LOCUS       NM_001413841            8921 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus sushi, nidogen and EGF-like domains 1 (Sned1),
            mRNA.
ACCESSION   NM_001413841 XM_039083767
VERSION     NM_001413841.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8921)
  AUTHORS   Villafuerte,B.C., Barati,M.T., Song,Y., Moore,J.P., Epstein,P.N.
            and Portillo,J.
  TITLE     Transgenic expression of insulin-response element binding protein-1
            in beta-cells reproduces type 2 diabetes
  JOURNAL   Endocrinology 150 (6), 2611-2617 (2009)
   PUBMED   19213832
  REMARK    GeneRIF: Increased gene transcription mediated through IRE-BP1 may
            contribute to beta-cell dysfunction in insulin resistance, and
            allow for the hypothesis that IRE-BP1 plays a role in the
            pathophysiology of type 2 diabetes.
REFERENCE   2  (bases 1 to 8921)
  AUTHORS   Chahal,J., Chen,C.C., Rane,M.J., Moore,J.P., Barati,M.T., Song,Y.
            and Villafuerte,B.C.
  TITLE     Regulation of insulin-response element binding protein-1 in obesity
            and diabetes: potential role in impaired insulin-induced gene
            transcription
  JOURNAL   Endocrinology 149 (10), 4829-4836 (2008)
   PUBMED   18566119
  REMARK    GeneRIF: study supports the notion that IRE-BP1 may be relevant to
            the action of insulin in vivo and may play a role in the
            development of insulin resistance and diabetes
REFERENCE   3  (bases 1 to 8921)
  AUTHORS   Villafuerte,B.C. and Kaytor,E.N.
  TITLE     An insulin-response element-binding protein that ameliorates
            hyperglycemia in diabetes
  JOURNAL   J Biol Chem 280 (20), 20010-20020 (2005)
   PUBMED   15753094
  REMARK    GeneRIF: stable constitutive expression of IRE-BP1 enhanced glucose
            transporter expression, glucose uptake, and glycogen accumulation
REFERENCE   4  (bases 1 to 8921)
  AUTHORS   Villafuerte,B.C., Phillips,L.S., Rane,M.J. and Zhao,W.
  TITLE     Insulin-response element-binding protein 1: a novel Akt substrate
            involved in transcriptional action of insulin
  JOURNAL   J Biol Chem 279 (35), 36650-36659 (2004)
   PUBMED   15194686
  REMARK    GeneRIF: identified a novel transcription factor,insulin-response
            element-binding protein 1, that binds and transactivates the
            insulin-response elements of the insulin-like growth factor-binding
            protein-3 and other insulin responsive genes
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000215.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001413841.2.
            
            On Nov 9, 2022 this sequence version replaced XM_039083767.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-361               JACYVU010000215.1  26843813-26844173
            362-649             JACYVU010000215.1  26860800-26861087
            650-790             JACYVU010000215.1  26863508-26863648
            791-953             JACYVU010000215.1  26864155-26864317
            954-1079            JACYVU010000215.1  26866298-26866423
            1080-1193           JACYVU010000215.1  26866757-26866870
            1194-1307           JACYVU010000215.1  26869483-26869596
            1308-1421           JACYVU010000215.1  26869723-26869836
            1422-1547           JACYVU010000215.1  26874849-26874974
            1548-1652           JACYVU010000215.1  26875253-26875357
            1653-1766           JACYVU010000215.1  26875477-26875590
