE   5  (bases 1 to 4694)
  AUTHORS   Fong,K.W., Leung,J.W., Li,Y., Wang,W., Feng,L., Ma,W., Liu,D.,
            Songyang,Z. and Chen,J.
  TITLE     MTR120/KIAA1383, a novel microtubule-associated protein, promotes
            microtubule stability and ensures cytokinesis
  JOURNAL   J Cell Sci 126 (Pt 3), 825-837 (2013)
   PUBMED   23264731
REFERENCE   6  (bases 1 to 4694)
  AUTHORS   Su,Q., Cai,Q., Gerwin,C., Smith,C.L. and Sheng,Z.H.
  TITLE     Syntabulin is a microtubule-associated protein implicated in
            syntaxin transport in neurons
  JOURNAL   Nat Cell Biol 6 (10), 941-953 (2004)
   PUBMED   15459722
REFERENCE   7  (bases 1 to 4694)
  AUTHORS   Boczan,J., Leenders,A.G. and Sheng,Z.H.
  TITLE     Phosphorylation of syntaphilin by cAMP-dependent protein kinase
            modulates its interaction with syntaxin-1 and annuls its inhibitory
            effect on vesicle exocytosis
  JOURNAL   J Biol Chem 279 (18), 18911-18919 (2004)
   PUBMED   14985338
  REMARK    GeneRIF: syntaphilin was identified as a molecular clamp that
            controls free syntaxin-1 and dynamin-1 availability and thereby
            regulates synaptic vesicle exocytosis and endocytosis. PKA
            phosphorylation of syntaphilin decreases its binding to syntaxin-1A
            in vitro.
REFERENCE   8  (bases 1 to 4694)
  AUTHORS   Das,S., Gerwin,C. and Sheng,Z.H.
  TITLE     Syntaphilin binds to dynamin-1 and inhibits dynamin-dependent
            endocytosis
  JOURNAL   J Biol Chem 278 (42), 41221-41226 (2003)
   PUBMED   12896979
REFERENCE   9  (bases 1 to 4694)
  AUTHORS   Das,S., Boczan,J., Gerwin,C., Zald,P.B. and Sheng,Z.H.
  TITLE     Regional and developmental regulation of syntaphilin expression in
            the brain: a candidate molecular element of synaptic functional
            differentiation
  JOURNAL   Brain Res Mol Brain Res 116 (1-2), 38-49 (2003)
   PUBMED   12941459
REFERENCE   10 (bases 1 to 4694)
  AUTHORS   Lao,G., Scheuss,V., Gerwin,C.M., Su,Q., Mochida,S., Rettig,J. and
            Sheng,Z.H.
  TITLE     Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly
  JOURNAL   Neuron 25 (1), 191-201 (2000)
   PUBMED   10707983
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC168917.1 and JAXUCZ010000003.1.
            
            On Mar 20, 2013 this sequence version replaced NM_001106525.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.19335.1,
                                           SRR26643293.19448.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2060              BC168917.1         1-2060
            2061-4694           JAXUCZ010000003.1  160558929-160561562 c
FEATURES             Location/Qualifiers
     source          1..4694
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..4694
                     /gene="Snph"
                     /note="syntaphilin"
                     /db_xref="GeneID:296267"
                     /db_xref="RGD:1305867"
     exon            1..170
                     /gene="Snph"
                     /inference="alignment:Splign:2.1.0"
     exon            171..277
                     /gene="Snph"
                     /inference="alignment:Splign:2.1.0"
     exon            278..374
                     /gene="Snph"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..1839
                     /gene="Snph"
                     /codon_start=1
                     /product="syntaphilin"
                     /protein_id="NP_001099995.1"
                     /db_xref="GeneID:296267"
