LOCUS       NM_022694               3475 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus staphylococcal nuclease and tudor domain
            containing 1 (Snd1), mRNA.
ACCESSION   NM_022694
VERSION     NM_022694.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3475)
  AUTHORS   Lin,S., Guo,H., You,X., Zhang,Z. and Ye,H.
  TITLE     SND1 aggravates mitochondrial damage, apoptosis and extracellular
            matrix degradation in IL-1beta-stimulated chondrocytes via
            PINK1/BECN1 pathway
  JOURNAL   Eur J Med Res 28 (1), 371 (2023)
   PUBMED   37749650
  REMARK    GeneRIF: SND1 aggravates mitochondrial damage, apoptosis and
            extracellular matrix degradation in IL-1beta-stimulated
            chondrocytes via PINK1/BECN1 pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3475)
  AUTHORS   Huang,C., Sun,L., Xiao,C., You,W., Sun,L., Wang,S., Zhang,Z. and
            Liu,S.
  TITLE     Circular RNA METTL9 contributes to neuroinflammation following
            traumatic brain injury by complexing with astrocytic SND1
  JOURNAL   J Neuroinflammation 20 (1), 39 (2023)
   PUBMED   36803376
  REMARK    GeneRIF: Circular RNA METTL9 contributes to neuroinflammation
            following traumatic brain injury by complexing with astrocytic
            SND1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3475)
  AUTHORS   Lv,M., Cai,Y., Hou,W., Peng,K., Xu,K., Lu,C., Yu,W., Zhang,W. and
            Liu,L.
  TITLE     The RNA-binding protein SND1 promotes the degradation of GPX4 by
            destabilizing the HSPA5 mRNA and suppressing HSPA5 expression,
            promoting ferroptosis in osteoarthritis chondrocytes
  JOURNAL   Inflamm Res 71 (4), 461-472 (2022)
   PUBMED   35320827
  REMARK    GeneRIF: The RNA-binding protein SND1 promotes the degradation of
            GPX4 by destabilizing the HSPA5 mRNA and suppressing HSPA5
            expression, promoting ferroptosis in osteoarthritis chondrocytes.
REFERENCE   4  (bases 1 to 3475)
  AUTHORS   Elbarbary,R.A., Miyoshi,K., Myers,J.R., Du,P., Ashton,J.M., Tian,B.
            and Maquat,L.E.
  TITLE     Tudor-SN-mediated endonucleolytic decay of human cell microRNAs
            promotes G1/S phase transition
  JOURNAL   Science 356 (6340), 859-862 (2017)
   PUBMED   28546213
REFERENCE   5  (bases 1 to 3475)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3475)
  AUTHORS   Li,C.L., Yang,W.Z., Chen,Y.P. and Yuan,H.S.
  TITLE     Structural and functional insights into human Tudor-SN, a key
            component linking RNA interference and editing
  JOURNAL   Nucleic Acids Res 36 (11), 3579-3589 (2008)
   PUBMED   18453631
REFERENCE   7  (bases 1 to 3475)
  AUTHORS   Rodriguez,L., Bartolome,N., Ochoa,B. and Martinez,M.J.
  TITLE     Isolation and characterization of the rat SND p102 gene promoter:
            putative role for nuclear factor-Y in regulation of transcription
  JOURNAL   Ann N Y Acad Sci 1091, 282-295 (2006)
   PUBMED   17341622
  REMARK    GeneRIF: Absence of TATA box and location and reverse orientation
            of the CCAAT boxes in the promoter region strongly suggest a role
            for NF-Y in the regulation of transcription of SND p102 gene.
REFERENCE   8  (bases 1 to 3475)
  AUTHORS   Palacios,L., Ochoa,B., Gomez-Lechon,M.J., Castell,J.V. and
            Fresnedo,O.
  TITLE     Overexpression of SND p102, a rat homologue of p100 coactivator,
            promotes the secretion of lipoprotein phospholipids in primary
            hepatocytes
  JOURNAL   Biochim Biophys Acta 1761 (7), 698-708 (2006)
   PUBMED   16798076
  REMARK    GeneRIF: cells overexpressing SND p102 secreted phospholipid-rich
            lipoproteins
REFERENCE   9  (bases 1 to 3475)
  AUTHORS   Foster,L.J., Zeemann,P.A., Li,C., Mann,M., Jensen,O.N. and
            Kassem,M.
  TITLE     Differential expression profiling of membrane proteins by
            quantitative proteomics in a human mesenchymal stem cell line
            undergoing osteoblast differentiation
  JOURNAL   Stem Cells 23 (9), 1367-1377 (2005)
   PUBMED   16210410
REFERENCE   10 (bases 1 to 3475)
  AUTHORS   Lienard,P., Riviere,M., Van Vooren,P., Szpirer,C. and Szpirer,J.
  TITLE     Assignment of SND1, the gene encoding coactivator p100, to human
            chromosome 7q31.3 and rat chromosome 4q23 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 90 (3-4), 253-254 (2000)
   PUBMED   11124528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC072471.1.