            1767-1883           JACYVU010000215.1  26876120-26876236
            1884-2000           JACYVU010000215.1  26877498-26877614
            2001-2117           JACYVU010000215.1  26877792-26877908
            2118-2231           JACYVU010000215.1  26878054-26878167
            2232-2405           JACYVU010000215.1  26878743-26878916
            2406-2519           JACYVU010000215.1  26883671-26883784
            2520-2633           JACYVU010000215.1  26884402-26884515
            2634-2747           JACYVU010000215.1  26884819-26884932
            2748-2861           JACYVU010000215.1  26885463-26885576
            2862-3158           JACYVU010000215.1  26885891-26886187
            3159-3342           JACYVU010000215.1  26886426-26886609
            3343-3455           JACYVU010000215.1  26886801-26886913
            3456-3737           JACYVU010000215.1  26887582-26887863
            3738-3882           JACYVU010000215.1  26889005-26889149
            3883-3965           JACYVU010000215.1  26889224-26889306
            3966-4061           JACYVU010000215.1  26890096-26890191
            4062-4178           JACYVU010000215.1  26893171-26893287
            4179-4266           JACYVU010000215.1  26893888-26893975
            4267-4348           JACYVU010000215.1  26898571-26898652
            4349-8921           JACYVU010000215.1  26899122-26903694
FEATURES             Location/Qualifiers
     source          1..8921
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..8921
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /note="sushi, nidogen and EGF-like domains 1"
                     /db_xref="GeneID:316638"
                     /db_xref="RGD:1566079"
     exon            1..361
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..4360
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /note="sushi, nidogen and EGF-like domain-containing
                     protein 1; insulin-responsive sequence DNA-binding protein
                     1"
                     /codon_start=1
                     /product="sushi, nidogen and EGF-like domain-containing
                     protein 1 precursor"
                     /protein_id="NP_001400770.1"
                     /db_xref="GeneID:316638"
                     /db_xref="RGD:1566079"
                     /translation="MRRGAAWALLLAAALGLGARGVRAAVALADFYPFGTKRGDAVTP
                     KQDDGGSGLQPLSVPFPFFGAEHSGLYVNNNGIISFLKEVSQFTPVAFPIAKDRCVVA
                     AFWADVDNRRAGDVYYREATDAAMLNRATEDIRRYFPELPDFSATWVFVATWYRVTFF
                     GGSSSSPVNTFQTVLITDGRFSFTIFNYESILWTTGTHASSGGDADGLGGIAAQAGFN
                     AGDGHRYFNIPGSRTADMAEVETTTNVGVPGRWAFRIDDAQVRVGGCGHTTSVCLVLR
                     PCLNGGKCIDDCVTGNPSYTCSCLAGFTGRRCHLDVNECASHPCQNGGTCTHGVNSFS
                     CQCPAGFQGPTCESAQSPCDNKVCQNGGQCQAESSSAVCVCQAGYTGATCETDVDECS
                     SDPCLNGGSCVDLVGNYSCICVEPFEGPQCETGSYVVPSPCLSNPCLNGGTCVDADQG
                     YVCECPEGFMGLDCRERILNDCDCRNGGRCLGANTTICQCPPGFFGLLCEFEVTATPC
                     NMNTQCPDGGYCMEYGGSYLCVCHTDHNISHSLPSPCDSDPCFNGGSCDAHEDSYTCE
                     CPRGFHGRHCEKARPHLCSSGPCRNGGTCKETGDEYRCTCPYRFTGRHCEIGKPDSCA
                     SGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCMNGGICEDLGTDFSCH
                     CQPGYTGHRCQAEVDCGQPEEVKHATMRLNGTRMGSVALYTCDPGFSLSVLSHMRVCQ
                     PQGVWSQPPQCIEVDECQSQPCLHKGSCQDLIAGYQCLCSPGYEGVHCELETDECQAQ
                     PCRNGGSCRDLPGAFICQCPEGFVGTHCETEVDACASSPCQHGGRCEDGGGAYLCVCP
