LOCUS       NM_031688                740 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus synuclein, gamma (Sncg), mRNA.
ACCESSION   NM_031688 XM_346481
VERSION     NM_031688.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 740)
  AUTHORS   Yang,H.M., Cheng,Y.Z., Hou,T.Z., Fan,J.K., Gu,L., Zhang,J.N. and
            Zhang,H.
  TITLE     Upregulation of Parkinson's disease-associated protein
            alpha-synuclein suppresses tumorigenesis via interaction with
            mGluR5 and gamma-synuclein in liver cancer
  JOURNAL   Arch Biochem Biophys 744, 109698 (2023)
   PUBMED   37487948
  REMARK    GeneRIF: Upregulation of Parkinson's disease-associated protein
            alpha-synuclein suppresses tumorigenesis via interaction with
            mGluR5 and gamma-synuclein in liver cancer.
REFERENCE   2  (bases 1 to 740)
  AUTHORS   Boyer,F., Balado,E., Piazza,P.V., Dreyer,J.L. and
            Deroche-Gamonet,V.
  TITLE     A decrease in gamma-synuclein expression within the nucleus
            accumbens increases cocaine intravenous self-administration in the
            rat
  JOURNAL   Addict Biol 16 (1), 120-123 (2011)
   PUBMED   20579003
  REMARK    GeneRIF: The present data reveal that GSyn exert a specific
            negative control on cocaine-induced reinforcing and incentive
            effects.
REFERENCE   3  (bases 1 to 740)
  AUTHORS   Greten-Harrison,B., Polydoro,M., Morimoto-Tomita,M., Diao,L.,
            Williams,A.M., Nie,E.H., Makani,S., Tian,N., Castillo,P.E.,
            Buchman,V.L. and Chandra,S.S.
  TITLE     alphabetagamma-Synuclein triple knockout mice reveal age-dependent
            neuronal dysfunction
  JOURNAL   Proc Natl Acad Sci U S A 107 (45), 19573-19578 (2010)
   PUBMED   20974939
REFERENCE   4  (bases 1 to 740)
  AUTHORS   Nishioka,K., Wider,C., Vilarino-Guell,C., Soto-Ortolaza,A.I.,
            Lincoln,S.J., Kachergus,J.M., Jasinska-Myga,B., Ross,O.A.,
            Rajput,A., Robinson,C.A., Ferman,T.J., Wszolek,Z.K., Dickson,D.W.
            and Farrer,M.J.
  TITLE     Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy
            body disease
  JOURNAL   Arch Neurol 67 (8), 970-975 (2010)
   PUBMED   20697047
REFERENCE   5  (bases 1 to 740)
  AUTHORS   Jeannotte,A.M., McCarthy,J.G. and Sidhu,A.
  TITLE     Desipramine induced changes in the norepinephrine transporter,
            alpha- and gamma-synuclein in the hippocampus, amygdala and
            striatum
  JOURNAL   Neurosci Lett 467 (2), 86-89 (2009)
   PUBMED   19818834
REFERENCE   6  (bases 1 to 740)
  AUTHORS   Galvin,J.E., Giasson,B., Hurtig,H.I., Lee,V.M. and Trojanowski,J.Q.
  TITLE     Neurodegeneration with brain iron accumulation, type 1 is
            characterized by alpha-, beta-, and gamma-synuclein neuropathology
  JOURNAL   Am J Pathol 157 (2), 361-368 (2000)
   PUBMED   10934140
REFERENCE   7  (bases 1 to 740)
  AUTHORS   Galvin,J.E., Uryu,K., Lee,V.M. and Trojanowski,J.Q.
  TITLE     Axon pathology in Parkinson's disease and Lewy body dementia
            hippocampus contains alpha-, beta-, and gamma-synuclein
  JOURNAL   Proc Natl Acad Sci U S A 96 (23), 13450-13455 (1999)
   PUBMED   10557341
REFERENCE   8  (bases 1 to 740)
  AUTHORS   Buchman,V.L., Hunter,H.J., Pinon,L.G., Thompson,J., Privalova,E.M.,
            Ninkina,N.N. and Davies,A.M.