                     /db_xref="RGD:1305867"
                     /translation="MAMSLQGSRRASAGSRRRTSPPVSVRDAYGTASLSSSSNSGSCK
                     GSDSSPTPRRSMKYTLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQDRLQD
                     RDTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIRQLKQVIDTVKNNLIDKD
                     KGLQKYFVDINIQNKKLETLLHSMEVAQNGVAKEEGTGESAGGSPARSLTRSSTYTKL
                     SDPAVCGDRQAGDPSNTPAEDRADSGFVAADDTLSRTEALEASSLLSSGVDCGFEEAS
                     LHSSFNLGPRFPASNTYEKLLCGMEAAVQASCMQERAIQTDFVQYQPDLNTILEKVGQ
                     AQGCSSVLKDRHSELDLHPSGPRDPDSAVVVTVGDEPEAPEPITRGPAIHRPAVNSNP
                     GLPVSVVCPVEEEEEAAAAAAAAAAATTTTTTTEKEPKSYWSRHYIVDLLAVVVPAVP
                     TVAWLCRSQRRQGQPIYNISSLLRGCCTVALHSIRRISCSLSQPSAGSSGGSQL"
     exon            375..482
                     /gene="Snph"
                     /inference="alignment:Splign:2.1.0"
     exon            483..632
                     /gene="Snph"
                     /inference="alignment:Splign:2.1.0"
     exon            633..4694
                     /gene="Snph"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcttccga ctggctcatc ccctccatcc acctctcctc ccccgccctc cacctctccc
       61 tccccccagc cccagcccca gcaagcaccc gctagccacc ttcagctggg gctcgggaga
      121 gcaatcctgc taccctcccg gggcagccta aaccatggaa gccttcgcag gttgctgatc
      181 atcgtcaggc ggctgctgca gcgactgcag aggcgctgcg ccaagctgcg ccggagtcgt
      241 gcgagccggc gggactgcgg agggcgagtg gacccagccc cgggaacacc gcccatcccg
      301 ccgctgacca ggacccgcag cctcatggcc atgtccctgc agggaagtag acgggcctct
      361 gccggatctc gcaggcgcac gtctccacct gtgagtgtgc gggacgccta cggcaccgct
      421 tccctcagca gcagcagcaa ctctggctcc tgcaagggca gtgacagcag ccccacaccg
      481 aggcgctcca tgaagtacac actctgcagt gacaaccatg gcatcaagcc tcccacccca
      541 gagcagtacc tgactccact gcagcagaag gaggtttgta tccggcacct gaaggcccgg
      601 ctcaaggaca cacaggaccg gctccaggat cgggacacag agatcgatga ccttaagacg
      661 cagctgtccc gcatgcagga ggactggatc gaggaggagt gccaccgcgt cgaggcccag
      721 ctggctctga aagaggcccg caaggagatc aggcagctca agcaggtcat cgacactgtc
      781 aagaacaacc tgatcgacaa ggacaagggg ctgcagaagt actttgtgga catcaacatc
      841 cagaacaaga agctggagac gctgctgcat agcatggagg tggctcagaa tggagtagcc
      901 aaggaggaag gaactgggga gtcggcaggc gggtcccctg cgcgctccct cacccgcagc
      961 tccacctaca ccaagctgag tgacccagcc gtctgtgggg accgccaggc aggggatccc
     1021 tccaacaccc ctgctgagga cagagctgat agcggctttg tggctgccga tgacaccctg
     1081 agtcggacgg aagccctgga ggccagtagc ctgctgtcat ctggagtgga ctgtggcttt
     1141 gaggaagcct cgctgcacag ctccttcaac ctgggccccc gcttccctgc cagcaacacg
     1201 tacgagaagc tgctgtgcgg catggaggct gctgtgcagg ccagctgcat gcaggagcgg
     1261 gccatccaga cagacttcgt gcagtaccag cctgacctga acaccatcct ggagaaagtg
     1321 ggccaggctc aggggtgcag ctcggtcctc aaggacaggc actcagagct ggatctccac
     1381 ccttcagggc ccagagaccc cgactcagca gtggtggtaa cagtaggtga cgagccggag
     1441 gccccagagc ccatcacccg cgggccagct atacaccggc ctgcagtcaa ctctaaccca
     1501 ggactgccag tgagtgtggt gtgtcccgtg gaagaggagg aggaggcagc cgccgccgcc
     1561 gccgccgccg ccgccgccac caccaccacc accaccaccg aaaaggaacc caagagttac
     1621 tggagccgcc actacatcgt ggatctgctg gctgtggtgg tgccagctgt gccaacggtg
     1681 gcctggctct gccgctccca gaggcgtcag ggccagccca tttacaacat cagctccctg
     1741 ctgcggggct gctgcacagt ggccttgcac tccatccgca ggatcagctg ttcactgagc
     1801 cagccgagcg ctggctcatc cggtggctcc cagctctgag gctgccagcc ctccactttg
     1861 ggcagcctga ccattgattg taggatgcca cttgctgccc tccatcccac ccccacccct