                     EGFFGYNCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGKDCTKELLPPTALRV
                     ERVEESGVSISWSPPEGTTARQVLDGYAVTYASSDGSSRRTDFVDRSRSSHQLRALAA
                     GRAYNISVFSVKRNTNNKNDISRPAALLTRTRPRPIEDFEVTNISANAISVQWALHRI
                     QHATVSRVRVSVLYPEDTVVQSTEVDRSVDRLTFGDLLPGRRYSVRLTTLSGPGGAEY
                     PTESLASAPLNVWTRPLPPANLTASRVTATSAHMVWDPPTPGISLEAYVINVTTSQNT
                     KSRYIPNGKLVSYTVRDLMPGRRYQLSVTAVQSTEQGQLHSEPAHLYIITSPRDGTDR
                     RWHQGGHHSRMLRNRPAPLRLPELRLLNDHGAPETPTQPPRFSELVDGRARVSARFGG
                     LPSRAVTVRSQPTTPVPLKNTEAPEQARLALQLPKNNSKDTESTPGSCSEDTCQNGGT
                     CVPGANAHSCDCRPGFKGRHCELACEKVPRPCTRLFSETKSFPVWEGDVCHHVYKKVY
                     KVHQDVCFKERCQSTSLKKLKQESN"
     exon            362..649
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            650..790
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..953
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1079
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1193
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1307
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1421
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1547
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1652
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1766
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1883
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2000
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2117
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2231
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2405
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2519
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2633
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2747
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2861
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..3158
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3342
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3343..3455
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..3737
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3738..3882
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3883..3965
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3966..4061
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4062..4178
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4179..4266
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4267..4348
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4349..8921
                     /gene="Sned1"
                     /gene_synonym="IRE-BP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtctgcggt cctgcctcgc accttcctga gctgagcggg tccccggagt gtgacccgag
       61 ctagcgggag aggacggtgc ggccagtcgg ccgtgcggtg actatagcca cctgcccgag
      121 ccccgtggcc cgccctctga tcttggcgat gcgccgtggc gccgcctggg cgctgctgct
      181 ggccgcagcc ctggggctcg gggcgcgcgg ggtgcgcgct gcggtggccc tcgccgactt
      241 ctacccgttc ggcacgaagc gtggcgacgc cgtcaccccg aagcaggacg acggcggctc
      301 agggctgcag cccctctcgg tgcccttccc gttcttcggc gccgagcact caggactcta
      361 cgtgaacaac aacgggatca tctccttcct gaaggaagtt tctcagttca cccctgtggc
      421 cttccccatc gccaaagacc gctgtgtggt agcggccttc tgggcagacg tggataaccg
      481 acgcgcaggc gacgtctact accgggaggc caccgacgca gccatgctga acagagccac
      541 ggaggacatc aggcggtact ttcctgagct cccggacttc tctgctacct gggtttttgt
      601 tgccacctgg taccgtgtga ccttcttcgg aggcagcagc tcttcccccg tcaacacatt