            
            On Oct 9, 2005 this sequence version replaced NM_022694.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072471.1, AY697864.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3475              BC072471.1         1-3475
FEATURES             Location/Qualifiers
     source          1..3475
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..3475
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /note="staphylococcal nuclease and tudor domain containing
                     1"
                     /db_xref="GeneID:64635"
                     /db_xref="RGD:631340"
     exon            1..276
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..2931
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /EC_number="3.1.31.1"
                     /note="p100 co-activator; 100 kDa coactivator; p105
                     coactivator; staphylococcal nuclease domain containing 1"
                     /codon_start=1
                     /product="staphylococcal nuclease domain-containing
                     protein 1"
                     /protein_id="NP_073185.2"
                     /db_xref="GeneID:64635"
                     /db_xref="RGD:631340"
                     /translation="MASAQSSGSSGGPAVPTVQRGIVKMVLSGCAIIVRGQPRGGPPP
                     ERQINLSNIRAGNLARRAAATQPDGKDTPDEPWAFPAREFLRKKLIGKEVCFTIENKT
                     PQGREYGMIYLGKDTNGENIAESLVAEGLASRREGMRANNPEQNRLSECEEQAKASKK
                     GMWSEGNGSHTIRDLKYTIENPRHFVDSHHQKPVNAIIEHVRDGSVVRALLLPDHYLV
                     TVMLSGIKCPTFRRETDGSETPEPFAAEAKFFTESRLLQRDVQIILESCHNQNILGTI
                     LHPNGNITELLLKEGFARCVDWSIAVYTRGAEKLRAAERFAKERRLRIWRDYVPPTAN
                     LDQKDKQFVAKVMQVLNADAIVVKLNSGDYKTIHLSSIRPPRLEGDNIQDKNKKLRPL
                     YDIPYMFEAREFLRKKLIGKKVSVTVDYIRPASPATETVPAFSERTCATVTIGGINIA
                     EALVSKGLATVIRYRQDDDQRSSHYDELLAAEARAIKNGKGLHSKKEVPIHRVADISG
                     DTQKAKQFLPFLQRAGRSEAVVEYVFSGSRLKLYLPKETCLITFLLAGIECPRGARNL
                     PGLVQEGEPFSEEATLFTKELVLQREVEVEVESMDKAGNFIGWLHMDGANLSVLLVEH
                     ALSKVHFTAERSAYYKPLLSAEEAAKQRKEKVWAHYEEQPVEEVMPVLEEKERSASYK
                     PVFVTEITDDLHFYVQDVETGTQLEKLMENMRSDISSHPPVEGAYAPRRGEFCIAKFV
                     DGEWYRARVEKVESPAKVHVFYIDYGNREILPSTRLGALPPAFSTRVLPAQATEYAFA
                     FIQVPQDEDARTDAVDSVVRDIQNTQCLLNVEHLSASCPHVTLQFADSKGDVGLGLVK
                     EGLVMVEVRKEKQFQKVITEYLNAQESAKSARLNLWRYGDFRADDADEFGYSR"
     exon            277..426
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            427..547
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            548..626
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            627..787
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            788..879
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1038
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1145
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1236
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1350
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1440
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1541
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1652
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1725
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1867
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1977
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2166
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2308
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2432
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2502
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2616
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2820
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..2865
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..3449
                     /gene="Snd1"
                     /gene_synonym="SND p102"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcggccga gatcgcgtct cctcttttgc ttccagtccc gctgctgtta tagtgtgcgc
       61 ctggcgcttc tatccagtcc accgacggta gcctgtcgtc cgccttctcc ttgtcgctgc
      121 aacctctcac cagcaccggc accctctctg acacttccag tccggccggc cgccccactc
