LOCUS       NM_080777               1225 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus synuclein, beta (Sncb), mRNA.
ACCESSION   NM_080777
VERSION     NM_080777.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1225)
  AUTHORS   Ramalingam,N. and Dettmer,U.
  TITLE     Temperature is a key determinant of alpha- and beta-synuclein
            membrane interactions in neurons
  JOURNAL   J Biol Chem 296, 100271 (2021)
   PUBMED   33428933
  REMARK    GeneRIF: Temperature is a key determinant of alpha- and
            beta-synuclein membrane interactions in neurons.
REFERENCE   2  (bases 1 to 1225)
  AUTHORS   Lodygin,D., Hermann,M., Schweingruber,N., Flugel-Koch,C.,
            Watanabe,T., Schlosser,C., Merlini,A., Korner,H., Chang,H.F.,
            Fischer,H.J., Reichardt,H.M., Zagrebelsky,M., Mollenhauer,B.,
            Kugler,S., Fitzner,D., Frahm,J., Stadelmann,C., Haberl,M.,
            Odoardi,F. and Flugel,A.
  TITLE     beta-Synuclein-reactive T cells induce autoimmune CNS grey matter
            degeneration
  JOURNAL   Nature 566 (7745), 503-508 (2019)
   PUBMED   30787438
  REMARK    GeneRIF: T cells directed against the neuronal protein
            beta-synuclein specifically invade the grey matter and is
            accompanied by the presentation of multifaceted clinical disease;
            findings reveal a previously unrecognized role of beta-synuclein in
            provoking T-cell-mediated pathology of the central nervous system
            Erratum:[Nature. 2019 Mar;567(7749):E15. doi:
            10.1038/s41586-019-1047-0.. PMID: 30867589]
REFERENCE   3  (bases 1 to 1225)
  AUTHORS   Brockhaus,K., Bohm,M.R.R., Melkonyan,H. and Thanos,S.
  TITLE     Age-related Beta-synuclein Alters the p53/Mdm2 Pathway and Induces
            the Apoptosis of Brain Microvascular Endothelial Cells In Vitro
  JOURNAL   Cell Transplant 27 (5), 796-813 (2018)
   PUBMED   29808713
  REMARK    GeneRIF: The aim of this study was to elucidate the age-dependent
            role of Sncb in brain microvascular endothelial cells.
REFERENCE   4  (bases 1 to 1225)
  AUTHORS   De Ricco,R., Valensin,D., Dell'Acqua,S., Casella,L., Gaggelli,E.,
            Valensin,G., Bubacco,L. and Mangani,S.
  TITLE     Differences in the binding of copper(I) to alpha- and
            beta-synuclein
  JOURNAL   Inorg Chem 54 (1), 265-272 (2015)
   PUBMED   25495902
REFERENCE   5  (bases 1 to 1225)
  AUTHORS   Vargas,K.J., Makani,S., Davis,T., Westphal,C.H., Castillo,P.E. and
            Chandra,S.S.
  TITLE     Synucleins regulate the kinetics of synaptic vesicle endocytosis
  JOURNAL   J Neurosci 34 (28), 9364-9376 (2014)
   PUBMED   25009269
REFERENCE   6  (bases 1 to 1225)
  AUTHORS   Murphy,D.D., Rueter,S.M., Trojanowski,J.Q. and Lee,V.M.
  TITLE     Synucleins are developmentally expressed, and alpha-synuclein
            regulates the size of the presynaptic vesicular pool in primary
            hippocampal neurons
  JOURNAL   J Neurosci 20 (9), 3214-3220 (2000)
   PUBMED   10777786
REFERENCE   7  (bases 1 to 1225)
  AUTHORS   Galvin,J.E., Uryu,K., Lee,V.M. and Trojanowski,J.Q.
  TITLE     Axon pathology in Parkinson's disease and Lewy body dementia
            hippocampus contains alpha-, beta-, and gamma-synuclein
  JOURNAL   Proc Natl Acad Sci U S A 96 (23), 13450-13455 (1999)
   PUBMED   10557341
REFERENCE   8  (bases 1 to 1225)
  AUTHORS   Nakajo,S., Shioda,S., Nakai,Y. and Nakaya,K.
  TITLE     Localization of phosphoneuroprotein 14 (PNP 14) and its mRNA
            expression in rat brain determined by immunocytochemistry and in
            situ hybridization
  JOURNAL   Brain Res Mol Brain Res 27 (1), 81-86 (1994)
   PUBMED   7877458
REFERENCE   9  (bases 1 to 1225)
  AUTHORS   Nakajo,S., Tsukada,K., Omata,K., Nakamura,Y. and Nakaya,K.