      661 ccaaacggtg ctcatcactg acggccggtt ctccttcacc atcttcaact atgagtccat
      721 cctgtggact acgggcacac acgccagcag tggtggtgat gctgatggct tgggaggcat
      781 tgcagcccag gcaggtttca acgcaggtga tgggcaccgc tacttcaaca tccctgggtc
      841 gcgcacagca gacatggctg aggtggagac caccaccaac gtgggcgtgc ccgggcgctg
      901 ggcgtttaga atcgatgatg cccaggtgcg cgtggggggc tgcggccata caacctctgt
      961 gtgcctagtc ctgcgtccgt gcctcaatgg tggcaagtgc atcgatgact gtgtcacggg
     1021 caatccctcc tacacctgtt cctgtctcgc tggcttcacg gggcgtagat gccacctgga
     1081 tgtgaacgag tgtgcttccc acccatgtca gaacggtggg acctgcaccc acggtgtcaa
     1141 cagcttcagt tgccagtgcc cagccggctt ccagggaccc acctgtgaat cagcccagtc
     1201 tccgtgtgac aacaaagtgt gtcaaaatgg tggccagtgc caggcagaga gcagctctgc
     1261 agtatgtgtg tgtcaagctg gatacactgg ggccacctgt gagaccgatg tggatgaatg
     1321 cagctctgac ccatgcctaa atggtggatc gtgtgttgac ctggttggaa actacagctg
     1381 tatttgtgtg gagccctttg aaggacctca gtgcgagaca ggaagctacg tggtgccttc
     1441 gccctgcctc tccaacccct gcctgaacgg gggcacctgt gtggatgctg accagggata
     1501 cgtgtgcgaa tgccctgaag gtttcatggg cttggactgc agagagagaa ttctcaatga
     1561 ctgcgattgc cggaatggag gcagatgcct gggtgccaac accaccatct gccagtgtcc
     1621 tccaggcttc tttgggctcc tctgtgaatt tgaagtcaca gccacgccct gcaacatgaa
     1681 cactcagtgt ccagatggag gctactgcat ggagtatggc ggaagctacc tatgtgtctg
     1741 ccacacggac cacaacatca gccattctct gccctcgccc tgcgactcag acccatgctt
     1801 taatggaggt tcctgtgacg cccacgagga ctcctacacg tgcgagtgcc ctcgtggatt
     1861 ccatggcagg cactgcgaga aagcccggcc acacctgtgc agctcagggc cctgccggaa
     1921 tgggggcaca tgcaaggaga ctggtgacga gtaccgctgc acctgccctt accggttcac
     1981 tgggagacac tgtgagattg gaaagccaga ctcctgtgcc tctggcccct gtcacaacgg
     2041 tggcacttgt ttccactaca ttggcaaata caagtgtgac tgccctccag gcttctctgg
     2101 tcggcactgt gagatagccc cctccccctg cttccggagc ccatgtatga atgggggtat
     2161 ctgcgaggat ctaggaacag atttctcctg ccactgccaa ccaggatata caggacaccg
     2221 gtgtcaggca gaggtggact gcggtcagcc tgaggaggta aaacatgcta ccatgcgtct
     2281 caatggaact cgcatgggct cggtggccct gtacacatgt gaccccggct tcagcctgag
     2341 cgtcctcagc catatgcgtg tctgtcagcc acaaggtgtc tggagccagc ctccccagtg
     2401 cattgaagta gatgagtgcc agtctcagcc atgcctgcat aaaggctcct gccaggacct
     2461 cattgctggt taccagtgcc tctgcagccc ggggtacgaa ggagtccact gtgagctaga
     2521 gacagacgag tgccaagcac agccctgcag aaatggaggc tcctgcaggg acctccccgg
     2581 ggctttcatc tgccagtgcc ctgaaggttt tgttggaacc cactgtgaaa cagaggtgga
     2641 tgcctgtgcc tccagcccct gccagcacgg aggccggtgt gaggacggtg gtggggccta
     2701 cctgtgcgtg tgtccagagg gcttcttcgg ctacaactgt gagacagtga gtgacccctg
     2761 cttctctagc ccctgtgggg gccgcggcta ctgcttggcc agcaacgggt cccacagctg
     2821 tacctgcaaa gtgggctaca caggcaagga ctgcaccaaa gagctcctcc caccaacagc
     2881 cctcagggta gaaagggtgg aggagagtgg ggtctccatc tcctggagcc cacccgaggg
     2941 caccacggcc agacaggtgc tggacggcta tgcagtcacc tatgcctcct cggatggatc
     3001 gtccaggcgc acggactttg tggaccggag ccgctcctct caccagcttc gggccctggc
     3061 agccggccgt gcctacaaca tctctgtttt ctcagtcaag agaaacacta acaacaaaaa
     3121 tgacatcagc aggcctgcag ccctgctcac ccgcacccga ccccgcccta ttgaagactt
     3181 cgaggtcacc aacatttcag ccaatgccat ctcagtgcag tgggctcttc ataggatcca
     3241 gcatgccact gtcagcaggg ttcgagtgtc tgtcctctac cctgaggaca ctgtggtcca
     3301 gtccacggag gtggacagga gtgtggaccg cctcacattt ggggacctgc tgccagggag
     3361 aagatacagt gtgcggctaa ccaccctcag tgggcctgga ggagctgaat atcctacaga