     1921 attggcttcc tcttaacttc ctttcaggcc cagaatagcg ccccccactc aagatatcag
     1981 tagtgtcagg gattcagaaa ggcatcgcaa aaacgtcaag agaaagggat taagatggct
     2041 aattgaagag ggagaaactg gtaagagcgc ccctccctct gtcccctcgg cccacccaga
     2101 ctctagacaa ggcaggccct gctcagaaag tctctggctt attgatctga ggatcctccc
     2161 ctcttttgaa ccattcttgt cagcacctgg cccactccat gccttctctt ccaggccacc
     2221 ccttgcccct ctccttgggc tcctggacca gtattacctc ctcaaatgga ggcagccagg
     2281 actcaaaata cagagaacca ctccacgcag ggtctggctt ccctggtccc accaaggctc
     2341 cagctctcct cccttgccta ggatgcagaa gtaaggtcca gctggaatga ccagctcagg
     2401 caggagggta ggttctgtgt ctgtctgtct gtcctcttgg cttctgggtg tgttagatct
     2461 ttgtgagatg tccaataccc atcactactc ctaacatgct tatcgtggga ttgggaggga
     2521 gcccttaccc aagccccagc tccccttggg caaatctgcc agcacagaga aggcaaggct
     2581 aaggcccttc accttctgag atgagtccac ctcatctgta gcctagaggt acctcagtga
     2641 gttgggaaag tcagaggtca cttaccacag gcccctttgg ccccaagccc tatctatgtt
     2701 tgcactcagc tccctgccca tcccagaaac cccgggctgc ttgctttctg ggatgaggac
     2761 ttctttcacc cagctgactc cagaggagga tgatggaaga tggctatcag ggggcacctc
     2821 cagatgagtt tctgaagcca caacatctgc ctctccatgc caaagcaggg tcccccaagt
     2881 gtgcttccca agcaggggaa tggccaggta gtgtgagcct gtctgtgctg ctcctggtcc
     2941 aggcctagtc agcctgagaa aatgctgcga tcctcacttc cctcttcttc ccagagaggt
     3001 catacctacc tgactggccc acctccaggg agctggtaga gccctgcatc tcaccctctc
     3061 tggcatggga gcctccctgg ttctctgcta aggtcgcttg tcctcactgt tgctccagtg
     3121 gccactactt gactcatgag ttctgcccca ccactctgtg ccctccaaag gggcacctgc
     3181 atgcactggg agtgggcagc agccagccta gccgtcaggg caagagccct ctgccgtgcg
     3241 ctttgtgcct ccaagccccc atccccacct tggttggggc tgcagacctg ccatccttgg
     3301 tggaacgttc ctaccccagc tgaaccaaac ccaaatgcct gaggcctcgc tggggctgcc
     3361 ccataggaca ctggggtggt accatggaga gacaggggat aaaactgatc caaagccaag
     3421 ccaggactgg ccacggaccc agtctcctgc gccgtgtact catggagctc catatgtctc
     3481 cctagcaaca gttgaagctc tgctgagaaa aataaatgta tgaactatat ttgacaacat
     3541 aaaatccata tatttttcac catttggcat ttagtccaac tttgcagccc ctctgttcca
     3601 tgtcttgctg tctgggcctt cttgtcgtgt ctcgtgtttg gtggacttgg gcagggctac
     3661 aactgtggtc tactctgttc ctgctgctgg agaagccact gagaagggtc caggtttgta
     3721 gaggcatcag gtgaactggc caccaccctg ctcctgccgt gaccctagcc ctgcctatgt
     3781 gatcgcctgt gaactcacct acagtagaga tcctctttcg tgagttctgc ctctcagaag
     3841 ggctctgctc cttgccagag caagtggagt gagcagctca ttacccagcc atgggatgac
     3901 cctggaaccc tgcaggctgg ggtaatggcc ctcttcttaa gtttatataa gccctgagtc
     3961 ccatatcctt acaaaggggt tgcagtgccc atgcagtccc aagaggtagg cttggaggta
     4021 gacacttgag cagcctgctg tttccagata tggagaaggg ggctgagagc aaggtggaac
     4081 tgggccaggc tccccttaga tgctcatccc caaagctccc cccttcccag ttggctgcag
     4141 ttttccctct tgcccttggc tcctggagca aaaatgttaa gggtgctcct ttcccctgcc
     4201 tccagtcaga gcagacaagg tcttgaggaa gtgtccccag gaactgcctt ctatagctcc
     4261 tgaggccttg gagcccagcg gcttgaagta gtggctcctt tgttctggag ccctctgaca
     4321 gggctccgtg aggacttctg aaaagaggca acgctgagca gagttcacgg tcaatgtgtc
     4381 caggcaggta gcatacatag cttttcaccg agactcctct tcacctgtac aggcacagga
     4441 caacatatcc caggctctag ggccaaaggc cactgagggg tctccaccct aggaactcat
     4501 agcccccttc cgatctaggc gacatgtaaa ctggccaccg tgcactcaca ttaggctatc
     4561 ttgacagatt ccaggggaca caggaggggg gctgtgggaa ggggtcataa ctctcagtct
     4621 cctttgtctc tttgttcaga cagagttgtg cctgtcgcag acagctctga attaaagcat
     4681 gaacacacac acag
//