      181 tctgtctttc cagctccaca catggcctcc gcgcagagca gcggctcctc cgggggaccc
      241 gcggtcccca ccgtgcaacg gggcatcgtc aagatggtcc tctctgggtg tgccatcatt
      301 gtccgagggc agccccgggg cggtccgcct ccagagaggc agatcaacct cagcaacatt
      361 cgagctggaa atctcgcccg tcgggcagct gctacgcaac cagatgggaa agatacccca
      421 gatgagccct gggcatttcc tgctagagag ttccttcgca agaagctgat tgggaaggaa
      481 gtctgtttca cgatagaaaa caagactccc caaggacgag agtatggaat gatctacctt
      541 ggaaaagata ctaatgggga aaacattgca gagtcgctag tcgcagaagg cttggcctcc
      601 cggagagaag gcatgagagc caataaccca gagcagaacc ggctttcaga atgcgaggaa
      661 caagcaaagg catcgaagaa agggatgtgg agtgagggga acgggtcaca caccatccgg
      721 gacctcaagt acaccattga gaacccaagg cactttgtgg actcacacca ccagaagcct
      781 gtcaatgcta tcattgagca tgttcgagac ggcagtgtgg tccgggccct gctccttccg
      841 gatcactacc ttgttaccgt catgctgtca gggattaagt gcccaacctt tcgtcgagaa
      901 acagatggta gtgaaacacc agagcccttc gctgcagaag ccaagttttt cacggagtct
      961 cgactgcttc agagagatgt tcagatcatt ctggagagct gccataatca gaacattctg
     1021 ggcaccatcc ttcatccaaa tggtaacatc actgaactcc tcctgaagga aggttttgcc
     1081 cgctgtgtgg actggtcaat tgcagtttac acccggggtg cagaaaagct gagggcagct
     1141 gagaggtttg ccaaggagcg taggctgaga atatggagag actatgtgcc tcctactgct
     1201 aatttggacc aaaaggacaa gcagtttgtt gccaaggtaa tgcaggtttt gaatgctgat
     1261 gccattgttg tgaagctgaa ttctggagac tacaagacca tccacctgtc aagcatccga
     1321 ccaccaaggt tggagggaga caacatacag gataagaata agaagctccg gcccctgtat
     1381 gacatcccct acatgtttga ggcccgggaa ttccttcgca aaaagctcat tgggaagaag
     1441 gtcagtgtga ctgtggacta cattagacca gccagcccag ccacagaaac agtgcctgcc
     1501 ttttctgagc gtacctgtgc cactgtcacc attggaggaa taaacattgc tgaggccctt
     1561 gtcagcaaag gcctagccac agtgatcaga taccggcagg atgatgacca gagatcttca
     1621 cactatgatg agctgctggc tgcagaggcc agagcgatta agaatggcaa aggattgcac
     1681 agcaagaagg aagtgcccat ccaccgagtt gcagacattt ctggggacac ccagaaagca
     1741 aagcagttcc tgccctttct tcagcgcgca ggccgttctg aggctgtggt ggagtatgtc
     1801 ttcagtggct ctcgcctcaa gctctactta cctaaggaga cctgtctcat caccttcctg
     1861 ctggcaggca ttgaatgtcc cagaggagca cgaaatctcc caggcttggt gcaggaagga
     1921 gagccattca gtgaggaagc cacacttttc accaaggaac tagtgctgca gcgagaggtg
     1981 gaggtggagg tagagagcat ggataaggct ggcaacttca ttggctggct acacatggat
     2041 ggggctaacc tgtctgtctt gctggtggag cacgcgctct ccaaggtcca cttcactgct
     2101 gagcgcagcg cctactataa gcctctcctg tctgctgagg aagctgccaa gcagaggaaa
     2161 gagaaggtct gggcccacta tgaggagcag cctgtggagg aggtaatgcc tgtactggaa
     2221 gagaaggagc gctcggccag ctacaagcca gtgtttgtga ccgagatcac agatgacctg
     2281 catttctatg tgcaagatgt ggagactggc acccagctgg aaaaactgat ggagaacatg
     2341 cgcagtgaca tctccagcca ccctcctgtt gagggtgcct acgccccacg ccggggagag
     2401 ttctgcattg ccaaatttgt agatggagaa tggtaccgcg cccgggtaga aaaagtggag
     2461 tcccctgcca aagtgcatgt cttctacatc gactatggca atagagagat cctgccatcc
     2521 acccgcctgg gtgccctacc acctgccttc agcactcgcg tgttgccagc tcaagccaca
     2581 gagtatgcct tcgccttcat ccaggtgccc caagatgagg acgctcgcac agatgctgtg
     2641 gacagtgtgg tgcgggacat ccaaaacact cagtgcctgc tcaacgtgga gcacctgagt
     2701 gccagctgcc cccatgtcac tctgcagttt gcggattcca aaggtgatgt ggggctgggc
     2761 ctggtgaagg aaggactcgt catggtagaa gttcggaagg agaagcagtt ccagaaagtg
     2821 atcacagagt acctgaatgc ccaggaatca gccaagagtg ccaggctgaa cctgtggcgc
     2881 tatggcgact tccgagctga cgatgctgat gagtttggct acagtcgcta aggagaactt
     2941 gcctggctcc cagcaccgct gatgccagac cttctccctc tgccaggaag ccgttttcaa
     3001 ctccagacct ggtcggggga gtatagattg ggtccagctt gcttcagaca gaaacctcct
     3061 ctgtcgcggg tagcattgga gctggggtgg agagcccaag gcttgctggg gcagaccccc
     3121 tcagtggtac tgccgtccag tctctcccag atgattttgt atttttattt gggggggggg
     3181 ggtgcttttt tttaattgtc ttcaaatcag gaaagaacca tgaaagactg tgtgttagtg
     3241 aagggtataa tcgtgacaca gaggcagctg tcagctggca cccacctctc ccccagacca
     3301 cccttcttcc caagctctgt ccaagtgttg attatgtgac ttctgataca tccgttctca
     3361 aattccagtg tgcccatatc tgcccccaca ccagcctgtt ctgtatttaa agcttttgag
     3421 acccaataaa atagtacctg ctgtctgcaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