     3421 gagcctggcc tcagctccgc tgaacgtgtg gacccggcct ttgcctccag caaacctgac
     3481 tgcctctcga gtcacagcga cctctgccca tatggtctgg gacccgccca ctccaggcat
     3541 ctcactggag gcttacgtca tcaatgtgac caccagtcag aataccaaga gccgctacat
     3601 ccccaatggg aagctggtgt cctatacggt gcgtgatctg atgccaggtc ggcggtacca
     3661 gctctcggtc acagcggtgc agagcacaga gcagggccag ctgcacagtg agcctgcgca
     3721 cctctacatc atcacctccc ccagggatgg caccgacagg cgctggcacc agggaggaca
     3781 ccactcacga atgctcagaa ataggccggc ccctttgcgc ctgccagaac tgcgcctcct
     3841 caatgaccac ggtgcccctg aaacaccaac ccagccaccc aggttctcag agcttgtaga
     3901 cggaagagca agagtgagtg ccaggtttgg tggattgccc agcagagcag taactgtgag
     3961 atcacaaccc actactccgg tgccgctcaa gaacacagag gcccctgagc aggcccgtct
     4021 ggcccttcag ctacccaaga acaacagcaa ggacacagaa agtacccctg gcagctgttc
     4081 agaagacacc tgtcagaatg gaggcacctg tgtcccaggt gccaatgccc acagctgtga
     4141 ctgcaggcct gggttcaaag gcagacactg tgagcttgcc tgtgaaaaag tgccccgccc
     4201 ctgcacacgg ctgttctctg agaccaagtc atttcctgtc tgggaaggag atgtctgcca
     4261 ccatgtgtat aagaaagtct acaaagttca ccaggacgtg tgttttaagg agcgctgcca
     4321 gagcacaagc ctcaaaaagc tcaaacagga atcaaattaa cagtcaaaca ctgaagaaat
     4381 cttaaggtac attctccttc ataccaagat ctgttgagaa ctggagacac catcataccc
     4441 agcaccttgg acaactgatg gtgcaaactt agcactgtgc tattacagac ccaaccagga
     4501 aggttccaga attccctgtc tatagcctcc caatagacat aacctggtct ggccttccat
     4561 atgaatccac tttcaggtgg aaatgactct ctgggggagg ggcaaatgca gaccagttac
     4621 aatgaggcac aagaatcacc tggccccttc aggacagtgg gcctgggtgt tagatggatc
     4681 aaggatgcca aacaatcctg ggggtgctag gaaggaccta aggacatacc ctcaagccct
     4741 atgaatagca ttctactggt ggaaaagggc gggagccttg tcatgtaacc tgcaggtgat
     4801 cctaaataga gcctctcact gggagagata tcatggatcc tggaattcta agcactaata
     4861 accctgaagt gaaagaaact ttgcctgctt gatccagcat gtcccacccc accctcccca
     4921 tacataaact gtgagatgtc aaagggcatt ggaaaatttt tttcacaagc ctgggaaata
     4981 ctgggttaca ctacagagat ccctgtatag cctgaactca gccccaacac tgacttactg
     5041 atgggacatc aattggaaac gagagactgg ctggccagag acatttcact cctctccctt
     5101 ggaggagcca gaacagtaca tctgtgcagt ggtgggagag aggcagatct ggaagcctgc
     5161 caggagtgaa tcacctttgt tctacagtgt aggacgtgaa ggagaaatgt cacccaaagg
     5221 cctaagaaca aagaagagca aagcagttct gggcgaaggt catccgaaga gaaaagtgtc
     5281 tacagtaaaa ggcagggcat caggagagcg ggctctcaga caggcctaag cagggcctgt
     5341 gcatcttgac catttcagat gtgaagactg caggaagagc agctgaccag actcaaatcc
     5401 tgtctactta acagcatcac cttttcacct cagcccccaa aaatgcacac aacaccctcc
     5461 aacacatgtg agcaacttca ttctggcaaa gatcaaaaat ccacaaatta tttggtttta
     5521 aaatatttac atggcagtaa gtcagatgaa atattaatgc aaaaaaagaa atattaatgc
     5581 atcctttaag aactcacaga aaactcattt ttagaaaaaa aatgagaatc cctaggtact
     5641 tatcacataa tggcttatag aaaacctatt ctcagagcaa cacacacaca cacacacaca
     5701 cacacacaca cacacacaca cacacatcac acacacccct tctctttctg aagaaaccag
     5761 aattcgccat ccacagctgc cctgagaaaa tgagcagtgc cacccgcccc taaggaaagg
     5821 cagcagagga ccagcaagca gcaaacttaa agccggaggc tgatcgcaag tgtcctaaga
     5881 ggtgcgtgtg tcccttccat cccgccctgc atcacagcca gctggaattc tggctcctgg
     5941 ggacaatgcc tgctgcctcc agagaaagac tggatataaa gaggagtgtg cctcagttca
     6001 ctgttactcc ttttgtcaaa aggaccggca tgtgctggta attctgtcca cacctcaagg
     6061 atttccaaaa cccaggaaat gaggttcaaa acttaaacgc caagctccca gcagtaggca
     6121 gtctccccga gatctctgtc ctccaaattc tagaaaagag acagccagac atgcacaccc