  TITLE     A new brain-specific 14-kDa protein is a phosphoprotein. Its
            complete amino acid sequence and evidence for phosphorylation
  JOURNAL   Eur J Biochem 217 (3), 1057-1063 (1993)
   PUBMED   8223629
REFERENCE   10 (bases 1 to 1225)
  AUTHORS   Tobe,T., Nakajo,S., Tanaka,A., Mitoya,A., Omata,K., Nakaya,K.,
            Tomita,M. and Nakamura,Y.
  TITLE     Cloning and characterization of the cDNA encoding a novel
            brain-specific 14-kDa protein
  JOURNAL   J Neurochem 59 (5), 1624-1629 (1992)
   PUBMED   1402909
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087579.1.
            
            On Oct 8, 2005 this sequence version replaced NM_080777.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087579.1, EV776731.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1225
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1225
                     /gene="Sncb"
                     /note="synuclein, beta"
                     /db_xref="GeneID:113893"
                     /db_xref="RGD:70992"
     exon            1..188
                     /gene="Sncb"
                     /inference="alignment:Splign:2.1.0"
     exon            189..318
                     /gene="Sncb"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..602
                     /gene="Sncb"
                     /note="PNP 14; phosphoneuroprotein 14"
                     /codon_start=1
                     /product="beta-synuclein"
                     /protein_id="NP_542955.2"
                     /db_xref="GeneID:113893"
                     /db_xref="RGD:70992"
                     /translation="MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKT
                     KEGVVQGVASVAEKTKEQASHLGGAVFSGAGNIAAATGLVKKEEFPTDLKPEEVAQEA
                     AEEPLIEPLMEPEGESYEDSPQEEYQEYEPEA"
     exon            319..360
                     /gene="Sncb"
                     /inference="alignment:Splign:2.1.0"
     exon            361..479
                     /gene="Sncb"
                     /inference="alignment:Splign:2.1.0"
     exon            480..569
                     /gene="Sncb"
                     /inference="alignment:Splign:2.1.0"
     exon            570..1202
                     /gene="Sncb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatcacccaa ggccggagca ctgctgcgct ccagctcagg gagggtgact caagagcctg
       61 accacggcag gaccccactg gccccgagcc cacccctacc cggcgtagcc cagccccgcg
      121 cgtctgctgg cagtagccgc cgctgccgcc accacagctc catcccccag cccggccccg
      181 aaacccaggc cgccaggatg gacgtgttca tgaagggcct gtccatggcc aaggagggcg
      241 ttgtggctgc agctgagaaa accaagcagg gggtcaccga ggcggcagag aagaccaagg
      301 aaggcgtcct ctacgtcgga agcaagacca aagagggagt ggtacaaggc gtggcctcag
      361 tggctgagaa aaccaaggag caggcatctc atctgggagg agctgtgttc tctggggctg
      421 ggaacattgc agcagccacc ggcctggtga agaaggagga gttccccaca gacctgaagc
      481 cagaggaagt ggcccaagaa gcggctgagg agcccctgat tgagcctctg atggagcctg
      541 aaggggaaag ttacgaggac tcaccccagg aggaatatca ggaatacgag ccagaggcgt
      601 aagggtccat gaggaccccg caccagcagc acaattcctt ccctgtcccc gccccattcc
      661 tcactcccca gagccagggc tgtccttata ccttttcccc caaacacgag ttcttccttc
      721 ggctccgagg cacttcctca gggcctgtgt tagtgtctgc cctgcccttc cgtctgtcct
      781 acctgcccgc gttcatccct gaggcgtgga ctagagtcgg gcagagaggt ccggctggga
      841 gccccgccct accagtgttg cccctcaccc tccatctggt ccagtgtctg ctcggatgta
      901 gcatgttcta tgtattttta aaccaagatg ggaaaactat ggctccttcc ccatcctaac
      961 agaggttctc caaggggccc ccgggcagcc ccacttcgac ccctaaaatg tttgtttttt
     1021 tttaacccaa accaggagcc aggtcgtgcc atgctccctc cctcagcccg ctcagtccaa
     1081 gcgcgggcgt cgtacgttgt gattgtggca tggagagtcc cccacccact gtgtgagcgt
     1141 gtcccgggtg ggcggccaag ccgctcccca gtgtgtccat gaataaagcc aatctgtctg
     1201 taaaaaaaaa aaaaaaaaaa aaaaa
//