  TITLE     Persyn, a member of the synuclein family, has a distinct pattern of
            expression in the developing nervous system
  JOURNAL   J Neurosci 18 (22), 9335-9341 (1998)
   PUBMED   9801372
REFERENCE   9  (bases 1 to 740)
  AUTHORS   Buchman,V.L., Adu,J., Pinon,L.G., Ninkina,N.N. and Davies,A.M.
  TITLE     Persyn, a member of the synuclein family, influences neurofilament
            network integrity
  JOURNAL   Nat Neurosci 1 (2), 101-103 (1998)
   PUBMED   10195122
REFERENCE   10 (bases 1 to 740)
  AUTHORS   Akopian,A.N. and Wood,J.N.
  TITLE     Peripheral nervous system-specific genes identified by subtractive
            cDNA cloning
  JOURNAL   J Biol Chem 270 (36), 21264-21270 (1995)
   PUBMED   7673161
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 30, 2020 this sequence version replaced NM_031688.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF975695.1, BG668479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787, SAMN16676788
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               JAXUCZ010000016.1  9711134-9711336     c
            204-245             JAXUCZ010000016.1  9710329-9710370     c
            246-373             JAXUCZ010000016.1  9709916-9710043     c
            374-433             JAXUCZ010000016.1  9707310-9707369     c
            434-740             JAXUCZ010000016.1  9706765-9707071     c
FEATURES             Location/Qualifiers
     source          1..740
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p15"
     gene            1..740
                     /gene="Sncg"
                     /note="synuclein, gamma"
                     /db_xref="GeneID:64347"
                     /db_xref="RGD:70996"
     exon            1..203
                     /gene="Sncg"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..454
                     /gene="Sncg"
                     /note="persyn; sensory neuron synuclein; synuclein, gamma
                     (breast cancer-specific protein 1)"
                     /codon_start=1
                     /product="gamma-synuclein"
                     /protein_id="NP_113876.2"
                     /db_xref="GeneID:64347"
                     /db_xref="RGD:70996"
                     /translation="MDVFKKGFSIAREGVVGAVEKTKQGVTEAAEKTKEGVMYVGTKT
                     KENVVQSVTSVAEKTKEQANAVSEAVVSSVNTVATKTVEEAENIVVTTGVVRKEDLEP
                     PAQDQEAKEQEEGEEAKSGGD"
     exon            204..245
                     /gene="Sncg"
                     /inference="alignment:Splign:2.1.0"
     exon            246..373
                     /gene="Sncg"
                     /inference="alignment:Splign:2.1.0"
     exon            374..433
                     /gene="Sncg"
                     /inference="alignment:Splign:2.1.0"
     exon            434..740
                     /gene="Sncg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgtcaata agaggcagcg gcagcagagg cagccctcca gttcgtagct tgcagcagcc
       61 aggtctcatc ctcacaacca ccatggacgt cttcaagaaa ggcttctcca ttgccaggga
      121 aggcgttgtg ggtgctgtgg agaagaccaa gcagggggtg accgaggcag ctgagaagac
      181 caaggaaggg gtcatgtatg tgggcaccaa aaccaaggag aacgtggtac aaagtgtaac
      241 ctcggtggct gagaagacca aggagcaggc caatgccgtg agtgaagctg tggtcagcag
      301 cgtcaacaca gtggccacca agaccgtgga ggaggcagaa aacatcgtgg tcaccaccgg
      361 cgtagtacgc aaggaggact tggaaccccc tgcacaggac caggaggcca aagagcaaga
      421 ggagggcgaa gaggccaaga gtggaggaga ctagaaggct tccagtcaac cacagaggct
      481 caagggacac ctctctgtct tggaccctgt cccaagctgg cacactgagt gccctgccta
      541 gagtgccctg caggttgccc acattctcca ctccctagcc cagtgccaca agcctatcca
      601 agcacgcatg cacgctactg acagcgccag cgccccctgc tggctcattt taccctatgg
      661 tccttcggat caccaaccag acgctgctgt gaattttttc tttttttaat gattccaaat
      721 aaaacctgag tcctaatcca
//