     6181 aaaggactcc tgccagggaa gcaacaatgc accctgctgc aacccagggt tgctgtttcc
     6241 gcagttctgg tcaatccctc tgtggagagt tacctgtgtt accaggctct ttgtgatgct
     6301 tctgtgctca gaaacccaca tccagatccc agtgccaaag aaaaagactc agctttcaca
     6361 agagatgcaa gagaggctgt gcagaaatag atgggctcta ccctgctcct cttctcattt
     6421 atactgatga cctaaagaag tgctaattct actatggtgg ggcttagaca cttggtctac
     6481 aactcagggg tggcagggca ggcagatgct caggcaggat tttgggctcc gcaggtagaa
     6541 tgacttgtac ctctggcaca cacccaaccc tgctactgta ctgccaacac catcacagat
     6601 gtagatagca tagctgtgtc ccaatgagac tgcatttaca aaaacaggca gcaggccata
     6661 gctggcagct ttataagatg atctagacct cagccttcct tctgcggaga aaaccatcct
     6721 gaatgacaag ttggcatcaa gacatgaaag acccctgaac tttcatagaa gaaaagcgat
     6781 caagacccct gctctgaaac ctgaggtaaa cttataccac agagcaggaa gagctacctg
     6841 ttcaaacctg tgacacaggg caggctggct ccaggagaca gggtccaagg cttcttgtaa
     6901 gctgtgcccc aactagacag ctgtggttca ccaaaacaaa aatattttac acagcctccg
     6961 ctttccatcc cactccgaac aaggctgtaa acagctgtcc tctccctgca gtaacatcac
     7021 aatcagaaaa gccgacatac cctgactcct tgctccagcc tgagcagagc tgactagaga
     7081 tccagcacca agaactacat cccaaccaga gaggcctcct gcccttcaga ggtcataaaa
     7141 acacagtttg aagcataacc ttttaagttt tattctcact aaaaacttct gaacctatgt
     7201 tatcacataa tttttttctc tttcaaaaac tcactactgt accttagata ctcgctagag
     7261 tcctggagac cgcataagct acagcgttag cagggagtgg caagctcagg tggcatcact
     7321 gaagagcaga tgggatcttt gtactttact actaacctca gggccctcac cgccaggccg
     7381 atgctgccac attcccattt ccagttggag cctgtgtttc aaacaagagt cagcctgctg
     7441 actgctgagt gtggagtgga gaaagactcg ctggtgctga ggaattagtg tatgacattc
     7501 cacacatgcg gtctctgctt tcttacatgc ctttcttatg cagactaatt aaatccctca
     7561 aaacagtcac tgtccactta agaaatgtca cagtgggggt tgggcattta gctcagtggt
     7621 agagggcttg cctaggaagc gcaaggccct gggttcagtc cccagctccg aaaaaaaaga
     7681 accaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaagaa atgtcacagt
     7741 ggaatcagaa tctaatggac aaggtggagt gtggagattt ttgtgttaaa ctgaagaggc
     7801 attcatgagt tgttgggttc accatgtgct aatcaaaact taagatgaac agacacctaa
     7861 ttgagctcag ggctagggtt ctattcagtt ctgatggagc ccaaagccaa atgccctatg
     7921 ttcagggaaa gtggagatca tgtcaaggcc acaaagggaa gagtaagcag cgaagaatgg
     7981 atcattggtc ttagtttcat ccacagccaa gaacaggcag aaggcattcc ctttctttac
     8041 tgcctatggg atgttggggt agacaggatg gctttctgtg gtgagtccaa caggcaagga
     8101 cccgcccttg ccaggaataa gcttgcctca cacagctgcc aaagtcagaa ctcctgactg
     8161 tgtgcaggag aatctgggaa tgactgcttt ccttgaacac cctcctcttt gcaatcaggc
     8221 tccaggcaag tcaaaagccc cacaccttgg tgctggttcc ttacaaaata cacctcagat
     8281 ccagcaagac ctctacttta aacagaaata cctggggtcc agttacaatc caaagttgtt
     8341 gtagtcacag gacttccatg ggccaggtct ttgagcagtt tctcagcatt ggcattgctt
     8401 tgtggactga tgtgtggtgc aatgtacgat cttttataac ctccctggct ctgatcagat
     8461 cccaaggcca tgacataaaa atatccccaa agattaccag gtgtctggag gaccaaggtc
     8521 attctcacat aagcactgaa ttcagtctaa acacaaggcc cacgtcgggg tttcacatga
     8581 ctgttaaatg ccaccaaatg gggaaaaaat atgagcaaag cattcctgac tttggtctct
     8641 gagcagctca ctctttagca caggctacag agccagagag atagggggcc ttgaggtggc
     8701 agcttgccca agcaggaagg gtcaggtcag caactgcaga gaagtgtatt gctagtctga
     8761 caactgtgtg actaaaggtc atgttactaa ccaactgcct ctcactctgc tgtacattcg
     8821 acatgtcaga aggccgggaa atggtgtcgg ataaagaaca tgcctatcgt gtgggaaacc
     8881 tgctacttgt tctcattaaa taaagtgcta tgacatacta a
//
